Chinedum O Eleazu, Uket N Obeten, Gerald Ozor, Canice C Njemanze, Kate C Eleazu, Agatha C Egedigwe-Ekeleme, Uchechukwu C Okorie, Shedrack C Ogunwa, Adewale I Adeolu, Petra-Favour N Okoh, Abigail O Kalu, Chinazaekpere J Onyia, Scholastica Onyia, Precious Ossai, Chioma C Chikezie, Bright C Odii, Valentine Obi, Valeria M Igwe, Chidiebere A Amobi, Ogechukwu J Ugada, Winner O Kalu, Shedrach Kanu
The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert-butylhydroquinone feed. FDW changed the serum leptin, triacylglycerol, very low-density lipoprotein, and C-reactive protein levels of the rats, inducing hypertriglyceridemia, oxidative stress, and inflammation in their liver (but not the skeletal muscle) and insulin resistance which were modulated with metformin and tBHQ as corroborated by liver and muscle histology...
October 17, 2022: Journal of Food Biochemistry