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inclusion body myositis

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https://www.readbyqxmd.com/read/29663456/label-free-identification-of-myopathological-features-with-coherent-anti-stokes-raman-scattering
#1
Daniel Niedieker, Frederik Großerüschkamp, Anja Schreiner, Katalin Barkovits, Carsten Kötting, Katrin Marcus, Klaus Gerwert, Matthias Vorgerd
INTRODUCTION: The aim of this study was the label-free identification of distinct myopathological features with coherent anti-Stokes Raman scattering (CARS) imaging, which leaves the sample intact for further analysis. METHODS: The protein distribution was determined without labels by CARS at 2930 cm-1 and was compared with the results of standard histological staining. RESULTS: CARS imaging enabled the visualization of glycogen accumulation in glycogen storage disease type 5 (McArdle) and of internal nuclei in centronuclear myopathy...
April 16, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29651121/classification-of-myositis
#2
REVIEW
Ingrid E Lundberg, Marianne de Visser, Victoria P Werth
The idiopathic inflammatory myopathies (IIMs; also known as myositis) are a heterogeneous group of disorders in which a common feature is chronic inflammation of skeletal muscle, leading to muscle weakness. Other organs are frequently affected in IIMs, such as the skin, joints, lungs, gastrointestinal tract and heart, contributing to morbidity and mortality. Currently, IIMs are most often subclassified into polymyositis, dermatomyositis and inclusion body myositis, but this subclassification has limitations as these subgroups often have overlapping clinical and histopathological features, and outcomes vary within the subgroups; additionally, subgroups without considerable myopathy are not included...
April 12, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29611059/new-developments-in-the-genetics-of-inclusion-body-myositis
#3
REVIEW
Kyla A Britson, Stephanie Y Yang, Thomas E Lloyd
PURPOSE OF REVIEW: Our goal is to review the recent literature pertaining to the genetics of sporadic inclusion body myositis (IBM). RECENT FINDINGS: In a study of 252 IBM patients, the class II MHC allele HLA-DRB1*03:01 showed the most significant association with IBM, and that risk could be largely attributed to amino acids within the peptide-binding pocket. Candidate gene sequencing identified rare missense variants in proteins regulating protein homeostasis including VCP and SQSTM1...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29607961/a-patient-with-hcv-infection-and-a-sustained-virological-response-to-direct-acting-antiviral-treatment-who-developed-inclusion-body-myositis
#4
Toru Kuwano, Norio Akuta, Fumitaka Suzuki, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Yoshiyuki Suzuki, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29595280/-idiopathic-inflammatory-myopathies
#5
Jiří Vencovský
Idiopathic inflammatory myopathies form a heterogeneous group of acquired inflammatory diseases afflicting striated muscles. The disease is frequently accompanied by systemic and organ involvement. Dermatomyositis, polymyositis, cancer associated myositis, immune mediated necrotizing myopathy, myositis in overlap syndromes, juvenile myositis and inclusion body myositis are the most frequently encountered subtypes. The basic manifestation is usually painless muscle weakness brought about by inflammation and by other immune changes at the impacted muscles...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29579291/sporadic-inclusion-body-myositis-magnetic-resonance-imaging-and-ultrasound-characteristics
#6
Kazuto Tsukita, Kaoru Yagita, Haruhi Sakamaki-Tsukita, Toshihiko Suenaga
No abstract text is available yet for this article.
March 22, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29546591/endoplasmic-reticulum-stress-induces-myostatin-high-molecular-weight-aggregates-and-impairs-mature-myostatin-secretion
#7
Rishibha Sachdev, Karin Kappes-Horn, Lydia Paulsen, Yvonne Duernberger, Catharina Pleschka, Philip Denner, Bishwajit Kundu, Jens Reimann, Ina Vorberg
Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disorder in the elderly with no defined etiology or effective therapy. Endoplasmic reticulum stress and deposition of myostatin, a secreted negative regulator of muscle growth, have been implicated in disease pathology. The myostatin signaling pathway has emerged as a major target for symptomatic treatment of muscle atrophy. Here, we systematically analyzed the maturation and secretion of myostatin precursor MstnPP and its metabolites in a human muscle cell line...
March 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29529264/rapamycin-for-inclusion-body-myositis-targeting-non-inflammatory-mechanisms
#8
James B Lilleker, Marwan Bukhari, Hector Chinoy
No abstract text is available yet for this article.
February 26, 2018: Rheumatology
https://www.readbyqxmd.com/read/29522204/revisiting-pathological-classification-criteria-for-adult-idiopathic-inflammatory-myopathies-in-depth-analysis-of-muscle-biopsies-and-correlation-between-pathological-diagnosis-and-clinical-manifestations
#9
Ying Hou, Yue-Bei Luo, Tingjun Dai, Kai Shao, Wei Li, Yuying Zhao, Jian-Qiang Lu, Chuanzhu Yan
The European Neuromuscular Centre (ENMC) pathological classification criteria of idiopathic inflammatory myopathies (IIMs) are debatable. The aim of this study was to explore their practicability and reproducibility. We conducted a retrospective analysis of 57 cases of IIMs excluding dermatomyositis (DM) and sporadic inclusion body myositis (sIBM) by in-depth analysis of muscle biopsies and comparisons of the clinical characteristics among polymyositis (PM), non-specific myositis (NSM) and necrotizing autoimmune myopathy (NAM)...
March 7, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29515464/localization-and-expression-of-nuclear-factor-of-activated-t-cells-5-in-myoblasts-exposed-to-pro-inflammatory-cytokines-or-hyperosmolar-stress-and-in-biopsies-from-myositis-patients
#10
Sandrine Herbelet, Elly De Vlieghere, Amanda Gonçalves, Boel De Paepe, Karsten Schmidt, Eline Nys, Laurens Weynants, Joachim Weis, Gert Van Peer, Jo Vandesompele, Jens Schmidt, Olivier De Wever, Jan L De Bleecker
Aims: Regeneration in skeletal muscle relies on regulated myoblast migration and differentiation, in which the transcription factor nuclear factor of activated T-cells 5 (NFAT5) participates. Impaired muscle regeneration and chronic inflammation are prevalent in myositis. Little is known about the impact of inflammation on NFAT5 localization and expression in this group of diseases. The goal of this study was to investigate NFAT5 physiology in unaffected myoblasts exposed to cytokine or hyperosmolar stress and in myositis...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29482084/electromyographic-findings-in-sporadic-inclusion-body-myositis
#11
Monika Nojszewska, Malgorzata Gawel, Biruta Kierdaszuk, Janusz Sierdziński, Elżbieta Szmidt-Sałkowska, Andrzej Seroka, Anna M Kamińska, Anna Kostera-Pruszczyk
INTRODUCTION: Clinically oriented diagnostic criteria can be as specific for diagnosis of sporadic inclusion body myositis (sIBM) as pathological criteria, especially at the time of presentation. EMG may provide an convincing proof that a muscle biopsy should be performed. AIMS: To compare the EMG results in patients with sIBM divided into subgroups based on the newest ENMC criteria for sIBM and to obtain the utility of EMG in the diagnostic process at the time of presentation...
February 11, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29465613/what-is-in-the-myopathy-literature
#12
David Lacomis
This review is focused on recent reports of sporadic inclusion body myositis (sIBM), myopathy in patients with human immunodeficiency virus type 1 (HIV) infection, and necrotizing autoimmune myopathy with antibodies to signal recognition particle. The sIBM articles cover associations with certain genetic polymorphisms, the possible pathogenic role of anti-cytosolic 5'-nucleotidase 1A antibody, and disease-related burden and health care costs. Another article addressed the possible pathogenic role of signal recognition particle antibody in necrotizing myopathy...
March 2018: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29428167/local-texture-anisotropy-as-an-estimate-of-muscle-quality-in-ultrasound-imaging
#13
Guillaume J R Dubois, Damien Bachasson, Lilian Lacourpaille, Olivier Benveniste, Jean-Yves Hogrel
This study introduces local pattern texture anisotropy as a novel parameter to differentiate healthy and disordered muscle and to gauge the severity of muscle impairments based on B-mode ultrasound images. Preliminary human results are also presented. A local pattern texture anisotropy index (TAI) was computed in one region of interest in the short head of the biceps brachii. The effects of gain settings and box sizes required for TAI computation were investigated. Between-day reliability was studied in patients with sporadic inclusion body myositis (n = 26)...
May 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29426734/inclusion-body-myositis-and-human-immunodeficiency-virus-type-1-a-new-case-report-and-literature-review
#14
Priscille Couture, Edoardo Malfatti, Geneviève Morau, Alexis Mathian, Fleur Cohen-Aubart, Hubert Nielly, Zahir Amoura, Patrick Cherin
Prevalence of muscle disease in human immunodeficiency virus (HIV) infection is less than 1% of patients with acquired immune deficiency syndrome. Sporadic inclusion body myositis (IBM) is observed in a few cases of patients infected by retroviruses such as HIV-1. A Caucasian man was diagnosed with HIV when he was 30 years old. The viral load was undetectable and CD4 cell count was 600/mm3 when the diagnosis of inclusion body myositis was confirmed. Histological findings were typical of IBM. The treatment consisted of immunoglobulin therapy for three years without effect...
January 10, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29409450/using-an-onset-anchored-bayesian-hierarchical-model-to-improve-predictions-for-amyotrophic-lateral-sclerosis-disease-progression
#15
Alex G Karanevich, Jeffrey M Statland, Byron J Gajewski, Jianghua He
BACKGROUND: Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling a subject's disease progression, which is measured by the ALS Functional Rating Scale (ALSFRS), very difficult. Consider the problem of predicting a subject's ALSFRS score at 9 or 12 months after a given time-point. METHODS: We obtained ALS subject data from the Pooled Resource Open-Access ALS Clinical Trials Database, a collection of data from various ALS clinical trials...
February 6, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29402601/mitophagy-in-three-cases-of-immune-mediated-necrotizing-myopathy-associated-with-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-autoantibodies-ultrastructural-and-immunohistochemical-studies
#16
Shiro Matsubara, Kota Bokuda, Yuri Asano, Ryo Morishima, Keizo Sugaya, Kazuhito Miyamoto, Reiji Koide, Takashi Komori, Shigeaki Suzuki, Ichizo Nishino
Immune-mediated necrotizing myopathy (IMNM) associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies occurs in patients both with and without history of statin-intake. The mechanisms of muscle fiber degeneration in this condition remain unknown. We studied pathological changes in muscle biopsies from three patients lacking history of statin-intake. Ultrastructural observations showed accumulation of degenerating mitochondria, glycogen granules and autophagic vacuoles, forming large composites in three cases, along with various nonspecific changes...
January 11, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29396013/coexistence-of-anti-jo1-and-anti-signal-recognition-particle-antibodies-in-a-polymyositis-patient
#17
Enrique Melguizo Madrid, Patricia Fernández Riejos, Francisco Javier Toyos Sáenz de Miera, Berta Fernández Pérez, Concepción González Rodríguez
Idiopathic inflammatory myopathies are a heterogeneous group of potentially treatable myopathies. They are classified, on the basis of clinical and histopathological features, into four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune myositis and inclusion-body myositis. Myositis-associated antibodies and myositis-specific autoantibodies are frequently found in patients with idiopathic inflammatory myopathies, and are useful in the diagnosis and classification. Anti-histidyl transfer RNA synthetase antibody is the most widely prevalent and is highly specific for polymyositis...
January 25, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29363513/anti-nt5c1a-autoantibodies-are-associated-with-more-severe-disease-in-patients-with-juvenile-myositis
#18
Richard M Yeker, Iago Pinal-Fernandez, Takayuki Kishi, Katherine Pak, Ira N Targoff, Frederick W Miller, Lisa G Rider, Andrew L Mammen
OBJECTIVES: Autoantibodies recognising cytosolic 5'-nucleotidase 1A (NT5C1A) are found in adult patients with myositis and other autoimmune diseases. They are especially prevalent in adults with inclusion body myositis (IBM), in which they are associated with more severe weakness and higher mortality. This study was undertaken to define the prevalence and clinical features associated with anti-NT5C1A autoantibodies in juvenile myositis. METHODS: We screened sera from 380 patients with juvenile myositis, 30 patients with juvenile idiopathic arthritis (JIA) and 92 healthy control children for anti-NT5C1A autoantibodies...
May 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29187847/a-multilayered-control-of-the-human-survival-motor-neuron-gene-expression-by-alu-elements
#19
REVIEW
Eric W Ottesen, Joonbae Seo, Natalia N Singh, Ravindra N Singh
Humans carry two nearly identical copies of Survival Motor Neuron gene: SMN1 and SMN2. Mutations or deletions of SMN1 , which codes for SMN, cause spinal muscular atrophy (SMA), a leading genetic disease associated with infant mortality. Aberrant expression or localization of SMN has been also implicated in other pathological conditions, including male infertility, inclusion body myositis, amyotrophic lateral sclerosis and osteoarthritis. SMN2 fails to compensate for the loss of SMN1 due to skipping of exon 7, leading to the production of SMNΔ7, an unstable protein...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29172005/cytokine-profiling-of-serum-allows-monitoring-of-disease-progression-in-inclusion-body-myositis
#20
Umesh A Badrising, Roula Tsonaka, Monika Hiller, Erik H Niks, Teresinha Evangelista, Hanns Lochmüller, Jan Jgm Verschuuren, Annemieke Aartsma-Rus, Pietro Spitali
BACKGROUND: Inclusion body myositis is a late onset inflammatory myopathy lacking reliable serum biomarkers for diagnosis and for disease progression. OBJECTIVE: To identify diagnostic and predictive biomarkers, cytokine profiling is used to assess the potential of cytokines to discriminate between cases and controls and to assess whether treatment with methotrexate can influence biomarkers associated with disease progression. METHODS: The diagnostic and follow-up potential of 48 cytokines was tested using Bioplex-assay and ELISA in sera of healthy individuals, IBM patients and patients with other neuromuscular disorders...
2017: Journal of Neuromuscular Diseases
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