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Michael T. Green

Waseem Akbar, Anilkumar Gowda, Jeffrey E Ahrens, Jason W Stelzer, Robert S Brown, Scott L Bollman, John T Greenplate, Jeffrey Gore, Angus L Catchot, Gus Lorenz, Scott D Stewart, David L Kerns, Jeremy K Greene, Michael D Toews, David A Herbert, Dominic D Reisig, Gregory A Sword, Peter C Ellsworth, Larry D Godfrey, Thomas L Clark
BACKGROUND: Plant bugs (Lygus spp.) and thrips (Thrips spp.) are two of the most economically important insect pest groups impacting cotton production in the USA today, but are not controlled by current transgenic cotton varieties. Thus, seed or foliar-applied chemical insecticides are typically required to protect cotton from these pest groups. Currently, these pests are resistant to several insecticides, resulting in fewer options for economically viable management. Previous publications documented the efficacy of transgenic cotton event MON 88702 against plant bugs and thrips in limited laboratory and field studies...
October 16, 2018: Pest Management Science
Janneke Aylward, Francois Roets, Leánne L Dreyer, Michael J Wingfield
BACKGROUND: Teratosphaeria gauchensis and T. zuluensis are closely related fungi that cause Teratosphaeria (previously Coniothyrium) stem canker disease on Eucalyptus species propagated in plantations for commercial purposes. This disease is present in many countries where Eucalyptus trees are planted, and continues to spread with international trade of infected plant germplasm. TAXONOMY: Fungi, Ascomycota, Pezizomycotina, Dothideomycetes, Dothideomycetidae, Capnodiales, Teratosphaeriaceae, Teratosphaeria IDENTIFICATION: The causal agents form dark masses of pycnidia that are visible on the surface of distinct stem cankers that typically form on young green stem tissues...
October 12, 2018: Molecular Plant Pathology
Gareth D Jones, Darren C James, Michael Thacker, David A Green
BACKGROUND: Rising-to-walk is an everyday transitional movement task rarely employed in gait rehabilitation. Sit-to-walk (STW) and sit-to-stand-and-walk (STSW), where a pause separates sit-to-stand and gait-initiation (GI) represent extremes of rising-to-walk behaviour. Delayed GI can indicate pathological impairment but is also observed in healthy individuals. We hypothesise that healthy subjects express consistent biomechanical parameters, among others that differ, during successful rising-to-walk task performance regardless of behaviour...
2018: PloS One
Kwan T Chow, Courtney Wilkins, Miwako Narita, Richard Green, Megan Knoll, Yueh-Ming Loo, Michael Gale
We examined the signaling pathways and cell type-specific responses of IFN regulatory factor (IRF) 5, an immune-regulatory transcription factor. We show that the protein kinases IKKα, IKKβ, IKKε, and TANK-binding kinase 1 each confer IRF5 phosphorylation/dimerization, thus extending the family of IRF5 activator kinases. Among primary human immune cell subsets, we found that IRF5 is most abundant in plasmacytoid dendritic cells (pDCs). Flow cytometric cell imaging revealed that IRF5 is specifically activated by endosomal TLR signaling...
October 8, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Josée G Lavoie, Amanda Ward, Sabrina T Wong, Naser Ibrahim, Darrien Morton, John D O'Neil, Michael Green
BACKGROUND: Indigenous peoples globally experience a disproportionate burden of mental illness due to forced policies and practices of colonization and cultural disruption. The objective of this study was to provide a baseline profile of hospitalization rates for mental health-related Ambulatory Care Sensitive Conditions among First-Nations living both on and off reserve in British Columbia, Canada, and explore the relationship between local access to health services and mental health-related hospitalization rates...
October 3, 2018: International Journal for Equity in Health
Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, Peter T Toth, Michael E Ragozzino, Khuong Le, Haider W Aljewari, Neil M O'Brien-Simpson, Eric C Reynolds, Keiko Watanabe
BACKGROUND: The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest that a gram-negative periodontal pathogen, Porphyromonas gingivalis (Pg) and/or its product gingipain is/are translocated to the brain. However, neuropathology resulting from Pg oral application is not known...
2018: PloS One
Evgenii G Belykh, Xiaochun Zhao, Claudio Cavallo, Michael A Bohl, Kaan Yagmurlu, Joseph L Aklinski, Vadim A Byvaltsev, Nader Sanai, Robert F Spetzler, Michael T Lawton, Peter Nakaji, Mark C Preul
Background We assessed a new robotic visualization platform with novel user-control features and compared its performance to the previous model of operative microscope. Methods In a neurosurgery research laboratory, we performed anatomical dissections and assessed robotic, exoscopic, endoscopic, fluorescence functionality. Usability and functionality were tested in the operating room over 1 year. Results The robotic microscope showed higher sensitivity for fluorescein sodium, higher detail in non-fluorescent background, and recorded/presented pictures with color quality similar to observation through the oculars...
July 30, 2018: Curēus
Stephen J Balevic, Michael Cohen-Wolkowiez, Amanda M Eudy, Thomas P Green, Laura E Schanberg, Megan E B Clowse
OBJECTIVE: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Hydroxychloroquine (HCQ) reduces disease activity and flares; however, pregnancy causes significant physiologic changes that may alter HCQ levels and lead to therapeutic failure. Therefore, our objective was to evaluate HCQ concentrations during pregnancy and relate levels to outcomes. METHODS: We performed an observational study of pregnant patients with rheumatic disease who were taking HCQ from a single center during 2013-2016...
October 1, 2018: Journal of Rheumatology
Wei Wang, Hu Huang, Michael Halagan, Cynthia Vierra-Green, Michael Heuer, Jason E Brelsford, Michael Haagenson, Richard H Scheuermann, Amalio Telenti, William Biggs, Nathaniel M Pearson, Julia Udell, Stephen Spellman, Martin Maiers, Caleb J Kennedy
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors...
October 9, 2018: Blood Advances
Anne D Bjorkman, Isla H Myers-Smith, Sarah C Elmendorf, Signe Normand, Nadja Rüger, Pieter S A Beck, Anne Blach-Overgaard, Daan Blok, J Hans C Cornelissen, Bruce C Forbes, Damien Georges, Scott J Goetz, Kevin C Guay, Gregory H R Henry, Janneke HilleRisLambers, Robert D Hollister, Dirk N Karger, Jens Kattge, Peter Manning, Janet S Prevéy, Christian Rixen, Gabriela Schaepman-Strub, Haydn J D Thomas, Mark Vellend, Martin Wilmking, Sonja Wipf, Michele Carbognani, Luise Hermanutz, Esther Lévesque, Ulf Molau, Alessandro Petraglia, Nadejda A Soudzilovskaia, Marko J Spasojevic, Marcello Tomaselli, Tage Vowles, Juha M Alatalo, Heather D Alexander, Alba Anadon-Rosell, Sandra Angers-Blondin, Mariska Te Beest, Logan Berner, Robert G Björk, Agata Buchwal, Allan Buras, Katherine Christie, Elisabeth J Cooper, Stefan Dullinger, Bo Elberling, Anu Eskelinen, Esther R Frei, Oriol Grau, Paul Grogan, Martin Hallinger, Karen A Harper, Monique M P D Heijmans, James Hudson, Karl Hülber, Maitane Iturrate-Garcia, Colleen M Iversen, Francesca Jaroszynska, Jill F Johnstone, Rasmus Halfdan Jørgensen, Elina Kaarlejärvi, Rebecca Klady, Sara Kuleza, Aino Kulonen, Laurent J Lamarque, Trevor Lantz, Chelsea J Little, James D M Speed, Anders Michelsen, Ann Milbau, Jacob Nabe-Nielsen, Sigrid Schøler Nielsen, Josep M Ninot, Steven F Oberbauer, Johan Olofsson, Vladimir G Onipchenko, Sabine B Rumpf, Philipp Semenchuk, Rohan Shetti, Laura Siegwart Collier, Lorna E Street, Katharine N Suding, Ken D Tape, Andrew Trant, Urs A Treier, Jean-Pierre Tremblay, Maxime Tremblay, Susanna Venn, Stef Weijers, Tara Zamin, Noémie Boulanger-Lapointe, William A Gould, David S Hik, Annika Hofgaard, Ingibjörg S Jónsdóttir, Janet Jorgenson, Julia Klein, Borgthor Magnusson, Craig Tweedie, Philip A Wookey, Michael Bahn, Benjamin Blonder, Peter M van Bodegom, Benjamin Bond-Lamberty, Giandiego Campetella, Bruno E L Cerabolini, F Stuart Chapin, William K Cornwell, Joseph Craine, Matteo Dainese, Franciska T de Vries, Sandra Díaz, Brian J Enquist, Walton Green, Ruben Milla, Ülo Niinemets, Yusuke Onoda, Jenny C Ordoñez, Wim A Ozinga, Josep Penuelas, Hendrik Poorter, Peter Poschlod, Peter B Reich, Brody Sandel, Brandon Schamp, Serge Sheremetev, Evan Weiher
The tundra is warming more rapidly than any other biome on Earth, and the potential ramifications are far-reaching because of global feedback effects between vegetation and climate. A better understanding of how environmental factors shape plant structure and function is crucial for predicting the consequences of environmental change for ecosystem functioning. Here we explore the biome-wide relationships between temperature, moisture and seven key plant functional traits both across space and over three decades of warming at 117 tundra locations...
October 2018: Nature
Stephen J Balevic, Thomas P Green, Megan E B Clowse, Amanda M Eudy, Laura E Schanberg, Michael Cohen-Wolkowiez
BACKGROUND: Hydroxychloroquine is an oral drug prescribed to pregnant women with rheumatic disease to reduce disease activity and prevent flares. Physiologic changes during pregnancy may substantially alter drug pharmacokinetics. However, the effect of pregnancy on hydroxychloroquine disposition and the potential need for dose adjustment remains virtually unknown. METHODS: We performed a population-pharmacokinetic analysis using samples from the Duke Autoimmunity in Pregnancy Registry from 2013 to 2016...
September 25, 2018: Clinical Pharmacokinetics
David A W Miller, Evan H Campbell Grant, Erin Muths, Staci M Amburgey, Michael J Adams, Maxwell B Joseph, J Hardin Waddle, Pieter T J Johnson, Maureen E Ryan, Benedikt R Schmidt, Daniel L Calhoun, Courtney L Davis, Robert N Fisher, David M Green, Blake R Hossack, Tracy A G Rittenhouse, Susan C Walls, Larissa L Bailey, Sam S Cruickshank, Gary M Fellers, Thomas A Gorman, Carola A Haas, Ward Hughson, David S Pilliod, Steven J Price, Andrew M Ray, Walt Sadinski, Daniel Saenz, William J Barichivich, Adrianne Brand, Cheryl S Brehme, Rosi Dagit, Katy S Delaney, Brad M Glorioso, Lee B Kats, Patrick M Kleeman, Christopher A Pearl, Carlton J Rochester, Seth P D Riley, Mark Roth, Brent H Sigafus
Changing climate will impact species' ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to climatic variability, using >500,000 time-series observations for 81 species across 86 North American study areas. The effect of climate on local colonization and persistence probabilities varies among eco-regions and depends on local climate, species life-histories, and taxonomic classification...
September 25, 2018: Nature Communications
Alix Green, Michael A Chadwick, Peter J S Jones
Seagrass meadows provide a multitude of ecosystem services, including a capacity to sequester carbon dioxide (CO2) within their sediments. Seagrass research in the UK is lacking and there is no published data on sediment carbon (C) within UK seagrass meadows. We sampled 13 Zostera marina meadows along the southwest coast of the UK to assess the variability in their sedimentary organic carbon (OC) stocks. The study sites were considered representative of sub-tidal Z. marina meadows in the UK, spanning a gradient of sheltered to exposed sites, varying in formation, size and density, but found along the same latitudinal gradient...
2018: PloS One
Larissa D Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D L Johnson, Sivaraman Natarajan, Meghan E Turnis, David Finkelstein, Joseph T Opferman, Charles Gawad, Douglas R Green
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to this goal. One such alternative function of autophagy proteins is LC3-associated phagocytosis (LAP), which functions in phagosome maturation and subsequent signaling events. Here, we show that impairment of LAP in the myeloid compartment, rather than canonical autophagy, induces control of tumor growth by tumor-associated macrophages (TAM) upon phagocytosis of dying tumor cells...
October 4, 2018: Cell
Andrew van der Vaart, Xianfang Meng, M Scott Bowers, Angela M Batman, Fazil Aliev, Sean P Farris, Jennifer S Hill, Thomas A Green, Danielle Dick, Jennifer T Wolstenholme, Michael F Miles
Understanding how ethanol actions on brain signal transduction and gene expression lead to excessive consumption and addiction could identify new treatments for alcohol dependence. We previously identified glycogen synthase kinase 3-beta (Gsk3b) as a member of a highly ethanol-responsive gene network in mouse medial prefrontal cortex (mPFC). Gsk3b has been implicated in dendritic function, synaptic plasticity and behavioral responses to other drugs of abuse. Here, we investigate Gsk3b in rodent models of ethanol consumption and as a risk factor for human alcohol dependence...
September 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Celestin Nzanzu Mudogo, Salesia Franziska Werner, Stefan Mogk, Christian Betzel, Michael Duszenko
Trypanosoma brucei, a flagellated protozoan causing the deadly tropical disease Human African Trypanosomiasis (HAT), affects people in sub-Saharan Africa. HAT therapy relies upon drugs which use is limited by toxicity and rigorous treatment regimes, while development of vaccines remains elusive, due to the effectiveness of the parasite´s antigenic variation. Here, we evaluate a hypothetical protein Tb427.10.13790, as a potential drug target. This protein is conserved among all kinetoplastids, but lacks homologs in all other pro- and eukaryotes...
December 2018: Acta Tropica
Michael Frumovitz, Marie Plante, Paula S Lee, Samith Sandadi, James F Lilja, Pedro F Escobar, Lilian T Gien, Diana L Urbauer, Nadeem R Abu-Rustum
BACKGROUND: Accurate identification of sentinel lymph nodes in patients with cancer improves detection of metastatic disease and decreases surgical morbidity. We sought to establish whether indocyanine green fluorescent dye is non-inferior to isosulfan blue dye in detecting sentinel lymph nodes in women with cervical and uterine cancers. METHODS: In this non-inferiority, within-patient comparison study, patients aged 18 years or older with clinical stage I endometrial or cervical cancer undergoing curative surgery were randomly assigned 1:1 to lymphatic mapping with isosulfan blue dye (visualised by white light) followed by indocyanine green (visualised by near-infrared imaging), or indocyanine green followed by isosulfan blue dye...
October 2018: Lancet Oncology
Jeremy T Goldbach, Harmony Rhoades, Daniel Green, Anthony Fulginiti, Michael P Marshal
BACKGROUND: Lesbian, gay, bisexual, and transgender (LGBT) youth are more than twice as likely to attempt suicide than their peers. Although LGBT-specific crisis services have been developed, little is known about the need for these services beyond that of general lifeline services. AIMS: The present study sought to (a) describe the primary reasons for calling a specialized provider as opposed to another and (b) examine sociodemographic differences in the primary reason by race, ethnicity, gender, age, and sexual orientation...
August 15, 2018: Crisis
Sirin Gandhi, Justin Mascitelli, Douglas Hardesty, Michael T Lawton
Posterior inferior cerebellar artery (PICA) aneurysms account for 3% to 4% of all intracranial aneurysms with an unusually high predilection towards a nonsaccular morphology making microsurgical clipping or endovascular reconstruction of the parent artery difficult. The management of these complicated aneurysms may require revascularization procedures for flow preservation with aneurysm trapping. Recently, there is an increasing inclination towards intracranial-intracranial (IC-IC) bypasses over traditional extracranial donors...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
Jose A Hernandez, Angel Ruiz, Luis F Fonseca, Michael T Pettes, Miguel Jose-Yacaman, Alfredo Benitez
Tin selenide (SnSe) has been the subject of great attention in the last years due to its highly efficient thermoelectricity and its possibilities as a green material, free of Pb and Te. Here, we report for the first time a thermoelectricity and transport study of individual SnSe micro- and nano-wires with diameters in the range between 130 nm and 1.15 μm. X-ray diffraction and transmission electron microscopy analyses confirm an orthorhombic SnSe structure with Pnma (62) symmetry group and 1:1 Sn:Se atomic ratio...
August 10, 2018: Scientific Reports
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