Lynn M Williams, Fiona E McCann, Marisa A Cabrita, Thomas Layton, Adam Cribbs, Bogdan Knezevic, Hai Fang, Julian Knight, Mingjun Zhang, Roman Fischer, Sarah Bonham, Leenart M Steenbeek, Nan Yang, Manu Sood, Chris Bainbridge, David Warwick, Lorraine Harry, Dominique Davidson, Weilin Xie, Michael Sundstrӧm, Marc Feldmann, Jagdeep Nanchahal
Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts. Using cells from freshly excised disease tissue from patients with Dupuytren's disease (DD), a localized fibrotic disorder of the palm, we sought to identify new therapeutic targets for fibrotic disease. We hypothesized that the persistent activity of myofibroblasts in fibrotic diseases might involve epigenetic modifications...
August 25, 2020: Proceedings of the National Academy of Sciences of the United States of America