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Samad Lotfollahzadeh, Masoumeh Heydari, Mohammad Reza Mohebbi, Maryam Hashemian
Tetanus is an acute, often fatal, infectious neuromuscular disease in all farmed mammals caused by Clostridium tetani. The disease is sporadic but outbreaks of tetanus have been described, as a result of wound contaminated with spores of C. tetani, which sporulates to the vegetative form and produce toxins. The present study reports an outbreak of tetanus in a sheep flock, shortly after ear tagging. Three sheep from a large flock (with a population of 1000 sheep) were presented with signs of: convulsion, limb stiffness, incoordination and trismus ("lock jaw")...
December 13, 2018: Veterinary Medicine and Science
Kang Zi Khor, Vuanghao Lim, Emmanuel J Moses, Nozlena Abdul Samad
Moringa oleifera , a fast-growing deciduous tree that is widely cultivated in tropical and subtropical regions of the world, is well known for its abundant uses. The tree is a source of food, shelter, and traditional medicine for many people, especially in developing countries. Many studies have been conducted to evaluate the various claims of traditional medicine practitioners that the moringa tree can improve health and treat various diseases. The tree has a high nutritional profile, especially the nutrient rich leaves...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yao Xu, Jing Jing Wang, Fei Fei Liu, Yue Wu, Yang Fang Wu, Sama Samadli, Huang Huang Luo, Dong Dong Zhang, Peng Hu
Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. 1200 children with HSP were recruited between January 2015 and December 2017. We reviewed their laboratory tests and medical histories associated with HSP onset...
December 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Abdus Samad, Hye Jung Kim, Young-Han Shin
Ferroelectricity in the ultra low thin films of the ferroelectric materials is a rare phenomenon due to the depolarization electric field established by the uncompensated surface charge. Using density functional theory based calculations, we design buckled honeycomb binary monolayer MoC, WC, WS, and WSe. The feasibility of their experimental synthesis is evident from their low formation energies, stable lattice vibrations, and high elastic stiffnesses. The difference in electronegativity of the building atoms and lack of inversion symmetry results in high spontaneous out-of-plane polarization whereas all the in-plane components cancel out...
November 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Mojtaba Ziaee, Sina Mashayekhi, Samad Ghaffari, Javad Mahmoudi, Parvin Sarbakhsh, Alireza Garjani
We assessed the prognostic value of serum levels of endocan in patients with the acute coronary syndrome (ACS) through its correlation with the Thrombolysis in Myocardial Infarction (TIMI) risk score and compared the possible association with clinical outcomes. In this prospective cross-sectional study, we enrolled 320 patients with documented ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) who underwent diagnostic coronary angiography. Endocan was measured soon after admission in the emergency department...
December 4, 2018: Angiology
Saba Zahid, Abdul Samad Khan, Aqif Anwar Chaudhry, Sarah Ghafoor, Qurat Ul Ain, Ahtasham Raza, Muhammad Imran Rahim, Oliver Goerke, Ihtesham Ur Rehman, Asma Tufail
Development of a guided occlusive biodegradable membrane with controlled morphology in order to restrict the ingrowth of epithelial cells is still a challenge in dental tissue engineering. A bilayer membrane with a non-porous upper layer (polyurethane) and porous lower layer (polycaprolactone and bioactive glass composite) with thermoelastic properties to sustain surgery treatment was developed by lyophilization. Morphology, porosity, and layers attachment were controlled by using the multi-solvent system. In vitro and in vivo biocompatibility, cell attachment, and cell proliferation were analyzed by immunohistochemistry and histology...
December 3, 2018: Journal of Biomaterials Applications
Gul Rukh, Nisar Ahmad, Abdur Rab, Naveed Ahmad, Hina Fazal, Fazal Akbar, Irfan Ullah, Sidra Mukhtar, Nadia Samad
Ajuga bracteosa (A. bracteosa) is one of the critically endangered and high-valued medicinal plants worldwide. Light is one of the major factor or stimulus involved in the morphogenic responses and bioactive compounds production in various medicinal plants. In this study, unique properties of colored lights have been observed on induction of somatic embryos from non-embryonic calli cultures of A. bracteosa. The maximum callogenic response (92.32%) from leaf explants was observed on Murashige and Skoog (MS) medium augmented with benzyl adenine (BA; 2...
November 20, 2018: Journal of Photochemistry and Photobiology. B, Biology
J Daniel Lafreniere, J T Toguri, Rishi R Gupta, Arif Samad, Dan M O'Brien, John Dickinson, Alan Cruess, Melanie Em Kelly, M E Seamone
BACKGROUND: Exogenous endophthalmitis is a potential complication of intraocular surgery and frequently results in visual impairment. Current treatment involves administration of intravitreal (IVT) antibiotics with or without vitrectomy surgery. Evidence for the use of adjunctive anti-inflammatory agents is conflicting. We set out to determine if bevacizumab, a humanized monoclonal IgG1 antibody targeted against Vascular Endothelial Growth Factor (VEGF), has anti-inflammatory properties in experimental models of Gram-positive and Gram-negative inflammation...
November 28, 2018: Clinical & Experimental Ophthalmology
Takavar Mohammadian, Mahdieh Nasirpour, Mohammad Reza Tabandeh, Amir Ali Heidary, Reza Ghanei-Motlagh, Seyed Samad Hosseini
The present study was tested how Oncorhynchus mykiss can respond to dietary supplementations of autochthonous probiotics, including Lactobacillus delbrukei subsp. bulgaricus and Lactobacillus acidophilus and Citrobacter farmeri by measuring different parameters. To address that, 300 fish weighing 19.08-32.9 g were fed by probiotics-enriched diets, containing 5 × 107  CFU g-1 for 60 days. Our results indicated that probiotics, especially L. acidophilus and L. bulgaricus are involved in enhancing the growth performance of this species as compared with the control group...
November 20, 2018: Fish & Shellfish Immunology
Angora Rémi Constant Ahoua, Aymeric Monteillier, Frédéric Borlat, Olivier Ciclet, Laurence Marcourt, Samad Nejad Ebrahimi, Mamidou Witabouna Koné, Bassirou Bonfoh, Philippe Christen, Muriel Cuendet
Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in Taï National Park have shown that they could be potential candidates for the search of new molecules useful for humans. Based on the screening of some of these plants, the fruits of Beilschmiedia mannii , whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two γ -pyrones, including desmethoxydihydromethysticin (1: ), found in a natural source for the first time, and a new congener, beilschmiediapyrone (2: ), as well as five known alkamides (3:  - 7: )...
November 22, 2018: Planta Medica
Younjung Kim, Paritosh K Biswas, Mohammad Giasuddin, Mahmudul Hasan, Rashed Mahmud, Yu-Mei Chang, Steve Essen, Mohammed A Samad, Nicola S Lewis, Ian H Brown, Natalie Moyen, Md Ahasanul Hoque, Nitish C Debnath, Dirk U Pfeiffer, Guillaume Fournié
We conducted a cross-sectional study in live bird markets (LBMs) in Dhaka and Chittagong, Bangladesh, to estimate the prevalence of avian influenza A(H5) and A(H9) viruses in different types of poultry and environmental areas by using Bayesian hierarchical logistic regression models. We detected these viruses in nearly all LBMs. Prevalence of A(H5) virus was higher in waterfowl than in chickens, whereas prevalence of A(H9) virus was higher in chickens than in waterfowl and, among chicken types, in industrial broilers than in cross-breeds and indigenous breeds...
December 2018: Emerging Infectious Diseases
Samad Esmaeilzadeh, Reza Farzizadeh, Hassan-Ali Kalantari, Asghar Mahmoudi, Inga Dziembowska, Alicja Kostencka, Mohammad Narimani, Seifollah Aghajani
BACKGROUND AND PURPOSE: Recent research demonstrates a significant relationship between weight status and impaired reaction time in young, adult, and elderly individuals. However, most such studies were performed on small samples, used only body mass index as the body obesity index, used simple reaction time, and oftentimes did not consider some potential confounders such as age, socioeconomic status, or physical activity in their studies. The present study explored the relationship between various reaction time tasks and various obesity indices in a sample of youth...
November 16, 2018: Eating and Weight Disorders: EWD
Thao N Pham, Krishan Kumar, Brian T DeCant, Meng Shang, Samad Z Munshi, Maria Matsangou, Kazumi Ebine, Hidayatullah G Munshi
BET inhibitors (BETis), which target transcription of key oncogenic genes, are currently being evaluated in early-phase clinical trials. However, since BETis show limited single agent activity, there is increasing interest in identifying signaling pathways to enhance the efficacy of BETis. Here, we demonstrate increased MNK kinases-dependent eIF4E phosphorylation following treatment with BETis, indicating activation of a pro-survival feedback mechanism in response to BETis. BET PROTACs, which promote degradation of BET proteins, also induced eIF4E phosphorylation in cancer cells...
November 16, 2018: Molecular Cancer Therapeutics
Saeed Soleyman-Jahi, Fatemeh Sadeghi, Ziba Afshari, Tahereh Barati, Sevil Ghasemi, Samad Muhammadnejad, Saeid Amanpour, Kazem Zendehdel
BACKGROUND: Aprotinin is a nonspecific serine protease inhibitor, which can inhibit plasminogen-plasmin system and matrix metalloproteinases. Aprotinin has been investigated as an antitumor agent. However, its antineoplastic effects on breast cancer (BC) have not been investigated yet. OBJECTIVES: The objective of this study was to assess the inhibitory effects of aprotinin on human BC cell lines. We assessed the effects of aprotinin on local invasion and survival of human BC cell lines MDA-MB-231, SK-BR-3 and MCF-7 in vitro...
November 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Md Nazibul Islam, Isteaque Ahmed, Muzahidul Islam Anik, Md Sakib Ferdous, Mohidus Samad Khan
Urinary or serum uric acid concentration is an indicator of chronic kidney condition. An increase in uric acid concentration may indicate renal dysfunction. Reliable instantaneous detection of uric acid without requiring sophisticated laboratory and analytical instrumentation, such as: chromatographic and spectrophotometric methods, would be invaluable for patients with renal complication. This paper reports the early development of a simple, low-cost, instantaneous and user-friendly paper based diagnostic device (PAD) for the qualitative and quantitative detection of uric acid in urine...
2018: Frontiers in Chemistry
Samad Rahimnejad, Kangle Lu, Ling Wang, Kai Song, Kangsen Mai, D Allen Davis, Chunxiao Zhang
This study examined the effects of replacing fish meal (FM) with three different types of soybean meal (SM) including untreated SM, Bacillus pumillus SE5 (BP) fermented SM (BPFSM) and Pseudozyma aphidis ZR1 (PA) fermented SM (PAFSM) in diets for Japanese seabass (Lateolabrax japonicus). A basal diet was formulated using FM (FM diet), and six other diets were produced by substituting 40 or 80% of FM with SM, BPFSM or PAFSM (SM40, SM80, BPFSM40, BPFSM80, PAFSM40 and PAFSM80 diets). Each diet was fed to triplicate groups of fish (7...
November 4, 2018: Fish & Shellfish Immunology
Marzieh Kafami, Mahmoud Hosseini, Saeed Niazmand, Esmaeil Farrokhi, Mosa Al-Reza Hajzadeh, Samad Nazemi
Background Although numerous studies have proven that estrogen (Est) has a protective effect on the development of hypertension, more research needs to be done to show its detailed mechanism in a variety of hypertension. The important role of active oxygen species in blood pressure is well defined. We examined whether or not sex hormones change the growth of reactive oxygen species (ROS) ‎in kidneys after central microinjection of angiotensin II (Ang II).‎ Materials and methods Female Wistar rats, 8 weeks old (200 ± 10 g) were used in this study...
November 6, 2018: Hormone Molecular Biology and Clinical Investigation
Samad Ghaffari, Neda Roshanravan
OBJECTIVE: Saffron as a natural product has long been used to impede and treat different disorders including cardiovascular disease (CVDs). Stigma is the most principal part of saffron. Various compounds such as carotenoids and flavonoids are the essential components of saffron stigma. The health benefits of saffron have been shown in previous studies; however, there is a lack of comprehensive data on the mechanistic aspects of its cardiovascular-health properties. This current comprehensive review focuses on the medicinal applications of saffron, and then the new findings regarding its cardiovascular-health effects and various cellular and molecular mechanisms of action will be debated...
November 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sina Mashayekhi, Mojtaba Ziaee, Alireza Garjani, Parvin Sarbakhsh, Samad Ghaffari
No abstract text is available yet for this article.
October 31, 2018: Journal of Emergency Medicine
Alireza Ala, Samad Shams Vahdati, Amir Ghaffarzad, Haleh Mousavi, Mohammad Mirza-Aghazadeh-Attari
INTRODUCTION: The most common cause of hospital emergency department visits is trauma resulting from a variety of underlying mechanisms. Unknown neck and spinal cord injuries and a lack of early diagnosis can have catastrophic consequences, such as paralysis of some or all limbs. The use of imaging techniques reduces the number of patients suffering from severe injuries. OBJECTIVE: To assess and compare the effectiveness and ease of utilizing two different sets of guidelines, the National Emergency X-Radiography Utilization Study guidelines (NEXUS) and the Canadian C-Spine guidelines (CCR), on trauma patients...
2018: PloS One
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