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Sajitha Biju, Sigfredo Fuentes, Dorin Gupta
Lentil (Lens culinaris, Medik.) is an important legume crop, which often experience drought stress especially at the flowering and grain filling phenological stages. The availability of efficient and robust screening tools based on relevant non-destructive quantifiable traits would facilitate research on crop improvement for drought tolerance. The objective of this study was to evaluate the drought tolerance of 37 lentil genotypes using infrared thermal imaging (IRTI), drought tolerance parameters and multivariate data analysis...
March 8, 2018: Plant Physiology and Biochemistry: PPB
Charles S Fuchs, Toshihiko Doi, Raymond W Jang, Kei Muro, Taroh Satoh, Manuela Machado, Weijing Sun, Shadia I Jalal, Manish A Shah, Jean-Phillipe Metges, Marcelo Garrido, Talia Golan, Mario Mandala, Zev A Wainberg, Daniel V Catenacci, Atsushi Ohtsu, Kohei Shitara, Ravit Geva, Jonathan Bleeker, Andrew H Ko, Geoffrey Ku, Philip Philip, Peter C Enzinger, Yung-Jue Bang, Diane Levitan, Jiangdian Wang, Minori Rosales, Rita P Dalal, Harry H Yoon
Importance: Therapeutic options are needed for patients with advanced gastric cancer whose disease has progressed after 2 or more lines of therapy. Objective: To evaluate the safety and efficacy of pembrolizumab in a cohort of patients with previously treated gastric or gastroesophageal junction cancer. Design, Setting, and Participants: In the phase 2, global, open-label, single-arm, multicohort KEYNOTE-059 study, 259 patients in 16 countries were enrolled in a cohort between March 2, 2015, and May 26, 2016...
March 15, 2018: JAMA Oncology
Olivier Beauchet, Cyrille P Launay, Harmehr Sekhon, Jennifer Gautier, Julia Chabot, Elise J Levinoff, Gilles Allali
BACKGROUND: Assessment of changes in higher levels of gait control with aging is important to better understand age-related gait instability, with the perspective to improve the screening of individuals at risk for falls. The comparison between actual Timed Up and Go test (aTUG) and its imagined version (iTUG) is a simple clinical way to assess age-related changes in gait control. The modulations of iTUG performances by body positions and motor imagery (MI) strategies with normal aging have not been evaluated yet...
2018: PloS One
Erin L Beatty, Alexandra Muller-Gass, Dorothy Wojtarowicz, Marie-Eve Jobidon, Ingrid Smith, Quan Lam, Oshin Vartanian
Humans rely on topographical memory to encode information about spatial aspects of environments. However, even though people adopt different strategies when learning new maps, little is known about the impact of those strategies on topographical memory, and their neural correlates. To examine that issue, we presented participants with 40 unfamiliar maps, each of which displayed one major route and three landmarks. Half were instructed to memorize the maps by focusing on the route, whereas the other half memorized the maps by focusing on the landmarks...
March 14, 2018: Neuroreport
Kurt P Spindler, Laura J Huston, Kevin M Chagin, Michael W Kattan, Emily K Reinke, Annunziato Amendola, Jack T Andrish, Robert H Brophy, Charles L Cox, Warren R Dunn, David C Flanigan, Morgan H Jones, Christopher C Kaeding, Robert A Magnussen, Robert G Marx, Matthew J Matava, Eric C McCarty, Richard D Parker, Angela D Pedroza, Armando F Vidal, Michelle L Wolcott, Brian R Wolf, Rick W Wright
BACKGROUND: The long-term prognosis and risk factors for quality of life and disability after anterior cruciate ligament (ACL) reconstruction remain unknown. Hypothesis/Purpose: Our objective was to identify patient-reported outcomes and patient-specific risk factors from a large prospective cohort at a minimum 10-year follow-up after ACL reconstruction. We hypothesized that meniscus and articular cartilage injuries, revision ACL reconstruction, subsequent knee surgery, and certain demographic characteristics would be significant risk factors for inferior outcomes at 10 years...
March 2018: American Journal of Sports Medicine
Elizabeth Ruvalcaba, Shang-En Chung, Cynthia Rand, Kristin A Riekert, Michelle Eakin
OBJECTIVE: Asthma disproportionately affects minority groups, low income populations, and young children under 5. Head Start (HS) programs predominantly serve this high-risk population, yet staff are not trained on asthma management. The objective of this study was to assess a 5-year, multicomponent HS staff asthma education program in Baltimore City HS programs. METHODS: All HS programs were offered annual staff asthma education by a medical research team that included didactic lectures and hands-on training...
March 15, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Pei Huang, Yuanqing Li, Xiao-Guang Yu, Wei-Bin Zhu, Shu-Yan Nie, Hao Zhang, Jin-Rui Liu, Ning Hu, Shao-Yun Fu
The mimicry of human skin to detect both oncoming and physical-contacting object is of great importance in the fields of manufacturing, artificial robots and vehicles, etc. Herein, a novel bio-inspired flexible and highly responsive dual-mode strain/magnetism composite sensor which works via both contact and contactless modes, is first fabricated by incorporating Fe3O4/silicone system into a carbon fiber aerogel. The distance-dependence of magnetic field endorses the CFA/Fe3O4/silicone composite possible for spatial sensing due to the introduction of Fe3O4 magnetic nanoparticles...
March 15, 2018: ACS Applied Materials & Interfaces
Hung-Hao Chang, Kannika Saeliw
OBJECTIVES: This study investigates the association between eating out and depressive symptoms among elderly people. Potential mediators that may link to elderly eating out and depressive symptoms are also discussed. METHODS: A unique dataset of 1,184 individuals aged 65 and older was drawn from the National Health and Nutrition Survey in 2008 in Taiwan. A bivariate probit model and an instrumental variable probit model were estimated to account for correlated, unmeasured factors that may be associated with both the decision and frequency of eating out and depressive symptoms in the elderly...
June 2017: Journal of Mental Health Policy and Economics
Cédric Garcia, Nicolas Montée, Julien Faccini, Jennifer Series, Olivier Meilhac, Anne-Valérie Cantero, Pauline Le Faouder, Meyer Elbaz, Bernard Payrastre, Cécile Vindis
BACKGROUND: While high-density lipoproteins (HDL) have anti-thrombotic effects by reducing platelet activation, the relationship between HDL levels and the risk of acute coronary syndrome (ACS) is unclear since HDL particles are heterogeneous in composition and biological properties OBJECTIVE: We characterized the effects of HDL2 and HDL3 subclasses from ACS patients and non-coronary artery disease (CAD) subjects on platelet activation. METHODS: We measured platelet aggregation and ex vivo thrombus formation, analyzed signaling pathways by flow cytometry and performed a targeted lipidomics analysis on HDL subclasses RESULTS: Analysis of human platelet aggregation in suspension, adhesion on von Willebrand factor and thrombus formation on collagen under arterial shear demonstrated that HDL2 subclass from ACS patients had a higher antiplatelet potency compared to ACS HDL3 particles and HDL subclasses from non-CAD subjects...
March 15, 2018: Journal of Thrombosis and Haemostasis: JTH
D A Gol'bin, V A Cherekaev
The article presents the literature data on the structural variability and age-related features of the midline anatomical structures of the anterior skull base (frontal sinus, ethmoid bone, anterior parasellar region, and medial orbital wall). This is the area of surgical interests of neurosurgeons and rhinosurgeons. The study objective is to analyze the literature data on the individual variability and age-related anatomy of these structures. The work is illustrated with original images from the authors' personal archive...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Myungho Lee, Gerd Bruder, Tobias Hollerer, Greg Welch
In this paper, we investigate factors and issues related to human locomotion behavior and proxemics in the presence of a real or virtual human in augmented reality (AR). First, we discuss a unique issue with current-state optical see-through head-mounted displays, namely the mismatch between a small augmented visual field and a large unaugmented periphery, and its potential impact on locomotion behavior in close proximity of virtual content. We discuss a potential simple solution based on restricting the field of view to the central region, and we present the results of a controlled human-subject study...
April 2018: IEEE Transactions on Visualization and Computer Graphics
Susan Woskie, Pornpimol Kongtip, Wiroj Thanasanpaiboon, Napaporn Kiatdamrong, Nantha Charoonrungsirikul, Noppanun Nankongnab, Anu Surach, Akkarat Phamonphon
The objective of this study was to evaluate whether prenatal exposures to organophosphate (OP) pesticides from maternal agricultural use are associated with neonatal neurobehavioral effects. A pilot study conducted in three provinces in Thailand measured maternal urinary metabolites of OP pesticides in pregnant women at 7 months gestation and at birth. Within 3 days of birth, 82 newborns underwent neurobehavioral testing using the Brazelton Neonatal Behavioral Assessment Scale (NBAS). Comparison of the NBAS test results with maternal OP metabolite levels found the neonates NBAS Habituation cluster score increased with maternal dimethylphosphate (DMP) levels (p = 0...
March 15, 2018: International Journal of Occupational and Environmental Health
Bruno Romeo, Lisa Blecha, Katia Locatelli, Amine Benyamina, Catherine Martelli
The objective of this meta-analysis is to assess the efficacy and safety of partial and complete dopamine agonists in the treatment of acute mood disorder episodes. Randomized, double-blind and placebo-controlled trials of dopamine agonists in the treatment of acute mood disorder episodes were identified in the MEDLINE and PsycINFO databases and included in the meta-analysis. In monotherapy of mania, improved remission rates were found for cariprazine (odds ratio (OR): 2.08, P < 0.01) and for high-dose aripiprazole (OR: 3...
March 1, 2018: Journal of Psychopharmacology
Lilian Roos, Wolfgang Taube, Carolin Tuch, Klaus Michael Frei, Thomas Wyss
PURPOSE: Session rating of perceived exertion (sRPE) is an often used measure to assess athletes' training load. However, little is known which factors could optimize the quality of data collection thereof. The aim of the present study was to investigate the effects of (i) the survey methods and (ii) the time points when sRPE was assessed on the correlation between subjective (sRPE) and objective (heart rate training impulse; TRIMP) assessment of training load. METHODS: In the first part, 45 well-trained subjects (30 men, 15 women) performed 20 running sessions with a heart rate monitor and reported sRPE 30 minutes after training cessation...
March 15, 2018: International Journal of Sports Physiology and Performance
Lin Lei, Dylan A Kovacevich, Michael P Nitzsche, Jihyun Ryu, Kutaiba Al-Marzoki, Gabriela Rodriguez, Lisa Klein, Andrei Jitianu, Jonathan P Singer
The electrospray process utilizes the balance of electrostatic forces and surface tension within a charged spray to produce charged microdroplets with a narrow dispersion in size. In electrospray deposition, each droplet carries a small quantity of suspended material to a target substrate. Past electrospray deposition results fall into two major categories: (1) continuous spray of films onto conducting substrates and (2) spray of isolated droplets onto insulating substrates. A cross-over regime, or a self-limited spray, has only been limitedly observed in the spray of insulating materials onto conductive substrates...
March 15, 2018: ACS Applied Materials & Interfaces
Yuko Hashimoto, Ko Matsudaira, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, Hisashi Naito, Steven N Blair
BACKGROUND: There are several studies on the relationship between low back pain and physical activity. However, the results of these studies vary, and the relationship between them remains unclear. Therefore, we conducted a cross-sectional study to evaluate the association between objectively measured physical activity and low back pain in Japanese men. METHODS: The study included 4022 Japanese men [average age: 47 (10) y]. Daily amount of moderate to vigorous physical activity and step counts were measured using an accelerometer...
March 15, 2018: Journal of Physical Activity & Health
Renata Valle Pedroso, José Maria Cancela, Carlos Ayán, Angelica Miki Stein, Gilson Fuzaro, José Luiz Riani Costa, Francisco J Fraga, Ruth Ferreira Santos-Galduróz
BACKGROUND: Evidence regarding the benefits of physical activity on the mental processing information of patients with Alzheimer's disease assessed objectively is scarce and can be observed through event-related potentials, such as the P300. The aim of the study was to identify the effects of physical exercises on mental processing information in the elderly with Alzheimer's disease through neurophysiological measures (P300 amplitude and latency) and reaction time. METHODS: A total of 31 patients with Alzheimer's disease participated in this study: 14 in functional exercise (FE) group and 17 in social gathering (SG) group who carried out three 1-hour sessions per week of FE and SG activities, respectively, for a 12-week period...
March 15, 2018: Journal of Physical Activity & Health
R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasemi
The objective of this study was to consider endocannabinoid system as inflammatory markers in bovine endometrium to better understand the role of this system in regulating many of the functions that are related to inflammatory condition. At day 26 post-partum, fourteen cows were divided into two groups depending on the inflammatory condition: 1- subclinical endometritis (n = 7, with purulent or mucopurulent uterine discharge detectable in the vagina) and 2- healthy (n = 7, No (muco)) purulent discharge...
March 14, 2018: Reproduction in Domestic Animals, Zuchthygiene
Sezen Cekic, Didier Grandjean, Olivier Renaud
This article proposes a systematic methodological review and an objective criticism of existing methods enabling the derivation of time, frequency, and time-varying Granger-causality statistics in neuroscience. The capacity to describe the causal links between signals recorded at different brain locations during a neuroscience experiment is indeed of primary interest for neuroscientists, who often have very precise prior hypotheses about the relationships between recorded brain signals. The increasing interest and the huge number of publications related to this topic calls for this systematic review, which describes the very complex methodological aspects underlying the derivation of these statistics...
March 15, 2018: Statistics in Medicine
Kelley Newlin Lew, Julie Wagner, Omar Braizat
OBJECTIVE: The study's objective is to examine differences in mental and physical health-related quality of life (HRQOL) in non-Hispanic Whites, non-Hispanic Blacks, and Hispanics adults with diabetes. DESIGN: A secondary analysis of 2014 Behavioral Risk Factor Surveillance System (BRFSS) data was conducted. A total of 26 states participated in the 2014 BRFSS core and optional diabetes models (n = 17,923). HRQOL was measured by the number of mentally and physically unhealthy days during the past month, respectively...
March 14, 2018: Journal of Racial and Ethnic Health Disparities
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