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Hypospadias

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https://www.readbyqxmd.com/read/29155192/external-genital-development-urethra-formation-and-hypospadias-induction-in-guinea-pig-a-double-zipper-model-for-human-urethral-development
#1
Shanshan Wang, Mingxin Shi, Dongqing Zhu, Ranjiv Mathews, Zhengui Zheng
OBJECTIVES: To determine whether the guinea pig phallus would be an appropriate model of human penile development, we characterized the embryology and sexual differentiation of guinea pig external genitalia and attend to induce hypospadias in males and tubular urethra formation in females pharmacologically. MATERIALS AND METHODS: The external genitalia of guinea pig were collected from genital swelling initiation to newborn stages and Scanning Electronic Microscopy and histology were performed to visualize the morphology and structure...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29155191/ultrasound-guided-pudendal-block-is-a-viable-alternative-to-caudal-block-for-hypospadias-surgery-a-single-surgeon-pilot-study
#2
Sarah Hecht, Jorge Piñeda, Aaron Bayne
OBJECTIVE: To evaluate pudendal nerve block as an alternative to caudal block for hypospadias surgery. METHODS: Data were obtained by chart review. Children who underwent hypospadias repair between 2012 and 2016 by a single surgeon at an academic institution were included. Patients received ultrasound-guided pudendal block (n=21) or caudal block (n=19) as a regional adjunct to general anesthesia. Primary outcomes included analgesic requirement and postoperative length of stay in the recovery unit...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29144927/re-can-separation-of-the-scrotal-sac-in-proximal-hypospadias-reliably-predict-the-need-for-urethral-plate-transection
#3
Douglas A Canning
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29137943/cystoscopic-assisted-laparoscopic-excision-of-prostatic-utricle
#4
Ibrahim A Mostafa, Mark N Woodward, Mohamed S Shalaby
We present a video of our technique for resection of a large prostatic utricle (PU) in a patient who presented initially with disordered sexual development. His karyotype was 46XY, and phenotypically had penoscrotal hypospadias, bifid scrotum, and retractile right testis. An initial micturating cystourethrogram (MCUG) demonstrated the utricle but failed to cannulate the bladder. Being asymptomatic, we carried out staged repair of his hypospadias. Later, he started to have recurrent epididymo-orchitis with resistance to multiple antibiotics...
October 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29135145/-aesthetic-criteria-in-surgical-treatment-of-hypospadias-in-children
#5
G V Kozyrev, A A Protasov, V V Nikolaev, F K Abdullaev, G A Abdulkarimov, M E Karmanov
Aesthetically acceptable cosmetic results of surgical correction of external genital organ defects are important for treatment evaluation along with well-known criteria of good functional outcomes.The purpose of this study was to improve the results of treating children with hypospadias by improving the assessment of results and introducing multi-step correction modalities. MATERIALS AND METHODS: From 2013 to 2015, 476 patients with various forms of hypospadias were treated at the Department of Uroandrology of RCCH...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29133164/pre-incision-urethral-plate-width-does-not-impact-short-term-tubularized-incised-plate-urethroplasty-outcomes
#6
N C Bush, W Snodgrass
INTRODUCTION: Two reports have found that urethral plate (UP) widths <8 mm before tubularized incised plate (TIP) incision increased urethroplasty complications. The present study measured pre-incision UP width in consecutive boys undergoing TIP to determine if it affected outcomes. METHODS: The present study followed the method previously used by Holland and Smith, and Sarhan et al. to measure UP width before creating glans wings or performing midline plate incision in consecutive patients with primary hypospadias and ventral curvature <30°, who all underwent TIP repair (Summary Fig...
June 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29132483/glanular-hypospadias-management-with-modified-circumcision-and-firlit-procedure
#7
Nadeem Iqbal, Ijaz Hussain, Muneeb Ahmad Cheema, Muhammad Taimur Hijazi, Meherunnisa Asif Khan, Omair Ul Haq Lodhi, Saeed Akhter
OBJECTIVE: To document the results of using simple technique of Firlit procedure with modified circumcision for treatment of glanular hypospadias. STUDY DESIGN: Descriptive case series. PLACE AND DURATION OF STUDY: Department of Urology, Shifa International Hospital, Islamabad, from January 2011 till May 2017. METHODOLOGY: The subjects included pediatric patients who underwent repair of glanular hypospadias by using modified circumcision and Firlit procedure...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29119034/a-unique-case-of-testicular-compromise-in-a-patient-with-ovotesticular-disorder-of-sexual-development-and-a-solitary-testicle
#8
Ethan Vargo, Lillianne Stanitsas, Mark Memo
Ovotesticular disorder of sexual development (OT-DSD), previously true hermaphroditism, is a condition in which one or both gonads contain testicular and ovarian tissue. A 23-year-old OT-DSD male patient presented with continuous pain in his right testicle which had been previously intermittent over the past five days. The patient had a prior history of left ovotestis removal with prosthesis placement, a right undescended testicle with aberrant anatomy, and hypospadias repair, all of which were corrected shortly after birth...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29118541/hypospadias-repair-during-adulthood-case-series
#9
Waleed M AlTaweel, Raouf M Seyam
Purpose: We report our complications and success rate in adult hypospadias repair. Patients and Methods: This was a retrospective study of patients aged ≥17 years who underwent hypospadias repair during 2006-2014. We analyzed two groups, one with primary repair and the other that had secondary repair after failed childhood hypospadias surgery. Outcome was compared between the two groups and among different surgical procedures. Descriptive statistics and Fisher's exact test were used and significance level was set at P < 0...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29118537/choosing-an-ideal-vascular-cover-for-snodgrass-repair
#10
Mamatha Basavaraju, Dhiraj K Balaji
Aim: The aim of this study is to compare tunica vaginalis (TV), dorsal dartos, and ventral dartos flap as a second layer vascular cover during Snodgrass repair. Materials and Methods: Data of 83 patients who underwent primary hypospadias repair with Snodgrass technique (age range: 1.6-12 years) were retrospectively collected and compared. They were divided into three groups. Group A (26 patients) included cases using TV flap, Group B (36 patients) included those where dorsal dartos from prepuce was used as second cover, and Group C (21 patients) included those with ventral dartos as cover...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29112520/maternal-diabetes-mellitus-and-genital-anomalies-in-male-offspring-a-nationwide-cohort-study-in-two-nordic-countries
#11
Linn Håkonsen Arendt, Morten Søndergaard Lindhard, Tine Brink Henriksen, Jørn Olsen, Sven Cnattingius, Gunnar Petersson, Erik Thorlund Parner, Cecilia Høst Ramlau-Hansen
BACKGROUND: Diabetes in pregnancy has been associated with an increased risk of congenital malformations overall, but studies on genital anomalies in boys are conflicting and possible causal mechanisms are not well understood. Previous studies have mainly assessed pre-gestational and gestational diabetes in combination. Yet considering the vulnerable time windows for the genital anomalies, associations could well differ between types of diabetes and between the two genital anomalies and we therefore aimed to study this further...
November 6, 2017: Epidemiology
https://www.readbyqxmd.com/read/29108977/sexual-dysfunction-in-urethral-reconstruction-a-review-of-the-literature
#12
REVIEW
Cooper R Benson, Ly Hoang, Jonathan Clavell-Hernández, Run Wang
INTRODUCTION: Urethral stricture disease accounts for 5,000 hospitalizations and 1.5 million office visits per year. Urethral reconstruction has become more commonplace with the recognition of the poor long-term success of the endoscopic management of stricture disease. Sexual dysfunction related to the surgical management of urethral strictures is an under-recognized sequela. AIM: To characterize and elucidate the various factors that contribute to sexual dysfunction after urethroplasty and hypospadias reconstruction to improve surgical decision making and patient counseling...
November 3, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29107132/staged-urethroplasty-for-penile-urethral-strictures-from-lichen-sclerosus-and-failed-hypospadias-repair
#13
Bradley D Figler, Andrew Gomella, Logan Hubbard
OBJECTIVE: To present our technique for staged urethroplasty with buccal mucosa graft. METHODS: The patient presented is a 42 year-old male with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self intermittent dilation. Recently, dilation became more difficult, and he was referred for reconstruction. Work-up revealed a high-grade stricture extending from the meatus to the site of the previous anastomosis at the penoscrotal junction...
October 26, 2017: Urology
https://www.readbyqxmd.com/read/29080015/expression-of-xenobiotic-biomarkers-cyp1-family-in-preputial-tissue-of-patients-with-hypospadias-and-phimosis-and-its-association-with-dna-methylation-level-of-srd5a2-minimal-promoter
#14
Seiichiroh Ohsako, Toshiki Aiba, Mami Miyado, Maki Fukami, Tsutomu Ogata, Yutaro Hayashi, Kentaro Mizuno, Yoshiyuki Kojima
Several epidemiological studies have suggested that the incidence of male reproductive organ malformations, including hypospadias or cryptorchidism, has increased due to fetal-stage exposure to environmental pollutants. However, the association of chemical exposure with the expression of target regulatory genes in the tissues of patients has not yet been reported. Because experimental approaches or clinical trials in human studies are limited, especially those using fetal and/or infants, it is difficult to obtain clear physiological evidence of mechanisms underlying male reproductive malformations...
October 27, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29071560/sevoflurane-affects-oxidative-stress-and-alters-apoptosis-status-in-children-and-cultured-neural-stem-cells
#15
Xue Zhou, Dihan Lu, Wen-da Li, Xiao-Hui Chen, Xiao-Yu Yang, Xi Chen, Zhi-Bin Zhou, Jiang-Hong Ye, Xia Feng
Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery were randomized to receive sevoflurane (SG, n = 24) or propofol (PG, n = 23) general anesthesia. Venous blood was collected at three different times-immediately after induction, 2 h, and 3 days after surgery...
October 25, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29071335/prevalence-of-untreated-surgical-conditions-in-rural-rwanda-a-population-based-cross-sectional-study-in-burera-district
#16
Rebecca G Maine, Allison F Linden, Robert Riviello, Emmanuel Kamanzi, Gita N Mody, Georges Ntakiyiruta, Grace Kansayisa, Edmond Ntaganda, Francine Niyonkuru, Joel M Mubiligi, Tharcisse Mpunga, John G Meara, Bethany L Hedt-Gauthier
Importance: In low- and middle-income countries, community-level surgical epidemiology is largely undefined. Accurate community-level surgical epidemiology is necessary for surgical health systems planning. Objective: To determine the prevalence of surgical conditions in Burera District, Northern Province, Rwanda. Design, Setting, and Participants: A cross-sectional study with a 2-stage cluster sample design (at village and household level) was carried out in Burera District in March and May 2012...
October 25, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29071159/mathieu-technique-with-incision-of-the-urethral-plate-versus-standard-tubularised-incised-plate-urethroplasty-in-primary-repair-of-distal-hypospadias-a-prospective-randomised-study
#17
Mostafa Khalil, Tarek Gharib, Waleed El-Shaer, Ahmed Sebaey, Basheer Elmohamady, Khalid Elgamal
OBJECTIVE: To compare outcomes of the Mathieu incised-plate (Mathieu-IP) technique vs the standard tubularised incised-plate (TIP) technique for primary management of distal hypospadias. PATIENTS AND METHODS: Between April 2012 and August 2015, 66 patients (aged 15-60 months) with primary distal hypospadias were randomly allocated to two groups. Group 1 included 34 patients who underwent Mathieu-IP repair and Group 2 included 32 patients managed using the TIP technique for primary management of distal hypospadias...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29071158/lingual-mucosal-graft-two-stage-bracka-technique-for-redo-hypospadias-repair
#18
Ahmed Sakr, Ehab Elkady, Mohamed Abdalla, Amr Fawzi, Mostafa Kamel, Esam Desoky, Mohamed Seleem, Mohamed Omran, Ehab Elsayed, Salem Khalil
OBJECTIVES: To report our initial experience in redo hypospadias repair with a lingual mucosal graft (LMG) using a two-stage Bracka technique. PATIENTS AND METHODS: This study was prospectively conducted and included 26 patients with hypospadias with failed previous repairs. All the patients had a LMG using a two-stage Bracka technique. In the first stage, the harvested LMG, from the ventro-lateral surface of the tongue, was implanted in a well-prepared vascularised bed in the ventral aspect of the penis...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29064654/an-unusual-presentation-of-urethral-duplication-presenting-with-chronic-bladder-retention-left-scrotal-transposition-and-left-renal-agenesis
#19
Antonio Macedo, Marcela Leal da Cruz, João Luiz Gomes Parizi, Gustavo Marconi Caetano Martins, Riberto Liguori, Sérgio Leite Ottoni, Bruno Leslie, Gilmar Garrone
INTRODUCTION AND OBJECTIVE: Urethral duplication is a rare congenital anomaly, with roughly 200 cases reported in the literature (1). It is more frequent in males, with few cases reported in females. The clinical presentation differs according to the anatomical variant present. The duplication most commonly occurs in the sagittal plane with one urethra located ventrally and the other dorsally (2). Usually the ventral urethra is the more functional of both. Duplications occurring in the coronal plane are quite rare and they are usually associated with bladder duplication (3)...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29061174/de-novo-chromosome-7q36-1q36-2-triplication-in-a-child-with-developmental-delay-growth-failure-distinctive-facial-features-and-multiple-congenital-anomalies-a-case-report
#20
Muna A Al Dhaibani, Diane Allingham-Hawkins, Ayman W El-Hattab
BACKGROUND: Studying human genome using chromosomal microarrays has significantly improved the accuracy and yield of diagnosing genomic disorders. Chromosome 7q36 deletions and duplications are rare genomic disorders that have been reported in a limited number of children with developmental delay, growth retardation, and congenital malformation. Altered dosage of SHH and HLXB9, both located in 7q36.3, is believed to play roles in the phenotypes associated with these rearrangements. In this report we describe a child with 7q36...
October 23, 2017: BMC Medical Genetics
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