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Haiyun Ye, Ce Zheng, Xiaoping Lan, Limin Zhao, Tong Qiao, Xiaoyan Li, Yidan Zhang
PURPOSE: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA). METHODS: Sixty-two children with OSAS (124 eyes; 5.94 ± 1.64 years old; 53.2% boys) were enrolled in this study. Their retinal vascular network density indices, including vascular diameter (VD), vascular area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI) on the macular superficial/deep capillary plexus (SCP/DCP), and the size of the foveal avascular zone (FAZ) were analyzed by OCTA before treatment and at 1 month after the adenoidectomy...
December 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Akiko Inoue, Shintaro Chiba, Kentaro Matsuura, Hiroshi Osafune, Robson Capasso, Kota Wada
OBJECTIVE: Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal treatment by using data obtained at clinical examination...
December 8, 2018: Auris, Nasus, Larynx
Kadriye Serife Ugur, Muradiye Acar, Duygu Ozol, Elif Dagli, Murat Oznur, Aydin Kosus, Mehmet Gunduz
BACKGROUND/AIMS: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA). METHODS: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG)...
December 11, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Attila Frigy, Irma Varga, Zoltán Fogarasi, Boglárka Belényi, Ildikó Kocsis
OBJECTIVE: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF). METHODS: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Heart rhythm (mean heart rate, arrhythmias, pauses, QT-interval, heart rate variability) and blood pressure (mean systolic and diastolic values, variability, Circadian variation) parameters were obtained for the whole day and for nighttime (22:00-06:00)...
December 11, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Lisiane Stefani Dias, Otto Henrique Nienov, Fernanda Dapper Machado, Camila Perlin Ramos, Daiane Rodrigues, Rodrigo Koprovsky Menguer, Helena Schmid
BACKGROUND: Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. The aim of this study was to evaluate the prevalence of PNP in severely obese (SO) women without DM or common nutritional deficiencies in order to determine factors associated with the presence of PNP...
December 7, 2018: Obesity Surgery
Myrian Vinan-Vega, Tamara Diaz Vico, Enrique F Elli
BACKGROUND: Indications and outcomes of bariatric surgery in the elderly remain controversial. We aimed to evaluate and compare safety and early outcomes of bariatric procedures in this age group. STUDY DESIGN: We performed a retrospective case-control study of Mayo Clinic bariatric surgery patients from January 1, 2016, to January 31, 2018. Data collection included surgery type, sex, age, body mass index (BMI), and comorbidities (hypertension, diabetes mellitus, hyperlipidemia, and obstructive sleep apnea (OSA))...
December 7, 2018: Obesity Surgery
Qingshi Chen, Guofu Lin, Jiefeng Huang, Gongping Chen, Xiaoyun Huang, Qichang Lin
PURPOSE: Long non-coding RNAs (lncRNAs) are a recently identified class of regulatory molecules involved in the regulation of numerous biological processes, but their functions in a rat model of chronic intermittent hypoxia (CIH) remain largely unknown. Therefore, for further investigation, we aimed to explore lncRNA expression profiles and reveal their potential functional roles in rat models of CIH. METHODS: We used a well-established CIH rat model and conducted lncRNA microarray experiments on the heart samples of rats with CIH and under normoxia control...
December 7, 2018: Sleep & Breathing, Schlaf & Atmung
Wei Wang, Changping Di, Skaff Mona, Lin Wang, Mark Hans
Obstructive sleep apnea (OSA) is a common but still underrecognized disorder. A mandibular repositioning appliance (MRA) is used to treat OSA by advancing the mandible and thereby reducing the collapsibility of the upper airway. It has been found that an MRA increases the volume of the upper airway, especially the velopharyngeal area, in OSA patients. We hypothesize that this increase in the velopharyngeal volume is associated with an anterior displacement of the tongue, but likely not with a stretching of the soft tissue connecting the soft palate, lateral pharynx, palatopharyngeal arch, and mandible...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Fernando Vaquerizo-Villar, Daniel Álvarez, Leila Kheirandish-Gozal, Gonzalo C Gutiérrez-Tobal, Verónica Barroso-García, Andrea Crespo, Félix Del Campo, David Gozal, Roberto Hornero
BACKGROUND: The gold standard for pediatric sleep apnea hypopnea syndrome (SAHS) is overnight polysomnography, which has several limitations. Thus, simplified diagnosis techniques become necessary. OBJECTIVE: The aim of this study is twofold: (i) to analyze the blood oxygen saturation (SpO2) signal from nocturnal oximetry by means of features from the wavelet transform in order to characterize pediatric SAHS; (ii) to evaluate the usefulness of the extracted features to assist in the detection of pediatric SAHS...
2018: PloS One
Rami S Kantar, Michael J Cammarata, William J Rifkin, Allyson R Alfonso, Evellyn M DeMitchell-Rodriguez, Daphney Y Noel, Jason A Greenfield, Dina Levy-Lambert, Eduardo D Rodriguez
INTRODUCTION: Orthognathic surgery plays an important role in restoring aesthetic facial contour, correcting dental malocclusion, and the surgical treatment of obstructive sleep apnea. However, the rate of complications following bimaxillary as compared with single-jaw orthognathic surgery remains unclear. The authors therefore sought to evaluate complication rates following bimaxillary as compared with single-jaw orthognathic surgery MATERIALS AND METHODS:: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify comparison groups...
December 10, 2018: Journal of Craniofacial Surgery
Tom Van Steenkiste, Willemijn Groenendaal, Dirk Deschrijver, Tom Dhaene
Sleep apnea is one of the most common sleep disorders and the consequences of undiagnosed sleep apnea can be very severe, ranging from increased blood pressure to heart failure. However, many people are often unaware of their condition. The gold standard for diagnosing sleep apnea is an overnight polysomnography in a dedicated sleep laboratory. Yet, these tests are expensive and beds are limited as trained staff needs to analyze the entire recording. An automated detection method would allow a faster diagnosis and more patients to be analyzed...
December 10, 2018: IEEE Journal of Biomedical and Health Informatics
Daphné Michelet, Florence Julien-Marsollier, Thomas Vacher, Myriam Bellon, Alia Skhiri, Béatrice Bruneau, Julien Fournier, Thierno Diallo, Virginie Luce, Christopher Brasher, Souhayl Dahmani
OBJECTIVES: The main objective of this meta-analysis was to assess the accuracy of the Sleep-Related Breathing Disorder (SRBD) Scale in the diagnosis of obstructive sleep apnea syndrome (OSAS) in children. PATIENTS/METHODS: A literature search of studies comparing SRBD to polysomnography for the diagnosis of OSAS in children was performed. Risks of biases were quantified using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Analyses determined the summary receiver operator characteristic area under the curve (SROC), the pooled sensitivity (Se), the specificity (Sp), and the positive and negative likelihood ratios (LR+ and LR-)...
October 28, 2018: Sleep Medicine
Anastasia Polytarchou, Georgia Katsouli, Marina Tsaoussoglou, Evangelia Charmandari, Christina Kanaka-Gantenbein, George Chrousos, Athanasios G Kaditis
OBJECTIVE: Children with Prader-Willi syndrome (PWS) have a high prevalence of obstructive sleep apnea syndrome (OSAS). In most typically developing children with OSAS, more obstructive apneas and hypopneas occur during rapid eye movement (REM) than during non-REM (NREM) sleep. It was hypothesized that patients with PWS are even more prone to obstructive events in REM sleep than otherwise healthy subjects with OSAS. METHODS: Polysomnographic data of patients with PWS and of typically developing children (controls) with OSAS (apnea-hypopnea index [AHI] > 1 episode/h) were analyzed...
October 28, 2018: Sleep Medicine
Felipe da Silva Paulitsch, Linjie Zhang
BACKGROUND: It remains uncertain whether continuous positive airway pressure (CPAP) therapy would significantly impact hard clinical outcomes in patients with obstructive sleep apnea (OSA). This meta-analysis aimed to assess the effects of CPAP in survival and secondary prevention of major cardiovascular events in patients with OSA and cardiovascular disease (CVD). METHODS: PubMed, Cochrane CENTRAL, LILACS, and SciElo databases (up to January 2018) were searched for randomized trials that compared CPAP with no active treatment in adults with OSA and CVD...
October 30, 2018: Sleep Medicine
Teresa Macheda, Kelly Roberts, Danielle N Lyons, Emma Higgins, Kyle J Ritter, Ai-Ling Lin, Warren J Alilain, Adam D Bachstetter
Sleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer's disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10% - 20% of adults in the United States have sleep-disordered breathing (SDB) disorder, with obstructive sleep apnea accounting for the majority of the SBD cases. The clinical and epidemiological data clearly support a link between sleep apnea and AD; yet, almost no experimental research is available exploring the mechanisms associated with this correlative link...
December 6, 2018: Neuroscience
Dominika Urbanik, Paweł Gać, Helena Martynowicz, Małgorzata Poręba, Maciej Podgórski, Marta Negrusz-Kawecka, Grzegorz Mazur, Małgorzata Sobieszczańska, Rafał Poręba
PURPOSE: This study aimed to analyze the relationship between the occurrence of obstructive sleep apnea (OSA) and heart rate variability (HRV) in a group of patients with clinical suggestion of OSA. METHODS: 104 patients with clinical suspicion of OSA were qualified to participate in the study (age: 53.15 ± 13.43 years). All participants took part in a survey and were subjected to laboratory tests, 24-hour ECG Holter monitoring, and polysomnography. The participants were divided into groups depending on the criterion of the presence of OSA...
October 11, 2018: Sleep Medicine
Tae Kyung Koh, Eun-Ju Kang, Woo Yong Bae, Sung Wan Kim, Chul Hoon Kim, Soo Kweon Koo, Sang Jun Kim, Moon Sung Kim, Jae Hoon Lee
OBJECTIVE: To evaluate the relationship between obstructive sleep apnea (OSA) severity and carotid arterial calcification by quantitative analysis using airway computed tomography (CT). METHODS: This study included a total of 180 consecutive OSA patients aged 45-80years underwent polysomnography and airway CT between March 2014 and October 2016. The subjects were divided into three groups based on the results of the respiratory disturbance index (RDI): mild (RDI 5-14, n=29), moderate (RDI 15-29, n=50), and severe (RDI≥30, n=101)...
December 6, 2018: Auris, Nasus, Larynx
Elizabeth Silaid Muxfeldt, Bernardo Chedier, Cibele Isaac Saad Rodrigues
Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity...
December 6, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Abdulmohsen Al-Terki, Mohamed Abu-Farha, Irina AlKhairi, Preethi T Cherian, Devarajan Sriraman, Ambika Shyamsundar, Shamsha Ali, Fahd Almulla, Jaakko Tuomilehto, Jehad A Abubaker
Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules...
2018: Frontiers in Endocrinology
Christoph Jansen, Stephan Hodel, Thomas Penzel, Martin Spott, Dagmar Krefting
Physiological networks (PN) model couplings between organs in a high-
 dimensional parameter space. Machine learning methods, in particular artifical neural
 networks (ANNs), are powerful on high-dimensional classification tasks. However,
 lack of interpretability of the resulting models has been a drawback in research. We
 assess relevant PN topology changes in obstructive sleep apnea (OSA) by novel ANN
 interpretation techniques.
 Approach: ANNs are trained to classify OSA based on the PNs of 48 patients
 and 48 age and gender matched healthy controls...
November 14, 2018: Physiological Measurement
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