Kitty K Lui, Abhishek Dave, Kate E Sprecher, Miranda G Chappel-Farley, Brady A Riedner, Margo B Heston, Chase E Taylor, Cynthia M Carlsson, Ozioma C Okonkwo, Sanjay Asthana, Sterling C Johnson, Barbara B Bendlin, Bryce A Mander, Ruth M Benca
BACKGROUND: Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer's disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM versus NREM sleep on memory is not completely characterized. Here, we examined the impact of OSA, as well as the moderating effects of AD risk factors, on verbal memory in a sample of middle-aged and older adults with heightened AD risk...
May 9, 2024: Alzheimer's Research & Therapy