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Michael T. Green

Craig T Parker, Kerry K Cooper, Steven Huynh, Timothy P Smith, James L Bono, Michael Cooley
Produce contaminated with Shiga toxin-producing Escherichia coli (STEC) is a continuing source of foodborne illness in the United States. This report documents the complete genome sequences of eight STEC strains isolated from livestock and water samples taken from a major agricultural region for leafy greens in California.
July 2018: Microbiology resource announcements
Ophir Vermesh, Amin Aalipour, T Jessie Ge, Yamil Saenz, Yue Guo, Israt S Alam, Seung-Min Park, Charlie N Adelson, Yoshiaki Mitsutake, Jose Vilches-Moure, Elias Godoy, Michael Bachmann, Chin Chun Ooi, Jennifer K Lyons, Kerstin Mueller, Hamed Arami, Alfredo Green, Edward I Solomon, Shan X Wang, Sanjiv S Gambhir
The detection and analysis of rare blood biomarkers is necessary for early cancer diagnosis and to facilitate the development of tailored therapies. However, current methods for the isolation of circulating tumor cells (CTCs) or nucleic acids present in a standard clinical sample of only 5-10 mL of blood provide inadequate yields for early cancer detection and comprehensive molecular profiling. We have developed a flexible magnetic wire that can retrieve rare biomarkers from the subject's blood in vivo at a much higher yield...
2018: Nature Biomedical Engineering
Ophir Vermesh, Amin Aalipour, T Jessie Ge, Yamil Saenz, Yue Guo, Israt S Alam, Seung-Min Park, Charlie N Adelson, Yoshiaki Mitsutake, Jose Vilches-Moure, Elias Godoy, Michael H Bachmann, Chin Chun Ooi, Jennifer K Lyons, Kerstin Mueller, Hamed Arami, Alfredo Green, Edward I Solomon, Shan X Wang, Sanjiv S Gambhir
The detection and analysis of rare blood biomarkers is necessary for early diagnosis of cancer and to facilitate the development of tailored therapies. However, current methods for the isolation of circulating tumour cells (CTCs) or nucleic acids present in a standard clinical sample of only 5-10 ml of blood provide inadequate yields for early cancer detection and comprehensive molecular profiling. Here, we report the development of a flexible magnetic wire that can retrieve rare biomarkers from the subject's blood in vivo at a much higher yield...
September 2018: Nature Biomedical Engineering
Matthew T Finn, Darshan Doshi, Jacob Cleman, Lei Song, Akiko Maehara, Raja Hatem, Björn Redfors, Sanjog Kalra, Justin A Fried, Ming Liao, Candido Batres, Jeffery W Moses, Manish A Parikh, Michael B Collins, Tamim M Nazif, Khady N Fall, Phillip Green, Ajay J Kirtane, Ziad A Ali, Martin B Leon, Gary S Mintz, Dimitri Karmpaliotis
OBJECTIVES: We sought to determine the 1-year outcomes of patients receiving successful chronic total occlusion (CTO) percutaneous coronary intervention (PCI) procedures comparing subintimal versus intraplaque wire tracking patterns. BACKGROUND: CTO PCI utilizes both intraluminal and subintimal wire tracking to achieve successful percutaneous revascularization. Intravascular ultrasound (IVUS) can be used to precisely determine the path of wire tracking. METHODS: From 2014 to 2016, data from patients undergoing CTO PCI were collected in a single-center database...
November 29, 2018: Catheterization and Cardiovascular Interventions
Nina T Lichtenberg, Brian Lee, Vadim Kashtelyan, Bharadwaja S Chappa, Henok T Girma, Elizabeth A Green, Shir Kantor, Dave A Lagowala, Matthew A Myers, Danielle Potemri, Meredith G Pecukonis, Robel T Tesfay, Michael S Walters, Adam C Zhao, R James R Blair, Joseph F Cheer, Matthew R Roesch
Rats exhibit 'empathy' making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA release in two paradigms: one that involved cues predictive of unavoidable shock to the conspecific and another that allowed the rat to refrain from reward when there were harmful consequences to the conspecific...
November 28, 2018: ELife
Theodore S Kalbfleisch, Edward S Rice, Michael S DePriest, Brian P Walenz, Matthew S Hestand, Joris R Vermeesch, Brendan L O Connell, Ian T Fiddes, Alisa O Vershinina, Nedda F Saremi, Jessica L Petersen, Carrie J Finno, Rebecca R Bellone, Molly E McCue, Samantha A Brooks, Ernest Bailey, Ludovic Orlando, Richard E Green, Donald C Miller, Douglas F Antczak, James N MacLeod
Recent advances in genomic sequencing technology and computational assembly methods have allowed scientists to improve reference genome assemblies in terms of contiguity and composition. EquCab2, a reference genome for the domestic horse, was released in 2007. Although of equal or better quality compared to other first-generation Sanger assemblies, it had many of the shortcomings common to them. In 2014, the equine genomics research community began a project to improve the reference sequence for the horse, building upon the solid foundation of EquCab2 and incorporating new short-read data, long-read data, and proximity ligation data...
2018: Communications biology
Aavishkar A Patel, Michael J Lawler, Eun-Ah Kim
A mysterious incoherent metallic (IM) normal state with T-linear resistivity is ubiquitous among strongly correlated superconductors. Recent progress with microscopic models exhibiting IM transport has presented the opportunity for us to study new models that exhibit direct transitions into a superconducting state out of IM states within the framework of connected Sachdev-Ye-Kitaev "quantum dots." Here, local Sachdev-Ye-Kitaev interactions within a dot produce IM transport in the normal state, while local attractive interactions drive superconductivity...
November 2, 2018: Physical Review Letters
Michael P Pender, Peter A Csurhes, Corey Smith, Nanette L Douglas, Michelle A Neller, Katherine K Matthews, Leone Beagley, Sweera Rehan, Pauline Crooks, Tracey J Hopkins, Stefan Blum, Kerryn A Green, Zara A Ioannides, Andrew Swayne, Blake T Aftab, Kaye D Hooper, Scott R Burrows, Kate M Thompson, Alan Coulthard, Rajiv Khanna
BACKGROUND: Increasing evidence indicates a role for EBV in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS because of defective cytotoxic CD8+ T cell immunity. We sought to determine the feasibility and safety of treating progressive MS patients with autologous EBV-specific T cell therapy. METHODS: An open-label phase I trial was designed to treat 5 patients with secondary progressive MS and 5 patients with primary progressive MS with 4 escalating doses of in vitro-expanded autologous EBV-specific T cells targeting EBV nuclear antigen 1, latent membrane protein 1 (LMP1), and LMP2A...
November 15, 2018: JCI Insight
Sabrina T Wong, Julia M Langton, Alan Katz, Martin Fortin, Marshall Godwin, Michael Green, Eva Grunfeld, Kasra Hassani, Claire Kendall, Clare Liddy, Jenny Ploeg, Walter P Wodchis, Jeannie L Haggerty
AimTo describe the process by which the 12 community-based primary health care (CBPHC) research teams worked together and fostered cross-jurisdictional collaboration, including collection of common indicators with the goal of using the same measures and data sources. BACKGROUND: A pan-Canadian mechanism for common measurement of the impact of primary care innovations across Canada is lacking. The Canadian Institutes for Health Research and its partners funded 12 teams to conduct research and collaborate on development of a set of commonly collected indicators...
November 6, 2018: Primary Health Care Research & Development
Jessica B Graham, Jessica L Swarts, Sunil Thomas, Kathleen M Voss, Aimee Sekine, Richard Green, Renee C Ireton, Michael Gale, Jennifer M Lund
Background: A challenge to the design of improved therapeutics and prevention strategies for neuroinvasive infection and associated disease is the lack of known natural immune correlates of protection. A relevant model to study such correlates is offered by the Collaborative Cross (CC), a panel of recombinant inbred mouse strains that exhibit a range of disease manifestations upon infection. Methods: We performed an extensive screen of CC-F1 lines infected with West Nile virus (WNV), including comprehensive immunophenotyping, to identify groups of lines that exhibited viral neuroinvasion, neuroinvasion with disease, and lines that remained virus- and disease-free...
October 26, 2018: Journal of Infectious Diseases
Waseem Akbar, Anilkumar Gowda, Jeffrey E Ahrens, Jason W Stelzer, Robert S Brown, Scott L Bollman, John T Greenplate, Jeffrey Gore, Angus L Catchot, Gus Lorenz, Scott D Stewart, David L Kerns, Jeremy K Greene, Michael D Toews, David A Herbert, Dominic D Reisig, Gregory A Sword, Peter C Ellsworth, Larry D Godfrey, Thomas L Clark
BACKGROUND: Plant bugs (Lygus spp.) and thrips (Thrips spp.) are two of the most economically important insect pest groups impacting cotton production in the USA today, but are not controlled by current transgenic cotton varieties. Thus, seed or foliar-applied chemical insecticides are typically required to protect cotton from these pest groups. Currently, these pests are resistant to several insecticides, resulting in fewer options for economically viable management. Previous publications documented the efficacy of transgenic cotton event MON 88702 against plant bugs and thrips in limited laboratory and field studies...
October 16, 2018: Pest Management Science
Janneke Aylward, Francois Roets, Leánne L Dreyer, Michael J Wingfield
BACKGROUND: Teratosphaeria gauchensis and T. zuluensis are closely related fungi that cause Teratosphaeria (previously Coniothyrium) stem canker disease on Eucalyptus species propagated in plantations for commercial purposes. This disease is present in many countries in which Eucalyptus trees are planted, and continues to spread with the international trade of infected plant germplasm. TAXONOMY: Fungi, Ascomycota, Pezizomycotina, Dothideomycetes, Dothideomycetidae, Capnodiales, Teratosphaeriaceae, Teratosphaeria...
October 12, 2018: Molecular Plant Pathology
Gareth D Jones, Darren C James, Michael Thacker, David A Green
BACKGROUND: Rising-to-walk is an everyday transitional movement task rarely employed in gait rehabilitation. Sit-to-walk (STW) and sit-to-stand-and-walk (STSW), where a pause separates sit-to-stand and gait-initiation (GI) represent extremes of rising-to-walk behaviour. Delayed GI can indicate pathological impairment but is also observed in healthy individuals. We hypothesise that healthy subjects express consistent biomechanical parameters, among others that differ, during successful rising-to-walk task performance regardless of behaviour...
2018: PloS One
Kwan T Chow, Courtney Wilkins, Miwako Narita, Richard Green, Megan Knoll, Yueh-Ming Loo, Michael Gale
We examined the signaling pathways and cell type-specific responses of IFN regulatory factor (IRF) 5, an immune-regulatory transcription factor. We show that the protein kinases IKKα, IKKβ, IKKε, and TANK-binding kinase 1 each confer IRF5 phosphorylation/dimerization, thus extending the family of IRF5 activator kinases. Among primary human immune cell subsets, we found that IRF5 is most abundant in plasmacytoid dendritic cells (pDCs). Flow cytometric cell imaging revealed that IRF5 is specifically activated by endosomal TLR signaling...
November 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Josée G Lavoie, Amanda Ward, Sabrina T Wong, Naser Ibrahim, Darrien Morton, John D O'Neil, Michael Green
BACKGROUND: Indigenous peoples globally experience a disproportionate burden of mental illness due to forced policies and practices of colonization and cultural disruption. The objective of this study was to provide a baseline profile of hospitalization rates for mental health-related Ambulatory Care Sensitive Conditions among First-Nations living both on and off reserve in British Columbia, Canada, and explore the relationship between local access to health services and mental health-related hospitalization rates...
October 3, 2018: International Journal for Equity in Health
Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, Peter T Toth, Michael E Ragozzino, Khuong Le, Haider W Aljewari, Neil M O'Brien-Simpson, Eric C Reynolds, Keiko Watanabe
BACKGROUND: The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest that a gram-negative periodontal pathogen, Porphyromonas gingivalis (Pg) and/or its product gingipain is/are translocated to the brain. However, neuropathology resulting from Pg oral application is not known...
2018: PloS One
Evgenii G Belykh, Xiaochun Zhao, Claudio Cavallo, Michael A Bohl, Kaan Yagmurlu, Joseph L Aklinski, Vadim A Byvaltsev, Nader Sanai, Robert F Spetzler, Michael T Lawton, Peter Nakaji, Mark C Preul
Background We assessed a new robotic visualization platform with novel user-control features and compared its performance to the previous model of operative microscope. Methods In a neurosurgery research laboratory, we performed anatomical dissections and assessed robotic, exoscopic, endoscopic, fluorescence functionality. Usability and functionality were tested in the operating room over 1 year. Results The robotic microscope showed higher sensitivity for fluorescein sodium, higher detail in non-fluorescent background, and recorded/presented pictures with color quality similar to observation through the oculars...
July 30, 2018: Curēus
Stephen J Balevic, Michael Cohen-Wolkowiez, Amanda M Eudy, Thomas P Green, Laura E Schanberg, Megan E B Clowse
OBJECTIVE: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Hydroxychloroquine (HCQ) reduces disease activity and flares; however, pregnancy causes significant physiologic changes that may alter HCQ levels and lead to therapeutic failure. Therefore, our objective was to evaluate HCQ concentrations during pregnancy and relate levels to outcomes. METHODS: We performed an observational study of pregnant patients with rheumatic disease who were taking HCQ from a single center during 2013-2016...
October 1, 2018: Journal of Rheumatology
Wei Wang, Hu Huang, Michael Halagan, Cynthia Vierra-Green, Michael Heuer, Jason E Brelsford, Michael Haagenson, Richard H Scheuermann, Amalio Telenti, William Biggs, Nathaniel M Pearson, Julia Udell, Stephen Spellman, Martin Maiers, Caleb J Kennedy
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors...
October 9, 2018: Blood Advances
Anne D Bjorkman, Isla H Myers-Smith, Sarah C Elmendorf, Signe Normand, Nadja Rüger, Pieter S A Beck, Anne Blach-Overgaard, Daan Blok, J Hans C Cornelissen, Bruce C Forbes, Damien Georges, Scott J Goetz, Kevin C Guay, Gregory H R Henry, Janneke HilleRisLambers, Robert D Hollister, Dirk N Karger, Jens Kattge, Peter Manning, Janet S Prevéy, Christian Rixen, Gabriela Schaepman-Strub, Haydn J D Thomas, Mark Vellend, Martin Wilmking, Sonja Wipf, Michele Carbognani, Luise Hermanutz, Esther Lévesque, Ulf Molau, Alessandro Petraglia, Nadejda A Soudzilovskaia, Marko J Spasojevic, Marcello Tomaselli, Tage Vowles, Juha M Alatalo, Heather D Alexander, Alba Anadon-Rosell, Sandra Angers-Blondin, Mariska Te Beest, Logan Berner, Robert G Björk, Agata Buchwal, Allan Buras, Katherine Christie, Elisabeth J Cooper, Stefan Dullinger, Bo Elberling, Anu Eskelinen, Esther R Frei, Oriol Grau, Paul Grogan, Martin Hallinger, Karen A Harper, Monique M P D Heijmans, James Hudson, Karl Hülber, Maitane Iturrate-Garcia, Colleen M Iversen, Francesca Jaroszynska, Jill F Johnstone, Rasmus Halfdan Jørgensen, Elina Kaarlejärvi, Rebecca Klady, Sara Kuleza, Aino Kulonen, Laurent J Lamarque, Trevor Lantz, Chelsea J Little, James D M Speed, Anders Michelsen, Ann Milbau, Jacob Nabe-Nielsen, Sigrid Schøler Nielsen, Josep M Ninot, Steven F Oberbauer, Johan Olofsson, Vladimir G Onipchenko, Sabine B Rumpf, Philipp Semenchuk, Rohan Shetti, Laura Siegwart Collier, Lorna E Street, Katharine N Suding, Ken D Tape, Andrew Trant, Urs A Treier, Jean-Pierre Tremblay, Maxime Tremblay, Susanna Venn, Stef Weijers, Tara Zamin, Noémie Boulanger-Lapointe, William A Gould, David S Hik, Annika Hofgaard, Ingibjörg S Jónsdóttir, Janet Jorgenson, Julia Klein, Borgthor Magnusson, Craig Tweedie, Philip A Wookey, Michael Bahn, Benjamin Blonder, Peter M van Bodegom, Benjamin Bond-Lamberty, Giandiego Campetella, Bruno E L Cerabolini, F Stuart Chapin, William K Cornwell, Joseph Craine, Matteo Dainese, Franciska T de Vries, Sandra Díaz, Brian J Enquist, Walton Green, Ruben Milla, Ülo Niinemets, Yusuke Onoda, Jenny C Ordoñez, Wim A Ozinga, Josep Penuelas, Hendrik Poorter, Peter Poschlod, Peter B Reich, Brody Sandel, Brandon Schamp, Serge Sheremetev, Evan Weiher
The tundra is warming more rapidly than any other biome on Earth, and the potential ramifications are far-reaching because of global feedback effects between vegetation and climate. A better understanding of how environmental factors shape plant structure and function is crucial for predicting the consequences of environmental change for ecosystem functioning. Here we explore the biome-wide relationships between temperature, moisture and seven key plant functional traits both across space and over three decades of warming at 117 tundra locations...
October 2018: Nature
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