Noriyoshi Sawabata, Kohei Morita, Shigenobu Tatsumi, Tomomi Fujii, Takeshi Nishikawa, Takeshi Kawaguchi, Toru Arakane, Yoshiaki Tominaga, Hirokazu Sakaguchi, Taro Kobayashi, Shigeto Hontsu, Yoshifumi Yamamoto, Nobuhiro Fujioka, Noriko Ouji-Sageshima, Toshihiro Ito, Chiho Ohbayashi
BACKGROUND/AIM: Circulating tumor cells (CTCs) have garnered attention as biomarkers for therapeutic response and prognosis in malignant neoplasms. Nonetheless, existing literature predominantly relies on surrogate markers of tumor cells or focuses on single-cell CTC, failing to adequately address the challenge of detecting cluster-forming CTCs, which bear considerable prognostic implications. This prospective study aims to validate the efficacy of a novel filtration membrane, namely Soft Micro Pore Filter (S-MPF® ), for rare cell recovery in detecting CTCs through the analysis of clinical samples...
October 2023: Anticancer Research