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https://www.readbyqxmd.com/read/29783572/re-pudendal-versus-caudal-block-in-children-undergoing-hypospadias-surgery-a-randomized-controlled-trial
#1
Douglas A Canning
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29780414/antibiotic-prophylaxis-with-trimethoprim-sulfamethoxazole-versus-no-treatment-after-mid-to-distal-hypospadias-repair-a-prospective-randomized-study
#2
Elizabeth B Roth, John V Kryger, Charles T Durkee, Melissa A Lingongo, Ruth M Swedler, Travis W Groth
Purpose: To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Materials and Methods: Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29767687/hormone-responsive-genes-in-the-shh-and-wnt-%C3%AE-catenin-signaling-pathways-influence-urethral-closure-and-phallus-growth
#3
Yu Chen, Hongshi Yu, Andrew J Pask, Asao Fujiyama, Yutaka Suzuki, Sumio Sugano, Geoff Shaw, Marilyn B Renfree
Environmental endocrine disruptors (EEDs) that affect androgen or estrogen activity may disrupt gene regulation during normal phallus development to cause hypospadias or a masculinized clitoris. We treated developing male tammar wallabies with estrogen and females with androgen from day 20-40 postpartum (pp) during the established androgen imprinting window. Administration of estrogen to males inhibited phallus elongation but had no effect on urethral closure and did not significantly depress testicular androgen synthesis...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29761139/prophylactic-antibiotics-after-stented-distal-hypospadias-repair-randomized-pilot-study
#4
Stephen Canon, Mary K Marquette, Adam Crane, Ashay Patel, Ismael Zamilpa, Shasha Bai
The usage of prophylactic oral antibiotics following distal hypospadias repair with stenting has been recently challenged. This study evaluated the incidence of symptomatic urinary tract infections (UTIs) following stented, distal hypospadias repair and the impact of prophylactic antibiotic therapy. Subjects 0 to 5 years of age with distal hypospadias were randomized to either Group 1 (antibiotics) or Group 2 (no prophylactic therapy). Urinalysis/urine culture was obtained intraoperatively with no preoperative antibiotics given...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29743143/the-wilms-tumour-1-gene-as-a-factor-in-non-syndromic-hypospadias-evidence-and-controversy
#5
REVIEW
Gergely Buglyó, Dániel Beyer, Sándor Biró, Éva Oláh
Hypospadias is one of the most frequent congenital anomalies of the male external genitalia. Its pathogenesis is due to largely unknown or poorly understood genetic factors and is further complicated by environmental-intrauterine-risk factors. One of the genes currently in focus by molecular biologists and clinicians studying syndromic forms of hypospadias is the Wilms' tumour 1 (WT1) gene. There is controversy over whether WT1 defects are also responsible for isolated hypospadias. In this review, we briefly cover the role of WT1 as a transcription factor and discuss proposed pathogenic pathways leading to hypospadias, outlining possible directions for research...
May 7, 2018: Pathology
https://www.readbyqxmd.com/read/29740335/amniotic-fluid-insl3-measured-during-the-critical-time-window-in-human-pregnancy-relates-to-cryptorchidism-hypospadias-and-phthalate-load-a-large-case-control-study
#6
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A G Jönsson, Jens-Peter Bonde, David M Hougaard, Christian H Lindh, Gunnar Toft, Morten S Lindhard, Richard Ivell
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccessibility. We have used a large national biobank of amniotic fluid samples collected at routine amniocentesis to determine the impacts of exogenous endocrine disruptor load on specific fetal biomarkers at this critical time. While adrenal and testicular steroids are highly correlated, they are also mostly positively influenced by increasing phthalate load, represented by the metabolites 7cx-MMeHP and 5cx-MEPP, by perfluorooctane sulfonate (PFOS) exposure, and by smoking, suggesting an adrenal stress response...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#7
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29738174/-hypospadias-induced-by-maternal-exposure-to-di-n-butyl-phthalate-and-its-mechanisms-in-male-rat-offspring
#8
En-Hui Li, Hai-Bin Wei, Bang-Gao Lhuangi, En-Hui Li, Qi Zhang, Zhi-Hui Xu, Da-Hong Zhang
Objective: To induce hypospadias in male rat offspring by maternal exposure to di-n-butyl phthalate (DBP) during late pregnancy and further investigate its mechanisms. METHODS: We randomly divided 20 pregnant rats into a DBP exposure and a control group, the former treated intragastrically with DBP while the latter with soybean oil at 750 mg per kilogram of the body weight per day from gestation days (GD) 14 to 18. On postnatal day (PND) 1, we recorded the incidence rate of hypospadias and observed the histopathological changes in the genital tubercle of the hypospadiac rats...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29738062/-ultrasound-guided-penile-nerve-block-for-pediatric-hypospadias-surgery
#9
Neşe Türkyılmaz, Yavuz Gürkan, Sevim Cesur, Alparslan Kuş, Mine Solak
An ultrasound-guided dorsal penile nerve (DPN) block was performed for postoperative analgesia in a 6-year-old, 19 kg, American Society of Anesthesiologists class II patient undergoing hypospadias surgery. The block was applied following the induction of general anesthesia. Anesthesia maintenance was provided with sevoflurane 2% in a 1:2 ratio of oxygen and nitrous oxide. The DPN block was performed using 0.2 mL/kg of 0.25% bupivacaine. Almost 24 hours of analgesia was provided following surgery.
April 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29734759/trends-in-the-prevalences-of-selected-birth-defects-in-korea-2008%C3%A2-2014
#10
Jung-Keun Ko, Dirga Kumar Lamichhane, Hwan-Cheol Kim, Jong-Han Leem
Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth defects using health insurance claim data obtained from the Korea National Health Insurance Service (NHIS). Prevalence rate ratios were calculated using Poisson regression to analyze trends over the 7-year study period...
May 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29727541/-modified-snodgrass-technique-for-hypospadias
#11
Fei-Wu Song, Du-Miao Li, Ya-Li Xu, He Huang, Xing-He Chen
Objective: To investigate the clinical effect of modified Snodgrass surgical technique in the treatment of hypospadias. METHODS: We retrospectively analyzed the clinical data about 212 cases of hypospadias treated by urethroplasty from January 2008 to October 2016, 94 with the modified Snodgrass technique, namely with a silk line in addition to the urethral suture to make easier postoperative removal of the suture (group A), and the other 118 with the conventional Snodgrass technique (group B)...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29723568/family-history-is-under-estimated-in-children-with-isolated-hypospadias-a-french-multicenter-report-of-88-families
#12
Margot Ollivier, Francoise Paris, Pascal Philibert, Sarah Garnier, Amandine Coffy, Nadège Fauconnet-Servant, Mirna Haddad, Jean Michel Guys, Rachel Reynaud, Alice Faure, Thierry Merrot, Kathy Wagner, Jean Bréaud, Jean Stéphane Valla, Eric Dobremez, Laura Gaspari, Jean-Pierre Daures, Charles Sultan, Nicolas Kalfa
Whereas familial forms of complex disorders/differences of sex development have been widely reported, data regarding isolated hypospadias are sparse and a family history is thought to be less frequent. We aimed 1-to determine the frequency of hypospadias in families of hypospadiac boys 2-to determine if theses familial forms exhibit a particular phenotype 3-to evaluate the prevalence of genetic defects of the main candidate genes. A prospective inclusion of 395 hypospadiac boys screened for family history with a standardized questionnaire, extensive clinical description, family tree and sequencing of AR, SF1, SRD5A2 and MAMLD1 was performed...
April 30, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29717506/width-proportion-of-the-urethral-plate-to-the-glans-can-serve-as-an-appraisal-index-of-the-urethral-plate-in-hypospadias-repair
#13
Wei Ru, Jing Shen, Daxing Tang, Shan Xu, Dehua Wu, Chang Tao, Guangjie Chen, Lei Gao, Xiaohao Wang, Yiding Shen
OBJECTIVES: To find a new appropriate evaluation for urethral plate quality in hypospadias repair, with particular interest in the width proportion of the urethral plate to the glans, serving as an appraisal index. METHODS: Data were prospectively collected from prepubertal boys who underwent primary tubularized incised plate hypospadias repair between January 2014 and April 2016 in one center. Intrinsic parameters of the penis (meatal location, glans width, urethral plate width and curvature degree) were measured during the operation...
May 1, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29714466/the-relation-between-isolated-micropenis-in-childhood-with-cag-and-ggn-repeat-polymorphisms-in-the-androgen-receptor-gene
#14
Esra Tuğ, Sezen Güntekin Ergün, Mehmet Ali Ergün, Fatma Nihal Dilek, Emriye Ferda Perçin
Background/aim: In micropenis cases accompanied by external genital abnormalities such as hypospadias and cryptorchidism, infertility and spermatogenic failures have been reported to correlate with androgen receptor ( AR ) gene CAG and GGN repeat polymorphisms. While there is one study on isolated micropenis and CAG repeats, no study related to GGN repeats has been reported. We investigated the relation between CAG and GGN repeats in the AR gene with development of penis length in boys with isolated micropenis...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29703688/histological-and-morphological-characteristics-of-the-prepuce-of-penis-skin-structure-in-different-age-groups
#15
A Dossanova, V Lozovoy, K Manekenova, Y Lozovaya, M Seidakhmetov, B Dossanov, T Omarov, A Botabaeva, A Shakeeva, Z Baubekov
BACKGROUND: Hypospadias is one of the most common congenital abnormalities in childhood. The number of cases has rapidly grown in recent years. OBJECTIVES: The purpose of this research was to analyze the histological and morphological differences of the foreskin samples taken from boys in three age groups. STUDY DESIGN: A total of 30 Asian patients participated in the research. Clinical materials obtained via biopsy were divided into three age groups...
March 23, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29692525/hernia-uteri-inguinalis-in-ovotesticular-disorder-of-sexual-differentiation-a-rare-complication-and-role-of-imaging
#16
Janardhana Ponnatapura
Neonate with ambiguous genitalia can cause great apprehension for the family as well as for healthcare providers. We report a rare complication of delayed diagnosis of hernia uteri inguinalis in ovotesticular disorder of sexual differentiation (DSD) in 20-year-old male patient who presented with pain and swelling in left inguinal region since 1 month. He had a past surgical history of repair of hypospadias 10 years back. On imaging, the left inguinal hernia sac contained nonfunctioning uterus and one ovary in the left scrotal sac and one testis in the right scrotal sac...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29681271/transitioning-patients-with-hypospadias-and-other-penile-abnormalities-to-adulthood-what-to-expect
#17
REVIEW
Keith Rourke, Luis H Braga
Hypospadias patients presenting to adult urologists do so with a wide range of symptoms and problems, including urethral stricture (45-72%), lower urinary tract symptoms (with or without stricture) (50-82%), urethrocutaneous fistula (16-30%), persisting hypospadias (14-43%), micturition spraying (24%), ventral curvature (14-24%), urinary tract infection (15-25%), or lichen sclerosus (13%; range 8-43). Many of these men have concurrent complications as the result of multiple operations and a variety of techniques...
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29680277/does-grafted-tubularized-incided-plate-improve-the-outcome-after-repair-of-primary-distal-hypospadias-a-prospective-randomized-study
#18
Tamer E Helmy, Wael Ghanem, Hesham Orban, Helmy Omar, Mahmoud El-Kenawy, Ashraf T Hafez, Mohammed Dawaba
OBJECTIVE: To detect whether grafting the incised plate during Snodgrass repair would improve outcome. MATERIALS AND METHODS: Sixty patients with primary distal hypospadias were included. Patients were equally randomized using closed envelop method to either Snodgrass or grafted tubularized incised plate repair (GTIP). All operations were performed by a single surgeon. All intaroperative data were recorded. All patients were followed up for 1 year. Success was defined as slit shaped meatus at the tip of the glans with no stenosis, fistula or diverticulum...
March 21, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29680275/can-sacral-development-as-a-marker-for-caudal-regression-help-identify-associated-urologic-anomalies-in-patients-with-anorectal-malformation
#19
Alejandra Vilanova-Sanchez, Carlos A Reck, Yuri V Sebastião, Molly Fuchs, Devin R Halleran, Laura Weaver, D Gregory Bates, Alessandra C Gasior, Tassiana Maloof, Erin J Hoover, Jordan Jaggers, Renae Gagnon, Christina C Ching, Daniel Dajusta, Venkata R Jayanthi, Marc A Levitt, Richard J Wood
BACKGROUND AND AIM: The sacral ratio (SR) is a well-established tool to quantify sacral development in patients with anorectal malformations (ARM) and can be used as a predictor of fecal continence. We hypothesized that a lower SR correlated with the presence of urologic and renal malformations. METHODS: We retrospectively reviewed the medical records of patients with ARM treated at our center from 2014 to 2016. We measured the lateral SR as a marker for sacral development and assessed the spine for the presence of tethered cord (TC)...
March 23, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29671932/contemporary-outcomes-of-hypospadias-retrieval-surgery-in-adults
#20
R B Aldamanhori, N I Osman, R D Inman, C R Chapple
PURPOSE: Adults with complications of childhood hypospadias surgery, present a significant reconstructive challenge due to the combination of anatomical and cosmetic deformity, which often results in major functional and psychosexual sequelae. We describe the surgical approach and outcomes in the treatment of those patients. MATERIALS AND METHODS: An analysis of prospectively collected data on 79 adults with complications of childhood hypospadias surgery, who were operated on between 2004-2016, was undertaken...
April 19, 2018: BJU International
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