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Holistic cancer treatment

Shinjini Ganguly, Ayan Chandra, Indu B Chatterjee
Urothelial cancer of the renal pelvis (CRP) is predominantly associated with cigarette smoking. However, the molecular pathogenesis of initiation and progression of cigarette smoke (CS)-induced CRP is unknown. Majority of CRP is high grade and high stage at presentation and has a high recurrence rate even after surgery. Earlier we reported that prolonged treatment (24 weeks) of a guinea pig model with p-benzoquinone (p-BQ), a product of CS in vivo, produced carcinoma in situ in the renal pelvis, a noninvasive cancer...
2018: Toxicology Reports
Dolors Mateo-Ortega, Joaquín T Limonero, Jorge Maté-Méndez, Elba Beas, Jesús González-Barboteo, Elisabeth Barbero, Sara Ela, Xavier Gómez-Batiste
OBJECTIVE: The goal of this study is to describe the development of a new tool, the Psychosocial and Spiritual Needs Evaluation scale Instrumento de Evaluación de Necesidades Psicosociales y Espirituales del Enfermo al Final de Vida (ENP-E), designed to assess the psychosocial needs of end-of-life (EOL) patients. And, secondarily, to describe the face validity and psychometric properties of this instrument in the Spanish-speaking context. METHOD: The scale was developed through a seven-stage process: (1) literature review; (2) expert panel establishment; (3) discussion and agreement on the most relevant dimensions of psychosocial care; (4) description of key indicators and consensus-based questions to evaluate such dimensions; (5) assessment of the scale by external palliative care (PC) professionals; (6) evaluation by patients; and (7) analysis of scale's psychometrics properties...
October 16, 2018: Palliative & Supportive Care
Sarah Lea, Ana Martins, Sue Morgan, Jamie Cargill, Rachel M Taylor, Lorna A Fern
Purpose: The Internet is a fully integrated part of young people's life and it is pivotal that online resources are developed to maximize the potential of the Internet to support those living with and beyond cancer. We sought to understand how young people with a cancer diagnosis use the Internet and to what extent information and support needs are met by existing online resources. Patients and methods: This was a participatory action research study involving 21 young people participating in workshops and individual interviews...
2018: Adolescent Health, Medicine and Therapeutics
Marta Qualizza, Valentina Bressan, Antonio Rizzuto, Simone Stevanin, Giampiera Bulfone, Lucia Cadorin, Luca Ghirotto
The aim was to conduct a systematic review and a meta-synthesis of primary qualitative studies exploring experiences of head and neck cancer patients (HNC) undergoing radio and/or chemotherapy, in order to provide a better understanding of this phenomenon and supply new directions for care and clinical practice. Six databases were systematically searched, and 13 studies were included. The meta-synthesis methodology was adopted to conceptualise the way in which patients lived their cancer journey and the impact of treatments on their daily life...
October 4, 2018: European Journal of Cancer Care
Md Serajul Islam
Haematological malignancies can have devastating effects on the patients' physical, emotional, psycho-sexual, educational and economic health. With the improvement of therapies patients with these malignancies are living longer, however significant proportion these patient show poor quality of life (QoL) due to various physical and psychological consequences of the disease and the treatments. Health-related QoL (HRQoL) is multi-dimensional and temporal, relating to a state of functional, physical, psychological and social/family well-being...
July 4, 2018: Oncology Reviews
Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray, Yvonne L Hauck
BACKGROUND: Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with gynaecological cancer are not being met and provision of holistic care is a priority area for action. Knowledge on gynaecological cancer supportive care needs is limited, specifically comparison of needs and cancer gynaecological subtype. Our aim was to identify supportive care needs of Western Australian women experiencing gynaecological cancer, their satisfaction with help and explore associations between participant's demographic characteristics and identified needs...
September 21, 2018: BMC Cancer
Gunver S Kienle, Milena Mussler, Dieter Fuchs, Helmut Kiene
BACKGROUND: Integrative cancer care (ICC) is used by approximately 50% of cancer patients to complement oncologic treatments and to address unmet needs. One ICC practice is anthroposophic medicine, integrating conventional and complementary cancer care. It specifically provides mistletoe therapy (MT), but also intensive counselling, natural remedies, creative and movement therapies, nursing procedures, nutrition, and others. The objective of this study was to explore perceptions, themes, goals, procedures, and observations of experienced AM doctors with regard to the subjective dimensions of ICC...
August 1, 2018: Explore: the Journal of Science and Healing
Christina Signorelli, Claire E Wakefield, Joanna E Fardell, Tali Foreman, Karen A Johnston, Jon Emery, Elysia Thornton-Benko, Afaf Girgis, Hanne C Lie, Richard J Cohn
BACKGROUND: Primary care physicians (PCPs) are well placed to provide holistic care to survivors of childhood cancer and may relieve growing pressures on specialist-led follow-up. We evaluated PCPs' role and confidence in providing follow-up care to survivors of childhood cancer. SUBJECTS, MATERIALS, AND METHODS: In Stage 1, survivors and parents (of young survivors) from 11 Australian and New Zealand hospitals completed interviews about their PCPs' role in their follow-up...
August 31, 2018: Oncologist
Prashanth Panta, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
Oral submucous fibrosis (OSF) is an oral potentially malignant disorder (OPMD) associated with prolonged betel-quid (BQ) use. It affects both physiological and psychological dimensions, leading to a significant morbidity. Some challenges in OSF research include: Assessment and correction of: (i) Quality of life, (ii) burning sensation, and (iii) nutritional deficiency. There are numerous medical treatments for OSF, but most of them fail to offer complete rehabilitation. This is because some underpinnings of this condition like "mental factors" that contribute to habit continuation at root level, "poor quality of life," and "nutritional deficiencies" are still uncorrected...
August 1, 2018: Journal of Contemporary Dental Practice
Catharyn Stern, Franca Agresta
With improved survival rates from cancer, young people can expect to lead a normal life, including having their own children. However, cancer or other serious disease itself, and more often its treatment, often leads to a significant reduction in fertility or premature gonadal insufficiency. There is increasing acknowledgement for the importance of fertility preservation (FP) options to be discussed and offered to young people whose fertility is at risk, ideally before the gonadotoxic therapy begins. FP options currently include oocyte, embryo and ovarian tissue cryopreservation; ovarian protection during chemotherapy and semen, sperm and testicular tissue cryopreservation...
August 1, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Sarah B Garrett, Corey M Abramson, Katharine A Rendle, Daniel Dohan
PURPOSE: The treatment decisions of melanoma patients are poorly understood. Most research on cancer patient decision-making focuses on limited components of specific treatment decisions. This study aimed to holistically characterize late-stage melanoma patients' approaches to treatment decision-making in order to advance understanding of patient influences and supports. METHODS: (1) Exploratory analysis of longitudinal qualitative data to identify themes that characterize patient decision-making...
August 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Cristian P Moiola, Carlos Lopez-Gil, Silvia Cabrera, Angel Garcia, Tom Van Nyen, Daniela Annibali, Tina Fonnes, August Vidal, Alberto Villanueva, Xavier Matias-Guiu, Camilla Krakstad, Frédéric Amant, Antonio Gil-Moreno, Eva Colas
Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with histological observations, reliably improves EC classification and enhances patient management. Patient-derived xenograft models (PDX) represent nowadays a promising tool for translational research, since they closely resemble patient tumour features and retain molecular and histological features...
August 17, 2018: International Journal of Molecular Sciences
Nikhil Chakravarty, Caitlyn Kellogg, Jason Alvarez, Ozlem Equils, Margie Morgan
Exposure to various types of ultraviolet (UV) radiation from the sun has been linked to skin cancer. Use of sunscreen can reduce the damaging and carcinogenic effects of UV radiation. However, multiple chemicals in sunscreen can trigger allergic responses, making people less inclined to use sunscreen. Thus, finding natural, plant-based alternatives to sunscreen with similar efficacy has become an important area of research. Myrrh oil, extracted from the shrub Commiphora myrrha, has been used in the treatment of topical wounds and studies have shown that it may provide protection against solar radiation...
August 1, 2018: Journal of Drugs in Dermatology: JDD
Sathyaraj Venkatesan, Sweetha Saji
Effective doctor patient relationships are predicated on doctors' relational engagement and affective/holistic communication with the patients. On the contrary, the contemporary healthcare and patient-clinician communication are at odds with the desirable professional goals, often resulting in dehumanization and demoralization of patients. Besides denigrating the moral agency of a patient such apathetic interactions and unprofessional approach also affect the treatment and well-being of the sufferer. Foregrounding multifaceted doctor-patient relationships, graphic pathographies are a significant cultural resource which recreate the embodied moment of clinical encounters as they also lay bare qualitative tensions between patient' illness experience with doctor's professional understanding of the same...
August 17, 2018: Journal of Medical Humanities
Austyn Snowden, Jenny Young, Jan Savinc
BACKGROUND: It is increasingly internationally recognized that a cancer diagnosis impacts on people practically and financially as well as physically and psychologically. It is less clear what to do about this. This study introduces an original community service designed to mitigate this wider impact. Nonclinical "link officers" use holistic needs assessment (HNA) to help newly diagnosed people identify and quantify the severity of their physical, psychological, practical, financial, and social concerns...
September 2018: Cancer Medicine
Margaret M Haigh, Siddhartha Baxi, Marilyn Lyford, Shelley Cheetham, Sandra C Thompson
This paper examines the supportive care in place to meet the needs of patients receiving radiotherapy at a regional oncology service in Bunbury, Western Australia. Semi-structured in-depth interviews with 21 service providers and 17 adults diagnosed with cancer who underwent radiotherapy at the Service were recorded, transcribed and analysed thematically. Key themes relevant were co-operation and collaboration of interdisciplinary team members; support from organisations to assist with accommodation, transport, emotional support and provision of practical assistance, as well as barriers to accessing support...
August 7, 2018: European Journal of Cancer Care
Gaurav Narula, Maya Prasad, Shalini Jatia, Papagudi G Subramanian, Nikhil Patkar, Prashant Tembhare, Dhanlaxmi Shetty, Nehal Khanna, Siddharth Laskar, Tanuja Shet, Sridhar Epari, Seema Kembhavi, Sneha Shah, Sajid Qureshi, Sumeet Gujral, Shripad D Banavali
INTRODUCTION: The Pediatric Hematolymphoid Disease Management Group (PHL-DMG) at a tertiary cancer care hospital developed extensive patient support programs to improve retention and outcomes while focusing on protocols adapted to meet patient needs. An audit of measures and outcomes was done for a 7-year period from January 2010 to December 2016. MATERIALS AND METHODS: DMG protocols and patient support activities over the study period were documented and audited...
October 2017: Indian Journal of Cancer
Eric H Nguyen, William L Murphy
The inhibition of angiogenesis is a critical element of cancer therapy, as cancer vasculature contributes to tumor expansion. While numerous drugs have proven to be effective at disrupting cancer vasculature, patient survival has not significantly improved as a result of anti-angiogenic drug treatment. Emerging evidence suggests that this is due to a combination of unintended side effects resulting from the application of anti-angiogenic compounds, including angiogenic rebound after treatment and the activation of metastasis in the tumor...
October 2018: Biomaterials
Anu Viitala, Marita Saukkonen, Juho T Lehto, Mira Palonen, Päivi Åstedt-Kurki
The purposes of this study were to describe the coping processes and support needs of patients with incurable cancer. The study was conducted as a qualitative study. The research data were gathered by conducting thematic interviews with outpatients with incurable cancer (n = 16) and analyzed by means of inductive content analysis. The results of the study indicate that the lives of patients were temporarily interrupted by the incurable illness. A sympathetic family was perceived as strength, and after the initial shock, the patients began to rebuild their lives...
April 2018: Journal of Hospice and Palliative Nursing: JHPN
Takayuki Aoki, Yoshihide Ota, Takatsugu Suzuki, Yuya Denda, Ken-Ichi Aoyama, Takeshi Akiba, Mariko Naito, Toshihiro Arai
BACKGROUND: There are few quality of life (QOL) studies that have focused on the experiences of oral cancer patients. Therefore, the present study aimed to investigate how the QOL for patients with oral cancer changed perioperatively. METHODS: Eighty-three participants undergoing radical therapy completed assessments of QOL at pre-treatment, treatment completion, and 1-, 3-, and 6-months post-treatment. The Japanese version of the FACT-H&N, comprising the subscales of "physical well-being (PWB)," "social/family well-being (SWB)," "emotional well-being (EWB)," "functional well-being (FWB)," and "additional head- and neck-specific concerns(HN)" was used to assess QOL...
July 25, 2018: International Journal of Clinical Oncology
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