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Holistic cancer treatment

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https://www.readbyqxmd.com/read/30101561/proactive-community-support-tailored-to-holistic-needs-a-cohort-study
#1
Austyn Snowden, Jenny Young, Jan Savinc
BACKGROUND: It is increasingly internationally recognized that a cancer diagnosis impacts on people practically and financially as well as physically and psychologically. It is less clear what to do about this. This study introduces an original community service designed to mitigate this wider impact. Nonclinical "link officers" use holistic needs assessment (HNA) to help newly diagnosed people identify and quantify the severity of their physical, psychological, practical, financial, and social concerns...
August 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30084525/cancer-support-services-are-they-meeting-the-needs-of-rural-radiotherapy-patients
#2
Margaret M Haigh, Siddhartha Baxi, Marilyn Lyford, Shelley Cheetham, Sandra C Thompson
This paper examines the supportive care in place to meet the needs of patients receiving radiotherapy at a regional oncology service in Bunbury, Western Australia. Semi-structured in-depth interviews with 21 service providers and 17 adults diagnosed with cancer who underwent radiotherapy at the Service were recorded, transcribed and analysed thematically. Key themes relevant were co-operation and collaboration of interdisciplinary team members; support from organisations to assist with accommodation, transport, emotional support and provision of practical assistance, as well as barriers to accessing support...
August 7, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/30082544/clinicoepidemiological-profiles-clinical-practices-and-the-impact-of-holistic-care-interventions-on-outcomes-of-pediatric-hematolymphoid-malignancies-a-7-year-audit-of-the-pediatric-hematolymphoid-disease-management-group-at-tata-memorial-hospital
#3
Gaurav Narula, Maya Prasad, Shalini Jatia, Papagudi G Subramanian, Nikhil Patkar, Prashant Tembhare, Dhanlaxmi Shetty, Nehal Khanna, Siddharth Laskar, Tanuja Shet, Sridhar Epari, Seema Kembhavi, Sneha Shah, Sajid Qureshi, Sumeet Gujral, Shripad D Banavali
INTRODUCTION: The Pediatric Hematolymphoid Disease Management Group (PHL-DMG) at a tertiary cancer care hospital developed extensive patient support programs to improve retention and outcomes while focusing on protocols adapted to meet patient needs. An audit of measures and outcomes was done for a 7-year period from January 2010 to December 2016. MATERIALS AND METHODS: DMG protocols and patient support activities over the study period were documented and audited...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30077137/customizable-biomaterials-as-tools-for-advanced-anti-angiogenic-drug-discovery
#4
REVIEW
Eric H Nguyen, William L Murphy
The inhibition of angiogenesis is a critical element of cancer therapy, as cancer vasculature contributes to tumor expansion. While numerous drugs have proven to be effective at disrupting cancer vasculature, patient survival has not significantly improved as a result of anti-angiogenic drug treatment. Emerging evidence suggests that this is due to a combination of unintended side effects resulting from the application of anti-angiogenic compounds, including angiogenic rebound after treatment and the activation of metastasis in the tumor...
July 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/30063573/the-coping-and-support-needs-of-incurable-cancer-patients
#5
Anu Viitala, Marita Saukkonen, Juho T Lehto, Mira Palonen, Päivi Åstedt-Kurki
The purposes of this study were to describe the coping processes and support needs of patients with incurable cancer. The study was conducted as a qualitative study. The research data were gathered by conducting thematic interviews with outpatients with incurable cancer (n = 16) and analyzed by means of inductive content analysis. The results of the study indicate that the lives of patients were temporarily interrupted by the incurable illness. A sympathetic family was perceived as strength, and after the initial shock, the patients began to rebuild their lives...
April 2018: Journal of Hospice and Palliative Nursing: JHPN
https://www.readbyqxmd.com/read/30047071/longitudinal-changes-in-the-quality-of-life-of-oral-cancer-patients-during-the-perioperative-period
#6
Takayuki Aoki, Yoshihide Ota, Takatsugu Suzuki, Yuya Denda, Ken-Ichi Aoyama, Takeshi Akiba, Mariko Naito, Toshihiro Arai
BACKGROUND: There are few quality of life (QOL) studies that have focused on the experiences of oral cancer patients. Therefore, the present study aimed to investigate how the QOL for patients with oral cancer changed perioperatively. METHODS: Eighty-three participants undergoing radical therapy completed assessments of QOL at pre-treatment, treatment completion, and 1-, 3-, and 6-months post-treatment. The Japanese version of the FACT-H&N, comprising the subscales of "physical well-being (PWB)," "social/family well-being (SWB)," "emotional well-being (EWB)," "functional well-being (FWB)," and "additional head- and neck-specific concerns(HN)" was used to assess QOL...
July 25, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30042369/comorbidities-complications-and-non-pharmacologic-treatment-in-idiopathic-pulmonary-fibrosis
#7
REVIEW
Paloma Millan-Billi, Candela Serra, Ana Alonso Leon, Diego Castillo
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. The treatment is challenging and nowadays a comprehensive approach based not only in pharmacological strategies is necessary. Identification and control of comorbidities, non-pharmacological treatment, prevention and management of exacerbations as well as other areas of care (social, psychological) are fundamental for a holistic management of IPF. Gastroesophageal reflux, pulmonary hypertension, obstructive sleep apnea, combined with emphysema, lung cancer and cardiovascular involvement are the main comorbidities associated with IPF...
July 24, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30028673/comparative-effectiveness-of-surgical-options-for-patients-with-ductal-carcinoma-in-situ-an-instrumental-variable-approach
#8
Lewei Duan, Aniket A Kawatkar
CONTEXT: Many patients with ductal carcinoma in situ (DCIS) receive treatment that is too extensive. OBJECTIVE: To take a holistic approach in comparing the effectiveness in cancer prevention between mastectomy and breast-conserving surgery (BCS) for patients with DCIS. DESIGN: Female Kaiser Permanente Southern California members who underwent surgery for treatment of single primary DCIS from 2004 to 2014 were identified by the Kaiser Permanente Southern California cancer registry and HealthConnect database...
July 31, 2018: Permanente Journal
https://www.readbyqxmd.com/read/30027403/mutual-concessions-and-compromises-between-stromal-cells-and-cancer-cells-driving-tumor-development-and-drug-resistance
#9
REVIEW
Pritish Nilendu, Sachin C Sarode, Devashree Jahagirdar, Ishita Tandon, Shankargouda Patil, Gargi S Sarode, Jayanta K Pal, Nilesh Kumar Sharma
BACKGROUND: Various cancers have been found to be associated with heterogeneous and adaptive tumor microenvironments (TMEs) and to be driven by the local TMEs in which they thrive. Cancer heterogeneity plays an important role in tumor cell survival, progression and drug resistance. The diverse cellular components of the TME may include cancer-associated fibroblasts, adipocytes, pericytes, mesenchymal stem cells, endothelial cells, lymphocytes and other immune cells. These components may support tumor development through the secretion of growth factors, evasion from immune checkpoints, metabolic adaptations, modulations of the extracellular matrix, activation of oncogenes and the acquisition of drug resistance...
July 19, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/30022641/a-practical-guide-to-understanding-using-and-including-patient-reported-outcomes-in-clinical-trials-in-ovarian-cancer
#10
REVIEW
Michelle K Wilson, Rebecca Mercieca-Bebber, Michael Friedlander
Health related quality of life (HRQOL) is a key priority for patients with ovarian cancer as there is significant morbidity associated with the disease and the treatment. It is therefore essential to include measures of HRQOL and patient reported outcomes (PROs) in all clinical trials and ideally report them in the initial manuscript. The results of these analyses help interpret the primary trial endpoints which are typically progression free survival and overall survival from the perspective of the patients, but can also assist with regulatory approval of new drugs and inform future patients regarding the potential benefits and downsides of the treatment as well as help support clinical recommendations...
September 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/30021570/protocol-for-a-longitudinal-mixed-methods-realist-evaluation-of-holistic-needs-assessment-and-care-planning-for-people-affected-by-cancer
#11
Lucy Johnston, Karen Campbell
BACKGROUND: In 2012, approximately 14 million new cases of cancer were diagnosed. As a result of advances in treatment, screening and prevention programmes the number of people surviving cancer globally is also increasing. The growing understanding of the diversity and scale of the need for support, compounded by the increasing prevalence of cancer survivors has fuelled the development and evaluation of a range of services and models to meet them. A key intervention is the holistic needs assessment and care planning, however there is little homogeneity in its actual delivery to cancer survivors...
July 18, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30002779/poor-science-poorly-trained-scientists-poor-policies-major-deterrents-to-the-war-on-cancer
#12
Leslie C Costello
Although the availability of funding has been described as the major limitation on advances in cancer, the progress in the war on cancer has been deterred mainly by poor science, poorly trained scientists, and poor NIH policies. This is the result of NIH policies of its extreme focus on molecular biology (genomics, molecular genetics, molecular biology) identification of the molecular factors and pathways; which are required for the acceptability of treatment and preventive protocols. As such, this has influenced virtually all agencies that provide grants for medical research to adopt the NIH policies...
2018: Journal of Cancer Research Updates
https://www.readbyqxmd.com/read/29989063/oncograms-visualize-factors-influencing-long-term-survival-of-cancer-patients-treated-with-adenoviral-oncolytic-immunotherapy
#13
Otto Hemminki, Minna Oksanen, Kristian Taipale, Ilkka Liikanen, Anniina Koski, Timo Joensuu, Anna Kanerva, Akseli Hemminki
The first US Food and Drug Administration (FDA)- and EMA-approved oncolytic virus has been available since 2015. However, there are no markers available that would predict benefit for the individual patient. During 2007-2012, we treated 290 patients with advanced chemotherapy-refractory cancers, using 10 different oncolytic adenoviruses. Treatments were given in a Finnish Medicines Agency (FIMEA)-regulated individualized patient treatment program (the Advanced Therapy Access Program [ATAP]), which required long-term follow-up of patients, which is presented here...
June 29, 2018: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29953901/novel-therapeutic-strategy-for-cancer-and-autoimmune-conditions-modulating-cell-metabolism-and-redox-capacity
#14
REVIEW
Xing-Xing Fan, Hu-Dan Pan, Ying Li, Rui-Jin Guo, Elaine Lai-Han Leung, Liang Liu
Dysregulation of cell metabolism and redox balance is implicated in the pathogenesis and progression of cancer and autoimmune diseases. Because the cell proliferation and apoptotic regulatory pathways are interconnected with metabolic and redox signalling pathways, the current mono-target treatment is ineffective, and multi-drug resistance remains common. Complex diseases are often implicated in a network-based context of pathology; therefore, a new holistic intervention approach is required to block multi-crosstalk in such complicated circumstances...
June 25, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29908579/herbal-sun-protection-agents-human-studies
#15
Lana Rabinovich, Viktoryia Kazlouskaya
Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Herbal substances may work as adsorbents of the UV rays and antioxidants and potentially have few side effects...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29875530/stress-and-quality-of-life-in-cancer-patients-medical-and-psychological-intervention
#16
Prasad Vijay Barre, Gadiraju Padmaja, Suvashisa Rana, Tiamongla
Background: Cancer pervades many dimensions of an individual's life - demanding a holistic treatment approach. However, studies with combined medical and psychological interventions (MPIs) are sparse. High-level stress and poor quality of life (QoL) can hinder patients' prognosis. The study thus aimed to analyze the impact of combined medical and psychological (psychoeducation, relaxation technique-guided imagery, and cognitive therapy) interventions on stress and QoL of cancer patients - head and neck, breast, and lung cancers...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29860978/characterization-of-the-degree-of-food-processing-in-relation-with-its-health-potential-and-effects
#17
Anthony Fardet
Up today technological processes are intended to produce safe and palatable food products. Yet, it is also expected that processing produces healthy and sustainable foods. However, due to the dramatic increase of chronic diseases prevalence worldwide, i.e., obesity, type 2 diabetes, cardiovascular diseases, and some cancers, ultraprocessing has been pointed out as producing unhealthy foods, rich in energy and poor in protective micronutrients and fiber, i.e., "empty" calories. Indeed the 1980s saw massive arrivals of ultraprocessed foods in supermarkets, i...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29784140/telephone-follow-up-after-treatment-for-endometrial-cancer-a-qualitative-study-of-patients-and-clinical-nurse-specialists-experiences-in-the-endcat-trial
#18
S Williamson, K Beaver, A Gardner, P Martin-Hirsch
PURPOSE: Endometrial cancer is the sixth most common female cancer worldwide. There is little evidence that routine hospital surveillance increases survival or decreases morbidity following treatment. Gynaecology Oncology clinical nurse specialists (CNSs) are ideally placed to provide the care, information and support to enable women with a gynaecological cancer to self-manage and live well. A multi-centre randomised controlled trial (RCT) compared hospital follow-up (HFU) with telephone follow-up (TFU) by CNSs...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29769644/translational-models-of-prostate-cancer-bone-metastasis
#19
REVIEW
Richard B Berish, Aymon N Ali, Patrick G Telmer, John A Ronald, Hon S Leong
Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to accurately recapitulate the spread of prostate cancer to bone - the most common site of metastasis - is critical to the development of novel metastasis-directed therapies. Several translational models of prostate cancer bone metastasis have been developed, including animal models, cell line injection models, 3D in vitro models, bone implant models, and patient-derived xenograft models. The use of these models has led to numerous advances in elucidating the molecular mechanisms of metastasis and innovations in targeted therapy...
July 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29735851/cancer-prevention-the-need-to-preserve-the-integrity-of-the-genome-at-all-cost
#20
REVIEW
M T Okafor, T U Nwagha, C Anusiem, U A Okoli, N I Nubila, F Al-Alloosh, I J Udenyia
Introduction: The entire genetic information carried by an organism makes up its genome. Genes have a diverse number of functions. They code different proteins for normal proliferation of cells. However, changes in the base sequence of genes affect their protein by-products which act as messengers for normal cellular functions such as proliferation and repairs. Salient processes for maintaining the integrity of the genome are hinged on intricate mechanisms put in place for the evolution to tackle genomic stresses...
May 2018: Nigerian Journal of Clinical Practice
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