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Rıza Altunbaş, Mehmet Ali Eren, İbrahim Halil Altıparmak, Hüseyin Karaaslan, Tevfik Sabuncu
BACKGROUND: Although hyperthyroidism may be associated with atherosclerosis, its pathogenesis is not well known. TSH receptor antibody (TRAb) has been shown to be responsible for increased orbital fat tissue in Graves ophthalmopathy. Epicardial fat tissue thickness (EFT) has been found to be increased in case of overt hyperthyroidism. In our study, we aimed to investigate if TRAb is associated with the increased EFT in newly diagnosed hyperthyroidism. METHODS: Twenty six TRAb positive (group 1) and 26 TRAb negative (group 2) newly diagnosed patients with hyperthyroidism, and 26 healthy control subjects (group 3) were enrolled...
August 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Aicha Hennia, Maria Graça Miguel, Said Nemmiche
Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids...
August 11, 2018: Medicines (Basel, Switzerland)
Jia Yan, Yun Xia, Mi Yang, Jiaqi Zou, Yingzhu Chen, Dawei Zhang, Liang Ma
Despite increasing reports of low-level linezolid-resistant enterococci worldwide, the mechanism of this resistance remains poorly understood. Previous transcriptome studies of low-level linezolid-resistant Enterococcus faecalis isolates have demonstrated a number of significantly up-regulated genes potentially involved in mediation of drug resistance. However, whether the transcriptome faithfully reflects the proteome remains unknown. In this study, we performed quantitative proteomics analysis of membrane proteins in an E...
2018: Frontiers in Microbiology
Ehtasham Ahmad, Kashif Hafeez, Muhammad Fahad Arshad, Jimboy Isuga, Apostolos Vrettos
Primary hypothyroidism is a common endocrine condition, most commonly caused by autoimmune thyroiditis (Hashimoto's disease) while Graves' disease is the most common cause of hyperthyroidism. Hypothyroidism is usually a permanent condition in most patients requiring lifelong levothyroxine treatment. Transformation from Hashimoto's disease to Graves' disease is considered rare but recently been increasingly recognised. We describe a case of a 61-year-old lady who was diagnosed with hypothyroidism approximately three decades ago and treated with levothyroxine replacement therapy...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Pernille Bendtsen, Anette Andersen, Mogens Trab Damsgaard, Pernille Due, Mette Rasmussen, Bjørn E Holstein
OBJECTIVE: This study examined whether social inequality in frequent drunkenness among Danish adolescents changed from 1991 to 2014. METHOD: We used data from the international Health Behaviour in School-aged Children (HBSC) study, which provided nationally representative samples of 15-year-olds from seven comparable cross-sectional studies in Denmark (N = 8,655). The students provided data about frequency of drunkenness and parents' occupation. RESULTS: In total, 38...
July 2018: Journal of Studies on Alcohol and Drugs
Lin-Chau Chang, Chien-Ching Chang, Pei-Lung Chen, Shun-Huo Wang, Yi-Hsuan Chen, Yung-Hsin Tsai, Shyang-Rong Shih, Wei-Yih Chiu, Cathy Shen-Jang Fann, Wei-Shiung Yang, Tien-Chun Chang
BACKGROUND: Antithyroid drugs (ATDs) are known to cause various adverse drug reactions (ADRs) that can lead to treatment complexity and unpredictable risks. With the aim of ensuring safer drug use, we assessed whether thyrotropin receptor antibody (TRAb) titers are associated with ATD-induced cutaneous reactions and/or hepatotoxicity, and examined potential genetic predisposition factors. METHODS: We compared TRAb titers of 37 Graves' disease (GD) patients who had experienced carbimazole/methimazole-induced cutaneous reactions and/or hepatotoxicity with those of 40 normal individuals, or 78 GD patients without the aforementioned ATD-induced ADRs...
August 1, 2018: Expert Opinion on Drug Safety
Elzemiek Geuverink, Ken Kraaijeveld, Marloes van Leussen, Fangying Chen, Jeroen Pijpe, Maarten H K Linskens, Leo W Beukeboom, Louis van de Zande
Transformer (tra) is the central gear in many insect sex determination pathways and transduces a wide range of primary signals. Mediated by transformer-2 (tra2) it directs sexual development into the female or male mode. Duplications of tra have been detected in numerous Hymenoptera, but a function in sex determination has been confirmed only in Apis mellifera. We identified a tra2 ortholog (Lc-tra2), a tra ortholog (Lc-tra) and a tra paralog (Lc-traB) in the genome of Leptopilina clavipes (Hymenoptera: Cynipidae)...
July 24, 2018: Insect Molecular Biology
Xun Chu, Minjun Yang, Zhen-Ju Song, Yan Dong, Chong Li, Min Shen, Yong-Qiang Zhu, Huai-Dong Song, Sai-Juan Chen, Zhu Chen, Wei Huang
BACKGROUND: The classical human leucocyte antigen (HLA) genes were the most important genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal variants of the HLA genes. METHODS: We applied imputation with a Pan-Asian HLA reference panel to thoroughly investigate themajor histocompatibility complex (MHC) associations with GD down to the amino acid level of classical HLA genes in 1468 patients with GD and 1490 controls of Han Chinese...
July 9, 2018: Journal of Medical Genetics
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang
BACKGROUND: Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves' disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation. We chose miRNAs which were previously reported to be differentially expressed in peripheral blood mononuclear cells (PBMCs) in patients with GD with different disease stage, detected the expression of those miRNAs in serum, corroborated the findings in thyroid tissue, and validated the target gene in vitro to investigate the possible role of circulating miRNAs in GD...
July 5, 2018: Journal of Translational Medicine
Gregg S Pettis
The hallmark of mycelial spore-forming bacteria of the genus Streptomyces is their prolific production of antibiotics and other bioactive secondary metabolites as part of a complex morphological and physiological developmental program. They are further distinguished by a conjugation mechanism that differs substantially from the single-strand mode of DNA transfer via Type IV secretion, which is exhibited by numerous unicellular Gram-negative and Gram-positive bacteria. At the crux of the novel intermycelial transfer event in Streptomyces spp...
June 14, 2018: Environmental Microbiology Reports
Nadia Pariani, Mark Willis, Ilaria Muller, Sarah Healy, Taha Nasser, Anne McGowan, Greta Lyons, Joanne Jones, Krishna Chatterjee, Colin Dayan, Neil Robertson, Alasdair Coles, Carla Moran
Context: Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves' disease (GD) with a reportedly indolent course. Objective: To determine the type, frequency and course of thyroid dysfunction (TD) in a cohort of alemtuzumab-treated MS patients in the UK. Design: Case records of alemtuzumab-treated patients who developed TD were reviewed. Results: 41.1% (102/248; 80F, 22M) of patients developed TD, principally GD (71...
June 6, 2018: Journal of Clinical Endocrinology and Metabolism
Lei Zhang, Giulia Masetti, Giuseppe Colucci, Mario Salvi, Danila Covelli, Anja Eckstein, Ulrike Kaiser, Mohd Shazli Draman, Ilaria Muller, Marian Ludgate, Luigi Lucini, Filippo Biscarini
Graves' Disease (GD) is an autoimmune condition in which thyroid-stimulating antibodies (TRAB) mimic thyroid-stimulating hormone function causing hyperthyroidism. 5% of GD patients develop inflammatory Graves' orbitopathy (GO) characterized by proptosis and attendant sight problems. A major challenge is to identify which GD patients are most likely to develop GO and has relied on TRAB measurement. We screened sera/plasma from 14 GD, 19 GO and 13 healthy controls using high-throughput proteomics and miRNA sequencing (Illumina's HiSeq2000 and Agilent-6550 Funnel quadrupole-time-of-flight mass spectrometry) to identify potential biomarkers for diagnosis or prognosis evaluation...
May 30, 2018: Scientific Reports
Simon David Lytton, Anke Schluter, Paul J Banga
Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
Anupam Kotwal, Marius Stan
PURPOSE: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. METHODS: We reviewed and analyzed the literature reporting TRAb assays and their clinical utility...
July 2018: Ophthalmic Plastic and Reconstructive Surgery
Mira Siderova, Kiril Hristozov, Aleksandra Tsukeva
OBJECTIVE: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). SUBJECTS AND METHODS: Forty seven women with Graves' disease, mean age 55...
March 2018: Archives of Endocrinology and Metabolism
Nami Suzuki, Jaeduk Yoshimura Noh, Toshiaki Kameda, Ai Yoshihara, Hidemi Ohye, Miho Suzuki, Masako Matsumoto, Yo Kunii, Kenji Iwaku, Natsuko Watanabe, Koji Mukasa, Ai Kozaki, Toshu Inoue, Kiminori Sugino, Koichi Ito
Background: Euthyroid Graves' disease (EGD) is a rare condition defined as the presence of thyroid-associated ophthalmopathy (TAO) in patients with normal thyroid function. Due to the rarity of this disease, only a limited number of studies and case reports are available for further evaluation of the characteristics of the disease. The aim of this study was to examine the changes in the thyroid function, thyrotropin receptor antibodies (TRAb) and eye symptoms, and then determine whether TRAb is related to TAO in EGD patients...
2018: Clinical Ophthalmology
Paula Gala-Alarcón, César Calvo-Lobo, Ana Serrano-Imedio, Alejandro Garrido-Marín, Patricia Martín-Casas, Gustavo Plaza-Manzano
OBJECTIVE: The purpose of this study was to describe ultrasound (US) changes in muscle thickness produced during automatic activation of the transversus abdominis (TrAb), internal oblique (IO), external oblique (EO), and rectus abdominis (RA), as well as the cross-sectional area (CSA) of the lumbar multifidus (LM), after 1 year of Pilates practice. METHODS: A 1-year follow-up case series study with a convenience sample of 17 participants was performed. Indeed, TrAb, IO, EO, and RA thickness, as well as LM CSA changes during automatic tests were measured by US scanning before and after 1 year of Pilates practice twice per week...
June 2018: Journal of Manipulative and Physiological Therapeutics
Anita Rogowicz-Frontczak, Stanislaw Pilacinski, Anna Teresa Chwialkowska, Dariusz Naskret, Dorota Zozulinska-Ziolkiewicz
To investigate the effect of insulin resistance (IR) on thyroid function, thyroid autoimmunity (AIT) and thyroid volume in type 1 diabetes (T1DM). 100 consecutive patients with T1DM aged 29 (±6) years with diabetes duration 13 (±6) years were included. Exclusion criteria were: history of thyroid disease, current treatment with L-thyroxin or anti-thyroid drugs. Evaluation of thyroid stimulating hormone (TSH), free thyroid hormones and anti-thyroid antibodies was performed. Thyroid volume was measured by ultrasonography...
July 2018: Scandinavian Journal of Clinical and Laboratory Investigation
R M Dixon, D B Coates, R J Mayer, C P Miller
Rib bone biopsy samples are often used to estimate changes in skeletal mineral reserves in cattle but differences in sampling procedures and the bone measurements reported often make interpretation and comparisons among experiments difficult. 'Full-core' rib bone biopsy samples, which included the external cortical bone, internal cortical bone and trabecular bone (CBext, CBint and Trab, respectively), were obtained from cattle known to be in phosphorus (P) adequate (Padeq) or severely P-deficient (Pdefic) status...
April 19, 2018: Animal: An International Journal of Animal Bioscience
Emmanouela Koutouridou, Tereza Planck, Erik Uddman, Mikael Lantz
Subacute thyroiditis is a common inflammatory disorder of the thyroid gland, possibly of viral etiology, that typically presents with neck pain, fever and tenderness on palpation of the thyroid gland. Graves' disease is an autoimmune thyroid disorder caused by stimulation of the thyroid gland by thyrotropin receptor antibodies (TRAb). The development of Graves´ disease and subacute thyroiditis simultaneously is an uncommon condition and only a few cases have been reported. In this article we present a case of a 46-year old woman diagnosed with Graves´ disease who was started on thiamazole and weeks later developed high fever...
April 13, 2018: Läkartidningen
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