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Tuberculosis AND Brazil

Rarianne Carvalho Peruhype, Fernando Mitano, Juliana Feliciati Hoffmann, Catiucia de Andrade Surniche, Pedro Fredemir Palha
OBJECTIVE: to investigate the planning pathways in the transfer of Directly Observed Treatment of tuberculosis. METHOD: a qualitative study conducted using interviews and a semi-structured guide, administered to five subjects who were among the coordinators and managers of the tuberculosis control programs, and the secretary of health of a municipality in the south of Brazil. Situational Strategic Planning and Discourse Analysis of the French matrix were the theoretical and analytical references used, respectively...
August 9, 2018: Revista Latino-americana de Enfermagem
I Takenami, C C de Oliveira, J D Petrilli, A Machado, L W Riley, S Arruda
SETTING: Salvador, Bahia, Brazil. OBJECTIVE: To evaluate the immunoglobulin (Ig)M and total IgG antibody response to cardiolipin (CL), phosphatidylcholine (PTC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and sulfatide (SL-I) as biosignatures that can be used to diagnose pulmonary tuberculosis (TB) and its applicability for monitoring the efficacy of anti-tuberculosis treatment. DESIGN: Serum samples from 37 adult pulmonary TB patients and 48 controls (16 healthy household contacts, 19 household contacts with latent tuberculous infection [LTBI] and 13 non-TB patients with lung disease) were screened using enzyme-linked immunosorbent assays (ELISAs) for IgM and total IgG against phospholipids...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
Betânia M F Nogueira, Valéria C Rolla, Kevan M Akrami, Susan M Kiene
[This corrects the article DOI: 10.1371/journal.pone.0195409.].
2018: PloS One
Andrea B V Lomonte, Sebastião C Radominski, Flora M D Marcolino, Claiton V Brenol, Cristiano A F Zerbini, Erika G García, Ermeg L Akylbekova, Ricardo Rojo, Dario Ponce de Leon
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Efficacy and safety of tofacitinib in Brazilian patients from Phase 2 (P2) and Phase 3 (P3) global studies of up to 24 months' duration were evaluated. METHODS: Data were pooled from Brazilian patients with RA and an inadequate response to conventional synthetic or biologic disease-modifying antirheumatic drugs enrolled in P2/P3 tofacitinib studies who received tofacitinib 5 or 10 mg twice daily (BID), or placebo, as monotherapy or in combination with methotrexate...
August 2018: Medicine (Baltimore)
Danielle Mann, Flávia Marinho Sant'Anna, Carolina Arana Stanis Schmaltz, Dayvison Francis Saraiva Freitas, Valeria Cavalcanti Rolla, Solange Cesar Cavalcante, Maria Clara Gutierrez-Galhardo
BACKGROUND: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported. OBJECTIVE: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. METHODS: We describe a series of 15 CTB and HIV cases, based on secondary data from 2000 to 2016. Diagnosis was based on isolation of Mycobacterium tuberculosis in culture or clinical response to anti-tuberculous treatment associated with positive smear or histopathologic findings from affected skin or an adjacent lymph node...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Regyane Ferreira Guimarães Dias, Luciana Oliveira Bento, Camila Tavares, Hélio Ranes Filho, Melisia Adelaide Cesário da Silva, Luciene Carneiro Moraes, Ana Amélia Freitas-Vilela, Marcos Lázaro Moreli, Ludimila Paula Vaz Cardoso
Knowledge about epidemiological distribution patterns of HIV infection in different geographic regions is relevant to understand the dynamics of the disease in Brazil. This study aims to characterize the epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, from 2005 to 2015. A standardized questionnaire was used to collect clinical-epidemiological, virological, and immunological data from the medical records of all HIV-infected patients (n=539) who were followed at the regional reference center of Jatai, Goias State, Brazil, from 2005 to 2015...
July 19, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Rodolfo Augusto Bacelar de Athayde, Fábio Eiji Arimura, Ronaldo Adib Kairalla, Carlos Roberto Ribeiro Carvalho, Bruno Guedes Baldi
OBJECTIVE: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the alveolar accumulation of surfactant, which is composed of proteins and lipids. PAP is caused by a deficit of macrophage activity, for which the main treatment is whole-lung lavage (WLL). We report the experience at a referral center for PAP in Brazil. METHODS: This was a retrospective study involving patients with PAP followed between 2002 and 2016. We analyzed information regarding clinical history, diagnostic methods, treatments, and outcomes, as well as data on lung function, survival, and complications...
May 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Daniele M Pelissari, Fredi A Diaz-Quijano
Background: Alcohol and illicit drugs are associated with the discontinuation of tuberculosis (TB) treatment and can compromise the immune system. We estimated the impact of alcohol disorder and the use of illicit drug on TB treatment outcomes, considering the interaction of both substances in patients from São Paulo state, Brazil. Methods: This is a retrospective cohort of patients diagnosed with TB from 2011 to 2015. We estimated the relative risk (RR) of an unsuccessful outcome associated with alcohol disorder, use of illicit drugs and their interaction using a multiple regression model...
2018: Archives of Public Health, Archives Belges de Santé Publique
Marciane Kessler, Elaine Thumé, Suele Manjourany Silva Duro, Elaine Tomasi, Fernando Carlos Vinholes Siqueira, Denise Silva Silveira, Bruno Pereira Nunes, Pâmela Moraes Volz, Amanda Amaral Dos Santos, Sandra Mattos França, Janaina Duarte Bender, Tamires Piccinini, Luiz Augusto Facchini
OBJETIVO: to investigate the provision of health education and promotion actions in primary care, and their association with demographic characteristics and Family Health Strategy (FHS) coverage in Rio Grande do Sul state, Brazil. METHODS: this is a cross-sectional study conducted with 816 teams that adhered to the 2012 Primary Care Access and Quality Improvement Program. RESULTS: the most frequent actions were directed towards people with diabetes (91...
June 28, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
D T Santos, C Nunes, L S Alves, A A R Queiroz, M J Miranda, L H Arroyo, M Yamamura, A S Belchior, M P Popolin, M A M Arcoverde, T Z Berra, A C V Ramos, I C Pinto, P F Palha, B M A Gabardo, E M Dessunti, R A Arcêncio
The goal of this study was to analyse the spatial pattern of tuberculosis (TB) mortality using different approaches, namely: mortality rates (MR), spatial relative risks (RR) and Bayesian rates (Global and Local) and their association with human development index (HDI), Global and its three dimensions: education, longevity and income. An ecological study was developed in Curitiba, Brazil based on data from Mortality Information System (2008-2014). Spatial scan statistics were used to compute RR and identify high-risk clusters...
July 11, 2018: Epidemiology and Infection
Raphaela Honorato Barletta-Naveca, Felipe Gomes Naveca, Vanessa Alves de Almeida, Jorge Ivan Rebelo Porto, George Allan Villarouco da Silva, Mauricio Morishi Ogusku, Aya Sadahiro, Rajendranath Ramasawmy, Antonio Luiz Boechat
Tuberculosis (TB), caused by mycobacterial species of the Mycobacterium tuberculosis complex, is a serious global health issue. Brazil is among the 22 countries with the highest number of TB cases, and the state of Amazonas has the highest incidence of TB cases in the country. Toll-like receptors (TLRs) are important pattern recognition receptors of the innate immunity and play a key role in orchestrating an effective immune response. We investigated whether the single-nucleotide polymorphisms (SNPs) 1805T/G TLR1 , 2258G/A TLR2 , 896A/G and 1196C/T of TLR4 , 745T/C TLR6 , and -1237A/G and -1486A/G of TLR9 are associated with the predisposition to TB and/or bacillary load...
2018: Frontiers in Immunology
Fabiana Cristina Fulco Santos, Laís Ariane de Siqueira Lira, Rosana de Albuquerque Montenegro, Juliana Figueirêdo da Costa Lima, Andrea Santos Lima, Haiana Charifker Schindler, Lílian Maria Lapa Montenegro
INTRODUCTION: This study evaluated the performance of the IS6110-TaqMan® assay in different types of biological samples and tissues for laboratory diagnosis of extrapulmonary tuberculosis. METHODS: 143 biological samples and tissues from patients with suspected extrapulmonary tuberculosis from the health services of Recife/Pernambuco/Brazil were evaluated with the IS6110-TaqMan® assay. RESULTS: The sensitivities of the IS6110-TaqMan® assay calculated for blood, urine, both blood and urine samples, tissue biopsies, extrapulmonary body fluid samples, and all samples from patients calculated together were 55...
May 2018: Revista da Sociedade Brasileira de Medicina Tropical
Eunice Atsuko Totumi Cunha, Marli Marques, Maria do Socorro Nantua Evangelista, Maurício Antonio Pompilio, Renata Terumi Shiguematsu Yassuda, Albert Schiaveto de Souza
INTRODUCTION: High endemic levels of pulmonary tuberculosis in prisons result from overcrowding, limited access to healthcare, delayed diagnosis, sustained transmission owing to poor control measures, and multidrug resistance. This study evaluated locally implemented measures for early pulmonary tuberculosis diagnosis and evaluated resistance to anti-tuberculosis drugs. METHODS: This transversal study employed data from the Mato Grosso do Sul State Tuberculosis Control Program obtained from 35 correctional facilities in 16 counties for 2 periods (2007-2010 and 2011-2014)...
May 2018: Revista da Sociedade Brasileira de Medicina Tropical
Ethel Leonor Noia Maciel, Carolina Maia Martins Sales, Adelmo Inácio Bertolde, Barbara Reis-Santos
No abstract text is available yet for this article.
July 2, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Sandra Maria do Valle Leone de Oliveira, Elizeu Ferreira da Silva, Ana Rita Coimbra Motta-Castro, Vivianne de Oliveira Landgraf de Castro, Andréa Cristina Stábile, Anamaria Mello Miranda Paniago, Anete Trajman
BACKGROUND: WHO recommends treatment for latent tuberculosis infection (LTBI) in the homeless and people who use drugs (PWUD). The optimal test for LTBI screening is uncertain. METHODS: A cross-sectional study was conducted among the homeless and drug-rehabilitation clinic clients chronically using crack in Western Brazil. Participants were interviewed and offered HIV testing plus tuberculin skin testing (TST) and QuantiFeron®-Gold-in-Tube (QFT). We considered LTBI when either TST or QFT were positive...
June 29, 2018: International Journal on Drug Policy
Maria do Socorro Nantua Evangelista, Rosalia Maia, João Paulo Toledo, Ricardo Gadelha de Abreu, José Uereles Braga, Draurio Barreira, Anete Trajman
OBJECTIVE: The value of sputum smear microscopy (SSM) after 2 months of treatment in the management of pulmonary tuberculosis is controversial. We analysed second month-SSM conversion as a predictor of treatment success in Brazil. RESULTS: Overall successful outcome rate was 89.4%. The predictive value of second month-SSM conversion for successful outcomes was 85.2% 72,479/85,118), while the predictive value of non-conversion for unfavourable outcomes was 26.9% (2712/10,071)...
June 28, 2018: BMC Research Notes
Anete Trajman, Valeria Saraceni, Betina Durovni
No abstract text is available yet for this article.
June 21, 2018: Cadernos de Saúde Pública
Marcos Augusto Moraes Arcoverde, Thais Zamboni Berra, Luana Seles Alves, Danielle Talita Dos Santos, Aylana de Sousa Belchior, Antônio Carlos Vieira Ramos, Luiz Henrique Arroyo, Ivaneliza Simionato de Assis, Josilene Dália Alves, Ana Angélica Rêgo de Queiroz, Mellina Yamamura, Pedro Fredemir Palha, Francisco Chiaravalloti Neto, Reinaldo Antonio Silva-Sobrinho, Oscar Kenji Nihei, Ricardo Alexandre Arcêncio
BACKGROUND: The World Health Organization (WHO) launched the "End TB Strategy", which aims to reduce tuberculosis (TB) mortality by 95% by 2035, Brazil has made a commitment to this, however, one challenge is achieving the goal in the border region, where the TB situation is more critical. The proposal was to analyse the spatial mortality due to TB and its socio-economic determinants in the general population, around the border areas of Brazil, Paraguay and Argentina, as well as the temporal trend in this region...
June 26, 2018: BMC Public Health
Vaidehi Nafade, Madlen Nash, Sophie Huddart, Tripti Pande, Nebiat Gebreselassie, Christian Lienhardt, Madhukar Pai
BACKGROUND: Tuberculosis (TB) research is a key component of the End TB Strategy. To track research output, we conducted a bibliometric analysis of TB research from the past decade. METHODS: The Web of Science database was searched for publications from January 2007 to December 2016 with "tuberculosis" in the title. References were analysed using the R bibliometrix package. A year-stratified 5% random subset was drawn to extract funding sources and identify research areas...
2018: PloS One
Marcio Roberto Silva, Adalgiza da Silva Rocha, Flábio Ribeiro Araújo, Antônio Augusto Fonseca-Júnior, Andrea Padilha de Alencar, Philip Noel Suffys, Ronaldo Rodrigues da Costa, Maria Aparecida Scatamburlo Moreira, Mark Drew Crosland Guimarães
BACKGROUND: The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study. OBJECTIVE: The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes...
June 11, 2018: Memórias do Instituto Oswaldo Cruz
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