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Sylvie Tarillon, Christelle Andrianne, Sandie Balcaen, Sarah Bole, Carole Genty, Sandrine Godin, Eva Lemarchand, Jérôme Mouchebeuf, Isabelle Mussot, Anne Wallart, Tamim Alsuliman, Yohann Desbrosses, Jean El Cheikh, Marie Agnès Guerout-Verite, John De Vos, Laure Tardieu, Ibrahim Yakoub-Agha, Sophie Porcheron
JACIE (Joint Accreditation Committee ISTC EBMT) regulations and standards impose a quality and safety requirement for graft reinjection by nurses. However, the standards do not provide a step-by-step graft reinjection procedure. Because of high medical team turnover, the opening of new transplant centers, and continual questions from colleagues trying to decipher the JACIE standards, the need for a specific procedure goes without saying. We collected graft reinjection procedures from each SFGM-TC center that participated in our survey, thus creating an inventory of the different steps that make up graft reinjection...
December 7, 2018: Bulletin du Cancer
Zuhair K Ballas
No abstract text is available yet for this article.
April 2018: Journal of Allergy and Clinical Immunology
Zuhair K Ballas
No abstract text is available yet for this article.
December 2018: Journal of Allergy and Clinical Immunology
Jaci SuLynn Mester
No abstract text is available yet for this article.
December 2018: Nursing Management
Edouard Forcade, Agnès Bonnin, Judith Desoutter, Francisca Nacimento, Isabelle Roch-Torreilles, Flore Vigneron, Jean-Michel Boiron, Ibrahim Yakoub-Agha, Nicolas Simon
Since, several years the integration of a clinical pharmacist in medical units led to improve the patients' care in France. In the frame of stem cell engraftment, patients belong to a particularly complex population, notably due to pediatric patients or because the age to engraft adult patients is higher. Moreover, because of many reasons, such as numerous medications intake or long-term immunosuppression, these patients are very fragile and at risk of complications. Since the 6th edition, the JACIE standard gives a definition of the role of clinical pharmacist with its competence area and its place in the medical ward...
November 16, 2018: Bulletin du Cancer
Ethan Chernivec, Jacie Cooper, Kari Naylor
Current treatments for Parkinson's disease (PD) only alleviate symptoms doing little to inhibit the onset and progression of the disease, thus we must research the mechanism of Parkinson's. Rotenone is a known inducer of parkinsonian conditions in rats; we use rotenone to induce parkinsonian cellular conditions in Dictyostelium discoideum . In our model we primarily focus on mitochondrial dynamics. We found that rotenone disrupts the actin and microtubule cytoskeleton but mitochondrial morphology remains intact...
November 8, 2018: Cells
Luciana Maria Ribeiro Antinarelli, Isabela de Oliveira Souza, Priscila Vanessa Zabala Capriles, Jacy Gameiro, Elizandra Aparecida Britta, Celso Vataru Nakamura, Wallace Pacienza Lima, Adilson David da Silva, Elaine Soares Coimbra
Currently, available treatment options for leishmaniasis are limited and unsatisfactory. In a previous study, a quinoline derivative (AMQ-j), exhibited a strong effect against Leishmania amazonensis and its antileishmanial activity was preliminarily associated with mitochondrial dysfunction. The present study further explores the antileishmanial effect of this compound against L. amazonensis, as well as determines the main cellular processes involved in the death of the parasite. Moreover, this study evaluated the in vivo effect of the AMQ-j in BALB/c mice experimentally infected by L...
December 2018: Experimental Parasitology
Zebulon Timmons, Jaci Timmons, Christina Conrad, Tamir Miloh
Purpose: There is a lack of scholarly reports on pediatric emergency department (PED) exposure to hyperbilirubinemia. We aimed to describe the epidemiology of hyperbilirubinemia in patients presenting to a PED over a three-year period. Methods: This was a retrospective cohort study, completed at an urban quaternary academic PED. Patients were included if they presented to the PED from 2010 to 2012, were 0 to 18 years in age, and had an elevated serum bilirubin for age...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Ingo Helbig, Erin Rooney Riggs, Carrie-Anne Barry, Karl Martin Klein, David Dyment, Courtney Thaxton, Bekim Sadikovic, Tristan T Sands, Jacy L Wagnon, Khalida Liaquat, Maria Roberta Cilio, Ghayda Mirzaa, Kristen Park, Erika Axeen, Elizabeth Butler, Tanya M Bardakjian, Pasquale Striano, Annapurna Poduri, Rebecca K Siegert, Andrew R Grant, Katherine L Helbig, Heather C Mefford
The field of epilepsy genetics is advancing rapidly and epilepsy is emerging as a frequent indication for diagnostic genetic testing. Within the larger ClinGen framework, the ClinGen Epilepsy Gene Curation Expert Panel is tasked with connecting two increasingly separate fields: the domain of traditional clinical epileptology, with its own established language and classification criteria, and the rapidly evolving area of diagnostic genetic testing that adheres to formal criteria for gene and variant curation...
November 2018: Human Mutation
Lindsey M Christman, Lisa L Dean, Camilla Bueno Almeida, Jacy R Weissburg
Peanut skins are a low-value byproduct of the peanut processing industry. Following their removal during the preparation of common peanut products, they are either discarded or used as a minor component of animal feed. Studies have found peanuts skins to be rich in health promoting phenolic compounds and thus have potential as a functional food ingredient. The aim of this study was to evaluate a new product that included the encapsulated phenolic extract from peanut skins in a flavored coating for peanuts. The phenolic compounds were extracted from peanut skins and then encapsulated in 10...
October 2018: Journal of Food Science
Jacie L Shuman, David J Coughlin
Climate change affects the thermal environment of aquatic organisms. Changes in the thermal environment may affect muscle function in the eurythermal rainbow smelt, Osmerus mordax, and relatively more stenothermal rainbow trout, Oncorhynchus mykiss. Literature suggests that the trout will be more sensitive to changes in environmental temperature, as they experience a more limited range of environmental temperatures. To examine the effects of thermal environment on red muscle function, both the smelt and trout were thermally acclimated to either a warm (12-15°C) or cold (4-5°C) temperature, after which studies of swimming performance and muscle mechanics were performed...
August 12, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Meltem Kurt Yüksel, Osman İlhan
Hematopoietic Stem Cell Transplantation (HSCT) is a well estabished treatment modality for patients with severe disorders of the hematopoietic system. HSCT is the pioneer of not the adoptive immunotherapy but also cellular therapies. It was first performed in 1957; since then the transplantation numbers have increased every year in almost all parts of the World. However, the increase in the quality of this procedure was not as fast as the numbers. The first Standards for hematopoeietic cell collection, processing and transplantation in Europe was established in 1998 by the European Group for Bone Marrow Transplantation (EBMT) and The International Society for Hematotherapy and Graft Engineering Europe I (SHAGE Europe) and the Joint Accreditation Committee of ISCT EBMT (JACIE) was founded...
April 2018: Transfusion and Apheresis Science
Erin M Baker, Christopher H Thompson, Nicole A Hawkins, Jacy L Wagnon, Eric R Wengert, Manoj K Patel, Alfred L George, Miriam H Meisler, Jennifer A Kearney
OBJECTIVE: De novo mutations of SCN8A, encoding the voltage-gated sodium channel NaV 1.6, have been associated with a severe infant onset epileptic encephalopathy. Individuals with SCN8A encephalopathy have a mean age of seizure onset of 4-5 months, with multiple seizure types that are often refractory to treatment with available drugs. Anecdotal reports suggest that high-dose phenytoin is effective for some patients, but there are associated adverse effects and potential for toxicity...
June 2018: Epilepsia
Jacy L Wagnon, Niccolò E Mencacci, Bryan S Barker, Eric R Wengert, Kailash P Bhatia, Bettina Balint, Miryam Carecchio, Nicholas W Wood, Manoj K Patel, Miriam H Meisler
Variants in the neuronal sodium channel gene SCN8A have been implicated in several neurological disorders. Early infantile epileptic encephalopathy type 13 results from de novo gain-of-function mutations that alter the biophysical properties of the channel. Complete loss-of-function variants of SCN8A have been identified in cases of isolated intellectual disability. We now report a novel heterozygous SCN8A variant, p.Pro1719Arg, in a small pedigree with five family members affected with autosomal dominant upper limb isolated myoclonus without seizures or cognitive impairment...
July 2018: Human Mutation
Jacy L Young, Brianne M Collins
This commentary addresses a recent special section on psychobiography that appeared in the pages of the July-August 2017 American Psychologist . The claims made by the authors of these articles raise a number of serious ethical, scientific, and historical concerns about psychobiography. These concerns include the potential public harm from the indiscriminate analysis of public figures; the inherent problem of publicly analyzing individuals without their participation or consent; overly deterministic conclusions of such analyses; difficulties analyzing figures from a distance and in retrospect; the impossibility of validating psychological theories through singular accounts; the presumption that psychological knowledge is ahistorical; the highly selective nature of psychobiography; and a focus on largely White, male figures as historically significant...
April 2018: American Psychologist
Casey S O'Neil, Jacie L Beach, Todd D Gruber
DNA gel electrophoresis is a standard tool of biochemistry and molecular biology laboratories. The common dye ethidium bromide suffers from toxicity concerns and requires the use of damaging ultraviolet light. We observe that exposing plasmid DNA to a UV transilluminator for only 1 s results in detectable loss of colonies following transformation, suggesting rapid accumulation of DNA damage. SYBR Safe, a commercial product, is marketed as a safe alternative to ethidium bromide and has excellent sensitivity with nondamaging blue light, but suffers from prohibitively high costs...
June 2018: Electrophoresis
Gabriel Shimizu Bassi, Luis Ulloa, Victor Rodrigues Santos, Flávio Del Vecchio, Polianna Delfino-Pereira, Gerson Jhonatan Rodrigues, Jaci Airton Castania, Fernando de Queiróz Cunha, Hélio Cesar Salgado, Thiago Mattar Cunha, Norberto Garcia-Cairasco, Alexandre Kanashiro
The neuronal control of the immune system is fundamental to the development of new therapeutic strategies for inflammatory disorders. Recent studies reported that afferent vagal stimulation attenuates peripheral inflammation by activating specific sympathetic central and peripheral networks, but only few subcortical brain areas were investigated. In the present study, we report that afferent vagal stimulation also activates specific cortical areas, as the parietal and cingulate cortex. Since these cortical structures innervate sympathetic-related areas, we investigate whether electrical stimulation of parietal cortex can attenuate knee joint inflammation in non-anesthetized rats...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Fabiola Ceroni, Domingo Aguilera-Garcia, Nicolas Chassaing, Dorine Arjanne Bax, Fiona Blanco-Kelly, Patricia Ramos, Maria Tarilonte, Cristina Villaverde, Luciana Rodrigues Jacy da Silva, Maria Juliana Ballesta-Martínez, Maria Jose Sanchez-Soler, Richard James Holt, Lisa Cooper-Charles, Jonathan Bruty, Yvonne Wallis, Dominic McMullan, Jonathan Hoffman, David Bunyan, Alison Stewart, Helen Stewart, Katherine Lachlan, Alan Fryer, Victoria McKay, Joëlle Roume, Pascal Dureau, Anand Saggar, Michael Griffiths, Patrick Calvas, Carmen Ayuso, Marta Corton, Nicola K Ragge
GJA8 encodes connexin 50 (Cx50), a transmembrane protein involved in the formation of lens gap junctions. GJA8 mutations have been linked to early onset cataracts in humans and animal models. In mice, missense mutations and homozygous Gja8 deletions lead to smaller lenses and microphthalmia in addition to cataract, suggesting that Gja8 may play a role in both lens development and ocular growth. Following screening of GJA8 in a cohort of 426 individuals with severe congenital eye anomalies, primarily anophthalmia, microphthalmia and coloboma, we identified four known [p...
February 20, 2018: Human Genetics
Jacy B Parmera, Sonia Brucki, Ricardo Nitrini
No abstract text is available yet for this article.
February 6, 2018: Neurology
H Ozdogu, C Boga, M Yeral, I Kozanoglu, C Gereklioglu, P Aytan, M Kasar, S Asma, N Buyukkurt, S Solmaz, A Korur, C Sariturk
Adult patients with sickle cell disease (SCD) are highly susceptible to stem cell transplant complications, including drug toxicity, graft versus host disease (GVHD), and graft rejection due to SCD-related tissue damage, endothelial activation, and inflammation. The scarcity of compatible stem cells for transplantation further limits treatment options, with only 43 cases of adult allogeneic peripheral blood stem cell transplantation (allo-PSCT) from human leukocyte antigen (HLA)-identical sibling donors reported in the international registry for the period 1986-2013...
July 2018: Bone Marrow Transplantation
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