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Bavachin

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https://www.readbyqxmd.com/read/29913251/highly-efficient-inhibition-of-spring-viraemia-of-carp-virus-replication-in-vitro-mediated-by-bavachin-a-major-constituent-of-psoralea-corlifonia-lynn
#1
Chen Cheng, Shen Yu-Feng, Hu Yang, Liu Lei, Chen Wei-Chao, Wang Gao-Xue, Zhu Bin
As one of nine piscine viruses recognized by the International Office of Epizootics, spring viraemia of carp virus (SVCV) is an important pathogen bringing high mortality to cyprinids. Up to now, there is no approved therapy on SVCV, making them strong public health threat in aquaculture. In this study, the anti-SVCV activities of 12 plant crude extracts were investigated by using epithelioma papulosum cyprini (EPC) cells. Among these plants, Psoralea corylifolia Linn. showed the highest inhibition on SVCV replication, with an inhibitory percentage of 67...
June 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29518051/multi-target-anti-alzheimer-activities-of-four-prenylated-compounds-from-psoralea-fructus
#2
Qing-Xia Xu, Ying Hu, Gui-Yang Li, Wei Xu, Ying-Tao Zhang, Xiu-Wei Yang
Alzheimer's disease (AD) is an age-related neurodegenerative disease that is mediated by multiple signaling pathways. In recent years, the components of Psoralea Fructus (PF) have demonstrated some anti-Alzheimer effects both in vitro and in vivo. To further reveal the active compounds of PF and their mechanisms regulating key targets of AD, in this study, we identified four prenylated compounds from the 70% ethanolic aqueous extract of PF, namely bavachin, bavachinin, bavachalcone, and isobavachalcone. Multi-target bioactivity analysis showed that these compounds could differentially inhibit neuroinflammation, oxidative damage, and key AD-related protein targets, such as amyloid β-peptide 42, β-secretase, glycogen synthase kinase 3β, and acetylcholinesterase...
March 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29477912/bavachin-induces-the-apoptosis-of-multiple-myeloma-cell-lines-by-inhibiting-the-activation-of-nuclear-factor-kappa-b-and-signal-transducer-and-activator-of-transcription-3
#3
Tomoya Takeda, Masanobu Tsubaki, Yoshika Tomonari, Keishi Kawashima, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishida
Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. In this study, we examined the effect of bavachin in multiple myeloma (MM) cell lines. We found that bavachin decreased the viability of MM cell lines, but was not cytotoxic towards normal cells. It inhibited the activation of nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3). Furthermore, bavachin increased the expression of p53 and NOXA, and decreased the expression of X-linked inhibitor of apoptosis protein (XIAP), survivin, B cell lymphoma-extra large (Bcl-xL), and Bcl-2...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29425649/plasma-pharmacokinetics-and-cerebral-nuclei-distribution-of-major-constituents-of-psoraleae-fructus-in-rats-after-oral-administration
#4
Yan-Fang Yang, You-Bo Zhang, Zhi-Jing Chen, Ying-Tao Zhang, Xiu-Wei Yang
BACKGROUND: The fruit of Psoralea corylifolia L., Psoraleae fructus (PF), is widely used in traditional Chinese medicine as a well-known herbal tonic. Previous studies have shown that PF and its major constituents may have potential values in the treatment of Parkinson and Alzheimer diseases, though their pharmacokinetics and brain distribution were largely unknown. PURPOSE: To develop a liquid chromatographic-tandem mass spectrometry (LC-MS/MS) method for simultaneous studies of the plasma pharmacokinetics and cerebral nuclei (including cerebellum, thalamus, brainstem, hippocampus, corpus striatum and cortex) distribution in rats of eleven known PF compounds following as psoralen, isopsoralen, psoralidin, bavachin, bavachinin, isobavachin, isobavachalcone, bavachalcone, neobavaisoflavone, corylifol A, and corylin...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29187671/bavachin-induces-apoptosis-through-mitochondrial-regulated-er-stress-pathway-in-hepg2-cells
#5
Ying Yang, Xianglin Tang, Feiran Hao, Zengchun Ma, Yuguang Wang, Lili Wang, Yue Gao
As a traditional herbal medicine, the fruits of Psoralea corylifolia L. (Fructus Psoraleae (FP)) have been widely used for the treatment of various skin diseases for hundred years. Recently, the emerging FP-induced toxic effects, especially hepatotoxicity, in clinic are getting the public's attention. However, its exact toxic components and mechanisms underlying remain unclear. Bavachin, one of flavonoids in FP, has been documented as a hepatotoxic substance, and the present study aimed to determine the toxicity caused by bavachin and the possible toxic mechanisms involved using human hepatocellular carcinoma (HepG2) cells...
February 1, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28869337/rapid-separation-and-simultaneous-quantitative-determination-of-13-constituents-in-psoraleae-fructus-by-a-single-marker-using-high-performance-liquid-chromatography-with-diode-array-detection
#6
Yimin Zhang, Zhiyong Chen, Xiaokun Xu, Qiang Zhou, Xiaolong Liu, Liping Liao, Zijia Zhang, Zhengtao Wang
Psoraleae Fructus is one of the most popular traditional Chinese medicines. Coumarins, flavonoids, and meroterpenes are the main contributors to the biological activity of Psoraleae Fructus. In this study, a new method for the quality control of Psoraleae Fructus was developed, through the quantitative analysis of multicomponents by single marker with diode array detector. Thirteen components, including psoralenoside, isopsoralenoside, psoralen, isopsoralen, psoralidin, neobavaisoflavone, bavachin, corylin, isobavachalcone, corylifol A, bavachinin, bavachalcone, and bakuchiol were rapidly separated and identified within 12 min by the newly developed method...
November 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28777876/qualitative-analysis-of-psoraleae-fructus-by-hplc-dad-tof-ms-fingerprint-and-quantitative-analysis-of-multiple-components-by-single-marker
#7
Lianjun Luan, Xiaoyu Shen, Xuesong Liu, Yongjiang Wu, Manliang Tan
A variety of bioactive substances may account for the recognized efficacy and wide clinical application of Psoraleae Fructus in China. A high-performance liquid chromatography-diode array detector (HPLC-DAD) fingerprint method was developed to present the comprehensive phytochemical profile of the crude drug. Thirteen major compounds were separated and identified by HPLC coupled with time-of-flight mass spectrometry (HPLC/TOF-MS), namely psoralenoside (PO), isopsoralenoside (IPO), psoralen (PS), isopsoralen (IPS), neobavaisoflavone (NBF), bavachin (BC), corylin (CN), bavachromene (BCM), psoralidin (PD), isobavachalcone (IBC), bacachinin (BCN), corylifol A (CA) and bakuchiol (BK)...
February 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28216889/osteoblasts-proliferation-and-differentiation-stimulating-activities-of-the-main-components-of-epimedii-folium
#8
Mingming Liu, Haiyan Xu, Yong Ma, Jian Cheng, Zhen Hua, Guicheng Huang
BACKGROUND: Osteoporosis is a disease of bones that leads to an increased risk of fracture. Epimedii Folium is commonly used for treating bone fractures and joint diseases for thousands of years in China. METHODS: This study was aimed to screen active components, which might have the potency to stimulate osteoblasts proliferation and differentiation in Epimedii Folium. An HPLC method was established to analyze the main components in Epimedii Folium. The MTT and ALP methods were utilized for the assay of osteoblasts proliferation and differentiation activity...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27347410/effects-of-bavachin-and-its-regulation-of-melanin-synthesis-in-a375-cells
#9
Jing-Hua Wang, Yuan-Yuan Pei, Hong-Dan Xu, Li-Jing Li, Ye-Qiu Wang, Guo-Liang Liu, Yan Qu, Ning Zhang
The aim of the present study was to investigate the effect of bavachin treatment on A375 cells and the regulation of melanin synthesis. The cultured A375 cells in vitro were treated with bavachin; and the effect of bavachin on cell activity, tyrosinase (TYR) activity and melanin synthesis were respectively tested by the MTT assay, L-dopa oxidation assay and the NaOH lysis assay. The expression levels of TYR and c-Jun N-terminal kinases (JNK) proteins were tested by western blot analysis. The expression levels of TYR, tyrosinase-related protein-1 (TRP-1), TRP-2, extracellular signal-regulated kinase 1 (ERK1), ERK2 and JNK2 mRNA were tested by the reverse transcription-polymerase chain reaction assay...
July 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27070585/bavachin-from-psoralea-corylifolia-improves-insulin-dependent-glucose-uptake-through-insulin-signaling-and-ampk-activation-in-3t3-l1-adipocytes
#10
Hyejin Lee, Hua Li, Minsoo Noh, Jae-Ha Ryu
The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as "Bo-Gol-Zhee" in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total plasma cholesterol levels in type 2 diabetic rats. In this study, we purified six compounds from PC and investigated their anti-diabetic effect. Among the purified compounds, bavachin most potently accumulated lipids during adipocyte differentiation...
April 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26997699/quality-assessment-of-psoralea-fructus-by-hplc-fingerprint-coupled-with-multi-components-analysis
#11
F Z Yin, L Li, T L Lu, W D Li, B C Cai, W Yin
Psoralea Fructus, the dried and ripe fruit of Psoralea corylifolia L., have been used as traditional medicine. There is substantial evidence that multiple constituents are responsible for the beneficial effects of this medicine. To effectively control the quality of this herbal medicine, HPLC fingerprint analysis was performed on a SinoChrom ODS-BP column with mobile phase of a gradient prepared from H2O and CH3CN, which the conditions used for gradient elution were: 0-10 min, 5-45% CH3CN; 10-45 min, 45-70% CH3CN; 45-50 min, 70-100% CH3CN; 50-60 min, 100-100% CH3CN, and the flow rate was 1...
November 2015: Indian Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26773881/simultaneous-quantification-of-5-main-components-of-psoralea-corylifolia-l-in-rats-plasma-by-utilizing-ultra-high-pressure-liquid-chromatography-tandem-mass-spectrometry
#12
Qianqian Gao, Zisheng Xu, Genhua Zhao, Heng Wang, Zebin Weng, Ke Pei, Li Wu, Baochang Cai, Zhipeng Chen, Weidong Li
Psoralea corylifolia L. has long been used in traditional Chinese medicine for treating and preventing many diseases. A group of flavonoid components are regarded as the active principals within the seeds. In this research, a rapid, accurate and sensitive ultra high pressure liquid chromatography tandem mass spectrometry (UHPLC/MS/MS) method has been established for simultaneous quantification of its 5 main components, namely, neobavaisoflavone, bavachin, isobavachalcone, bavachinin and corylifol A in rats' plasma after the rats were orally administrated with Buguzhi extract...
February 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26587307/development-of-an-hplc-method-for-absolute-quantification-and-qams-of-flavonoids-components-in-psoralea-corylifolia-l
#13
Cuiping Yan, Yu Wu, Zebin Weng, Qianqian Gao, Guangming Yang, Zhipeng Chen, Baochang Cai, Weidong Li
The seeds of Psoralea corylifolia L. (Fabaceae) are a commonly used medicinal herb in eastern Asia with many beneficial effects in clinical therapies. In this study, a simple, sensitive, precise, and specific reverse phase high-performance liquid chromatography (HPLC) method was established for quantification of 9 flavonoids in P. corylifolia, including isobavachin, neobavaisoflavone, bavachin, corylin, bavachalcone, bavachinin, isobavachalcone, corylifol A, and 4'-O-methylbavachalcone. Based on this method, a quantitative analysis of multicomponents by single marker (QAMS) was carried out, and the relative correction factors (RCFs) were calculated for determining the contents of other flavonoids...
2015: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/26557867/evaluation-of-the-inhibitory-effects-of-bavachinin-and-bavachin-on-human-monoamine-oxidases-a-and-b
#14
Najla O Zarmouh, Elizabeth A Mazzio, Faisel M Elshami, Samia S Messeha, Suresh V K Eyunni, Karam F A Soliman
Monoamine oxidase B inhibitors (MAO-BIs) are used in the early management of Parkinson's disease (PD). Long-term suspected side effects of MAO-B classical inhibitors established the need for safer alternative therapeutic agents. In our study, the flavanone bavachinin (BNN) and its analog bavachin (BVN) found in the seeds of Psoralea corylifolia L. ethanolic extract (PCSEE) were investigated for their human MAO-A and MAO-B (hMAO-A and hMAO-B) inhibition. Both PCSEE and BNN effectively reduced hMAO-B activity more than hMAO-A while BVN had activating effects...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26419930/positive-skeletal-effect-of-two-ingredients-of-psoralea-corylifolia-l-on-estrogen-deficiency-induced-osteoporosis-and-the-possible-mechanisms-of-action
#15
Ze-Bin Weng, Qian-Qian Gao, Fang Wang, Gen-Hua Zhao, Fang-Zhou Yin, Bao-Chang Cai, Zhi-Peng Chen, Wei-Dong Li
Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, long-term supplement of estrogen may cause uterine hyperplasia and hypertension leading to a high risk of endometrial cancer and breast cancer. Psoralea corylifolia L. has long been used as tonic and food additives in many countries. Previous studies had found two ingredients in P. corylifolia L.: bavachin and bakuchiol exhibited osteoblastic activity. The present study was designed to investigate the protective effect of bakuchiol and bavachin on ovariectomy-induced bone loss and explore the possible mechanism...
December 5, 2015: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26348140/identification-and-characterization-of-naturally-occurring-inhibitors-against-udp-glucuronosyltransferase-1a1-in-fructus-psoraleae-bu-gu-zhi
#16
Xin-Xin Wang, Xia Lv, Shi-Yang Li, Jie Hou, Jing Ning, Jia-Yue Wang, Yun-Feng Cao, Guang-Bo Ge, Bin Guo, Ling Yang
As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the mechanism in FP-associated toxicity has not been well investigated yet. This study aimed to investigate the inhibitory effects of FP extract and its major constituents against human UDP-glucuronosyltransferase 1A1 (UGT1A1), the key enzyme responsible for metabolic elimination of bilirubin...
November 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26235583/biological-effects-of-the-herbal-plant-derived-phytoestrogen-bavachin-in-primary-rat-chondrocytes
#17
Gyeong-Je Lee, In-A Cho, Kyeong-Rok Kang, Do Kyung Kim, Hong-Moon Sohn, Jae-Won You, Ji-Su Oh, Yo-Seob Seo, Sang-Joun Yu, Jae-Seek You, Chun Sung Kim, Su-Gwan Kim, Hee-Jeong Im, Jae-Sung Kim
The aim of this study was to examine the anabolic and anticatabolic functions of bavachin in primary rat chondrocytes. With bavachin treatment, chondrocytes survived for 21 d without cell proliferation, and the proteoglycan content and extracellular matrix increased. Short-term monolayer culture of chondrocytes showed that gene induction of both aggrecan and collagen type II, major extracellular matrix components, was significantly upregulated by bavachin. The expression and activities of cartilage-degrading enzymes such as matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs were inhibited significantly by bavachin, while tissue inhibitors of metalloprotease were significantly upregulated...
2015: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/25132311/graphene-polydopamine-modified-polytetrafluoroethylene-microtube-for-the-sensitive-determination-of-three-active-components-in-fructus-psoraleae-by-online-solid-phase-microextraction-with-high-performance-liquid-chromatography
#18
Wenpeng Zhang, Wei Zhou, Zilin Chen
Determination of bioactive compounds in traditional Chinese medicines and biological samples is usually interfered with by coexisting components in matrices. In this work, we prepared novel multilayer functional graphene/polydopamine-modified polytetrafluoroethylene microtube for selective solid-phase microextraction of three bioactive compounds in Fructus Psoraleae. Functional graphene/polydopamine-modified polytetrafluoroethylene microtube showed good extraction efficiency toward bavachin, isobavachalcone, and bavachinin; enrichment from 357- to 737-fold was obtained for these compounds...
November 2014: Journal of Separation Science
https://www.readbyqxmd.com/read/24679826/screening-of-neuraminidase-inhibitors-from-traditional-chinese-medicines-by-integrating-capillary-electrophoresis-with-immobilized-enzyme-microreactor
#19
Haiyan Zhao, Zilin Chen
A simple and effective neuraminidase-immobilized capillary microreactor was fabricated by glutaraldehyde cross-linking technology for screening the neuraminidase inhibitors from traditional Chinese medicines. The substrate and product were separated by CE in short-end injection mode within 2 min. Dual-wavelength ultraviolet detection was employed to eliminate the interference from the screened compounds. The parameters relating to the separation efficiency and the activity of immobilized neuraminidase were systematically evaluated...
May 2, 2014: Journal of Chromatography. A
https://www.readbyqxmd.com/read/24220018/osteoblasts-proliferation-and-differentiation-stimulating-activities-of-the-main-components-of-fructus-psoraleae-corylifoliae
#20
Wei D Li, Cui P Yan, Y Wu, Ze B Weng, Fang Z Yin, Guang M Yang, Bao C Cai, Zhi P Chen
Osteoporosis is a disease of bones that leads to an increased risk of fracture. Fructus of Psoralea corylifolia L. (scurfpea fruit) is commonly utilized for treating bone fractures and joint diseases for thousands of years in China. This study was aimed to screen active principles, which might have the potency to stimulate osteoblasts proliferation and differentiation from scurfpea fruit. A HPLC method was established to analyze the main components in scurfpea fruit. Totally 11 compounds have been identified by comparing their retention time with correspondent standard substances...
March 15, 2014: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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