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Sang-Ahm Lee, Young-Joo No, Kwang-Deog Jo, Jee-Hyun Kwon, Jeong Yeon Kim, Dong-Jin Shin
OBJECTIVES: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE). METHODS: A total of 147 AWE who had been treated for >1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Subjective sleep disturbances were assessed with the Sleep Apnea of Sleep Disorder Questionnaire (SA-SDQ) and questionnaires about insomnia and restless legs syndrome (RLS). The Hospital Anxiety and Depression Scale (HADS) was also used...
December 1, 2018: Epilepsy & Behavior: E&B
Sherifa A Hamed
Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Areas covered: This review summarized central and peripheral nervous system complications of uremic syndrome of CKD and their pathogenic mechanisms. They include cognitive deterioration, encephalopathy, seizures, asterixis, myoclonus, restless leg syndrome, central pontine myelinosis, stroke, extrapyramidal movement disorders, neuropathies and myopathy...
December 2, 2018: Expert Review of Clinical Pharmacology
Christian Veauthier, Sophie K Piper, Gunnar Gaede, Thomas Penzel, Friedemann Paul
Background: The first night effect (FNE) is a polysomnography (PSG) habituation effect in the first of several consecutive in-laboratory PSGs (I-PSGs). The FNE is caused by the discomfort provoked by electrodes and cables and the exposure to an unfamiliar environment. A reverse FNE (RFNE) with an improved sleep in the first night is characteristic of insomnia, presumably because the video PSG in the sleep laboratory leads to a decrease in the negatively toned cognitive activity. Therefore, two or more I-PSGs are required for an accurate diagnosis...
2018: Nature and Science of Sleep
Mirjam Hug, Stefan Lakämper, Kristina Keller, Regula Wick
Daytime Sleepiness in Patients with Restless Legs Syndrome: A Risk Factor for Traffic Accidents? Abstract. Restless legs syndrome (RLS) is a symptom complex of predominantly leg-focused paraesthesias and the associated increased urge to move. Since evening exacerbations are typical, many patients suffer from sleep disorders, which can lead to increased daytime fatigue in the long term. The present retrospective data analysis investigated a potentially relevant relationship between RLS and an increased incidence of traffic accidents due to daytime sleepiness in Swiss road traffic...
November 2018: Praxis
Muzaffer Sarıaydın, Ersin Günay, Mehmet Ünlü
Introduction: We aimed to investigate the relationship between frequency of restless legs syndrome (RLS), depression, anxiety and sleep quality among medical school students. Materials and Methods: We applied a questionnaire to medical school students. This questionnaire includes some questions about demographic features of participants, questions related with RLS diagnosis, the pittsburgh sleep quality index (PSQI), beck-depression-scale (BDS), beck-anxiety scale (BAS) to all subjects...
September 2018: Tüberküloz Ve Toraks
Tomi Sarkanen, Anniina Alakuijala, Markku Partinen
Study objectives: To validate Ullanlinna Narcolepsy Scale (UNS) as a screening tool for narcolepsy in a clinical population and to compare it with Swiss Narcolepsy Scale (SNS) and Epworth Sleepiness Scale (ESS). Methods: UNS questionnaires of 267 subjects visiting Helsinki Sleep Clinic were analyzed. The diagnoses of the subjects were narcolepsy type 1 (NT1, n = 89), type 2 (NT2, n = 10), other hypersomnias (n = 24), sleep apnea (n = 37), restless legs or periodic limb movement disorder (n = 56), and other sleep-related disorders (n = 51)...
November 26, 2018: Sleep
Giovanni Rizzo, Giuseppe Plazzi
Neuroimaging studies provide information useful to understand the pathophysiology of restless legs syndrome. Molecular PET and SPECT imaging findings mainly supported dysfunction of dopaminergic pathways involving not only the nigrostriatal but also mesolimbic pathways. Magnetic resonance imaging (MRI) studies have used different techniques. Studies using iron-sensitive sequences supported the presence of a regionally variable low brain iron content, mainly at the level of substantia nigra and thalamus. The search for brain structural or microstructural abnormalities by voxel-based morphometry, diffusion tensor imaging or cortical thickness analysis has reported none or variable findings in restless legs syndrome patients, most of them in regions belonging to sensorimotor and limbic/nociceptive networks...
2018: International Review of Neurobiology
Piritta Auvinen, Pekka Mäntyselkä, Hannu Koponen, Hannu Kautiainen, Katariina Korniloff, Tiina Ahonen, Mauno Vanhala
BACKGROUND: Restless legs syndrome is a sensorimotor disorder associated with several mental illnesses particularly depression. METHODS: A cross-sectional study of primary care patients. The prevalence of restless legs symptoms was studied in 706 patients with depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire. The depressive symptoms were evaluated with the BDI and the psychiatric diagnosis was confirmed by means of a diagnostic interview (M...
December 2018: Journal of Psychosomatic Research
Manoel Alves Sobreira-Neto, Márcio Alexandre Pena-Pereira, Emmanuelle Silva Tavares Sobreira, Marcos Hortes Nisihara Chagas, Carlos Maurício Oliveira de Almeida, Regina Maria França Fernandes, Vitor Tumas, Alan Luiz Eckeli
INTRODUCTION: Excessive sleepiness (ES) can affect up to 60% of Parkinson's disease (PD) patients, and it has a multifactorial etiology. It is related to the neurodegenerative processes affecting brain regions responsible for the sleep-wake cycle, the effects of drugs acting on the central nervous system, and the excessive sleep fragmentation of this population. OBJECTIVES: To identify the factors associated with the presence of ES in patients with PD. METHODS: A cross-sectional study was performed involving 88 consecutive patients with PD from an outpatient clinic...
November 21, 2018: Neurological Research
Houzhen Tuo, Zelong Tian, Xiaoyang Ma, Yinong Cui, Yun Xue, Jingjing Che, Chunling Xu, Kui Chen, Yongbo Zhang, Liyan Zhang, Hongyan Bi, Weidong Le, William Ondo
BACKGROUND: Recent studies have suggested that cerebral ischemic infarction may contribute to the development of restless legs syndrome (RLS). This study analyzed the clinical and radiological profiles of RLS with onset after acute lacunar infarction. METHODS: In this retrospective study we enrolled 244 consecutive patients with acute lacunar infarction between January 2012 and June 2014. RLS was identified and evaluated based on the International RLS Rating Scale (IRLS-RS)...
June 26, 2018: Sleep Medicine
Tomohiko Shiina, Keisuke Suzuki, Madoka Okamura, Takeo Matsubara, Koichi Hirata
BACKGROUND: The clinical-radiological correlation between restless legs syndrome (RLS) or its variants and acute ischemic stroke remains unclear. METHODS: This study prospectively included 104 consecutive patients with acute ischemic stroke, confirmed by diffusion-weighted imaging. The frequency and clinical characteristics of RLS or RLS variants were evaluated according to the International RLS Study Group criteria, as was the topography of the associated lesions...
November 18, 2018: Acta Neurologica Scandinavica
Vishal Kwatra, Muhammad Adnan Khan, Syed A Quadri, Trevor S Cook
Restless legs syndrome (RLS) is a chronic neurological disorder affecting a growing number of people. Patients describe an irresistible urge to move their lower limbs in times of immobility. Due to its vague symptoms and similarity to other disorders, it has become increasingly difficult for primary care clinicians to properly diagnose and manage RLS. As a result, patients with RLS are routinely misdiagnosed and continue their lives without proper management. This literature review examines the current understanding of the disorder, provides key points to assist clinicians in differentiating RLS from similar disorders, and explores recently updated evidence-based guidelines for the effective management of RLS...
September 13, 2018: Curēus
Sara Mahvash Mohammadi, Majdi Alnowami, Sofia Khan, Derk-Jan Dijk, Adrian Hilton, Kevin Wells
Sleep is a process of rest and renewal that is vital for humans. However, there are several sleep disorders such as rapid eye movement (REM) sleep behaviour disorder (RBD), sleep apnea, and restless leg syndrome (RLS) that can have an impact on a significant portion of the population. These disorders are known to be associated with particular behaviours such as specific body positions and movements. Clinical diagnosis requires patients to undergo polysomnography (PSG) in a sleep unit as a gold standard assessment...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Dirk Czesnik, James Howells, Michael Bartl, Elisabeth Veiz, Rebecca Ketzler, Olga Kemmet, Arthur S Walters, Claudia Trenkwalder, David Burke, Walter Paulus
KEY POINTS: Restless legs patients complain about sensory and motor symptoms leading to sleep disturbances. Symptoms include painful sensations, an urge to move and involuntary leg movements. The responsible mechanisms of restless legs syndrome are still not known, although current studies indicate an increased neuronal network excitability. Reflex studies indicate the involvement of spinal structures. Peripheral mechanisms have not been investigated so far. In the present study, we provide evidence of increased hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated inward rectification in motor axons...
November 14, 2018: Journal of Physiology
Siraj Omar Wali, Bahaa Abaalkhail, Faris Alhejaili, S R Pandi-Perumal
PURPOSE: Restless legs syndrome is a movement sleep disorder that may be linked to dopaminergic dysfunction and in which vitamin D may play a role. This 12-week randomized, placebo-controlled trial elucidated the efficacy of vitamin D supplements in decreasing restless legs syndrome symptom severity. METHODS: Thirty-five subjects with restless legs syndrome, diagnosed using the International Restless Legs Syndrome Study Group criteria, were enrolled. The subjects were randomized to orally receive either vitamin D (50,000 IU caplets) or a placebo...
November 14, 2018: Sleep & Breathing, Schlaf & Atmung
Aaro V Salminen, Juliane Winkelmann
PURPOSE OF REVIEW: The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well as REM sleep behavior disorder (RBD), and periodic leg movement disorder (PLMD). RECENT FINDINGS: Traditionally, dopaminergic therapy has been considered the sole option for first-line treatment of RLS due to their impressive acute efficacy. Dopamine agonists such as oral pramipexole and ropinirole, as well as transdermal rotigotine are all effective treatment options...
November 9, 2018: Current Treatment Options in Neurology
Andrea Romigi, Valentina Franco, Fabio Placidi, Claudio Liguori, Emanuele Rastelli, Giuseppe Vitrani, Diego Centonze, Roberto Massa
PURPOSE OF REVIEW: To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2). RECENT FINDINGS: Sleep-disordered breathing (SDB), restless legs syndrome, periodic limb movements in sleep, hypersomnia, and REM sleep dysregulation are frequently described in DM1 patients...
October 31, 2018: Current Neurology and Neuroscience Reports
Ian C Dunican, Jennifer Walsh, Charles C Higgins, Maddison J Jones, Kathleen Maddison, John A Caldwell, Hillman David, Peter R Eastwood
The aim of this study was to determine the prevalence of sleep disorders in an elite rugby union team using in-laboratory polysomnography (PSG) and sleep questionnaires. Twenty-five elite rugby union players underwent a night of PSG during the "off-season" of the Super Rugby competition to assess their sleep. Of interest were measurements that detected the presence of obstructive sleep apnea (OSA; apnea-hypopnea index ≥5 events/hr) and the presence of moderate-severe periodic leg movements during sleep (PLMs; ≥15 events/hr)...
October 29, 2018: Journal of Sports Sciences
L Leclair-Visonneau, M-F Vecchierini, C Schröder, C Charley Monaca
No abstract text is available yet for this article.
October 23, 2018: Revue Neurologique
Lukasz A Myc, Ian T Churnin, Mark J Jameson, Eric M Davis
An association between restless legs syndrome (RLS) and obstructive sleep apnea (OSA) has been suggested for decades but has been questioned in recent years given the apparently similar prevalence of RLS among patients with OSA and the general population. Still, marked improvement in symptoms of RLS has been reported in patients with OSA treated with continuous positive airway pressure (CPAP). Whether the effect of OSA treatment on RLS extends to modalities of OSA treatment other than CPAP remains an open question...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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