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Arjola Bano, Earn Gan, Caroline Addison, Kilimangalam Narayanan, Jolanta U Weaver, Vasileios Tsatlidis, Salman Razvi
Context: Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves' disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear. Objective: We investigated: (i) the associations of TRAbs at diagnosis with thyroid hormones and relapse risk; (ii) potential factors that can influence these associations in GD. Design and Setting: A prospective study in GD patients from a single endocrine centre in the north-east of England, seen between January 2008 and March 2018...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
Antonio Rahal Junior, Priscila Mina Falsarella, Guilherme Falleiros Mendes, Jairo Tabacow Hidal, Danielle Macellaro Andreoni, José Flávio Ferreira Lúcio, Marcos Roberto Gomes de Queiroz, Rodrigo Gobbo Garcia
OBJECTIVE: To evaluate safety and effectiveness of nodule volume reduction and thyroid function after percutaneous laser ablation treatment in patients with benign nonfunctioning thyroid nodules. METHODS: Prospective single-center study, from January 2011 to October 2012, which evaluated 30 euthyroid and thyroid antibodies negative patients with benign solitary or dominant nodule with indication of treatment due to compressive symptoms and aesthetic disturbances...
November 29, 2018: Einstein
Carlos Romero Morales, Jaime Almazán Polo, David Rodríguez Sanz, Daniel López López, Sergio Vázquez González, José Luis Arias Buría, César Calvo Lobo
The purpose of this study was to assess and compare with rehabilitative ultrasound imaging (RUSI) the perimuscular connective tissue (PMCT) and interrecti distance (IRD) between elite and amateur basketball players. A sample of 22 healthy basketball players was included and divided into two groups: elite basketball players from Spanish 1st division (n = 11) and amateur basketball players from an entertainment Spanish division (n = 11). Ultrasound images of the external oblique (EO), internal oblique (IO), transversus abdominis (TrAb), rectus anterior (RA) and IRD PMCT were measured and analysed by the ImageJ software...
October 2018: Revista da Associação Médica Brasileira
Fabienne Delay, Vincent Dochez, Florence Biquard, Marie-Thérèse Cheve, Philippe Gillard, Chloe Arthuis, Norbert Winer
INTRODUCTION: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. OBJECTIVES: The principal objective of this retrospective study was to analyze the data that enabled the physicians to assess whether the goiter was hypo- or hyperthyroid and then to analyze the obstetric practices used in the Pays de Loire network to describe in detail the tools used to diagnose and characterize the goiters and the management chosen in these cases...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Yuyan Li, Ting Xu, Qinyun Mo, Weiling Fu, Chunyan Yao
BACKGROUND: Thyroid autoantibody has been associated with adverse pregnancy outcomes. However, thyroid-receptor antibody (TRAb) has not been considered as a potential risk assessment indicator for adverse pregnancy outcomes. Therefore, we assessed the role of TRAb in evaluation of the risk of adverse pregnancy outcomes. METHODS: Pregnant women residing in Chongqing were enrolled in the study from 2012 to 2014. The TRAb, thyroid-stimulating hormone (TSH), free thyroxine (FT4 ), and free triiodothyronine (FT3 ) of all patients were analyzed via electrochemiluminescence assays...
November 30, 2018: Clinical Biochemistry
Jessica L M Ting, Christopher J Rudnisky, Karim F Damji
OBJECTIVE: To compare the efficacy and safety of ab interno trabeculectomy with the Trabectome combined with cataract surgery (phaco-AIT) versus Trabeculectomy with mitomycin C combined with cataract surgery (phaco-Trab) in open-angle glaucoma. METHODS: A prospective randomized controlled trial with a single surgeon and surgical center was undertaken. Patients were recruited from July 2009 to October 2014. Primary outcomes were mean intraocular pressure (IOP) at 6 months and surgical complications...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Jonathan C P Roos, Carla Moran, V Krishna Chatterjee, Joanne Jones, Alasdair Coles, Rachna Murthy
Alemtuzumab-a monoclonal antibody targeting the CD52 glycoprotein expressed by most mature leucocytes-effectively decreases relapse rate and disability progression in early, relapsing-remitting multiple sclerosis (MS). However, secondary autoimmune disorders complicate therapy in nearly 50% of treated patients, with Graves' disease being the most common. Rarely, thyroid eye disease (TED) ensues; only seven such cases have been reported. Our aim was to analyse the largest series of MS patients developing thyroid eye disease after alemtuzumab treatment...
November 29, 2018: Eye
P Nalla, S Young, J Sanders, J Carter, M A Adlan, K Kabelis, S Chen, J Furmaniak, B Rees Smith, L D Premawardhana
OBJECTIVE: TSH receptor antibodies (TRAb) are responsible for autoimmune hyperthyroid disease (Graves' disease; GD) with TRAb levels tending to decrease following treatment. Measurement of TRAb activity during follow up could prove valuable to better understand treatment effectiveness. STUDY DESIGN: TRAb concentration and stimulating (TSAb) and blocking (TSBAb) activity of patient serum were assessed following different treatment modalities and follow up length...
November 28, 2018: Clinical Endocrinology
Margret Ehlers, Matthias Schott, Stephanie Allelein
Graves' disease (GD) is the most common cause for hyperthyroidism in iodine-replete areas. The disease is caused by the appearance of stimulating TSH receptor autoantibodies (TRAb) leading to hyperthyroidism. Blocking and neutral TRAb have, however, also been described. TRAb can be measured either by competition assays, assays using a bridge technology or bioassays (for discriminating stimulating vs. blocking antibodies). Therapy of GD with antithyroid drugs belonging to the group of thionamides is the first-line treatment to be continued for 12 up to 18 months...
January 1, 2019: Frontiers in Bioscience (Landmark Edition)
Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Joanna Synakiewicz, Edyta Gurgul, Marta Molińska-Glura, Marek Ruchała, Ryszard Żaba, Zygmunt Adamski
Introduction: Morphea, also known as localized scleroderma, is an autoimmune skin disease which is characterized by excessive accumulation of collagen that leads to the thickening of the dermis and subcutaneous tissue. There is an unclear relationship between morphea and other autoimmune diseases, especially related to the thyroid gland. Aim: To determine the occurrence of increased antithyroid antibodies in patients with morphea in relation to the clinical manifestations of the disease...
October 2018: Postȩpy Dermatologii i Alergologii
Ai Yoshihara, Kenji Iwaku, Jaeduk Yoshimura Noh, Natsuko Watanabe, Yo Kunii, Hidemi Ohye, Miho Suzuki, Masako Matsumoto, Nami Suzuki, Rie Tadokoro, Chihiro Sekiyama, Marino Hiruma, Kiminori Sugino, Koichi Ito
The serum TSH receptor antibody (TRAb) titers of Graves' disease (GD) patients is known to increase after radioiodine (RAI) therapy and remain high for years. The incidence of neonatal hyperthyroidism (NH) among the newborns born to mothers with GD who conceived after RAI therapy have not been reported in the past. Objective; To investigate the incidence of NH among the newborns born to mothers who conceived within 2 years after RAI therapy, and to identify predictors of NH. Patients; The cases of 145 GD patients who conceived within 2 years after RAI therapy were retrospectively reviewed, and information regarding their newborns was collected...
November 14, 2018: Thyroid: Official Journal of the American Thyroid Association
James Blackburn, Dinesh Giri, Barbara Ciolka, Nicole Gossan, Mohammad Didi, George Kokai, Alison Waghorn, Matthew Jones, Senthil Senniappan
Activating mutations in thyrotropin receptor ( TSHR ) have been previously described in the context of nonautoimmune hyperthyroidism and thyroid adenomas. We describe, for the first time, a mutation in TSHR contributing to follicular thyroid carcinoma (FTC) in an adolescent. A 12-year-old girl presented with a right-sided neck swelling, increasing in size over the previous four weeks. Clinical examination revealed a firm, nontender thyroid nodule. Ultrasound scan of the thyroid showed a heterogeneous highly vascular mass...
2018: Case Reports in Genetics
Jonathan C P Roos, Vignesh Paulpandian, Rachna Murthy
The Thyrotropin receptor antibody (TRAb) is the main driver of Graves' disease (GD) and its most common extra-thyroidal manifestation: thyroid eye disease (TED). Though key to diagnosis, it has not been used routinely as a marker of disease activity or to guide treatment. Here we demonstrate, through a retrospective review of 105 patients with TED, that serial TRAb levels vary with time, correlate with disease activity and are affected by smoking and endocrine control. Such serial measurements can guide the modern management of thyroid eye disease, helping to prevent the more serious manifestations...
November 6, 2018: Eye
Alanna Dunn, Anna Lam, Luis Hidalgo, Am James Shapiro, Peter A Senior
Context: Clinical islet transplantation (CIT) is an innovative strategy to treat highly selected individuals with type 1 diabetes mellitus (T1DM). Lymphodepletion with alemtuzumab or thymoglobulin is often used for induction therapy in CIT. Alemtuzumab was recently licensed as a treatment for relapsing remitting multiple sclerosis (RRMS). In RRMS, autoimmune thyroid disease (AITD) has developed in up to 40% of individuals treated with alemtuzumab. The appearance of AITD after CIT is not well described...
November 5, 2018: Journal of Clinical Endocrinology and Metabolism
Rossella Canese, Gianmauro Palombelli, Mattea Chirico, Paola Sestili, Marina Bagnoli, Silvana Canevari, Delia Mezzanzanica, Franca Podo, Egidio Iorio
Although several drugs are available to treat recurrences of human epithelial ovarian cancer (EOC), clinical responses often remain short lived and lead to only marginal improvements in patients' survival. One of the new drugs proposed for recurrent platinum-resistant EOC patients is trabectedin (Trab), a marine-derived antitumor agent initially isolated from the tunicate Ecteinascidia turbinata and currently produced synthetically. Predictive biomarkers of therapy response to this drug and the potential use of non-invasive functional MRI and MRS approaches for an early assessment of Trab efficacy have not yet been evaluated, although they might be relevant for improving the clinical management of EOC patients...
October 30, 2018: NMR in Biomedicine
Kashyap A Patel, Bridget Knight, Aftab Aziz, Tarig Babiker, Tamar Avades, Joanna Findlay, Sue Cox, Ioannis Dimitropoulos, Carolyn Tysoe, Vijay Panicker, Bijay Vaidya
OBJECTIVE: Patients with hyperthyroidism lacking autoimmune features but showing diffuse uptake on thyroid scintigram can have either Graves' disease or germline activating TSHR mutation. It is important to identify patients with activating TSHR mutation due to treatment implication but the overlapping clinical features with Graves' disease make it difficult to discriminate these two conditions without genetic testing. Our study aimed to assess the potential of systematic TSHR mutation screening in adults with hyperthyroidism, showing diffuse uptake on thyroid scintigraphy but absence of TSH receptor antibodies (TRAb) and clinical signs of autoimmunity...
October 29, 2018: Clinical Endocrinology
Bjørn E Holstein, Sanne Ellegaard Jørgensen, Pernille Due, Mogens Trab Damsgaard, Mette Rasmussen
The aim was to examine trends in social inequality in poor self-rated health (SRH) among adolescents in Denmark 1991-2014. The analysis included 18 996 11-15-year-old school children from the cross-sectional Health Behaviour in School-aged Children studies in 1991, 2002, 2006, 2010 and 2014. Across the five surveys, the prevalence of poor SRH was 14.2%, remaining almost unchanged from 1991 to 2014. The proportion with poor SRH was 12.2% in high, 14.3% in middle and 17.6% in low occupational social class. This social inequality in poor SRH was persistent during the entire study period, both in terms of absolute and relative social inequality...
December 1, 2018: European Journal of Public Health
Qiu-Ming Yao, Ling Li, Zhen-Yu Song, Bin Wang, Qiu Qin, Xiao-Fei An, Jin-An Zhang
Background: IL-36α is involved in the pathogenesis of a variety of autoimmune diseases, but the relationship between IL-36α and Graves' disease (GD) has rarely investigated. In the present study, we aimed to explore the expression of IL-36α and elucidate the potential role of IL-36α in GD. Methods: The expression of IL-36α mRNA in peripheral blood mononuclear cells (PBMCs) from 32 newly diagnosed GD patients, 15 refractory GD patients and 30 normal controls (NC) was examined using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Frontiers in Endocrinology
Huijuan Zheng, Junping Wei, Liansheng Wang, Qiuhong Wang, Jing Zhao, Shuya Chen, Fan Wei
Low selenium status is associated with increased risk of Graves' disease (GD). While several trials have discussed the efficacy of selenium supplementation for thyroid function, in GD patients, the effectiveness of selenium intake as adjuvant therapy remains unclear. In this systematic review and meta-analysis, we aimed to determine the efficacy of selenium supplementation on thyroid function in GD patients. Two reviewers searched PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and four Chinese databases for studies published up to October 31, 2017...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ilaria Muller, Mark Willis, Sarah Healy, Taha Nasser, Samantha Loveless, Sara Butterworth, Lei Zhang, Mohd Shazli Draman, Peter Taylor, Neil Robertson, Colin Dayan, Marian Ludgate
BACKGROUND Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30-40% of patients with relapsing multiple sclerosis (MS) following treatment with alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity to study the evolution of TRAb prior to clinical presentation. TRAb can stimulate (TSAb), block (TBAb) or not affect ("neutral": TNAb) the TSHR function, causing hyperthyroidism, hypothyroidism or euthyroidism, respectively...
October 23, 2018: Thyroid: Official Journal of the American Thyroid Association
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