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https://www.readbyqxmd.com/read/30546894/thymidine-phosphorylase-affects-clinical-outcome-following-surgery-and-mrna-expression-levels-of-four-key-enzymes-for-5-fluorouracil-metabolism-in-patients-with-stage-i-and-ii-non-small-cell-lung-cancer
#1
Naoya Himuro, Yumiko Niiya, Takao Minakata, Yutaka Oshima, Daisuke Kataoka, Shigeru Yamamoto, Takashi Suzuki, Mitsutaka Kadokura
The expression levels of thymidine phosphorylase ( TP ), dihydropyrimidine dehydrogenase ( DPD ), thymidylate synthase ( TS ) and orotate phosphoribosyltransferase ( OPRT ) may predict the clinical efficacy of 5-fluorouracil-based chemotherapy in patients with cancer. We herein investigated the differences in the mRNA levels of these enzymes in non-small-cell lung cancer (NSCLC) and evaluated their prognostic value for NSCLC treated by surgical resection. The intratumoral mRNA levels of TP, DPD, TS , and OPRT were quantified in 66 patients with pathological stage I and II NSCLC (adenocarcinoma or squamous cell carcinoma) following complete resection according to the Danenberg Tumor Profile method...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30545718/carotid-endarterectomy-with-autoarterial-remodeling-of-bifurcation-of-the-common-carotid-artery-and-carotid-endarterectomy-with-patch-closure-comparison-of-methods
#2
Pavel Ignatenko, Olga Novikova, Alexander Gostev, Vladimir Starodubtsev, Galina Zeidlits, Konstantin Kuznetsov, Alexandra Starodubtseva, Andrey Karpenko
BACKGROUND: The objectives of our research were to identify whether the new method of carotid endarterectomy (CEA) with autoarterial remodeling of bifurcation of the common carotid artery (ARBCCA) influences daily parameters of blood pressure and heart rate (HR) while monitoring them on a daily basis and to assess the efficacy of the suggested method. MATERIALS AND METHODS: It is a prospective randomized comparative study. The first group (n = 100) included patients that underwent ARBCCA, the second group (n = 100) included patients that underwent "classic" CEA with xenopericardial patch closure...
December 11, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/30544376/the-use-of-etview-endotracheal-tube-for-surveillance-after-tube-positioning-in-patients-undergoing-lobectomy-randomized-trial
#3
Hui-Hui Liu, Fang Dong, Jia-Yi Liu, Jian-Qi Wei, Yan-Kui Huang, Yong Wang, Tao Zhou, Wu-Hua Ma
The ETView tracheoscopic ventilation tube (TVT) is a tracheal tube (TT) incorporating a video camera and a light source in its tip. The view from the tip appears continuously on a portable monitor in the anesthesia area. We evaluated the effectiveness and usefulness of the single/double ETView TVT in monitoring the tracheal tube position during general anesthesia undergoing video-assisted thoracoscopic lobectomy.Eighty-three patients with pulmonary bullae (American Society of Anesthesiologists (ASA) I-III) undergoing lobectomy, with general anaesthesia, were included...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30543553/high-flow-nasal-cannula-oxygen-therapy-in-patients-undergoing-thoracic-surgery-current-evidence-and-practice
#4
Jakob Wittenstein, Lorenzo Ball, Paolo Pelosi, Marcelo Gama de Abreu
PURPOSE OF REVIEW: Patients undergoing thoracic surgery are at high risk for pulmonary and extra pulmonary complications, and may develop impairment of gas exchange during surgery and in the postoperative period. This review focuses on the potential benefits of high-flow nasal cannula (HFNC) oxygen therapy in those patients. RECENT FINDINGS: HFNC oxygen therapy can be used pre, intra and postoperatively. However, evidence for the use of HFNC oxygen therapy is still limited...
December 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/30543350/comparison-of-immediate-vs-deferred-cytoreductive-nephrectomy-in-patients-with-synchronous-metastatic-renal-cell-carcinoma-receiving-sunitinib-the-surtime-randomized-clinical-trial
#5
Axel Bex, Peter Mulders, Michael Jewett, John Wagstaff, Johannes V van Thienen, Christian U Blank, Roland van Velthoven, Maria Del Pilar Laguna, Lori Wood, Harm H E van Melick, Maureen J Aarts, J B Lattouf, Thomas Powles, Igle Jan de Jong Md PhD, Sylvie Rottey, Bertrand Tombal, Sandrine Marreaud, Sandra Collette, Laurence Collette, John Haanen
Importance: In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC) have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the optimal sequence of surgery and systemic therapy is unknown. Objective: To examine whether a period of sunitinib therapy before CN improves outcome compared with immediate CN followed by sunitinib. Design, Setting, and Participants: This randomized clinical trial began as a phase 3 trial on July 14, 2010, and continued until March 24, 2016, with a median follow-up of 3...
December 13, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30541730/intraoperative-facial-nerve-monitoring-revealed-the-origin-of-rapidly-progressing-schwannoma-in-the-cerebellopontine-angle-a-case-of-large-intermediate-nerve-schwannoma
#6
Makoto Hosoya, Naoki Oishi, Masaru Noguchi, Kento Kasuya, Takanori Nishiyama, Toru Ishikawa, Ken Kasahara, Hidemi Miyazaki, Kaoru Ogawa
Schwannoma arising from the intermediate nerve is very rare, with only a few cases reported in the literature. Here, we report a rare case of a rapidly growing schwannoma that originated from the intermediate nerve in a 17-year-old woman. We performed tumor resection using the translabyrinthine approach with continuous intraoperative monitoring, in which the facial nerve root was used to evoke muscle action potential. The monitoring revealed the tumor origin and enabled complete surgical resection with the preservation of facial nerve motor function...
December 12, 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/30541325/solid-pseudopapillary-tumor-of-the-pancreas-rare-neoplastic-disease-in-20-year-old-woman
#7
Fichtl Jakub, Skalický Tomáš, Vodička Josef, Třeška Vladislav, Tupý Radek, Hes Ondřej
INTRODUCTION: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively rare affliction representing less than 4% of cystic PC. Although the tumor is considered benign, metastasis, especially to the spleen, has been reported in approximately 0.5-4% patients. Despite R0 resection, vascular and perineural invasion is monitored in 20% of cases...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/30541293/optic-nerve-orbital-meningioma
#8
A Furdová, P Babál, D Kobzová
INTRODUCTION: Orbital meningioma treatment has achieved significant success over the last period. Primary optic nerve sheath meningiomas by the clinically progressive finding, but still persistent sufficient visual acuity, can be treated by fractionated stereotactic radiotherapy. Surgery is indicated for secondary meningiomas of the orbit. Surgical treatment is indicated due to intracranial tumor propagation of meningioma from the chiasm towards the orbit. MATERIAL AND METHODS: In the period 2014 - 2016 we monitored in dispensary 15 patients with meningioma of the orbit, who were checked at least in yearly intervals and underwent magnetic resonance examination of the orbit and brain...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30541263/-incidence-and-risk-factors-of-surgical-site-infection-following-caesarean-section-in-a-tunisian-maternity-unit
#9
Latifa Merzougui, Nedia Marwen, Hajer Hannachi, Massoudi Asma, Olfa Ben Elhaj, Manssouri Waddah, Ridha Fatnassi
INTRODUCTION: Surgical site infection (SSI) is a major health concern and is one of the most common complications following caesarean section, with an incidence of 3%-15%. With the worldwide increase in caesarean section rates, the incidence of SSI is expected to increase in parallel. This study was designed to estimate the incidence and determine the risk factors of SSI after caesarean section in an Obstetrics and Gynaecology department in the Kairouan region in Tunisia. METHODS: A prospective cohort study of all patients who delivered by caesarean section between December 2015 and February 2016 was conducted in the Kairouan Obstetrics and Gynaecology department...
May 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30540614/design-and-evaluation-of-a-wireless-electrocardiogram-monitor-in-an-operating-room-a-pilot-study
#10
Philippe Ariès, Kahina Bensafia, Ali Mansour, Benoît Clément, Jean-Louis Vincent, Ba Vinh Nguyen
BACKGROUND: Wired electrocardiogram monitors are an important component of current perioperative monitoring. Wireless monitoring units could help reduce the number of cables attached to patients and thus improve anesthesia ergonomics and patient management. However, there is concern that electromagnetic interference generated by electrosurgical units may prevent effective wireless signals in the operating room. To evaluate the extent of this problem, we developed a Bluetooth electrocardiogram prototype monitor and compared its electrocardiogram traces to those captured with a standard wired electrocardiogram monitor in our operating room...
December 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30540577/precise-anesthesia-in-thoracoscopic-operations
#11
Ming-Hui Hung, Jin-Shing Chen, Ya-Jung Cheng
PURPOSE OF REVIEW: The current review focuses on precise anesthesia for video-assisted thoracoscopic surgery (VATS) with the goal of enhanced recovery. RECENT FINDINGS: VATS has become an established and widely used minimally invasive approach with broad implementation on a variety of thoracic operations. In the current environment of enhanced recovery protocols and cost containment, minimally invasive VATS operations suggest adoption of individualized tailored, precise anesthesia...
December 11, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/30540559/standards-of-care-for-hypoparathyroidism-in-adults
#12
Aliya Aziz Khan, Christian Koch, Stanislaus Hendrikus Maria Van Uum, Jean Patrice Baillargeon, Jens Bollerslev, Maria Luisa Brandi, Claudio Marcocci, Lars Rejnmark, Rene Rizzoli, M Zakarea Shrayyef, Rajesh V Thakker, Bulent O Yildiz, Bart Clarke
PURPOSE: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included...
December 1, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/30538581/first-two-cases-of-craniomaxillofacial-fibrous-dysplasia-from-nepal-case-series
#13
Neha Mishra, Sourav Kumar Rout
Fibrous dysplasia is a benign fibro-osseous disease of the bone, which is most commonly associated with congenital mutations in cAMP regulating protein Gsα coded by GNAS-1 gene. Often it is seen involving the craniofacial skeleton and can range from an asymptomatic monostotic form to polyostotic variant involving almost all the bones of the skull, thereby leading to functional and esthetic problems. This requires a continuous monitoring of the involved region throughout the life of the patient, even after the surgical interventions...
2018: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/30538086/continuous-versus-intermittent-vital-signs-monitoring-using-a-wearable-wireless-patch-in-patients-admitted-to-surgical-wards-pilot-cluster-randomized-controlled-trial
#14
Candice Downey, Rebecca Randell, Julia Brown, David G Jayne
BACKGROUND: Vital signs monitoring is a universal tool for the detection of postoperative complications; however, unwell patients can be missed between traditional observation rounds. New remote monitoring technologies promise to convey the benefits of continuous monitoring to patients in general wards. OBJECTIVE: The aim of this pilot study was to evaluate whether continuous remote vital signs monitoring is a practical and acceptable way of monitoring surgical patients and to optimize the delivery of a definitive trial...
December 11, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30536273/refractory-severe-thrombocytopenia-during-pregnancy-how-to-manage
#15
Joana Gomes de Amorim, Manuel Rocha Abecasis, Filipa Maria Nogueira Lança Rodrigues
Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then...
December 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/30536020/clinical-characteristics-and-outcome-of-morbidly-obese-bariatric-patients-with-concurrent-hepatitis-c-viral-infection
#16
Ming-Lun Han, Wei-Jei Lee, Jung-Chien Chen, Kong-Han Ser, Shu-Chun Chen, Yi-Chih Lee
BACKGROUND: Hepatitis C virus (HCV) is an important cause of liver cirrhosis and its complications. The safety and efficacy of bariatric surgery in patients with HCV infection is not clear. METHODS: Charts were reviewed to identify patients with HCV infection before bariatric surgery. Bariatric surgical patients with non-alcoholic steatohepatitis (NASH) and without NASH (non-NASH) were recruited as comparative groups. Demographic variables, perioperative data, follow-up, and HCV-related parameters were extracted and compared...
December 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30535977/a-modified-method-of-local-infiltration-for-endoscopic-stapes-surgery-how-i-do-it
#17
Arnulfo Cornejo-Suarez, Maria Estela Chavez-Delgado, Ramon Perez-Ramirez, Isaac Montoya-Hernandez, Jose Regino Montoya-Valdez, Carlos Silvino Rosales-Orozco, Luis Humberto Govea-Camacho
PURPOSE: To present a modified method of local infiltration (MMLI) for endoscopic stapes surgery to reduce surgical time, bleeding and complications. MATERIALS AND METHODS: This study involved 70 patients who underwent stapes surgery for otosclerosis by endoscopic and microscopic approaches. The MMLI was applied as follows: local infiltration was performed with one hand while the other hand inserted the endoscope into the ear canal to observe vasoconstriction signs on the monitor; the single site of infiltration was located at the center of the anterior conchal cartilage...
December 10, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30534842/an-unusual-cause-of-acute-surgical-abdomen-benign-multicystic-peritoneal-mesothelioma-associated-with-adenomatous-tumor
#18
Cristian Meşină, Theodor Viorel Dumitrescu, Stelian Ştefăniţă Mogoantă, Mihai Călin Ciorbagiu, Daniel Alin Cristian, Mihaela Iustina Meşină-Botoran, Corina Lavinia Gruia, Maria Camelia Foarfă, Mihai Meşină, Marius Eugen Ciurea, Daniela Ciobanu
Benign multicystic peritoneal mesothelioma (BMPM) is a rare disease that primarily affects fertile women with previous abdominal surgery. BMPM associated with adenomatous tumor is a single case report, according to our opinion. The patient had a history of abdominal surgery nine years ago for ovarian cysts. Upon admission, the diagnosis was acute surgical abdomen with acute peritonitis signs. The treatment applied consisted in the removal of peritoneal cysts and partial omentectomy. Only immunohistochemical examination established the diagnosis...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30533272/lateral-position-and-utility-of-navigation-for-posterior-fixation-of-unstable-cervical-fracture-with-ankylosing-spondylitis
#19
Zubair Ahammad, Jason Milton, Kailash Narayan, Victor Awuor
Background: Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy within the spectrum of rheumatologic diseases. The systemic inflammation that characterizes AS leads to bone resorption and reformation. Pathologic remodeling may include kyphosis, osteoporosis, and multi-segment auto-fusion. Cervical fractures account for 53-78% of spinal trauma seen with AS. Surgical planning is often challenging owing to spinal deformity, medical comorbidities, the cervicothoracic foci of injury, and gross instability of these fracture...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30531660/cryo-compression-therapy-after-elective-spinal-surgery-for-pain-management-a-cross-sectional-study-with-historical-control
#20
Vugar Nabi Nabıyev, Selim Ayhan, Prashant Adhıkarı, Engin Cetın, Selcuk Palaoglu, R Emre Acaroglu
Objective: Postoperative dynamic cryo-compression (DC) therapy has been proposed as a method of reducing pain and the inflammatory response in the early postoperative period after orthopedic joint reconstruction surgery. Our aim was to analyze the analgesic efficacy of DC therapy after adult lumbar spinal surgery. Methods: DC was applied for 30 minutes every 6 hours after surgery. Pain was measured by a visual analogue scale (VAS) in the preoperative period, immediately after surgery, and every 6 hours postoperatively for the first 72 hours of the hospital stay...
September 9, 2018: Neurospine
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