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Tuberculosis AND Brazil

Carolina Maia Martins Sales, Mauro Niskier Sanchez, Walter Ramalho, Adelmo Inácio Bertolde, Ethel Leonor Noia Maciel
INTRODUCTION: This study aimed to analyze social factors involved in the spatial distribution and under-reporting of tuberculosis (TB) in the city of Vitória, Espírito Santo State, Brazil. METHODS: This was an ecological study of the reported cases of TB between 2009 and 2011, according to census tracts. The outcome was TB incidence for the study period and the variables of exposure were proportions of literacy, inhabitants with an income of up to half the minimum monthly wage (MMW), and inhabitants associated with sewer mains or with access to safe drinking water...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
Anália Zuleika de Castro, Adriana Rezende Moreira, Jaqueline Oliveira, Paulo Albuquerque Costa, Carolyne Lalucha Alves Lima Da Graça, Mauricio de Andrade Pérez, Afrânio Kritski, Maria Claudia Vater
INTRODUCTION: The molecular test Xpert MTB/RIF (Xpert) has been recommended for use in the diagnosis of pulmonary tuberculosis (PTB); however, data on the cost of incorporating it under routine conditions in high-burden countries are scarce. The clinical impact and costs incurred in adopting the Xpert test in routine PTB diagnosis was evaluated in a prospective study conducted from November 2012 to November of 2013, in the City of Rio de Janeiro, Brazil. METHODS: The diagnostic and therapeutic cascade for TB treatment was evaluated using Xpert in the first stage (S1), and sputum smear microscopy (SSM) in the second stage (S2)...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
M B V Silveira, M A G Ferrarini, P O Viana, R C Succi, M T Terreri, B Costa-Carvalho, F Carlesse, M I de Moraes-Pinto
SETTING: As conclusive data on the performance of interferon-gamma release assays (IGRAs) in paediatric TB are lacking, many guidelines do not recommend their use for TB diagnosis in this population in Brazil. OBJECTIVE: To evaluate the performance of an IGRA by investigating its concordance with the tuberculin skin test (TST) and the role of IGRAs in clinical management and treatment outcomes in children with TB. DESIGN: A historic cohort study was used to evaluate the performance of T-SPOT®...
October 1, 2018: International Journal of Tuberculosis and Lung Disease
D M Pelissari, D C Kuhleis, P Bartholomay, D Barreira, C L P Oliveira, R S de Jesus, L A Possa, C A Jarczewski, L T Nemeth, N D de Araujo, P B L Alves, R de Souza, D Arakaki, D B Dal Molin, P Werlang, M Brouwer
SETTING: Tuberculosis (TB) remains a challenge in Brazil, particularly among prison inmates. OBJECTIVE: To assess TB prevalence by active case finding in a public prison in southern Brazil. DESIGN: Prison inmates were screened for TB using the presence of cough and chest X-ray (CXR) from October 2014 to August 2016. Presence of cough, irrespective of duration, and abnormal CXRs were further investigated using laboratory tests. RESULTS: Of 10 326 inmates screened, 196 had confirmed TB (1898/100 000 inmates screened)...
October 1, 2018: International Journal of Tuberculosis and Lung Disease
Alexandre Baumgarten, Juliana B Hilgert, Ione C Pinto, Fabiana C M Zacharias, Alexandre F Bulgarelli
BACKGROUND: Tuberculosis (TB) is still a major public health problem in many countries, including Brazil. Primary health care (PHC) services are a set of important services with infrastructure and resources to diagnose, treat, and cure several diseases, including the TB.AimThe aim of this study is to analyse aspects of the facility infrastructure of Brazilian PHC, regarding the control and treatment of TB from a countrywide perspective. METHODS: This is a cross-sectional study based on PHC services...
September 17, 2018: Primary Health Care Research & Development
Jennifer M Ross, Nathaniel J Henry, Laura A Dwyer-Lindgren, Andrea de Paula Lobo, Fatima Marinho de Souza, Molly H Biehl, Sarah E Ray, Robert C Reiner, Rebecca W Stubbs, Kirsten E Wiens, Lucas Earl, Michael J Kutz, Natalia V Bhattacharjee, Hmwe H Kyu, Mohsen Naghavi, Simon I Hay
BACKGROUND: Brazil has high burdens of tuberculosis (TB) and HIV, as previously estimated for the 26 states and the Federal District, as well as high levels of inequality in social and health indicators. We improved the geographic detail of burden estimation by modelling deaths due to TB and HIV and TB case fatality ratios for the more than 5400 municipalities in Brazil. METHODS: This ecological study used vital registration data from the national mortality information system and TB case notifications from the national communicable disease notification system from 2001 to 2015...
September 6, 2018: BMC Medicine
Maria Celeste de Freitas Quintero, Silvia Helena Figueiredo Vendramini, Maria de Lourdes Sperli Geraldes Santos, Marilene Rocha Dos Santos, Claudia Eli Gazetta, Luciano Garcia Lourenção, Zaida Aurora Sperli Geraldes Soler, Sonia Aparecida da Cruz Oliveira, Natalia Sperli Geraldes Marin Dos Santos Sasaki, Maria Amélia Zanon Ponce, Anneliese Domingues Wysocki, Lucia Marina Scatena, Tereza Cristina Scatena Villa
OBJETIVO : Evaluating access to tuberculosis diagnosis, from the perspective of patients. METHODS : Cross-sectional study with 108 tuberculosis patients. Data were collected using the brazilian instrument Primary Care Assessment Tool - PCAT-Brazil, adapted for attention to tuberculosis, including socio-economic and demographic indicators, location of diagnosis and diagnostic access tuberculosis. The analysis of the data was of frequency, average, standard deviation, confidence interval and Chi-square test...
January 2018: Revista de Salud Pública
Lucélia Guedes, Lauren Hubert Jaeger, Andersen Liryo, Claudia Rodrigues-Carvalho, Sheila Mendonça de Souza, Alena Mayo Iñiguez
Tuberculosis (TB) has been described in Native American populations prior to the arrival of European explorers, and in Brazilian populations dating from the Colonial Period. There are no studies demonstrating TB infection in native Brazilians, and the history and epidemiological scenario of TB in Brazil is still unknown. The aim of this study was to verify the presence of TB infection among the native Tenetehara-Guajajara population from Maranhão State, Brazil, 210 ± 40 years ago. A Tenetehara-Guajajara skeleton collection was submitted to paleopathological analysis, and rib bone samples (n = 17) were used for paleogenetic analysis based on Mycobacterium tuberculosis complex (MTC) targets...
2018: PloS One
Ntwali Placide Nsengiyumva, Benjamin Mappin-Kasirer, Olivia Oxlade, Mayara Bastos, Anete Trajman, Dennis Falzon, Kevin Schwartzman
Ensuring adherence and support during treatment of tuberculosis (TB) is a major public health challenge. Digital health technologies could help improve treatment outcomes. We considered their potential cost and impact on treatment for active or latent TB in Brazil.Decision analysis models simulated two adult cohorts with 1) drug-susceptible active TB, and 2) multidrug-resistant TB; and two cohorts treated with isoniazid for latent TB infection (LTBI): 1) close contacts of persons with active TB, and 2) others newly diagnosed with LTBI...
August 30, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Ana Paula Santos, Raquel da Silva Corrêa, Marcelo Ribeiro-Alves, Ana Carolina Oliveira Soares da Silva, Thiago Thomaz Mafort, Janaína Leung, Geraldo Moura Batista Pereira, Luciana Silva Rodrigues, Rogério Rufino
BACKGROUND: Pleural tuberculosis (PlTB) is the most common extrapulmonary manifestation of this infectious disease which still presents high mortality rates worldwide. Conventional diagnostic tests for PlTB register multiple limitations, including the lack of sensitivity of microbiological methods on pleural specimens and the need of invasive procedures such as pleural biopsy performance. In this scenario, the search for biological markers on pleural fluid (PF) has been the target of several studies as a strategy to overcome the limitations of PlTB diagnosis...
2018: PloS One
Rarianne Carvalho Peruhype, Fernando Mitano, Juliana Feliciati Hoffmann, Catiucia de Andrade Surniche, Pedro Fredemir Palha
OBJECTIVE: to investigate the planning pathways in the transfer of Directly Observed Treatment of tuberculosis. METHOD: a qualitative study conducted using interviews and a semi-structured guide, administered to five subjects who were among the coordinators and managers of the tuberculosis control programs, and the secretary of health of a municipality in the south of Brazil. Situational Strategic Planning and Discourse Analysis of the French matrix were the theoretical and analytical references used, respectively...
August 9, 2018: Revista Latino-americana de Enfermagem
I Takenami, C C de Oliveira, J D Petrilli, A Machado, L W Riley, S Arruda
SETTING: Salvador, Bahia, Brazil. OBJECTIVE: To evaluate the immunoglobulin (Ig)M and total IgG antibody response to cardiolipin (CL), phosphatidylcholine (PTC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and sulfatide (SL-I) as biosignatures that can be used to diagnose pulmonary tuberculosis (TB) and its applicability for monitoring the efficacy of anti-tuberculosis treatment. DESIGN: Serum samples from 37 adult pulmonary TB patients and 48 controls (16 healthy household contacts, 19 household contacts with latent tuberculous infection [LTBI] and 13 non-TB patients with lung disease) were screened using enzyme-linked immunosorbent assays (ELISAs) for IgM and total IgG against phospholipids...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
Betânia M F Nogueira, Valéria C Rolla, Kevan M Akrami, Susan M Kiene
[This corrects the article DOI: 10.1371/journal.pone.0195409.].
2018: PloS One
Andrea B V Lomonte, Sebastião C Radominski, Flora M D Marcolino, Claiton V Brenol, Cristiano A F Zerbini, Erika G García, Ermeg L Akylbekova, Ricardo Rojo, Dario Ponce de Leon
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Efficacy and safety of tofacitinib in Brazilian patients from Phase 2 (P2) and Phase 3 (P3) global studies of up to 24 months' duration were evaluated. METHODS: Data were pooled from Brazilian patients with RA and an inadequate response to conventional synthetic or biologic disease-modifying antirheumatic drugs enrolled in P2/P3 tofacitinib studies who received tofacitinib 5 or 10 mg twice daily (BID), or placebo, as monotherapy or in combination with methotrexate...
August 2018: Medicine (Baltimore)
Danielle Mann, Flávia Marinho Sant'Anna, Carolina Arana Stanis Schmaltz, Dayvison Francis Saraiva Freitas, Valeria Cavalcanti Rolla, Solange Cesar Cavalcante, Maria Clara Gutierrez-Galhardo
BACKGROUND: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported. OBJECTIVE: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. METHODS: We describe a series of 15 CTB and HIV cases, based on secondary data from 2000 to 2016. Diagnosis was based on isolation of Mycobacterium tuberculosis in culture or clinical response to anti-tuberculous treatment associated with positive smear or histopathologic findings from affected skin or an adjacent lymph node...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Regyane Ferreira Guimarães Dias, Luciana Oliveira Bento, Camila Tavares, Hélio Ranes Filho, Melisia Adelaide Cesário da Silva, Luciene Carneiro Moraes, Ana Amélia Freitas-Vilela, Marcos Lázaro Moreli, Ludimila Paula Vaz Cardoso
Knowledge about epidemiological distribution patterns of HIV infection in different geographic regions is relevant to understand the dynamics of the disease in Brazil. This study aims to characterize the epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, from 2005 to 2015. A standardized questionnaire was used to collect clinical-epidemiological, virological, and immunological data from the medical records of all HIV-infected patients (n=539) who were followed at the regional reference center of Jatai, Goias State, Brazil, from 2005 to 2015...
July 19, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Rodolfo Augusto Bacelar de Athayde, Fábio Eiji Arimura, Ronaldo Adib Kairalla, Carlos Roberto Ribeiro Carvalho, Bruno Guedes Baldi
OBJECTIVE: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the alveolar accumulation of surfactant, which is composed of proteins and lipids. PAP is caused by a deficit of macrophage activity, for which the main treatment is whole-lung lavage (WLL). We report the experience at a referral center for PAP in Brazil. METHODS: This was a retrospective study involving patients with PAP followed between 2002 and 2016. We analyzed information regarding clinical history, diagnostic methods, treatments, and outcomes, as well as data on lung function, survival, and complications...
May 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Daniele M Pelissari, Fredi A Diaz-Quijano
Background: Alcohol and illicit drugs are associated with the discontinuation of tuberculosis (TB) treatment and can compromise the immune system. We estimated the impact of alcohol disorder and the use of illicit drug on TB treatment outcomes, considering the interaction of both substances in patients from São Paulo state, Brazil. Methods: This is a retrospective cohort of patients diagnosed with TB from 2011 to 2015. We estimated the relative risk (RR) of an unsuccessful outcome associated with alcohol disorder, use of illicit drugs and their interaction using a multiple regression model...
2018: Archives of Public Health, Archives Belges de Santé Publique
Marciane Kessler, Elaine Thumé, Suele Manjourany Silva Duro, Elaine Tomasi, Fernando Carlos Vinholes Siqueira, Denise Silva Silveira, Bruno Pereira Nunes, Pâmela Moraes Volz, Amanda Amaral Dos Santos, Sandra Mattos França, Janaina Duarte Bender, Tamires Piccinini, Luiz Augusto Facchini
OBJETIVO: to investigate the provision of health education and promotion actions in primary care, and their association with demographic characteristics and Family Health Strategy (FHS) coverage in Rio Grande do Sul state, Brazil. METHODS: this is a cross-sectional study conducted with 816 teams that adhered to the 2012 Primary Care Access and Quality Improvement Program. RESULTS: the most frequent actions were directed towards people with diabetes (91...
June 28, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
D T Santos, C Nunes, L S Alves, A A R Queiroz, M J Miranda, L H Arroyo, M Yamamura, A S Belchior, M P Popolin, M A M Arcoverde, T Z Berra, A C V Ramos, I C Pinto, P F Palha, B M A Gabardo, E M Dessunti, R A Arcêncio
The goal of this study was to analyse the spatial pattern of tuberculosis (TB) mortality using different approaches, namely: mortality rates (MR), spatial relative risks (RR) and Bayesian rates (Global and Local) and their association with human development index (HDI), Global and its three dimensions: education, longevity and income. An ecological study was developed in Curitiba, Brazil based on data from Mortality Information System (2008-2014). Spatial scan statistics were used to compute RR and identify high-risk clusters...
October 2018: Epidemiology and Infection
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