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Hypospadias

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https://www.readbyqxmd.com/read/28638814/congenital-urogenital-abnormalities-in-children-with-congenital-hypothyroidism
#1
Parsa Yousefi Chaijan, Fatemeh Dorreh, Mojtaba Sharafkhah, Mohammad Amiri, Mohsen Ebrahimimonfared, Mohammad Rafeie, Fatemeh Safi
Background: Congenital hypothyroidism (CH), as one of the most common congenital endocrine disorders, may be significantly associated with congenital malformations. This study investigates urogenital abnormalities in children with primary CH (PCH). Methods: This case-control study was conducted on 200 children aged three months to 1 year, referred to Amir-Kabir Hospital, Arak, Iran. One hundred children with PCH, as the case group, and 100 healthy children, as the control group, were selected using convenient sampling...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28635116/maternal-smoking-alcohol-and-caffeine-exposures-and-risk-of-hypospadias
#2
Suzan L Carmichael, Chen Ma, Gary M Shaw
BACKGROUND: We examined the association of hypospadias risk with maternal smoking and consumption of alcohol and caffeine. METHODS: We analyzed data from mothers of 2437 moderate/severe cases and 5472 nonmalformed controls born from 1997 to 2011 who participated in the National Birth Defects Prevention Study (NBDPS). Exposures were assessed by maternal telephone interviews. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for mother's age, parity, race-ethnicity, education, vitamin/mineral supplement intake, obesity, and study center...
June 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/28632892/maternal-overweight-and-obesity-and-genital-anomalies-in-male-offspring-a-population-based-swedish-cohort-study
#3
Linn Håkonsen Arendt, Cecilia Høst Ramlau-Hansen, Morten Søndergaard Lindhard, Tine Brink Henriksen, Jørn Olsen, Yongfu Yu, Sven Cnattingius
BACKGROUND: Overweight and obese pregnant women face higher risk of several critical birth outcomes, including an overall increased risk of congenital abnormalities. Only few studies have focused on associations between maternal overweight and the genital anomalies in boys, cryptorchidism and hypospadias, and results are inconclusive. METHODS: We performed a population-based cohort study and assessed the associations between maternal body mass index (BMI) in early pregnancy and occurrence of cryptorchidism and hypospadias...
June 20, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28631919/-rehabilitation-of-patients-with-complicated-forms-of-urethral-obliterations
#4
M B Pryanichnikova, O V Zhurkina
The article describes open surgical modalities for managing patients with severe obliterations of the anterior urethra. The mean age of patients was 70 years. The causes of urethral strictures and obliteration included prostatic adenomectomy, scrotal abscess with pelvic bone osteomyelitis, accidental removal of the bulbar and penile urethra during herniotomy and a prolonged use of an indwelling urethral catheter. Two patients underwent perineostomy (median and trapezoidal). In the third patient, scrotal skin was used to form "scrotal hypospadias" (a modified Johansons operation) and the fourth patient underwent Mikhalovskiis operation...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631912/-results-of-urethral-reconstruction-in-adults-after-multiple-hypospadias-repairs
#5
S I Gamidov, M G Shneiderman, D Yu Pushkar, A O Vasil'ev, A V Govorov, R I Ovchinnikov, A Yu Popova, R D Dusmukhamedov
AIM: To improve treatment results in patients after multiple hypospadias repairs by optimizing the postoperative management. MATERIALS AND METHODS: Eighty-two patients (mean age 48.1+/-15.3 years) with urethral strictures secondary to failed hypospadias repairs underwent staged graft urethroplasty using oral mucosa (cheek, lip, tongue) as a grafting material. In 62 patients, at the end of surgery the bladder was drained with a standard Foley catheter. In twenty patients the bladder was drained with a modified silicone urethral catheter, which had an additional channel for delivering drugs and removing the urethral wound effluent, and a second additional channel for inflating a balloon fixed to the catheter tube at different parts of the catheter...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28630018/the-modified-ulaanbaatar-procedure-reduced-complications-and-enhanced-cosmetic-outcome-for-the-most-severe-cases-of-hypospadias
#6
V R Jayanthi, C B Ching, D G DaJusta, D J McLeod, S A Alpert
INTRODUCTION/OBJECTIVE: Proximal hypospadias is one of the most challenging conditions that pediatric urologists have to deal with. Many procedures have been devised over the years, but nothing has been proven to be the best option. Although there have been some attempts at correcting severe hypospadias in one procedure, most have advocated a staged approach. The classic approach - laying penile skin or a graft within a split glans followed by glanuloplasty at the second stage - by definition requires two operations on the glans...
May 18, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28629784/-from-paediatric-urological-care-to-adult-urology-assessment-of-a-transition-consultation-for-adolescents
#7
L Even, S Mouttalib, J Moscovici, M Soulie, P Rischmann, X Game, P Galinier, O Bouali
To provide an adequate lifelong urological care in the complex period of adolescence, a transition consultation conducted by a paediatric surgeon and an urologist was developed in our institution. As a real rite of passage, it allows the follow-up and the adapted care of urological conditions, sometimes complex, and permits the transition between childhood and the world of grown-ups. We reported our experience at the Children Hospital of our institution (paediatric surgery and urology departments). During a 6 months period (January-July 2015), forty-five young adults with a mean age of 17...
June 16, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28625592/a-critical-analysis-of-stented-and-unstented-tubularized-incised-plate-urethroplasty-through-a-prospective-randomized-study-and-assessment-of-factors-influencing-the-functional-and-cosmetic-outcomes
#8
Tarek M El-Karamany, Ahmed M Al-Adl, Rabea G Omar, Ashraf M Abdel Aal, Amr S Eldakhakhny, Shabieb A Abdelbaki
(1) OBJECTIVES: To compare functionally and aesthetically between stented and unstented tubularized incised plate urethroplasty (TIPU). In addition, predictors of repair success were investigated. (2) METHODS: 110 children with distal hypospadias included in this study. Length and width of the urethral plate (UP) and transverse glans diameter (TGD) were measured. Patients were randomized into two groups, stented and unstented TIPU. Postoperative assessment of pain using Face, Legs, Activity, Cry, Consolability (FLACC) scale and cosmetic outcome using hypospadias objective scoring evaluation (HOSE)...
June 15, 2017: Urology
https://www.readbyqxmd.com/read/28600871/substitution-urethroplasty-using-oral-mucosa-graft-for-male-anterior-urethral-stricture-disease-current-topics-and-reviews
#9
REVIEW
Akio Horiguchi
Male anterior urethral stricture is scarring of the subepithelial tissue of the corpus spongiosum that constricts the urethral lumen, decreasing the urinary stream. Its surgical management is a challenging problem, and has changed dramatically in the past several decades. Open surgical repair using grafts or flaps, called substitution urethroplasty, has become the gold standard procedure for anterior urethral strictures that are not amenable to excision and primary anastomosis. Oral mucosa harvested from the inner cheek (buccal mucosa) is an ideal material, and is most commonly used for substitution urethroplasty, and lingual mucosa harvested from the underside of the tongue has recently emerged as an alternative material with equivalent outcome...
June 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28599093/clinical-and-molecular-cytogenetic-characterization-of-four-unrelated-patients-carrying-2p14-microdeletions
#10
Marie-Laure Mathieu, Caroline Demily, Sandra Chantot-Bastaraud, Alexandra Afenjar, Cyril Mignot, Joris Andrieux, Marion Gerard, Jaume Catala-Mora, Pierre Simon Jouk, Audrey Labalme, Patrick Edery, Damien Sanlaville, Massimiliano Rossi
We report the clinical and molecular cytogenetic characterization of four unrelated patients from France and Spain, carrying 2p14 microdeletions and presenting with intellectual disability and dysmorphisms. 2p14 microdeletions are very rare. Seven patients have been reported so far harboring deletions including 2p14p15 and encompassing OTX1, whose haploinsufficiency is frequently associated with genitourinary defects. To date, only one patient has been reported carrying a more proximal 2p14 microdeletion which does not include OTX1...
June 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28597849/association-between-diacylglycerol-kinase-kappa-variants-and-hypospadias-susceptibility-in-a-han-chinese-population
#11
Hua Xie, Xiao-Ling Lin, Song Zhang, Ling Yu, Xiao-Xi Li, Yi-Chen Huang, Yi-Qing Lyu, Hai-Tao Chen, Jianfeng Xu, Fang Chen
Previous genome-wide association studies have identified variants in the diacylglycerol kinase kappa (DGKK) gene associated with hypospadias in populations of European descent. However, no variants of DGKK were confirmed to be associated with hypospadias in a recent Han Chinese study population, likely due to the limited number of single-nucleotide polymorphisms (SNPs) included in the analysis. In this study, we aimed to address the inconsistent results and evaluate the association between DGKK and hypospadias in the Han Chinese population through a more comprehensive analysis of DGKK variants...
June 9, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28588710/the-clinical-analysis-of-small-supernumerary-marker-chromosomes-in-17-children-with-mos-45-x-46-x-mar-karyotype
#12
Hongying Wang, Ting Wang, Naichao Yang, Yaxiang He, Linqi Chen, Liyi Hong, Xuejun Shao, Hong Li, Hong Zhu, Haibo Li
Small supernumerary maker chromosome (sSMC) is a type of structurally abnormal chromosome. In order to identify the origin, morphology and other characteristics of sSMCs in children with mos 45,X/46,X,+mar karyotype, 17 patients (16 females and 1 male) were analyzed. All patients underwent general physical examination, gonadal imaging and molecular cytogenetic analyses, including Giemsa banding, dual-color fluorescence in situ hybridization and detection of the sex-determining region Y gene by polymerase chain reaction...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588045/assessing-the-impact-of-in-utero-exposures-potential-effects-of-paracetamol-on-male-reproductive-development
#13
REVIEW
Karen R Kilcoyne, Rod T Mitchell
Human male reproductive disorders (cryptorchidism, hypospadias, testicular cancer and low sperm counts) are common and some may be increasing in incidence worldwide. These associated disorders can arise from subnormal testosterone production during fetal life. This has resulted in a focus on in-utero environmental influences that may result in reproductive effects on the offspring in later life. Over recent years, there has been a dramatic increase in the scientific literature describing associations between in-utero environmental exposures (eg, industrial chemicals and pharmaceuticals) and subsequent reproductive outcomes in male offspring...
June 6, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28587367/seasonal-trends-in-the-prevalence-of-hypospadias-aetiological-implications
#14
C Mamoulakis, G Avgenakis, C Gkatzoudi, G Duyker, I E Zisis, I Heretis, S Antypas, N Sofikitis, D A Spandidos, A M Tsatsakis, A Tzonou
The aim of the present study was to examine the seasonality of hypospadias in Greece in an attempt to elucidate the aetiology. All boys born between 1991-1998, who underwent hypospadias repair at 'Aghia Sophia' Children's Hospital, Athens (n=542) were analysed. All Greek live-born males during the same period (population at risk; m=421,175) served as the controls. Seasonality by month of birth was evaluated with specific statistical tools. Meteorological parameters were also analysed. All tests yielded significant results, suggesting a simple harmonic prevalence pattern (highest/lowest: autumn, peak in October/spring, trough in April)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585401/caudal-analgesia-hypospadias-and-urethrocutaneous-fistula-does-association-mean-causality
#15
EDITORIAL
David M Polaner, Nicole Almenrader, Vijaya Vemulakonda
No abstract text is available yet for this article.
July 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28579133/two-stage-flap-repair-of-severe-hypospadias-usefulness-of-the-tubularized-incised-plate-urethroplasty
#16
K H Tijani, H O Idiodi-Thomas, O A Elebute, F M Alakaloko, R W Ojewola, A O Ademuyiwa
PURPOSE: The use of flaps in the two-stage repair of posterior hypospadias associated with severe chordee has been well established. Despite the almost certain guarantee of flap take, complications such as diverticuli are still relatively high. While different applications of the tubularized incised plate have been described, experience with the application of the technique to the two-stage flap repair is very limited. A previous local review of 15 cases performed at the present institution during the period 1998-2003, using the technique as described by Rekit, revealed fistulae and diverticulum rates of 20% and 27%, respectively...
May 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28570466/risk-factors-for-urethrocutaneous-fistula-repair-after-hypospadias-surgery-a-retrospective-study
#17
Jun Feng, Zhe Yang, Yong Tang, Wen Chen, Mu-Xin Zhao, Ning Ma, Wei-Xin Wang, Li-Si Xu, Yang-Qun Li
OBJECTIVES: We review our experience in urethrocutaneous fistula (UCF) repair after hypospadias surgery to investigate the risk factors for unsuccessful outcome. METHODS: Two hundred eleven patients had undergone UCF repair in our department from January 2005 to December 2015. This study included 185 patients who were followed up for more than 6 months. The age of patients, size, site and number of UCFs, number of UCF repairs, urethral complications other than UCF, and postoperative infection were included as potential risk factors...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28566206/quality-of-reporting-for-randomized-controlled-trials-in-the-hypospadias-literature-where-do-we-stand
#18
Luis H Braga, Melissa McGrath, Bethany Easterbrook, Kizanee Jegatheeswaran, Linnea Mauro, Armando J Lorenzo
INTRODUCTION: To assess the quality of reporting of randomized controlled trials (RCTs) in the hypospadias literature using the 2010 Consolidated Standards of Reporting Trials (CONSORT) statement. It was hypothesized that hypospadias RCTs that contained clear descriptions of key methodological items, allocation concealment, blinding, and sample size justification would have higher overall quality of reporting scores (OQS). MATERIALS AND METHODS: A comprehensive search was conducted through MEDLINE to identify RCTs in hypospadias surgical techniques and postoperative management during the period 1990-2014...
April 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28559234/etiology-and-clinical-presentation-of-birth-defects-population-based-study
#19
Marcia L Feldkamp, John C Carey, Janice L B Byrne, Sergey Krikov, Lorenzo D Botto
Objective To assess causation and clinical presentation of major birth defects.Design Population based case cohort.Setting Cases of birth defects in children born 2005-09 to resident women, ascertained through Utah's population based surveillance system. All records underwent clinical re-review.Participants 5504 cases among 270 878 births (prevalence 2.03%), excluding mild isolated conditions (such as muscular ventricular septal defects, distal hypospadias).Main outcome measures The primary outcomes were the proportion of birth defects with a known etiology (chromosomal, genetic, human teratogen, twinning) or unknown etiology, by morphology (isolated, multiple, minors only), and by pathogenesis (sequence, developmental field defect, or known pattern of birth defects)...
May 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28556547/a-systematic-review-on-cell-seeded-tissue-engineering-of-penile-corpora
#20
REVIEW
Dorien E C M de Vocht, Vincent de Kemp, J D Iljas, J L H Ruud Bosch, Laetitia M O de Kort, Petra de Graaf
INTRODUCTION: Tissue engineering of corporal tissue is a new development in otherwise untreatable erectile dysfunction and in urethral reconstructions to treat hypospadias or severe urethral stricture disease. Multiple complications can arise with the current treatments, whereas engineered tissue, if well vascularized and existing of autologous cells, may lead to better results. The aim of this review was to provide an overview of literature on cell seeded based tissue engineering of corporal penile tissue...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
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