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T E Bjorness, V Booth, G R Poe
The theta rhythm during waking has been associated with voluntary motor activity and learning processes involving the hippocampus. Theta also occurs continuously during rapid eye movement (REM) sleep where it likely serves memory consolidation. Theta amplitude builds across wakefulness and is the best indicator of the homeostatic need for non-REM (NREM) sleep. Although REM sleep is homeostatically regulated independently of NREM sleep, the drivers of REM sleep regulation are under debate. The dynamics of theta within REM sleep bouts have not been thoroughly explored...
September 1, 2018: Archives Italiennes de Biologie
Vanessa K Thoma, Yoanna Schulz-Zhecheva, Christoph Oser, Christian Fleischhaker, Monica Biscaldi, Christoph Klein
OBJECTIVE: Relationships between sleep, screen-based media, and ADHD symptomatology were investigated using a case- and community-based approach. METHOD: N = 357 healthy and N = 61 children with ADHD (12.72 ± 2.83 years) completed a sleep and media questionnaire. To measure ADHD symptomatology, parents filled out the Strengths and Weaknesses of ADHD symptoms and Normal behavior (SWAN) scale. Two samples were formed: a matched ( N = 61 patients and N = 61 controls) and a community sample ( N = 357 healthy participants and N = 20 patients)...
October 8, 2018: Journal of Attention Disorders
Liane Sousa Teixeira, Carlos Augusto Costa Oliveira, Ronaldo Campos Granjeiro, Carine Petry, Adra Brasil Leitão Travaglia, Fayez Bahmad
OBJECTIVES: Tinnitus is an auditory sensation in the absence of any external stimulus. It has a negative impact on quality of life and interferes with concentration, sleep, social activities, and even emotional stability. The aim of this study was to compare sleep architecture in patients with and without chronic subjective tinnitus. METHODS: This was an observational, noninterventional, and prospective study. The sample consisted of 50 individuals of both sexes aged 20 to 60 years...
October 8, 2018: Annals of Otology, Rhinology, and Laryngology
Motohiko Suzuki, Meiho Nakayama, Kayoko Bhardwaj Ando, Sachie Arima, Yoshihisa Nakamura, Makoto Yokota, Shingo Murakami
Actigraphy is an easy and noninvasive method used to monitor human ultradian cycles. However, to our knowledge, it has been not applied to experiments with rodents. Therefore, using actigraphy, we assessed the ultradian cycles and behavior of rats. Rats with or without allergic rhinitis wore an actigraphy device, and triaxial acceleration was recorded. The counts that represent physical activity were lower from 8:00 to 20:00 than those from 20:00 to 8:00 in control rats, suggesting that their sleep phase was from 8:00 to 20:00 and their awake phase from 20:00 to 8:00...
2018: Tohoku Journal of Experimental Medicine
Vaclav Kremen, Benjamin Henry Brinkmann, Jamie J Van Gompel, Squire Matt M Stead, Erik K St Louis, Gregory A Worrell
OBJECTIVE: Automated behavioral state classification in intracranial EEG (iEEG) recordings may be beneficial for iEEG interpretation and quantifying sleep patterns to enable behavioral state dependent neuromodulation therapy in next generation implantable brain stimulation devices. Here, we introduce a fully automated unsupervised framework to differentiate between awake (AW), sleep (N2), and slow wave sleep (N3) using intracranial EEG (iEEG) only and validated with expert scored polysomnography...
October 2, 2018: Journal of Neural Engineering
Nicola Beindorff, Annika Bartelheimer, Kai Huang, Mathias Lukas, Catharina Lange, Eleonore L Huang, Jörg R Aschenbach, Janet F Eary, Ingo G Steffen, Winfried Brenner
AIM: The aim of this study was to establish normal values for thyroid uptake of 99mtechnetium pertechnetate (99m TcO4 ) as a function of age, sex and circadian rhythm in mice. METHODS: In 12 female (F) and 12 male (M) C57BL/6N mice, nine consecutive SPECT images of 10 min duration each were acquired as dynamic acquisitions beginning 5 min after intravenous injection of 80 MBq 99m TcO4 . Each mouse was imaged in follow-up studies up to 24 months (A: 1 month; B: 3 months; C: 6 months; D: 12 months; E: 24 months)...
September 2018: Nuklearmedizin. Nuclear Medicine
Elise M McGlashan, Angus C Burns, Jade M Murray, Tracey L Sletten, Michelle Magee, Shantha M W Rajaratnam, Sean W Cain
This study investigated the utility of the pupillary light reflex as a method of differentiating DSPD patients with delayed melatonin timing relative to desired/required sleep time (circadian type) and those with non-delayed melatonin timing (non-circadian type). All participants were young adults, with a total of 14 circadian DSPD patients (M = 28.14, SD = 5.26), 12 non-circadian DSPD patients (M = 29.42, SD = 11.51) and 51 healthy controls (M = 21.47 SD = 3.16) completing the protocol. All participants were free of central nervous system acting medications and abstained from caffeine and alcohol on the day of the assessment...
2018: PloS One
AboTaleb Saremi, Mohammad-Ali Shafiee, Mahdi Montazeri, Negin Rashidi, Mohammad Montazeri
BACKGROUND: Preeclampsia is a global burden with 10 million incidence annually and 210 daily deaths worldwide. Diagnosis is mainly based on the features following full presentation. OBJECTIVE: This study explored whether early pregnancy circadian changes of ambulatory blood pressure monitoring (ABPM) could predict preeclampsia and hypertension. METHODS: In a prospective study, 294 pregnant women who were referred to Sarem Women's Hospital, Iran were recruited...
September 24, 2018: Current Hypertension Reviews
Hiroki Okauchi, Chiaki Hashimoto, Reiko Nakao, Katsutaka Oishi
Inappropriate eating habits such as skipping breakfast and eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running (RW) and sedentary (SED) conditions to determine the effects of voluntary wheel-running activity on obesity induced in mice by feeding at inappropriate times...
September 13, 2018: Chronobiology International
Ewa Kurczewska, Ewa Ferensztajn-Rochowiak, Anna Jasińska-Mikołajczyk, Maria Chłopocka-Woźniak, J K Rybakowski
INTRODUCTION: The aim was to assess the efficacy of total sleep deprivation (TSD) with sleep phase advance (SPA) in treatment-resistant depression (TRD) and associated biochemical factors. METHODS: We studied nine males and 12 females, aged 49±14 years, with treatment-resistant unipolar or bipolar depression, receiving antidepressant and mood-stabilizing drugs. The four-day schedule included single TSD and three consecutive nights with SPA. Biochemical markers were measured on the day before and on 1st, 7th and 14th day after the TSD...
September 10, 2018: Pharmacopsychiatry
Kamila Weissová, Jitka Škrabalová, Kateřina Skálová, Kateřina Červená, Zdeňka Bendová, Eva Miletínová, Jana Kopřivová, Karel Šonka, Daniela Dudysová, Aleš Bartoš, Jitka Bušková
OBJECTIVE: To evaluate changes in the expression of clock genes and melatonin levels in patients with idiopathic REM sleep behavior disorder (RBD) as a potential early stage of synucleinopathies. METHODS: We assessed the rhythmicity of circadian clock genes using real time-quantitative polymerase chain reaction and 24-h blood melatonin profiles using radio-immunoassay in 10 RBD patients and nine age-matched controls. RESULTS: The RBD patients did not show circadian rhythmicity for clock genes Per2, Bmal1, and Nr1d1 but the rhythmicity of Per 1 remained, and the amplitude of Per3 was diminished...
August 9, 2018: Sleep Medicine
F Bat-Pitault, M Viorrain, D Da Fonseca, I Charvin, A Guignard-Perret, B Putois, V Herbillon, D Gérard, P Franco
INTRODUCTION: Adolescent sleep is characterized by a physiological delayed sleep phase disorder frequently exacerbated by the intensive use of information and communication technologies. The sleep restriction thus induced during schooling has consequences on the physical and psychological health of the adolescent. On the other hand, the sleep complaint may correspond to psychiatric disorders in the adolescent. Thus, when this complaint is associated with school absenteeism, the management of sleep alone is often insufficient...
August 16, 2018: L'Encéphale
Ali Kandeger, Umran Egilmez, Ayca A Sayin, Yavuz Selvi
Humans' sleep timing and the psychological construct "diurnal preference" determines their "chronotype" (i.e., morning or evening type). Diurnal preferences can affect sleep-awake rhythms and eating behaviors. Our aim in this study was to examine the relationship between night eating symptoms and disordered eating attitudes by evaluating insomnia and chronotype differences in university students. The participants, 383 university students, filled out a package of psychological tools, including the Morningness-Eveningness Questionnaire, the Insomnia Severity Index, the Night Eating Questionnaire, and the Eating Attitude Test...
October 2018: Psychiatry Research
Katsutaka Oishi, Chiaki Hashimoto
Feeding at unusual times of the day is thought to be associated with obesity and metabolic disorders in both experimental animals and humans. We previously reported that time-imposed feeding during the sleep phase (daytime feeding, DF) induces obesity and metabolic disorders compared with mice fed only during the active phase (nighttime feeding, NF). The present study aimed to determine whether leptin resistance is caused by DF, and whether it is involved in the underlying mechanisms of DF-induced obesity in mice, since leptin plays an essential role in regulating energy expenditure and adiposity in addition to food intake...
August 7, 2018: Chronobiology International
Sarah Hartley, Yves Dauvilliers, Maria-Antonia Quera-Salva
PURPOSE OF REVIEW: Sleep timing, quantity, and quality are controlled by homeostatic and circadian systems. Circadian clock systems are present in all cells and organs and their timing is determined by a transcriptional-translational feedback loop of circadian genes. Individual cellular clocks are synchronized by the central body clock, situated in the suprachiasmatic nucleus, which communicates with them through humoral and neural signals including melatonin. The circadian system controls both the circadian period: (i...
August 6, 2018: Current Neurology and Neuroscience Reports
Nora V de Camp, Silke Dietze, Markus Klaßen, Jürgen Bergeler
The method allows the recording of high-quality electroencephalograms (EEGs) from freely moving piglets directly in the pigpen. We use a one-channel telemetric electroencephalography system in combination with standard self-adhesive hydrogel electrodes. The piglets are calmed down without the use of sedatives. After their release into the pigpen, the piglets behave normally-they drink and sleep in the same cycle as their siblings. Their sleep phases are used for the EEG recordings.
July 13, 2018: Journal of Visualized Experiments: JoVE
Chiaki Nohara, Daigo Yokoyama, Wataru Tanaka, Tetsuya Sogon, Masanobu Sakono, Hiroyuki Sakakibara
The effects of daily consumption of anthocyanins on bioavailability has remained unclear. In this study, we evaluated whether daily consumption affects the absorption rate of anthocyanins in rats when consumed during the active and sleep phase. Eighty rats were randomly divided into two groups. The first group consumed AIN-93G control diets, and the second group consumed AIN-93G diets containing 1% bilberry extract for 2 weeks. After 12 h fast, anthocyanins were not detected in plasma of rats. Bilberry extract (500 mg/kg body weight) was then orally administered at the beginning of the diurnal light period (ZT0, sleep phase) or at the end of the diurnal light period (ZT12, active phase)...
August 1, 2018: Journal of Agricultural and Food Chemistry
Gabrielius Jakutis, Vytautas Juknevičius, Juratė Barysienė, Dalia Matačiūnienė, Birutė Petrauskienė, Žaneta Petrulionienė, Aleksandras Laucevičius
Introduction: Rapid eye movement (REM) sleep-related bradyarrhythmia syndrome is characterized by pathological asystoles during the REM sleep phase. It is a rare rhythm disorder, being reported only few times in the literature. Due to non-specific symptoms, REM sleep-related bradyarrhythmia might be often underdiagnosed. Other cardiac diseases associated with pathological sinus arrests must be excluded to establish the correct diagnosis of and appropriate therapy for REM sleep-related bradyarrhythmia...
2018: Acta Medica Lituanica
Guilherme Silva Umemura, João Pedro Pinho, Bruno da Silva Brandão Gonçalves, Fabianne Furtado, Arturo Forner-Cordero
We assessed the impact of a common sleep disturbance, the social jetlag, on postural control during a period involving workdays and free days. The sleep habits of 30 healthy subjects were registered with a wrist actimeter for nine days (starting on Friday) and they participated in a set of four postural control tests carried out on Friday and on Monday. In addition, the subjects filled questionnaires about their sleep conditions and preferences. Actimetry measurements were used to calculate the Mid Sleep Phase (MSP)...
June 20, 2018: Scientific Reports
Swenja Kröller-Schön, Andreas Daiber, Sebastian Steven, Matthias Oelze, Katie Frenis, Sanela Kalinovic, Axel Heimann, Frank P Schmidt, Antonio Pinto, Miroslava Kvandova, Ksenija Vujacic-Mirski, Konstantina Filippou, Markus Dudek, Markus Bosmann, Matthias Klein, Tobias Bopp, Omar Hahad, Philipp S Wild, Katrin Frauenknecht, Axel Methner, Erwin R Schmidt, Steffen Rapp, Hanke Mollnau, Thomas Münzel
Aims: Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Herein, we investigated effects of phagocyte-type NADPH oxidase (Nox2) knockout and different noise protocols (around-the-clock, sleep/awake phase noise) on vascular and cerebral complications in mice. Methods and results: C57BL/6j and Nox2-/- (gp91phox-/-) mice were exposed to aircraft noise (maximum sound level of 85 dB(A), average sound pressure level of 72 dB(A)) around-the-clock or during sleep/awake phases for 1, 2, and 4 days...
October 7, 2018: European Heart Journal
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