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Christian R Baumann
Central disorders of hypersomnolence are characterized by daily periods of irrepressible need to sleep or daytime lapses into sleep, as defined in the current version of the International Criteria of Sleep Disorders. Thus, the unifying symptom is excessive daytime sleepiness which is not caused by any other sleep-wake disorder. Relevant disorders including narcolepsy type 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, and insufficient sleep syndrome will be discussed. Other central disorders of hypersomnolence include hypersomnias due to medical or psychiatric disorders or because of medication or substance use...
October 20, 2018: Handbook of Experimental Pharmacology
Hatice Kose Ozlece, Volkan Solmaz, Sadık Altan Özal, Yahya Çelik
PURPOSE: According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness. METHODS: In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the "International RLS Study Group" criteria and 31 healthy subjects...
October 19, 2018: Sleep & Breathing, Schlaf & Atmung
Özge Altuğ-Gücenmez, Balahan Makay, Ayla Kaçar, Erbil Ünsal, Haluk Sarıhan, Murat Çakır
Altuğ-Gücenmez Ö, Makay B, Kaçar A, Ünsal E. Evaluation of restless legs syndrome and growing pains in children with familial Mediterranean fever. Turk J Pediatr 2018; 60: 159-164. Growing pains (GP) and restless leg syndrome (RLS) are one of the frequently seen pain syndromes of childhood. These two pain syndromes -GP and RLS- may be confused with exertional leg pain (ELP) of familial Mediterranean fever (FMF). The aim of this study was to evaluate the frequency of fulfilling the criterion for GP and RLS among children with FMF...
2018: Turkish Journal of Pediatrics
Maya Barake, Anne Klibanski, Nicholas A Tritos
Dopamine agonists (DAs) represent a cornerstone in the management of patients with hyperprolactinemia and have an important role in the treatment of neurologic disorders, including Parkinson’s disease and restless legs syndrome. A growing body of evidence has identified impulse control disorders (ICDs) as possible adverse effects of DA therapy. A variety of ICDs may occur in patients treated with DA, including compulsive shopping, pathologic gambling, stealing, hypersexuality and punding (repetitive performance of tasks, such as collecting, sorting, disassembling and assembling objects)...
September 24, 2018: European Journal of Endocrinology
Tayyabah Yousaf, Gennaro Pagano, Heather Wilson, Marios Politis
Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD)...
2018: Frontiers in Neurology
J L Mathias, M L Cant, A L J Burke
OBJECTIVES: Chronic pain, with or without an identified diagnosis or cause, is widespread and commonly associated with sleep disturbances. However, research has often used poor quality measures of sleep and focused on specific pain conditions, thereby limiting its reliability and applicability to the wider CP population. This study meta-analysed the findings from studies that used objective polysomnographic measures of sleep or examined diagnosed sleep disorders in people with CP. METHODS: Three databases were searched (PubMed, PsychINFO, Embase; inception to June 2017) for case-controlled polysomnography studies and studies that reported the prevalence of diagnosed sleep disorders in adults with CP...
June 11, 2018: Sleep Medicine
David Haschka, Chiara Volani, Ambra Stefani, Piotr Tymoszuk, Thomas Mitterling, Evi Holzknecht, Anna Heidbreder, Stefan Coassin, Zuzana Sumbalova, Markus Seifert, Stefanie Dichtl, Igor Theurl, Erich Gnaiger, Florian Kronenberg, Birgit Frauscher, Birgit Högl, Guenter Weiss
BACKGROUND: Restless legs syndrome is a sensorimotor neurological disorder of the limbs that impairs quality of life and disturbs sleep. However, there has been progress in understanding the disease involving the dopaminergic system as well as iron metabolism. The exact pathophysiological mechanisms of restless legs syndrome remain elusive. We tried to elucidate the underlying mechanisms in iron metabolism in restless legs syndrome subjects on a systemic, cellular, and mitochondrial level...
October 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Roshi, Vishal R Tandon, Annil Mahajan, Sudhaa Sharma, Vijay Khajuria
Introduction: Restless legs syndrome (RLS) is a neurological disorder characterized by an urge to move the legs usually accompanied by unpleasant leg sensations. RLS also impacts health related quality of life (QOL) in patients suffering from it. Further, it affects women more than men. Although a voluminous literature of studies is available evaluating the role of benzodiazepines (clonazepam and antidepressant (nortriptyline) in the treatment of RLS, but to the best of our knowledge, no comparative study is available comparing both of these drugs for efficacy and safety for the treatment of RLS QoL among 40 + years old women...
July 2018: Journal of Mid-life Health
Milena Pavlova, Véronique Latreille
Sleep disorders are frequent and can have serious consequences on patients' health and quality of life. While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions. We review the main diagnostic features of six major sleep disorders (insomnia, circadian rhythm disorders, sleep-disordered breathing, hypersomnia/narcolepsy, parasomnias, and restless legs syndrome/periodic limb movement disorder) to aid medical practitioners in screening and treating sleep disorders as part of clinical practice...
October 4, 2018: American Journal of Medicine
Sandesh Parajuli, Rachna Tiwari, Dana F Clark, Didier A Mandelbrot, Arjang Djamali, Kenneth Casey
In patients with chronic kidney disease (CKD) and kidney transplant recipients who continue to have some degree of CKD, the prevalence of sleep-related disorders is very high. Common sleep disorders in both groups include insomnia, sleep-disordered breathing (SDB), restless legs syndrome (RLS), excessive daytime sleepiness (EDS), and others. Depending on the kidney graft function, some patients see sleep disorders resolve after kidney transplantation, while others continue to have persistent sleep disorders or develop new ones...
September 26, 2018: Transplantation Reviews
Allan Wang, Keyana Foster, Patrick Skeba, Kasidet Hiranniramol, Christopher J Earley, Richard P Allen
No abstract text is available yet for this article.
August 17, 2018: Sleep Medicine
Cindy Geyer
Sleep disturbances are common in postmenopausal women and contribute to increased morbidity and mortality. Sleep apnea may be underdiagnosed in women, and other conditions such as insomnia and restless legs may coexist with sleep apnea. This case illustrates the complex interplay of anatomical, hormonal, metabolic and psychological factors that can interfere with restorative sleep, and the importance of both diagnostic testing and clinical history in identifying which combination of therapies will be most beneficial in improving sleep quality and quantity...
March 2018: American Journal of Lifestyle Medicine
Nans Florens, Laurent Juillard
Expanded haemodialysis (HDx) has emerged as a promising solution to improve haemodialysis effectiveness. A medium cut-off membrane allows the removal of a wider range of uraemic toxins. However, little is known about the potential interesting applications of HDx therapy. Feedback from the first routine use of HDx therapy under real-life conditions in European facilities was excellent for priming and rinse back. There was no adverse event after 5191 HDx treatments. Patients suffering from itching, restless legs syndrome, persistent asthenia or malnourishment could benefit from HDx therapy...
October 1, 2018: Nephrology, Dialysis, Transplantation
Alberto Raggi
The recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14-24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden.
October 2, 2018: Neurological Sciences
Shivam Om Mittal, Duarte Machado, Diana Richardson, Divyanshu Dubey, Bahman Jabbari
BACKGROUND: Restless Legs Syndrome (RLS) is a common movement disorder with an estimated prevalence of up to 12%. Previous small studies with onabotulinumtoxin A (OnaA) for RLS have shown inconsistent results. METHODS: Twenty-four patients with an International RLS score (IRLS) of >11 (moderate-severe) were enrolled in this blinded, placebo-controlled crossover study. Twenty-one patients completed the evaluations at 4, 6, and 8 weeks after each injection. One-hundred units of Incobotulinumtoxin A (IncoA) or normal saline were injected into tibialis anterior, gastrocnemius, and biceps femoris muscles each side...
September 29, 2018: Toxins
Keisuke Suzuki, Takeo Matsubara, Masayuki Miyamoto, Hiroaki Fujita, Toshiki Nakamura, Koichi Hirata
A 57-year-old woman had been suffered from insomnia due to restlessness and abnormal sensation of the left side of the body for 33 years. Since the preceding year of the first visit frequency of the symptoms increased, and the abnormal sensation was spread to the right leg. Her daughter had restless legs syndrome (RLS) since age 20. Neurological examination showed no abnormality. Laboratory test results showed normal ferritin levels. There was no renal dysfunction or anemia. A diagnosis of RLS was made, and her symptoms responded well to pramipexole treatment...
September 29, 2018: Rinshō Shinkeigaku, Clinical Neurology
Stacy M Endres-Dighe, Yuelong Guo, Tamir Kanias, Marion Lanteri, Mars Stone, Bryan Spencer, Ritchard G Cable, Joseph E Kiss, Steve Kleinman, Mark T Gladwin, Donald J Brambilla, Pam D'Andrea, Darrell J Triulzi, Alan E Mast, Grier P Page, Michael P Busch
BACKGROUND: The Red Blood Cell (RBC)-Omics study was initiated to build a large data set containing behavioral, genetic, and biochemical characteristics of blood donors with linkage to outcomes of the patients transfused with their donated RBCs. STUDY DESIGN AND METHODS: The cohort was recruited from four US blood centers. Demographic and donation data were obtained from center records. A questionnaire to assess pica, restless leg syndrome, iron supplementation, hormone use, and menstrual and pregnancy history was completed at enrollment...
September 28, 2018: Transfusion
Junya Mu, Xiaohui Liu, Shaohui Ma, Tao Chen, Xueying Ma, Peng Li, Dun Ding, Jixin Liu, Ming Zhang
Restless legs syndrome (RLS) is common in the end-stage renal disease (ESRD) population; however, their interrelationship remains largely unclear. In the current study, we aimed to investigate the brain structure variation in ESRD patients with RLS (ERSD-RLS) and its potential relation with the severity of RLS. Diffusion tensor imaging and T1-weighted imaging were obtained from 64 ERSD-RLS and 64 matched healthy controls. Voxel-based morphometry (VBM) analysis and tractography atlas-based analysis (TABS) were used to detect the alteration of gray matter (GM) volume and white matter (WM) microstructural characterization...
September 26, 2018: Brain Imaging and Behavior
Valérie Cochen De Cock, Nadège Girardot-Tinant, France Woimant, Aurélia Poujois
PURPOSE OF REVIEW: The aim of this article was to review the different sleep disorders associated with Wilson's disease (WD), their mechanisms and their treatments. RECENT FINDINGS: Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder. Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD)...
September 27, 2018: Current Treatment Options in Neurology
Sophie Ng Wing Tin, Hela G Zouari, Abir Wahab, Damien Sène, Jean-Pascal Lefaucheur
Objective: To determine whether clinical features of neuropathic pain differ with respect to the presence of small-fiber neuropathy (SFN) in patients with primary Sjögren's syndrome (pSS). Methods: We compared the clinical presentation of neuropathic pain between 15 patients with pSS and SFN detected by neurophysiological tests (laser-evoked potentials, cold and warm detection thresholds, sympathetic skin responses, and electrochemical skin conductance) and 15 patients with pSS but no neurophysiological evidence of SFN...
September 20, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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