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Hadi Hassankhani, Amin Soheili, Samad S Vahdati, Farough A Mozaffari, Justin F Fraser, Neda Gilani
STUDY OBJECTIVE: We evaluate the extent and nature of treatment delays and the contributing factors influencing them for patients with acute ischemic stroke, as well as main barriers to stroke care in an Iranian emergency department (ED). METHODS: A retrospective chart review was conducted on 394 patients with acute ischemic stroke who were referred to the ED of a tertiary academic medical center in northwest Iran from March 21 to June 21, 2017. The steps of this review process included instrument development, medical records retrieval, data extraction, and data verification...
October 11, 2018: Annals of Emergency Medicine
Ghasem Barati, Samad Nadri, Ramin Hajian, Ali Rahmani, Hossein Mostafavi, Yousef Mortazavi, Amir Hossein Taromchi
Tissue and stem cell encapsulation andtransplantation were considered as promising tools in the treatment of patients with diabetes mellitus. The aim of this study was to evaluate the effect of microfluidic encapsulation on the differentiation of trabecular meshwork mesenchymal stem cells (TM-MSC), into insulin-producing cells (IPCs) both in vitro and in vivo. The presence of differentiated cells in microfibers (three dimensional [3D]) and tissue culture plates (TCPS; two dimensional [2D]) culture was evaluated by detecting mRNA and protein expression of pancreatic islet-specific markers as well as measuring insulin release of cells in response to glucose challenges...
October 14, 2018: Journal of Cellular Physiology
Fatima Sharif, Aysha Khan, Muhammad Adeel Samad, Amna Aijaz, Iqra Asad, Maham Fatima, Usman Younis Panni, Abeel Irshad, Muhammad Bin Awais, Narjis Rizvi
OBJECTIVE: To assess the knowledge, attitude and reported practices of medical students regarding infection control measures. METHODS: The cross-sectional, questionnaire-based study was conducted at one public and one private medical university in Karachi from January to February 2016. The students enrolled were in their clinical years of the Bachelor of Medicine, Bachelor of Surgery course and their knowledge, attitude and practice were measured regarding infection control measures...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Yosra M Magdy, Omnyah A El-Kharashi, Dalia A A El-Waseef, Enas S Nabih, Abeer A Abd El Samad
OBJECTIVES: The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepatic nephropathy through induction of FXR. METHODS: Forty two male Wistar rats were used; naïve (n = 12); six of them were sacrificed after 4 weeks and six continued till the end of the experiment. Thirty rats were treated as follows: Rvs, silymarin, thioacetamide (TAA), TAA + Rvs and TAA + silymarin...
October 9, 2018: Experimental and Molecular Pathology
Abdus Samad Ansari, Brittany B Dennis, Nolan S Horner, Ming Zhu, Charlotte Brookes, Moin Khan, John A Grant
PURPOSE: To compare the clinical and functional outcomes of allograft and autograft reconstruction in patients with posterior cruciate ligament (PCL) deficiency. METHODS: The MEDLINE, Embase, and Cochrane Library databases were used to identify all relevant articles. Clinical outcomes including International Knee Documentation Committee, Tegner, and Lysholm scores; joint laxity; and posterior tibial displacement were evaluated. RESULTS: Among the 145 unique articles identified during the title screening, 25 studies published between 2002 and 2016 with a combined population of 900 patients were deemed eligible for inclusion in the review...
October 5, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Obada Hasan, Adeel Samad, Zohaib Nawaz, Tashfeen Ahmad, Zehra Abdul Muhammad, Shahryar Noordin
Introduction: Injuries are the second most common cause of disability, the fifth most common cause of healthy years of life lost per 1000 people and unfortunately 90% of mortality takes place in low-to middle-income countries. Trauma registries guide policymakers and health care providers in decision making in terms of resource allocation as well as enhancing trauma care outcomes. Furthermore data from these registries inform policy makers to decrease the rate of death and disability occurring as a result of injuries...
November 2018: Annals of Medicine and Surgery
Seyed Asaad Karimi, Iraj Salehi, Teimor Shykhi, Samad Zare, Alireza Komaki
There are many controversies about the safety of extremely low-frequency electromagnetic field (ELF-EMF) on body health and cognitive performance. In the present study, we explored the effects of ELF-EMF on oxidative stress and behaviors of rats. Seventy-two adult male Wistar rats were randomly divided into following groups, control, sham exposure group and the ELF-EMF exposure groups (1 μT, 100 μT, 500 μT, and 2000 μT). After 60 days exposure (2 h/day), elevated plus maze (EPM), Morris water maze (MWM) and Passive avoidance learning (PAL) tasks were used to evaluate the anxiety-like behavior, spatial and passive learning and memory, respectively...
October 2, 2018: Behavioural Brain Research
Jamil Amjad Hashmi, Ramziah Ahmed Safar, Sibtain Afzal, Alia M Albalawi, Feroz Abdu-Samad, Zafar Iqbal, Sulman Basit
Nephrotic syndrome (NS) represents a heterogeneous group of kidney disorders characterized by excessive proteinuria, hypoalbuminemia and edema. Defects in the filtration barrier of the glomeruli results in the development of NS. The genetic cause of NS remains to be fully elucidated. However, previous studies based on positional cloning of genes mutated in NS have provided limited insight into the pathogenesis of this disease. Mutations in phospholipase C ε‑1 (PLCE1) have been reported as a cause of early onset NS characterized by histology of diffuse mesangial sclerosis...
October 2, 2018: Molecular Medicine Reports
Anastasia Korolj, Carol Laschinger, Chris James, Erding Hu, Claire Velikonja, Nathaniel Smith, Irene Gu, Samad Ahadian, Robert Willette, Milica Radisic, Boyang Zhang
Most kidney diseases begin with abnormalities in glomerular podocytes, motivating the need for podocyte models to study pathophysiological mechanisms and new treatment options. However, podocytes cultured in vitro face a limited ability to maintain appreciable extents of differentiation hallmarks, raising concerns over the relevance of study results. Many key properties such as nephrin expression and morphology reach plateaus that are far from the in vivo levels. Here, we demonstrate that a biomimetic topography, consisting of microhemispheres arrayed over the cell culture substrate, promotes podocyte differentiation in vitro...
October 9, 2018: Lab on a Chip
Muhammad Tahir, Kashif Samad, Thomas Koenig, Prakash Viswanathan
The gastrointestinal tract is the most common site in the United States for extra-nodal lymphoma involvement. Primary colorectal involvement is very rare, only accounting for 0.3% of the large intestine cancers. There has been a small increase in the incidence in these high-risk patient populations which include IBD, Celiac disease, H. pylori and other autoimmune diseases. We report a case of 47 years old male with no risk factors, who presented to the hospital with non-specific signs and symptoms. Imaging revealed cecal mass with distended bowel and colonoscopy revealed large mass obstructing the whole lumen of the cecum...
2018: AME case reports
Samad Minaei, Shahram Shahabi, Shahram Seyyedi, Naser Ziaali, Habib Mohammadzadeh Hajipirloo
Severe or lethal damages, caused by Toxoplasma gondii infection in congenital cases and immunocompromised patients implies the necessity for development of a vaccine and an appropriate adjuvant would be needed to elicit a protective Th1 biased-immune response. The adjuvant activity of propranolol was surveyed and compared with alum by immunization of BALB/c mice with protein components of T. gondii tachyzoites. Five groups of BALB/c mice were immunized with phosphate buffered saline (negative control), Toxoplasma lysate antigen (TLA), alum plus TLA, Propranolol plus TLA, and alum, propranolol and TLA...
September 22, 2018: Experimental Parasitology
Hina Khalid, Fatima Suhaib, Shahreen Zahid, Suhaib Ahmed, Arshad Jamal, Muhammad Kaleem, Abdul Samad Khan
Glass fiber based materials have gained interest for the biomedical and dental application. The aim of this study was to make E-glass fiber bioactive by a novel method using microwave irradiation technique. Industrial E-glass fibers were used after surface activation with hydrolysis method. The ratio of calcium and phosphorous precursors were set at 1.67. After maintaining the pH of calcium solution, E-glass fibers in two ratios i.e. 30% (nHA/E30) and 50% (nHA/E50) wt/wt were added, later the phosphorous precursor was added and solution was irradiated in microwave to get nano-hydroxyapatite (nHA) particles on E-glass fibers...
September 25, 2018: Biomedical Materials
Soleiman E Helaly, Samad Ashrafi, Rémy B Teponno, Steffen Bernecker, Abdelfattah A Dababat, Wolfgang Maier, Marc Stadler
The new cyclic lipodepsipeptide ophiotine (1), two new arthrichitin derivatives named arthrichitins B (4) and C (5), a new xanthocillin-like alkaloid, xanthomide Z (2), and the previously described arthrichitin (3) were isolated from the liquid culture broth of a nematode-associated fungus with affinities to the genus Ophiosphaerella. The structural elucidation and determination of the absolute configuration of the new molecules were accomplished using a combination of spectroscopic and chemical techniques, including 1D and 2D NMR, HRMS, and Marfey's analysis...
September 20, 2018: Journal of Natural Products
Nureddin Ashammakhi, Samad Ahadian, Fan Zengjie, Kasinan Suthiwanich, Farnaz Lorestani, Gorka Orive, Serge Ostrovidov, Ali Khademhosseini
Three-dimensionally printed constructs are static and do not recapitulate the dynamic nature of tissues. Four-dimensional (4D) bioprinting has emerged to include conformational changes in printed structures in a predetermined fashion using stimuli-responsive biomaterials and/or cells. The ability to make such dynamic constructs would enable us to fabricate tissue structures that can undergo morphological changes. Furthermore, other fields (bioactuation, biorobotics, and biosensing) will benefit from developments in 4D bioprinting...
September 17, 2018: Biotechnology Journal
Azaam M Samad
No abstract text is available yet for this article.
2018: Adipocyte
Reza Safdari, Marjan Ghazi Saeedi, Hossein Masoumi-Asl, Peyman Rezaei-Hachesu, Kayvan Mirnia, Niloofar Mohammadzadeh, Taha Samad-Soltani
Background: Success of infection treatment depends on the availability of accurate, reliable, and comprehensive data, information, and knowledge at the point of therapeutic decision-making. The identification of a national minimum data set will support the development and implementation of an effective surveillance system. The goal of this study was to develop a national antimicrobial resistance surveillance minimum data set. Methods: In this cross-sectional and descriptive study, data were collected from selected pioneering countries and organizations which have national or international antimicrobial resistance surveillance systems...
September 2018: Iranian Journal of Medical Sciences
Mojtaba Heydari, Behnam Dalfardi, Samad Ej Golzari, Syed Mohd Abbas Zaidi, Kamran Bagheri Lankarani, Seyed Hamdollah Mosavat
Historical literature on portal hypertension is mainly focused on the contemporary advances in therapeutic methods, especially surgical ones. However, it seems that the origin of the human knowledge on the portal system, its association with the caval system, obstructive pathologies in this system and the gastrointestinal bleeding due to hepatic diseases might be much older than previously believed. Avicenna provided a detailed anatomy of the portal venous system and its feeding branches in the Canon of Medicine...
December 2017: Acta Medico-historica Adriatica: AMHA
Abdul Fatah A Samad, Muhammad Sajad, Jaeyres Jani, Abdul Munir Abdul Murad, Ismanizan Ismail
Degradome sequencing referred as parallel analysis of RNA ends (PARE) by modifying 5'-rapid amplification of cDNA ends (RACE) with deep sequencing method. Deep sequencing of 5' products allow the determination of cleavage sites through the mapping of degradome fragments against small RNAs (miRNA or siRNA) on a large scale. Here, we carried out degradome sequencing in medicinal plant, Persicaria minor , to identify cleavage sites in small RNA libraries in control (mock-inoculated) and Fusarium oxysporum treated plants...
October 2018: Data in Brief
Laura W Pappalardo, Omar A Samad, Shujun Liu, Pamela J Zwinger, Joel A Black, Stephen G Waxman
Astrogliosis is a hallmark of neuroinflammatory disorders such as multiple sclerosis (MS). A detailed understanding of the underlying molecular mechanisms governing astrogliosis might facilitate the development of therapeutic targets. We investigated whether Nav1.5 expression in astrocytes plays a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine model of MS. We created a conditional knockout of Nav1.5 in astrocytes and determined whether this affects the clinical course of EAE, focal macrophage and T cell infiltration, and diffuse activation of astrocytes...
September 8, 2018: Glia
Frank Battaglia, Samad Shah, Sabeena Jalal, Kiran Khurshid, Nupur Verma, Savvas Nicolaou, Sravanthi Reddy, Susan John, Faisal Khosa
OBJECTIVE: This study is intended to better understand how academic productivity and career advancement differs between men and women emergency radiologists in academic practices. MATERIALS AND METHODS: Parameters of academic achievement were measured, including number of citations, number of publications, and h-index, while also collecting information on academic and leadership ranking among emergency radiologists in North America. RESULTS: In emergency radiology, there are significantly fewer women than men (22...
September 7, 2018: Emergency Radiology
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