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B Estors Sastre, P Bragagnini Rodríguez, R Fernández Atuan, R Delgado Alvira, M A Rihuete Heras, J Gracia Romero
AIM OF THE STUDY: To investigate the association between endocrine disrupting chemicals (EDC) exposure and other paternal factors in the etiology of hipospadias and cryptorchidism. METHODS: A case-control study. Cases were infants between 0 and 6 years of age diagnosed with hypospadias or cryptorchidism in our pediatric urology and general pediatric surgery services during a period of 6 months, and controls were infants with the same range of age attending the same services without any urological problem...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Vanesa Rodríguez Fernández, Carlos López Ramón Y Cajal, Elena Marín Ortiz, Nerea Sarmiento Carrera
The hypospadias is the most common urogenital anomaly of male neonates but the prenatal diagnosis of this is often missed before birth. We present the prenatal diagnosis of a severe penoscrotal hypospadias using 2D and 3D ultrasounds. 3D sonography allowed us the best evaluation of the genitals and their anatomical relations. This ample detailed study allowed us to show the findings to the parents and the pediatric surgeon and to configure the best information about the prognosis and surgical treatment.
2016: Case Reports in Obstetrics and Gynecology
Marco Castagnetti, Vincenzo Bagnara, Waifro Rigamonti, Marcello Cimador, Ciro Esposito
OBJECTIVE: In principle, the prepuce can be reconstructed during hypospadias repair, but the procedure has not gained wide acceptance and preputial reconstruction (PR) is surrounded by several controversies. MATERIAL AND METHODS: A review is provided of the technique for PR, how PR combines with the other steps of hypospadias repair, the risks of complications related to the urethroplasty and specific to PR, and the results of PR with particular regard to the relevance for the patient and his family...
September 22, 2016: Journal of Pediatric Urology
Douglas A Canning
No abstract text is available yet for this article.
November 2016: Journal of Urology
Christopher J Long, Douglas A Canning
Hypospadias surgery is a humbling art form. The evolution of surgical techniques has made distal hypospadias outcomes favorable, but recent publications suggest that our complication rates for proximal hypospadias are much higher than previously reported. To explain these shortcomings, we examine the literature and focus on the lack of standardized documentation, the subsequent inability to objectify the severity of the phenotype, and the underestimation of complications due to lack of long-term follow up. The variability in surgical technique and the fact that the literature abounds with small case series from single institutions also limits our ability to compare outcomes...
2016: F1000Research
K L M Pfistermüller, S Manoharan, D Desai, P M Cuckow
INTRODUCTION: Repair of severe primary and revision hypospadias is a demanding procedure. Debate continues as to whether a two-stage approach or single-stage technique is superior. The two-stage procedure with a free graft involves penile straightening followed by application of a graft for the neourethral plate at stage one; with tubularization at stage two after graft maturation. OBJECTIVE: To report the outcomes of a single surgeon's experience with the two-stage repair using a free graft for both severe primary and revision hypospadias with long-term follow-up...
September 29, 2016: Journal of Pediatric Urology
Haci Polat, Umut Gulacti
PURPOSE: To find answers to some catheter-related questions in hypospadias repair such as which type of catheter should be used, with which catheter balloon inflation volume, and when should the catheter be removed from the urethra? As catheter use and post-op retention time varies among surgeons in hypospadias repair. MATERIAL AND METHODS: Fifty-four 10 French all-silicone- and 54 latex Foley catheters were prepared and assigned to groups as senary. The catheter's balloons were inflated with 2, 3 and 5 mL of sterile water...
October 10, 2016: Urology Journal
Chen Shuzhu, Wu Min, Liu Yidong, Ye Weijing
BACKGROUND: Over the past two decades, Snodgrass tubularized incised plate (TIP) urethroplasty has become one of the dominant surgical techniques with wide applications and excellent cosmetic results. However, TIP has many limitations. We performed a retrospective study at our department and assessed the outcome of the inlay internal preputial graft for extending the applications of TIP. METHODS: Between January 2009 and December 2013, we performed a retrospective study consisting of approximately 508 primary distal and moderate cases...
2016: SpringerPlus
H Suzuki, S Matsushita, K Suzuki, G Yamada
Androgen is an essential factor involved in masculinization of external genitalia. Failure of the exposure to 5α-dihydrotestosterone (DHT) causes a hypoplastic penile size and urethral abnormality. The main pathology of hypospadias is defective urethral closure on the ventral side of the penis. Hormone-dependent genes are suggested as the causative factors. However, the detailed mechanisms of DHT functions on urethral tube formation remain unknown. Androgen is both a positive and negative regulator of cell proliferation...
October 1, 2016: Andrology
Kirtikumar Rathod, Jaskiren Loyal, Bharat More, Ashok Rajimwale
BACKGROUND: To describe a modification of PATIO repair for urethrocutaneous fistula repair and evaluate its outcome. METHODS: We studied 15 boys who underwent modified PATIO repair from Jan 2010 to Sept 2015. Parameters studied included age, type of hypospadias, age at first urethroplasty, hypospadias repair technique, number of urethroplasties required, location of fistula, time gap between urethroplasty and fistula repair, method of fistula repair, and outcome of fistula repair...
October 1, 2016: Pediatric Surgery International
Tuncer Ahmet Ali, Karavelioğlu Afra, Baskin Embleton Didem, Elmas Muhsin
Holt-Oram syndrome (HOS) is a rare autosomal dominant disorder, characterized by upper limb dysplasia and congenital cardiac defect. We report two cases with HOS, first associated with renal agenesis, coronal hypospadias, urethral duplication and second associated with duodenal atresia and horseshoe kidney that have not been reported in English literature.
October 2016: Journal of Indian Association of Pediatric Surgeons
Nathan Y Hoy, Keith F Rourke
OBJECTIVES: To describe the spectrum of adult presentations with hypospadias-related complications and examine the effect of childhood surgical repair on these adult presentations. METHODS: A retrospective chart review over a 10-year period, from Aug. 2004-Dec. 2014, demonstrated 93 adult patients who presented to a reconstructive urologist with complications related to hypospadias. Patients were divided into two groups: those with no prior hypospadias surgery (Group 1, N=19) and those who underwent surgical correction as a child (Group 2, N=74)...
September 27, 2016: Urology
Ann Nozohoor Ekmark, Einar Arnbjörnsson, Henry Svensson, Emma Hansson
PURPOSE: Long-term evaluation of the surgical outcome after puberty, particularly patient reported outcome is rare in the literature. The aims of this study were to investigation the patients' satisfaction with the long-term results and their views and memories of their childhood surgery and follow-up. METHODS: A modified version of previously used questionnaire was sent to 134 patients ages 18 years or older previously primarily repaired due to hypospadias by one of the authors (HS) between 1989 -2009...
August 9, 2016: Journal of Plastic Surgery and Hand Surgery
Nicolas Fernández, Jaime Perez, Ignacio Zarante
No abstract text is available yet for this article.
September 8, 2016: Journal of Pediatric Urology
Ryo Sueyoshi, Shogo Seo, Takanori Ochi, Hiroshi Murakami, Yuta Yazaki, Masahiro Takeda, Hiroki Nakamura, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: CHARGE is our technique for reinforcing the ventral penile shaft with pedicled pericordal/scrotal fat, pedicled perimeatal connective tissue, or a combination of these at the time of initial hypospadias surgery. Such pedicled grafts "charge" poorly developed urethral plates and thin ventral foreskin prior to urethroplasty to improve compromised vascular perfusion that could prevent post-urethroplasty complications (post-UPC). METHODS: We reviewed post-UPC in 179 staged hypospadias repair patients (1997-2015)...
September 16, 2016: Journal of Pediatric Surgery
Warren G Foster, Jane A Evans, Julian Little, Laura Arbour, Aideen Moore, Reg Sauve, Juan Andrés León, Wei Luo
Congenital anomalies are an important cause of infant mortality and disability. Developmental exposure to environmental contaminants is thought to increase the risk for congenital anomalies. Herein, we describe a critical review of the literature conducted between February and March 2014 yielding 3057 references from which 97 unique relevant articles published from 2003 through 2014 were evaluated. Common congenital anomalies including hypospadias, cryptorchidism, anogenital distance (AGD), congenital heart defects and oral clefts were well represented in the literature whereas other outcomes such as neural tube defects, limb deficiency defects and gastroschisis were rarely described...
August 11, 2016: Critical Reviews in Toxicology
K Cox, A Kyriakou, B Amjad, S O'Toole, M E Flett, M Welsh, S F Ahmed, S Cascio
INTRODUCTION: Anogenital distance (AGD) is a recognised marker of in utero androgen action. OBJECTIVE: This study aimed to evaluate the relationship between severity of hypospadias and AGD. STUDY DESIGN: Boys undergoing hypospadias repair in a single tertiary centre between May 2012 and February 16 were included in the study. Anogenital distance was measured from the centre of the anus to the base of the penis, and anoscrotal distance (ASD) from the centre of the anus to the junction between the smooth perineal skin and scrotal skin...
September 9, 2016: Journal of Pediatric Urology
Gaurav Prakash, Manmeet Singh, Apul Goel, Ankur Jhanwar
An 11-year-old girl presented with poor urinary stream with vaginal voiding since childhood. She had palpable bladder and raised serum creatinine (671 µmol/L). Suprapubic catheterisation was performed after a failed urethral attempt. Following catheterisation she improved symptomatically. She underwent cystoscopy through the suprapubic portal as a guide wire could be negotiated through bladder neck; external urethral meatus was found as a dimple higher up in anterior vaginal wall. Female hypospadias is usually an incidental diagnosis during catheterisation for various reasons...
2016: BMJ Case Reports
Emir Tas, Jessica Sebastian, Suneeta Madan-Khetarpal, Philip Sweet, Alexander N Yatsenko, Nijole Pollock, Aleksandar Rajkovic, Francis X Schneck, Svetlana A Yatsenko, Selma Feldman Witchel
Hand-Foot-Genital syndrome is a rare autosomal dominant condition characterized by distal limb anomalies and urogenital malformations. This disorder is associated with loss-of-function mutations in the HOXA13 gene. HOXA13 plays an important role in the development of distal limbs and lower genitourinary tract of the fetus. We report a novel familial 589 kb deletion in the 7p15.2 region identified in a male toddler and his mother. The proband had severe penoscrotal hypospadias, mild skeletal anomalies of the hands and feet, cardiac, renal, and gastrointestinal anomalies...
September 20, 2016: American Journal of Medical Genetics. Part A
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