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Holistic cancer treatment

Ning Li, Yong-Wei Tian, Yue Xu, Dan-Dan Meng, Ling Gao, Wen-Jie Shen, Zong-Lan Liu, Zhi-Qiao Xu
To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with radiochemotherapy) and the control group (45 cases, radiochemotherapy) by a randomized non-blind method. Comparisons of therapeutic efficacies, immune functions, life qualities and survival rates were analyzed between the two groups...
December 3, 2018: Pathology Oncology Research: POR
Sarah Lea, Rachel M Taylor, Ana Martins, Lorna A Fern, Jeremy S Whelan, Faith Gibson
Purpose: Teenage and young adult cancer care in England is centralized around 13 principal treatment centers, alongside linked "designated" hospitals, following recommendations that this population should have access to age-appropriate care. The term age-appropriate care has not yet been defined; it is however the explicit term used when communicating the nature of specialist care. The aim of this study was to develop an evidence-based, contextually relevant and operational model defining age-appropriate care for teenagers and young adults with cancer...
2018: Adolescent Health, Medicine and Therapeutics
Jiahui Zheng, Min Wu, Haiyan Wang, Shasha Li, Xin Wang, Yan Li, Dong Wang, Shao Li
Health-strengthening ( Fu-Zheng ) herbs is a representative type of traditional Chinese medicine (TCM) widely used for cancer treatment in China, which is in contrast to pathogen eliminating ( Qu-Xie ) herbs. However, the commonness in the biological basis of health-strengthening herbs remains to be holistically elucidated. In this study, an innovative high-throughput research strategy integrating computational and experimental methods of network pharmacology was proposed, and 22 health-strengthening herbs were selected for the investigation...
November 21, 2018: Cancers
Ragnhild J Tveit Sekse, Gail Dunberger, Mette Linnet Olesen, Maria Østerbye, Lene Seibaek
AIM AND OBJECTIVES: To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. BACKGROUND: While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalization has become shorter in relation to treatment. This has increased the need for follow-up and rehabilitation. DESIGN: Integrative literature review using the Equator PRISMA guidelines...
November 21, 2018: Journal of Clinical Nursing
Christiane Hildebrandt, Hanna Mayer, Antje Koller
OBJECTIVE: The purpose of this meta-synthesis was to explore the experience of living with symptoms caused by colorectal cancer (CRC) and its treatment from the perspectives of those affected. METHODS: In a systematic search of qualitative studies published up to September 2017, seventeen relevant papers were identified. The meta-ethnography followed the approach developed by Noblit and Hare. To relate key themes from one paper to similar themes of different papers, a 'reciprocal translation' was carried out...
November 17, 2018: Psycho-oncology
Gary Mitchell, Sam Porter, Elizabeth Manias
BACKGROUND: Healthcare professionals are encouraged to promote concordance, a shared agreement about prescription and administration of medications, in their communication with patients. However, there is a paucity of research regarding the impact of communication about self-administered oral chemotherapy. The aim of this study was to examine the changing dynamics of communication through the patient journey from diagnosis of colorectal cancer to post treatment of chemotherapy. METHODS: Over 60 hours of observational data were digitally recorded from interactions between 15 healthcare professionals, 8 patients with colorectal cancer prescribed Capecitabine and 11 family members over a six-month period in outpatient departments within one hospital in the United Kingdom...
November 16, 2018: Psycho-oncology
R Srinivas, Ajit Pratap Singh, Ayush Aman Gupta, Piyush Kumar
Global scarcity of freshwater has been gearing towards an unsustainable river basin management and corresponding services to the humans. It needs a holistic approach, which exclusively focuses on effective river water quality monitoring and quantification and identification of pollutant sources, in order to address the issue of sustainability. These days, rivers are heavily contaminated due to the presence of organic and metallic pollutants released from several anthropogenic sources, such as industrial effluents, domestic sewage, and agricultural runoff...
November 14, 2018: Environmental Monitoring and Assessment
Ming Yang, Jialei Chen, Liwen Xu, Xiufeng Shi, Xin Zhou, Rui An, Xinhong Wang
Ban-Xia-Xie-Xin-Tang (BXXXT) is a classical formula from Shang-Han-Lun which is one of the earliest books of TCM clinical practice. In this work, we investigated the therapeutic mechanisms of BXXXT for the treatment of multiple diseases using a network pharmacology approach. Here three BXXXT representative diseases (colitis, diabetes mellitus, and gastric cancer) were discussed, and we focus on in silico methods that integrate drug-likeness screening, target prioritizing, and multilayer network extending. A total of 140 core targets and 72 representative compounds were finally identified to elucidate the pharmacology of BXXXT formula...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Beste Turanli, Kubra Karagoz, Gizem Gulfidan, Raghu Sinha, Adil Mardinoglu, Kazim Yalcin Arga
A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system...
November 5, 2018: Current Pharmaceutical Design
Georgi Georgievski, Wendy Shama, Sonia Lucchetta, Mark Niepage
RESEARCH APPROACH: Photovoice, a participatory action research methodology, is a novel and promising intervention for adolescents with cancer. Photovoice was used as an intervention for eliciting and addressing the psychosocial needs of adolescents on active cancer treatment. PARTICIPANTS: Six adolescents, aged thirteen to seventeen years old, who were on active treatment or had completed treatment in the three months prior to recruitment participated in a seven-week photovoice group that took place from March to May 2017...
October 29, 2018: Journal of Psychosocial Oncology
Xianxiong Ma, Ruikang Tao, Lei Li, Hengyu Chen, Zongtao Liu, Jie Bai, Xiaoming Shuai, Chuanqing Wu, Kaixiong Tao
miRNA‑gene axes have been reported to serve an important role in the carcinogenesis of pancreatic cancer (PC). The aim of the present study was to systematically identity the microRNA signature and hub molecules, as well as hub miRNA‑gene axes, and to explore the potential biomarkers and mechanisms associated with the carcinogenesis of PC. Eleven microRNA profile datasets were obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) and ArrayExpress databases, and a meta‑analysis was performed to identify the differentially expressed miRNAs (DEMs) between tumor tissue and normal tissue...
October 24, 2018: Oncology Reports
Shinjini Ganguly, Ayan Chandra, Indu B Chatterjee
Urothelial cancer of the renal pelvis (CRP) is predominantly associated with cigarette smoking. However, the molecular pathogenesis of initiation and progression of cigarette smoke (CS)-induced CRP is unknown. Majority of CRP is high grade and high stage at presentation and has a high recurrence rate even after surgery. Earlier we reported that prolonged treatment (24 weeks) of a guinea pig model with p-benzoquinone (p-BQ), a product of CS in vivo, produced carcinoma in situ in the renal pelvis, a noninvasive cancer...
2018: Toxicology Reports
Dolors Mateo-Ortega, Joaquín T Limonero, Jorge Maté-Méndez, Elba Beas, Jesús González-Barboteo, Elisabeth Barbero, Sara Ela, Xavier Gómez-Batiste
OBJECTIVE: The goal of this study is to describe the development of a new tool, the Psychosocial and Spiritual Needs Evaluation scale Instrumento de Evaluación de Necesidades Psicosociales y Espirituales del Enfermo al Final de Vida (ENP-E), designed to assess the psychosocial needs of end-of-life (EOL) patients. And, secondarily, to describe the face validity and psychometric properties of this instrument in the Spanish-speaking context. METHOD: The scale was developed through a seven-stage process: (1) literature review; (2) expert panel establishment; (3) discussion and agreement on the most relevant dimensions of psychosocial care; (4) description of key indicators and consensus-based questions to evaluate such dimensions; (5) assessment of the scale by external palliative care (PC) professionals; (6) evaluation by patients; and (7) analysis of scale's psychometrics properties...
October 16, 2018: Palliative & Supportive Care
Sarah Lea, Ana Martins, Sue Morgan, Jamie Cargill, Rachel M Taylor, Lorna A Fern
Purpose: The Internet is a fully integrated part of young people's life and it is pivotal that online resources are developed to maximize the potential of the Internet to support those living with and beyond cancer. We sought to understand how young people with a cancer diagnosis use the Internet and to what extent information and support needs are met by existing online resources. Patients and methods: This was a participatory action research study involving 21 young people participating in workshops and individual interviews...
2018: Adolescent Health, Medicine and Therapeutics
Marta Qualizza, Valentina Bressan, Antonio Rizzuto, Simone Stevanin, Giampiera Bulfone, Lucia Cadorin, Luca Ghirotto
The aim was to conduct a systematic review and a meta-synthesis of primary qualitative studies exploring experiences of head and neck cancer patients (HNC) undergoing radio and/or chemotherapy, in order to provide a better understanding of this phenomenon and supply new directions for care and clinical practice. Six databases were systematically searched, and 13 studies were included. The meta-synthesis methodology was adopted to conceptualise the way in which patients lived their cancer journey and the impact of treatments on their daily life...
October 4, 2018: European Journal of Cancer Care
Md Serajul Islam
Haematological malignancies can have devastating effects on the patients' physical, emotional, psycho-sexual, educational and economic health. With the improvement of therapies patients with these malignancies are living longer, however significant proportion these patient show poor quality of life (QoL) due to various physical and psychological consequences of the disease and the treatments. Health-related QoL (HRQoL) is multi-dimensional and temporal, relating to a state of functional, physical, psychological and social/family well-being...
July 4, 2018: Oncology Reviews
Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray, Yvonne L Hauck
BACKGROUND: Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with gynaecological cancer are not being met and provision of holistic care is a priority area for action. Knowledge on gynaecological cancer supportive care needs is limited, specifically comparison of needs and cancer gynaecological subtype. Our aim was to identify supportive care needs of Western Australian women experiencing gynaecological cancer, their satisfaction with help and explore associations between participant's demographic characteristics and identified needs...
September 21, 2018: BMC Cancer
Gunver S Kienle, Milena Mussler, Dieter Fuchs, Helmut Kiene
BACKGROUND: Integrative cancer care (ICC) is used by approximately 50% of cancer patients to complement oncologic treatments and to address unmet needs. One ICC practice is anthroposophic medicine, integrating conventional and complementary cancer care. It specifically provides mistletoe therapy (MT), but also intensive counselling, natural remedies, creative and movement therapies, nursing procedures, nutrition, and others. The objective of this study was to explore perceptions, themes, goals, procedures, and observations of experienced AM doctors with regard to the subjective dimensions of ICC...
September 2018: Explore: the Journal of Science and Healing
Christina Signorelli, Claire E Wakefield, Joanna E Fardell, Tali Foreman, Karen A Johnston, Jon Emery, Elysia Thornton-Benko, Afaf Girgis, Hanne C Lie, Richard J Cohn
BACKGROUND: Primary care physicians (PCPs) are well placed to provide holistic care to survivors of childhood cancer and may relieve growing pressures on specialist-led follow-up. We evaluated PCPs' role and confidence in providing follow-up care to survivors of childhood cancer. SUBJECTS, MATERIALS, AND METHODS: In Stage 1, survivors and parents (of young survivors) from 11 Australian and New Zealand hospitals completed interviews about their PCPs' role in their follow-up...
August 31, 2018: Oncologist
Prashanth Panta, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
Oral submucous fibrosis (OSF) is an oral potentially malignant disorder (OPMD) associated with prolonged betel-quid (BQ) use. It affects both physiological and psychological dimensions, leading to a significant morbidity. Some challenges in OSF research include: Assessment and correction of: (i) Quality of life, (ii) burning sensation, and (iii) nutritional deficiency. There are numerous medical treatments for OSF, but most of them fail to offer complete rehabilitation. This is because some underpinnings of this condition like "mental factors" that contribute to habit continuation at root level, "poor quality of life," and "nutritional deficiencies" are still uncorrected...
August 1, 2018: Journal of Contemporary Dental Practice
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