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https://www.readbyqxmd.com/read/30413072/ophiopogonin-d-a-steroidal-glycoside-abrogates-stat3-signaling-cascade-and-exhibits-anti-cancer-activity-by-causing-gsh-gssg-imbalance-in-lung-carcinoma
#1
Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Gautam Sethi, Kwang Seok Ahn
Natural medicinal plants are multi-targeted in nature and their anti-cancer activities are also complex and varied, thus requiring a more systematic analysis of their modes of action. Since the activation of signal transducer and activator of transcription 3 (STAT3) is often deregulated in non-small cell lung carcinoma (NSCLC) cells and tissue specimens, its negative regulation can form the basis for identification of targeted therapy. In this report, we analyzed the possible anti-cancer effects of ophiopogonin D (OP-D) and the underlying mechanisms by which OP-D exerts its actions in NSCLC...
November 8, 2018: Cancers
https://www.readbyqxmd.com/read/30372822/ophiopogonin-b-induces-the-autophagy-and-apoptosis-of-colon-cancer-cells-by-activating-jnk-c-jun-signaling-pathway
#2
Guang-Yi Gao, Jun Ma, Peng Lu, Xuan Jiang, Cheng Chang
OBJECTIVE: To investigate the effect of Ophiopogonin B (OP-B) on the autophagy and apoptosis of colon cancer cells via the regulation of JNK/c-Jun signaling pathway. METHODS: Colon cancer cell lines (HT-29 and HCT-116) were treated with various concentrations of OP-B (0, 5, 10and 20 μmol/l) and JNK inhibitor SP600125. MTT assay, flow cytometry, immunofluorescence staining were used to detect the biological function ofHT-29 and HCT-116 cells, and expressions of autophagy-,apoptotic- and pathway-related proteins were measured by Western Blot...
December 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30327544/multiple-circulating-saponins-from-intravenous-shenmai-inhibit-oatp1bs-in-vitro-potential-joint-precipitants-of-drug-interactions
#3
Olajide E Olaleye, Wei Niu, Fei-Fei Du, Feng-Qing Wang, Fang Xu, Salisa Pintusophon, Jun-Lan Lu, Jun-Ling Yang, Chuan Li
ShenMai, an intravenous injection prepared from steamed Panax ginseng roots (Hongshen) and Ophiopogon japonicus roots (Maidong), is used as an add-on therapy for coronary artery disease and cancer; saponins are its bioactive constituents. Since many saponins inhibit human organic anion-transporting polypeptides (OATP)1B, this investigation determined the inhibition potencies of circulating ShenMai saponins on the transporters and the joint potential of these compounds for ShenMai-drug interaction. Circulating saponins and their pharmacokinetics were characterized in rats receiving a 30-min infusion of ShenMai at 10 mL/kg...
October 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/30227401/ophiopogonin-d-reduces-myocardial-ischemia-reperfusion-injury-via-upregulating-cyp2j3-eets-in-rats
#4
Xiaoyan Huang, Yuguang Wang, Yi Wang, Liang Yang, Jia Wang, Yue Gao
BACKGROUND/AIMS: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase (CYP) metabolites of arachidonic acid and have multiple cardiovascular effects. Ophiopogonin D (OP-D) is an important effective monomeric component in Shenmai injection (SM-I). Both have been reported to have a variety of biological functions, including anti-inflammatory, anti-oxidant, and anti-apoptotic effects. We previously demonstrated that OP-D-mediated cardioprotection involves activation of CYP2J2/3 and enhancement of circulating EETs levels in vitro and can be developed as a novel drug for the therapy of myocardial ischemia-reperfusion (MI/R) injury...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30186179/ginsenoside-rb1-and-rd-remarkably-inhibited-the-hepatic-uptake-of-ophiopogonin-d-in-shenmai-injection-mediated-by-oatps-oatps
#5
Xiaopei Liu, Lin Chen, Mingyi Liu, Hong Zhang, Shibo Huang, Yuqing Xiong, Chunhua Xia
Shenmai injection (SMI) is derived from traditional Chinese herbal prescription Shendong yin and widely used for treating cardiovascular diseases. Ophiopogonin D (OPD) is one of the main active components of SMI. The hepatic uptake of OPD is mediated by organic anion-transporting polypeptides (OATPs/oatps) and inhibited by some other components in SMI. This study aimed to identify the active components of SMI responsible for the inhibitory effects on hepatic uptake of OPD in rats and explore the compatibility mechanisms of complex components in SMI based on OATPs/oatps...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30031164/an-immunopotentiator-ophiopogonin-d-encapsulated-in-a-nanoemulsion-as-a-robust-adjuvant-to-improve-vaccine-efficacy
#6
Ya-Nan Tong, Liu-Yang Yang, Yun Yang, Zhen Song, Liu-Sheng Peng, Ji-Ning Gao, Hao Zeng, Quan-Ming Zou, Hong-Wu Sun, Xu-Hu Mao
As an ingredient of vaccines, adjuvants are indispensable for enhancing and directly inducing robust and extensive adaptive immune responses associated with vaccine antigens. In this study, we initially determined that a new molecular immunopotentiator, ophiopogonin D (OP-D), enhanced the antibody response to antigen. Because OP-D has certain disadvantages, including poor solubility, we next encapsulated OP-D in a nanoemulsion adjuvant (nanoemulsion-encapsulated OP-D, NOD) using low-energy emulsification methods...
September 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29961188/anti-inflammatory-activities-of-ophiopogonis-radix-on-hydrogen-peroxide-induced-cellular-senescence-of-normal-human-dermal-fibroblasts
#7
Yumi Kitahiro, Atsushi Koike, Aska Sonoki, Mei Muto, Kazuo Ozaki, Makio Shibano
Ophiopogonis Radix (Ophiopogon root), which nourishes the yin, has been used in clinical practice to promote fluid secretion and to moisturize the lungs and skin in traditional Chinese and Japanese (Kampo) medicine. To evaluate this traditional medicinal effect, we investigated the anti-chronic inflammatory effect of Radix Ophiopogonis on senescent cells. Conversely, although several phenotypes of Ophiopogon japonicus Ker-Gawler (Liliaceae) are prevalent in Japan and China, we used these Ophiopogon roots by considering them as one crude drug, Ophiopogonis Radix...
September 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29956803/ophiopogonin-b-suppresses-the-metastasis-and-angiogenesis-of-a549-cells-in-vitro-and-in-vivo-by-inhibiting-the-epha2-akt-signaling-pathway
#8
Meijuan Chen, Cheng Hu, Yuanyuan Guo, Rilei Jiang, Huimin Jiang, Yu Zhou, Haian Fu, Mianhua Wu, Xu Zhang
Lung adenocarcinoma is the most common metastatic cancer, and is associated with high patient mortality. Therefore, investigation of anti‑metastatic treatments for lung adenocarcinoma is crucial. Ophiopogonin B (OP‑B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary disease. Screening of transcriptome and digital gene expression (DGE) profiling data in NSCLC cell lines showed that OP‑B regulated the epithelial‑mesenchymal transition (EMT) pathway in A549 cells...
September 2018: Oncology Reports
https://www.readbyqxmd.com/read/29944058/modulation-of-transporter-activity-of-oatp1b1-and-oatp1b3-by-the-major-active-components-of-radix-ophiopogonis
#9
Lin Chen, Linlin Liu, Yu Chen, Mingyi Liu, Yuqing Xiong, Hong Zhang, Shibo Huang, Chunhua Xia
Radix Ophiopogonis is often an integral part of many traditional Chinese formulas, such as Shenmai injection used to treat cardio-cerebrovascular diseases. The present study aimed to investigate the influence of the four active components of Radix Ophiopogonis on the transport activity of OATP1B1 and OATP1B3. The uptake of rosuvastatin in OATP1B1-HEK293T cells were stimulated by methylophiopogonanone A (MA) and ophiopogonin D' (OPD') with EC50 calculated to be 11.33±2.78 and 4.62±0.64 μM, respectively. However, there were no remarkable influences on rosuvastatin uptake in the presence of methylophiopogonanone B (MB) or ophiopogonin D (OPD)...
June 26, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29935180/ophiopogonin-d-alleviates-cardiac-hypertrophy-in-rat-by-upregulating-cyp2j3-in-vitro-and-suppressing-inflammation-in-vivo
#10
Yuan Wang, Xiaoyan Huang, Zengchun Ma, Yuguang Wang, Xiangmei Chen, Yue Gao
Ophiopogonin D (OPD) is the chief pharmacological active component of the traditional Chinese herbal prescription drug-Shenmai injection (SMI), which has been used to prevent and treat cardiovascular diseases. In the present study, we investigated whether OPD protectively relieve cardiac hypertrophy against inflammation via inhibiting the expression of NF-κB and examined whether cytochrome P450 2J3 (CYP2J3)was involved in this pathway. H9c2 cells were treated with Angiotensin II (Ang II). Hypertrophy in rat was induced by administration of Ang II infusion...
September 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29760660/ophiopogonin-d-a-natural-product-from-radix-ophiopogonis-induces-in-vitro-and-in-vivo-ripk1-dependent-and-caspase-independent-apoptotic-death-in-androgen-independent-human-prostate-cancer-cells
#11
Zongliang Lu, He Wang, Mingxing Zhu, Wei Song, Jiajia Wang, Changpeng Wu, Ya Kong, Jing Guo, Na Li, Jie Liu, Yanwu Li, Hongxia Xu
Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine ( Radix Ophiopogonis ) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-8 assay was used to assess the viability of prostate cancer cells. The cell morphology was examined by an ultrastructural analysis via transmission electron microscopy. Cells in apoptosis (early and late stages) were detected using an Annexin V-FITC/propidium iodide kit with a FACSCaliber flow cytometer...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29705132/ophiopogonin-d-improves-osteointegration-of-titanium-alloy-implants-under-diabetic-conditions-by-inhibition-of-ros-overproduction-via-wnt-%C3%AE-catenin-signaling-pathway
#12
Xiang-Yu Ma, Xin-Xin Wen, Xiao-Jiang Yang, Da-Peng Zhou, Qiong Wu, Ya-Fei Feng, Hai-Jiao Ding, Wei Lei, Hai-Long Yu, Bing Liu, Liang-Bi Xiang, Tian-Sheng Wang
A high failure rate of titanium implants in diabetic patients has been indicated in clinical evidences. Excessive oxidative stress at the bone-implant interface plays an important role in the impaired osteointegration under diabetic conditions. While the underlying mechanisms remain unknown and the targeted treatments are urgently needed. Ophiopogonin D (OP-D), isolated from Chinese herbal Radix Ophiopogon japonicus, is generally reported to be a potent antioxidant agent. In the present study, we hypothesized that OP-D exerted promotive effects on osteointegration against oxidative stress, and investigated the underlying mechanisms associated with alteration of Wnt/β-catenin signaling pathway...
September 2018: Biochimie
https://www.readbyqxmd.com/read/29552858/-effect-of-ophiopogonin-d-in-resisting-vascular-endothelial-cell-apoptosis-induced-by-ang%C3%A2-through-up-regulating-cyp2j2-eets
#13
Xiao-Yan Huang, Yu-Guang Wang, Yi Wang, Yue Gao
This study aimed to investigate the effect and mechanism of ophiopogonin D (OP-D) on Ang Ⅱ-induced HUVECs apoptosis, in order to provide a reliable basis for the safety and efficacy of traditional Chinese medicines. The effect of Ang Ⅱ on survival and total proteins content of HUVECs were measured by MTT and Western blotting. The effect of OP-D on Ang Ⅱ-induced lactate dehydrogenase (LDH) release rate in HUVECs was measured by enzyme standard instrument. The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang Ⅱ were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH)...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29496169/ophiopogonin-d-modulates-multiple-oncogenic-signaling-pathways-leading-to-suppression-of-proliferation-and-chemosensitization-of-human-lung-cancer-cells
#14
Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
BACKGROUND: Ophiopogonin D (OP-D), a steroidal glycoside obtained from the Chinese medicinal plant Ophiopogonin japonicas (the root portion), has been traditionally used to treat fever, inflammation, cough, sputum etc. However, the detailed molecular mechanism(s) underlying its therapeutic actions is still unknown. HYPOTHESIS: Because nuclear factor-κB (NF-κB), PI3K/AKT, and activator protein-1 (AP-1) signaling cascades have significant functions in cell proliferation, inflammation, and angiogenesis in tumor cells, we hypothesized that OP-D may disrupt these signaling cascades to exert its anticancer effects in human lung-cancer cells...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29425641/cardioprotection-of-sheng-mai-yin-a-classic-formula-on-adriamycin-induced-myocardial-injury-in-wistar-rats
#15
Kai Zhang, Jingyan Zhang, Xurong Wang, Lei Wang, Michela Pugliese, Annamaria Passantino, Jianxi Li
BACKGROUND: Sheng Mai Yin (SMY), a well-known Chinese herbal medicine, is widely used to treat cardiac diseases characterized by the deficiency of Qi and Yin syndrome in China. SMY-based treatment has been derived from Traditional Chinese Medicine (TCM), officially recorded in the Chinese Pharmacopoeia. PURPOSE: We aimed to clarify whether SMY attenuates myocardial injury induced by adriamycin in Wistar rats with chronic heart failure (CHF). METHODS: To quantify ginsenoside Rg1, ophiopogonin D, ophiopogonin D', schisandrin by HPLC...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423112/ophiopogonin-b-sensitizes-trail-induced-apoptosis-through-activation-of-autophagy-flux-and-downregulates-cellular-flice-like-inhibitory-protein
#16
Uddin Md Nazim, Jae-Kyo Jeong, Sang-Youel Park
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a type II transmembrane protein, belongs to the TNF superfamily. Compared to other family members, TRAIL is a promising anti-cancer agent that can selectively induce apoptosis of various types of transformed cells and xenografts, with negligible cytotoxicity against normal tissues. Ophiopogonin B is a bioactive ingredient of Radix Ophiopogon japonicus , which is frequently used in traditional Chinese medicine to treat cancer. In this study, we report that Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is the key determinant mediating TRAIL resistance in A549 cells and Ophiopogonin B downregulates c-FLIP and enhances TRAIL-induced apoptosis by activating autophagy flux...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/28855686/novelty-application-of-multi-omics-correlation-in-the-discrimination-of-sulfur-fumigation-and-non-sulfur-fumigation-ophiopogonis-radix
#17
Shengyun Dai, Zhanpeng Shang, Fei Wang, Yanfeng Cao, Xinyuan Shi, Zhaozhou Lin, Zhibin Wang, Ning Li, Jianqiu Lu, Yanjiang Qiao, Jiayu Zhang
A rapid and sensitive approach to differentiate sulfur-fumigated (SF) Ophiopogonis Radix based on Multi-Omics Correlation Analysis (MOCA) strategy was first established. It was characterized by multiple data-acquisition methods (NIR, HPLC, and UHPLC-HRMS) based metabonomics and multivariate statistical analysis methods. As a result, SF and non-sulfur fumigated (NSF) Ophiopogonis Radix samples were efficaciously discriminated. Moreover, based on the acquired HRMS data, 38 sulfur-containing discriminatory markers were eventually characterized, whose NIR absorption could be in close correlation with the discriminatory NIR wavebands (5000-5200 cm(-1)) screened by NIR metabonomics coupled with SiPLS and 2D-COS methods...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587983/ophiopogonin-d-and-eets-ameliorate-ang-ii-induced-inflammatory-responses-via-activating-ppar%C3%AE-in-huvecs
#18
Xiaoyan Huang, Yuguang Wang, Zhaoyan Zhang, Yuan Wang, Xiangmei Chen, Yi Wang, Yue Gao
CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs have been shown owning diverse biological effects. Our previous study found that ophiopogonin D (OP-D) suppressed drug-induced endoplasmic reticulum (ER) stress by upregulating the levels of CYP2J3/EETs in cardiomyocytes. The aim of this research was to investigate whether CYP2J2/EETs-PPARα pathway involved in endothelium protective effects of OP-D in human umbilical vein endothelial cells (HUVECs)...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28299617/methyl-caffeate-and-some-plant-constituents-inhibit-age-related-inflammation-effects-on-senescence-associated-secretory-phenotype-sasp-formation
#19
Hyun Lim, Byung Kyu Park, Sook Young Shin, Yong Soo Kwon, Hyun Pyo Kim
During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of IL-6 production, a representative SASP marker. These plant constituents included anthraquinones such as aurantio-obtusin, flavonoids including astragalin, iristectorigenin A, iristectorigenin B, linarin, lignans including lariciresinol 9-O-glucoside and eleutheroside E, phenylpropanoids such as caffeic acid and methyl caffeate, steroid (ophiopogonin), and others like centauroside, rhoifolin and scoparone...
April 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28284426/influence-of-ultrafiltration-membrane-on-ophiopogonins-and-homoisoflavonoids-in-ophiopogon-japonicus-as-measured-by-ultra-fast-liquid-chromatography-coupled-with-ion-trap-time-of-flight-mass-spectrometry
#20
Chun-Hua Liu, Jin Qi, Da-Zheng Zhou, Ai-Chun Ju, Bo-Yang Yu
Ultrafiltration is one of the most fascinating technologies, which makes it possible to improve the quality of traditional medicines for application in the pharmaceutical industry. However, researchers have paid little attention to the effect of ultrafiltration membrane on traditional medicines chemical constituents. In this work, Ophiopogon japonicus (L.f) Ker-Gawl. was used as an example to illuminate the influence of ultrafiltration with different material and molecular weight cut-off (MWCO) membrane on natural chemical constituents as measured by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UFLC-IT-TOF/MS)...
February 2017: Chinese Journal of Natural Medicines
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