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JOURNAL ARTICLE
Amy E Kynman, Travis S Grimes, Jacy K Conrad, Simon M Pimblott, Gregory P Horne
Careful manipulation of the plutonium oxidation states is essential in the study and utilization of its rich redox chemistry. To achieve this level of control, a comprehensive mechanistic understanding of radiation-induced plutonium redox chemistry is critical due to the unavoidable exposure of plutonium to ionizing radiation fields, both inherent and from in-process applications. To this end, we have developed an experimentally evaluated multiscale computer model for the prediction of gamma radiation-induced Pu(IV) redox chemistry in concentrated nitric acid solutions (1...
April 24, 2024: Inorganic Chemistry
#2
JOURNAL ARTICLE
Márcia Regina Fumagalli Marteleto, Jacy Perissinoto
BACKGROUND: During development, children face a number of demands and cognitive, behavioral, and social challenges necessary for growth. Cognitive skills make individuals competent and allow them to interact with their environment. OBJECTIVE: To identify the cognitive skills that promote better social insertion in children with autism spectrum disorder within 12 months. DESIGN AND SETTING: Prospective cohort study. METHODS: In this study, 21 children aged 3-12 years were assessed, and their mothers were interviewed...
2024: São Paulo Medical Journal
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JOURNAL ARTICLE
Shelbie D Kirkendoll, Ashley B Hink, Deborah A Kuhls, Frederick P Rivara, Joseph V Sakran, Lauren L Agoubi, Alex S Winchester, Jacy Richards, Christopher Hoeft, Bhavin Patel, Holly Michaels, Avery B Nathens
INTRODUCTION: While the U.S. has high quality data on firearm-related deaths, less information is available on those who arrive at trauma centers alive, especially those discharged from the emergency department. This study sought to describe characteristics of patients arriving to trauma centers alive following a firearm injury, postulating that significant differences in firearm injury intent might provide insights into injury prevention strategies. METHODS: This was a multi-center prospective cohort study of patients treated for firearm-related injuries at 128 U...
April 24, 2024: Journal of Trauma and Acute Care Surgery
#4
JOURNAL ARTICLE
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D White, Heather E Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad, Magdy Gohar, Benedikt R Dürr, Marianne Richter, Himani Patel, Gregory Kryukov, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Karla Rubio, Antonio Villanueva, Junbing Zhang, Maolin Ge, Farah Makram, Hanna Griesshaber, Drew Harrison, Ann-Sophie Koglin, Samuel Ojeda, Barbara Karakyriakou, Alexander Healy, George Popoola, Inbal Rachmin, Neha Khandelwal, Jason R Neil, Pei-Chieh Tien, Nicholas Chen, Tobias Hosp, Sanne van den Ouweland, Toshiro Hara, Lillian Bussema, Rui Dong, Lei Shi, Martin Q Rasmussen, Ana Carolina Domingues, Aleigha Lawless, Jacy Fang, Satoshi Yoda, Linh Phuong Nguyen, Sarah Marie Reeves, Farrah Nicole Wakefield, Adam Acker, Sarah Elizabeth Clark, Taronish Dubash, John Kastanos, Eugene Oh, David E Fisher, Shyamala Maheswaran, Daniel A Haber, Genevieve M Boland, Moshe Sade-Feldman, Russell W Jenkins, Aaron N Hata, Nabeel M Bardeesy, Mario L Suvà, Brent R Martin, Brian B Liau, Christopher J Ott, Miguel N Rivera, Michael S Lawrence, Liron Bar-Peled
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed "DrugMap," an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability varies across cancer cell lines, and we attribute this to differences in cellular redox states, protein conformational changes, and genetic mutations...
April 17, 2024: Cell
#5
JOURNAL ARTICLE
Jonathan D Mosley, John P Shelley, Alyson L Dickson, Jacy Zanussi, Laura L Daniel, Neil S Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P Jarvik, Elisabeth A Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J Kullo, Theresa L Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J Cox, Dan M Roden, Stephan G Frangakis, Brett Vanderwerff, C Michael Stein, Sara L Van Driest, Scott C Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P Chung, Vivian K Kawai
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGSWBC ) comprising single nucleotide polymorphisms not associated with disease. A predisposition to lower WBC counts was associated with a decreased risk of identifying pathology on a bone marrow biopsy performed for a low WBC count (odds-ratio = 0...
April 22, 2024: Nature Communications
#6
EDITORIAL
Stuart E Turvey, Catherine M Biggs, Elliot L James, Kyla J Hildebrand
No abstract text is available yet for this article.
April 20, 2024: Journal of Allergy and Clinical Immunology
#7
EDITORIAL
Carole Ober, Christine L M Joseph, John Novembre
No abstract text is available yet for this article.
April 18, 2024: Journal of Allergy and Clinical Immunology
#8
JOURNAL ARTICLE
Kristina Link, Lina Muhandes, Anastasia Polikarpova, Tim Lämmermann, Michael Sixt, Reinhard Fässler, Axel Roers
BACKGROUND: Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association. OBJECTIVE: We sought to elucidate the molecular basis of the MC-blood vessel interaction and to determine its relevance for IgE-mediated immune responses...
April 15, 2024: Journal of Allergy and Clinical Immunology
#9
Claudia Wei, Dominique Wreh, Jacy Gressen, Anvinh Nguyen
A 62-year-old female presented for a scheduled coronary artery bypass graft (CABG) and was found to have an unexpected subglottic stenosis during routine intubation. The case was aborted and six days later, the patient underwent lasering of the stenotic subglottic region and airway balloon dilation. In this case report, causes of subglottic stenosis and surgical/anesthetic management of the condition are discussed. The management of subglottic stenosis in this patient was complicated by concurrent severe coronary artery disease (CAD) involving the left main coronary artery and timing of airway surgery relative to interventions for her CAD...
March 2024: Curēus
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JOURNAL ARTICLE
Ralf Jäger, Martin Purpura, Jaci Davis, Nikolas Keratsopoulos, Mandy E Parra, Ariane H Secrest, Grant M Tinsley, Lem Taylor
Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion...
March 30, 2024: Nutrients
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REVIEW
Thomas B Casale, Alessandro Fiocchi, Matthew Greenhawt
The recent approval of omalizumab for the treatment of IgE-mediated food allergy is an important step forward for the millions of food allergy patients in the US. Through the depletion of circulating IgE and the subsequent reduction of FCεR1 on key effector cells, patients increase their tolerance to food allergens. However, omalizumab does not permit patients to eat foods that they are allergic to with impunity. Rather, it protects them from most accidental exposures. In addition, omalizumab does not cure food allergy and has not demonstrated true immunomodulation...
April 8, 2024: Journal of Allergy and Clinical Immunology
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JOURNAL ARTICLE
Quang Luu Quoc, YeJi Kim, Gunwoo Park, Thi Bich Tra Cao, Youngwoo Choi, Yong Hwan Park, Hae-Sim Park
BACKGROUND: Neutrophilic asthma (NA) is a severe asthma phenotype associated with steroid resistance and IL-1β overproduction; however, the exact mechanism remains unclear. Moreover, the dysfunction of tumor necrosis factor-alpha signaling pathway, a regulator of IL-1β production, was associated with the deficiency of OTU deubiquitinase with linear linkage specificity (otulin) in autoimmune patients. OBJECTIVE: We hypothesized that otulin downregulation in macrophages (Mφ) could trigger Mφ activation via the nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome signaling pathway...
April 8, 2024: Journal of Allergy and Clinical Immunology
#13
JOURNAL ARTICLE
Xingxing Jian, Guixue Hou, Liqiao Li, Zhuo Diao, Yingfang Wu, Jiayi Wang, Lu Xie, Cong Peng, Liang Lin, Jie Li
BACKGROUND: Population-based studies have highlighted the link between chronic urticaria (CU) and metabolic syndrome, and metabolic alterations have been revealed in CU. However, to our knowledge, a comprehensive metabolomics study on a large cohort of CU patients has not been reported. OBJECTIVE: To explore the underlying metabolic subtypes and novel metabolite biomarkers for CU diagnosis and therapy. METHODS: Plasma samples from 80 CU patients and 82 healthy controls (HCs) were collected for metabolomics quantification and performed bioinformatics analysis...
April 8, 2024: Journal of Allergy and Clinical Immunology
#14
JOURNAL ARTICLE
Douglas P Mack, Timothy E Dribin, Paul J Turner, Richard L Wasserman, Mariam A Hanna, Marcus Shaker, Mimi L K Tang, Pablo Rodríguez Del Río, Brad Sobolewski, Elissa M Abrams, Aikaterini Anagnostou, Stefania Arasi, Sakina Bajowala, Philippe Bégin, Scott B Cameron, Edmond S Chan, Sharon Chinthrajah, Andrew T Clark, Paul Detjen, George du Toit, Motohiro Ebisawa, Arnon Elizur, Jeffrey M Factor, Justin Greiwe, Jonathan O'B Hourihane, Sarah W Hughes, Douglas H Jones, Antonella Muraro, Anna Nowak-Wegrzyn, Nandinee B Patel, Amy M Scurlock, Atul N Shah, Sayantani B Sindher, Stephen Tilles, Brian P Vickery, Julie Wang, Hugh H Windom, Matthew Greenhawt
BACKGROUND: Despite the promise of oral immunotherapy (OIT) to treat food allergies, this procedure is associated with potential risk. There is no current agreement about what elements should be included in the preparatory or consent process. OBJECTIVE: We developed consensus recommendations about the OIT process considerations and patient-specific factors that should be addressed before initiating OIT and developed a consensus OIT consent process and information form...
March 28, 2024: Journal of Allergy and Clinical Immunology
#15
JOURNAL ARTICLE
Suzanne M Barshow, Maidul Islam, Scott Commins, Matthew S Macauley, James C Paulson, Michael D Kulis
BACKGROUND: Siglec-3 (CD33) is a major Siglec expressed on human mast cells and basophils and engagement of CD33 leads to inhibition of cellular signaling via immunoreceptor tyrosine-based inhibitory motifs (ITIMs). OBJECTIVE: We sought to inhibit human basophil degranulation by simultaneously recruiting inhibitory CD33 to the IgE-FcεRI complex using monoclonal anti-IgE directly conjugated to CD33 ligand (CD33L). METHODS: Direct and indirect basophil activation tests (BAT) were used to assess both antigen-specific (peanut) and antigen non-specific (polyclonal anti-IgE) stimulation...
April 7, 2024: Journal of Allergy and Clinical Immunology
#16
EDITORIAL
Mirna Chehade, Elizabeth T Jensen, Benjamin L Wright
No abstract text is available yet for this article.
April 7, 2024: Journal of Allergy and Clinical Immunology
#17
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Journal of Allergy and Clinical Immunology
#18
EDITORIAL
Wanda Phipatanakul
No abstract text is available yet for this article.
April 3, 2024: Journal of Allergy and Clinical Immunology
#19
JOURNAL ARTICLE
Blanca García-Solís, María Tapia-Torres, Ana García-Soidán, Elisa Hernández-Brito, María Teresa Martínez-Saavedra, José M Lorenzo Salazar, Sonia García-Hernández, Ana Van Den Rym, Karan Mayani Mayani, José Vicente Govantes-Rodríguez, Adrian Gervais, Paul Bastard, Anne Puel, Jean-Laurent Casanova, Carlos Flores, Rebeca Pérez de Diego, Carlos Rodríguez-Gallego
BACKGROUND: Monoallelic loss-of-function IKZF1 (IKAROS) variants cause B-cell deficiency or combined immunodeficiency, whereas monoallelic gain-of-function IKZF1 variants have recently been reported to cause hypergammaglobulinemia, abnormal plasma cell differentiation, autoimmune and allergic manifestations, and infections. METHODS: We studied seven relatives with autoimmune/inflammatory diseases and lymphoproliferative diseases. We analysed biopsy results and performed whole-exome sequencing and immunological studies...
April 3, 2024: Journal of Allergy and Clinical Immunology
#20
JOURNAL ARTICLE
Aya Konno-Yamamoto, Vinay Goswamy, Agustin Calatroni, Peter J Gergen, Molly Johnson, Ronald L Sorkness, Leonard B Bacharier, George T O'Connor, Meyer Kattan, Robert A Wood, Lisa Gagalis, Cynthia M Visness, James E Gern
BACKGROUND: Allergic sensitization and low lung function in early childhood are risk factors for subsequent wheezing and asthma. However, it is unclear how allergic sensitization impacts lung function over time. OBJECTIVE: To test whether allergy influences lung function and whether these factors synergistically increase the risk of continued wheezing in childhood. METHODS: We analyzed longitudinal measurements of lung function (spirometry, impulse oscillometry) and allergic sensitization (aeroallergen skin tests, serum allergen-specific IgE) throughout early childhood in the Urban Environmental and Childhood Asthma study which included high-risk urban children living in disadvantaged neighborhoods...
April 2, 2024: Journal of Allergy and Clinical Immunology
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