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Choroidal neovascular membrane

Serena Fragiotta, Talia R Kaden, K Bailey Freund
Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes. Case presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination...
2018: International Journal of Retina and Vitreous
Kai Wang, Haoran Li, Ruipu Sun, Chaxian Liu, Yunfei Luo, Shuhua Fu, Ying Ying
Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression. Wet AMD, which is characterized by angiogenesis on the choroidal membrane, is uncommonly seen but more severe. Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD. Emerging evidence has shown that transforming growth factor-β (TGF-β) signaling plays a significant role in the progression of wet AMD...
November 29, 2018: Acta Biochimica et Biophysica Sinica
Rajan Gupta, Rajeev R Pappuru, Vivek P Dave, Jay Chhablani
Combined hamartoma of retina and retinal pigment epithelium (CHRRPE) has been considered as a congenital benign entity with evidence of choroidal neovascularization membranes (CNVM) being associated with it in literature. This case series gives insight into the pathogenesis and the predisposing factors leading to CNVM formation in peripapillary CHRRPE using swept-source optical coherence tomography. In addition, lack of typical markers of CNVM (subretinal fluid/pigment epithelial detachment) in CHRRPE highlights the utility of optical coherence tomography angiography and the subtle optical coherence tomography findings such as "Bridge Sign" that could be instrumental in early diagnosis of CNVM in CHRRPE...
December 2018: Indian Journal of Ophthalmology
Manish Nagpal, Jayesh Khandelwal, Rakesh Juneja, Navneet Mehrotra
Purpose: To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospective, interventional study. Methods: Patients with wet AMD were treated with 3 injections of intravitreal anti-VEGF at monthly intervals for 3 months and followed at 1, 2, 3, and 6 months postinjection...
December 2018: Indian Journal of Ophthalmology
Riccardo Francesco Bellanca, Fabio Scarinci, Mariacristina Parravano
PURPOSE: To evaluate the role of multimodal imaging in the diagnosis and monitoring of patients with osteogenesis imperfecta complicated with choroidal neovascularization. CASE REPORT: A 28-year-old man, diagnosed with osteogenesis imperfecta, was referred 2 months after the appearance of central scotoma and metamorphopsia in the right eye. The patient underwent a complete ophthalmological evaluation including visual acuity examination as well as ophthalmoscopy, spectral-domain optical coherence tomography, optical coherence tomography angiography, fundus autofluorescence imaging, fluorescein angiography and microperimetry...
November 8, 2018: European Journal of Ophthalmology
Luca Di Antonio, Lisa Toto, Alessandra Mastropasqua, Lorenza Brescia, Emanuele Erroi, Alessia Lamolinara, Marta Di Nicola, Leonardo Mastropasqua
The aim of the study was to assess retinal vascular changes using optical coherence tomography angiography (OCTA) and aqueous humour changes of vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) levels in treatment-naïve myopic choroidal neovascularization (mCNV) after aflibercept intravitreal injection. To explore the correlation between clinical and laboratory parameters. Fifteen eyes of 15 patients with treatment-naïve mCNV underwent 2 intravitreal injections of aflibercept. Main outcome measures were best corrected visual acuity (BCVA), central retinal thickness (CRT) and external limiting membrane (ELM) visualization at OCT, lesion area and leakage at fluorescein angiography (FA), OCTA flow area and selected area at baseline and after the injections...
October 23, 2018: Scientific Reports
Katherine G Chen, Panos G Christakis, Emily Y Chew
PURPOSE: To provide long-term, natural history data of a case of a subclinical choroidal neovascular membrane (CNVM) in the setting of age-related macular degeneration. METHODS: Retrospective review of the 10-year clinical course of a patient including multimodal imaging. RESULTS: A 75-year-old white female with macular degeneration presented with visual acuity of 20/25 in the right eye and 20/40 in the left eye. In the left eye, a retinal pigment epithelial detachment with associated subretinal and intraretinal fluid was found on spectral domain optical coherence tomography...
October 15, 2018: Retinal Cases & Brief Reports
Craig Wilde, Ali Poostchi, Rajnikant L Mehta, Jonathan G Hillman, Hamish K MacNab, Marco Messina, Gaspare Monaco, Stephen A Vernon, Winfried M Amoaku
PURPOSE: There is paucity of data on the epidemiology of peripapillary choroidal neovascularisartion (PPCNV). Our aim was to determine prevalence of PPCNV in the elderly UK population of Bridlington residents aged ≥65 years. METHODS: Eyes with PPCNV in the Bridlington eye assessment project (BEAP) database of 3475 participants were analysed. PPCNV outline was drawn, its area measured, and clock-hour involvement of disc circumference recorded. Location and shortest distance from the lesion edge to fovea were recorded...
October 12, 2018: Eye
Yasuo Yanagi, Valencia Hui Xian Foo, Akitoshi Yoshida
In Asian populations, polypoidal choroidal vasculopathy (PCV), a distinct phenotype of neovascular age-related macular degeneration (AMD), is more prevalent than Caucasians. Recently, there has been significant focus on how PCV differs from typical AMD. Although typical AMD and PCV share a variety of mechanisms by which abnormal angiogenic process occurs at the retinochoroidal interface, PCV has different clinical characteristics such as aneurysm-like dilation at the terminal of choroidal neovascular membranes, less frequent drusen and inner choroidal degeneration due to the thickened choroid...
October 12, 2018: Eye
Marie Krogh Nielsen, Yousif Subhi, Christopher Rue Molbech, Line Lynge Nilsson, Mogens Holst Nissen, Torben Lykke Sørensen
PURPOSE: Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age-related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). METHODS: This was a prospective case-control study. A total of 125 participants were included consecutively during a period of 18 months. We included 46 patients with neovascular AMD, 46 patients with GA without any sign of choroidal neovascularization in either eye, and 33 healthy aged controls...
October 4, 2018: Acta Ophthalmologica
Saskia Helena Margaretha van Romunde, Antonio Polito, Antonio Peroglio Deiro, Laura Bertazzi, Massimo Guerriero, Grazia Pertile
PURPOSE: To describe the change in the retinal morphology after full macular translocation (FMT) for exudative age-related macular degeneration (AMD) and identify predictive factors for the visual outcome. METHODS: All patients who underwent FMT from December 2008 through July 2013 were selected. Exclusion criteria were FMT for other disease than AMD, age <60 years, <12 months of follow-up or no available images. Spectral domain optical coherence tomography, fundus autofluorescence, fluorangiography and indocyanine green angiography were evaluated...
October 3, 2018: Acta Ophthalmologica
Hironori Uehara, Timilai Lesuma, Parker Stocking, Nathan Jensen, Sangeetha Ravi Kumar, Mingyang Aaron Zhang, Susie Choi, Xiaohui Zhang, Bonnie Archer, Lara Carroll, Balamurali K Ambati
Optical coherence tomography (OCT) angiography is a dye-free and non-invasive angiography which allows visualization of retinal and choroid vascular flow, enabling observation of highly permeable and three dimensional vasculature. Although OCT angiography is providing new insights in human retinal and choroidal diseases, a few studies have been reported in experimental mice. In this study, to determine the potential of OCT angiography in experimental mice, we sought to examine whether OCT angiography can detect vascular change in type I diabetic mice...
September 27, 2018: Experimental Eye Research
Irini Chatziralli, George Saitakis, Eleni Dimitriou, Alexandros Chatzirallis, Sofia Stoungioti, George Theodossiadis, Panagiotis Theodossiadis
PURPOSE: To stratify the literature on angioid streaks, from pathophysiology to treatment. METHODS: Review of the current literature. RESULTS: Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers-Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Various diagnostic methods, including infrared and red-free retinography, autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, are useful to diagnose, evaluate, and monitor angioid streaks...
September 26, 2018: Retina
Alan Cunningham, Ajay Kotagiri
BACKGROUND: Dense Deposit Disease is a rare condition affecting the Bruch's membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow up period, longer than any previous report. CASE PRESENTATION: A 44 year old male presented with pigmentary changes at the macula noted by his optician. Best corrected visual acuity at presentation was good in both eyes. Fundoscopy showed pigmentary changes and drusen, and investigation using intravenous fundus fluorescein angiography did not demonstrate any choroidal neovascular membrane...
September 14, 2018: BMC Ophthalmology
Dhanashree Ratra, Sarika Gopalakrishnan, Daleena Dalan, Vineet Ratra, Deepali Damkondwar, Gella Laxmi
BACKGROUND: Patients with central scotoma have poor fixation stability and poor visual acuity. Acoustic biofeedback training can be an effective way to train such patients to eccentrically fixate. This study analyses the mean retinal sensitivity, saccadic velocity, and fixation stability after acoustic biofeedback training and shows correlation with age and scotoma size. METHODS: Patients with irreversible central scotoma in both the eyes secondary to macular diseases were selected...
September 25, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Vishal Raval, Srinivas Rao, Taraprasad Das
Epiretinal membrane over macula secondary to toxoplasmosis compromises vision. We describe the outcome of pars plana vitrectomy and epiretinal membrane removal after adequate treatment of acute infection. The average age of all four male patients was 36 years (range 20-60 years). Following surgery there was an average three or more lines visual acuity improvement, restoration of foveal contour with reduction in central macular thickness. One patient developed choroidal neovascular membrane postsurgery and was effectively treated with intravitreal bevacizumab...
October 2018: Indian Journal of Ophthalmology
Yong Liu, Hai Wei Xu, Lei Wang, Shi Ying Li, Cong Jian Zhao, Jie Hao, Qi You Li, Tong Tao Zhao, Wei Wu, Yi Wang, Qi Zhou, Cheng Qian, Liu Wang, Zheng Qin Yin
Stem cell therapy may provide a safe and promising treatment for retinal diseases. Wet age-related macular degeneration (wet-AMD) is a leading cause of blindness in China. We developed a clinical-grade human embryonic stem cell (hESC) line, Q-CTS-hESC-2, under xeno-free conditions that differentiated into retinal pigment epithelial cells (Q-CTS-hESC-2-RPE). A clinical trial with three wet-AMD patients was initiated in order to study the safety and tolerance to Q-CTS-hESC-2-RPE cell transplants. The choroidal neovascularization membrane was removed and then a suspension of 1 × 106 Q-CTS-hESC-2-RPE cells were injected into a subfoveal pocket...
2018: Cell Discovery
Scott M McClintic, Simon Gao, Jie Wang, Ahmed Hagag, Andreas K Lauer, Christina J Flaxel, Kavita Bhavsar, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey
Purpose: To use optical coherence tomography angiography (OCTA) derived quantitative metrics to assess the response of choroidal neovascularization to pro-re-nata (PRN) anti-endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (AMD). Design: Prospective longitudinal cohort study. Participants: Fourteen eyes from 14 study participants with treatment-naïve neovascular AMD were enrolled. Methods: Subjects were evaluated monthly and treated with intravitreal anti-VEGF agents under a PRN protocol for one year...
September 2018: Ophthalmology Retina
Vaidehi S Dedania, Cem Ozgonul, Cagri G Besirli
The authors report three cases of persistent fetal vasculature (PFV) presenting with an atypical peripheral fibrovascular stalk. A 5-month-old with congenital exotropia with a vitreous hemorrhage in the right eye underwent vitrectomy, and a mid-peripheral vitreal vascular stalk was visualized within the area of hemorrhage. The second case is of an 8-year-old with two fetal vascular remnants in the right eye: (1) a stalk superotemporally extending from the pars plana to the mid-peripheral retina that was associated with a retinal break and (2) a focal lens opacity...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Gloria Paulina Trujillo-Sanchez, Juan Carlos Martinez-Camarillo, Christine K Spee, David R Hinton, Mark S Humayun, Andrew C Weitz
BACKGROUND AND OBJECTIVE: To evaluate a stereological method in optical coherence tomography (OCT) as an in vivo volume measurement of laser-induced choroidal neovascularization (L-CNV) lesion size. PATIENTS AND METHODS: Laser photocoagulation was applied in rats to rupture Bruch's membrane and induce L-CNV. In vivo OCT images of neovascular lesions were acquired with a spectral-domain OCT system at days 0, 3, 7, 10, and 14 after laser surgery. A stereological image-processing method was used to calculate lesion volumes from the OCT images...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
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