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Colitis, ulcerative

Vanessa Fernandes Rodrigues, Márcia Paulliny Soares Bahia, Núbia Rangel Cândido, João Marcelo Peixoto Moreira, Vinicius Gustavo Oliveira, Emília Souza Araújo, Jailza Lima Rodrigues Oliveira, Michelle de Carvalho Rezende, Ary Correa, Deborah Negrão-Corrêa
Helminth infection can reduce the severity of inflammatory bowel disease. However, the modulatory mechanisms elicited by helminth infection are not yet fully understood and vary depending on the experimental model. Herein we evaluated the effect of acute infection of BALB/c mice with Strongyloides venezuelensis on the clinical course of ulcerative colitis induced by Dextran Sulfate Sodium (DSS) treatment of these animals. For the experiments, S. venezuelensis-infected BALB/c mice were treated orally with 4% DSS solution for seven days...
August 14, 2018: Cytokine
A Moeser, M Lerche, H Wirtz, A Stallmach
The incidence of pulmonary manifestations of inflammatory bowel disease (IBD) appears to be much higher than previously assumed. In prospective studies, subclinical pulmonary interstitial infiltrates or pathological lung function were found in 40%-60% of IBD patients, both in children and adults. Pulmonary disorders can affect any part of the respiratory system, the most frequent pattern being inflammation of the large airways often associated with bronchiectasis. The differential diagnosis should include drug-related pulmonary disease and infectious causes when receiving immunosuppressive therapy...
August 16, 2018: Der Internist
Daniele Maria-Ferreira, Adamara Machado Nascimento, Thales Ricardo Cipriani, Arquimedes Paixão Santana-Filho, Paulo da Silva Watanabe, Debora de Mello Gonçales Sant Ana, Fernando Bittencourt Luciano, Karla Carolina Paiva Bocate, René M van den Wijngaard, Maria Fernanda de Paula Werner, Cristiane Hatsuko Baggio
Natural polysaccharides have emerged as an important class of bioactive compounds due their beneficial biological effects. Here we investigated the protective and healing effects of rhamnogalacturonan (RGal) isolated from Acmella oleracea (L.) R.K. Jansen leaves in an experimental model of intestinal inflammation in mice and in heterogeneous human epithelial colorectal adenocarcinoma cells (Caco-2). The findings demonstrated that RGal treatment for 7 days reduced the severity of DSS-induced colitis by protecting mice from weight loss, macroscopic damage and reduction of colon length...
August 16, 2018: Scientific Reports
Kumaresan Sandrasegaran, Christine O Menias
Autoimmune pancreatitis (AIP) is steroid-responsive fibroinflammatory disorder of the pancreas. There are 2 distinct subtypes of AIP, types 1 and 2. Type 1 is associated with systemic immunoglobulin (Ig)G4 disease and may affect multiple organs in the body. Type 2 is confined to the pancreas and shows an association with ulcerative colitis. This article describes the imaging findings of AIP and IgG4 disease in the liver, bile ducts, kidneys, and the retroperitoneal regions. The imaging differentiation of AIP from pancreas cancer is discussed...
September 2018: Gastroenterology Clinics of North America
Kellie E Cunningham, Elizabeth A Novak, Garret Vincent, Vei Shaun Siow, Brian D Griffith, Sarangarajan Ranganathan, Matthew R Rosengart, Jon D Piganelli, Kevin P Mollen
The incidence and prevalence of inflammatory bowel disease (IBD) are increasing worldwide. IBD is known to be multifactorial, but inflammatory signaling within the intestinal epithelium and a subsequent failure of the intestinal epithelial barrier have been shown to play essential roles in disease pathogenesis. CaMKIV is a multifunctional protein kinase associated with inflammation and cell cycle regulation. CaMKIV has been extensively studied in autoimmune diseases, but a role in idiopathic intestinal inflammation has not been described...
August 16, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
S M Oke, J Segal, S K Clark, A L Hart, S M Gabe
Introduction Restorative proctocolectomy is a surgical treatment for patients with medically refractory ulcerative colitis and some cases of familial adenomatous polyposis. Intestinal failure, defined as an inability to maintain adequate hydration and micronutrient balances when on a conventionally accepted normal diet, is a rare complication of restorative proctocolectomy. We describe our experience of patients with restorative proctocolectomy who have developed intestinal failure requiring parenteral support...
August 16, 2018: Annals of the Royal College of Surgeons of England
Justin Cheeley, Brenda Morales-Pico, Suzana John
No abstract text is available yet for this article.
August 2018: JAAD Case Reports
Yiqing Wang, Qichun Tang, Peibei Duan, Lihua Yang
Ulcerative colitis (UC) is a chronic, relapsing, remitting, and inflammatory disorder that afflicts millions of people around the world. It carries a substantial economic burden, reducing the quality of life, ability to work, and increasing disability. Conventional medical treatment of UC includes the use of aminosalicylates, corticosteroids, and immunosuppressive drugs. However, these medicines are not always effective due to some serious side effects. Nuclear factor-kappa B (NF-κB) is a key factor in the inflammatory setting and strongly affects the course of mucosal inflammation in UC...
August 15, 2018: Immunopharmacology and Immunotoxicology
Xiao-Mei Wang, Ge Tian, Qiang-Jun Duan, Da-Qiang Wu, Jing Shao, Tian-Ming Wang, Chang-Zhong Wang
To investigate the mechanism of n-butanol extract of Pulsatilla decoction (BAEB) against murine ulcerative colitis (UC) model induced by DSS combined with Candida albicans (CA) colonization, mice were randomly divided into normal control group, DSS group, DSS+CA group, BAEB high, medium and low dose group, and positive drug Mesalazine group. The general condition of mice was observed, fungal loads of murine intestinal contents were detected by plate method, colonic pathological change of mice was examined by HE staining...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xin-Lin Chen, Yi Wen, Zu-Chun Wu, Bei-Ping Zhang, Zheng-Kun Hou, Jun-Lin Xiao, Man-Qing Lin, Yue Hu, Zhe-Li Wu, Jie-Min Deng, Feng-Bin Liu, Tian-Wen Liu
The aim of this study was to develop and validate the large intestine dampness-heat syndrome questionnaire (LIDHSQ) for patients with ulcerative colitis (UC). The domains and items of the LIDHSQ were developed according to standard procedures, namely, construct definition, item generation, language testing, content validity, pilot study, and validation study. At first, a total of 20 items in 3 domains were generated based on literature review and expert consultation. After the item selection, the LIDHSQ contains 11 items in three domains: disease-related domain (diarrhoea, abdominal pain, bloody purulent stool, and mucus stool), heat domain (fever, dry mouth, red tongue, yellow fur, and anal burning), and dampness domain (greasy fur and defecation disorder)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Lindsay A Sobotka, Syed G Husain, Somashekar G Krishna, Alice Hinton, Ravi Pavurula, Darwin L Conwell, Cheng Zhang
INTRODUCTION: The Center for Medicare and Medicaid Services established 30-day readmission rate as a key metric in measuring high-value, cost-conscious care; therefore, our aim is to develop a risk score for 30-day readmission in ulcerative colitis (UC) patients undergoing colectomy or proctectomy. METHODS: This study used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant user file (2011-2015). Patients with UC undergoing colectomy or proctectomy were identified using ICD-9, 10, and CPT codes...
August 15, 2018: Clinical and Translational Gastroenterology
Bente Mertz Nørgård, Bjarne Magnussen, Jens Fedder, Punyanganie S de Silva, Sonja Wehberg, Sonia Friedman
Backgroud: Women with inflammatory bowel disease (IBD) might have an increased tendency to choose an elective abortion due to a fear that their fetus could be harmed by use of medications, disease flares during pregnancy, or for genetic reasons. We examined the risk of elective abortions in women with ulcerative colitis (UC) and Crohn's disease (CD) compared with women without IBD. Methods: This nationwide cohort study, based on Danish health registries, comprises all registered pregnancies from 1996 through 2015...
August 10, 2018: Inflammatory Bowel Diseases
Bo Xiao, Qiubing Chen, Zhan Zhang, Lixin Wang, Timothy Denning, Yuejun Kang, Didier Merlin
Pro-resolving factors that are critical for colonic epithelial restitution were down-regulated during the treatment with inhibitor of pro-inflammatory cytokines (e.g., anti-TNFα antibody) in ulcerative colitis (UC) therapy. We hypothesized that increased amounts of factors such as interleukin-22 (IL-22) during the therapeutic inhibition of TNFα could facilitate the resolution of intestinal inflammation. As combination therapy is an emerging strategy for UC treatment, we attempt to treat established UC based on the combination of TNFα siRNA (siTNF) and IL-22...
August 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Nan Lan, Tracy H Hull, Bo Shen
BACKGROUND AND AIMS: Pouch sinus may be a serious adverse event in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to compare endoscopic sinusotomy and redo pouch surgery in the management of pouch sinus. METHODS: All consecutive ulcerative colitis patients with chronic pouch sinuses treated with endoscopic sinusotomy versus redo surgery from 2006 to 2016 were identified. The primary outcomes were recurrence-free and surgery-free survivals...
August 11, 2018: Gastrointestinal Endoscopy
Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kaori Takahashi, Kyoko Nakayama, Yuko Ebata, Ken-Ichi Fukuda, Kazutaka Ikeda
AIM: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers...
June 2018: Neuropsychopharmacology reports
Yan Zhou, Hanyang Liu, Jun Song, Liang Cao, Liming Tang, Chunjian Qi
Sinomenine (SIN), a pure alkaloid isolated from Sinomenium acutum, has been widely used in arthritis for its anti‑inflammatory effect, but little is known about the effect of SIN on human ulcerative colitis (UC). In the present study, the effect and mechanism of SIN was examined in a dextran sulfate sodium (DSS)‑induced murine colitis model, which mimics human UC. Oral administration of SIN significantly suppressed the elevated disease activity index and ameliorated colonic histological damage in a DSS‑induced colitis model...
August 10, 2018: Molecular Medicine Reports
Jingyun Xu, Lijia Wu, Pengcheng Yu, Mingxu Liu, Yixin Lu
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease (CD), is a chronic autoimmune disease. Parasitic infections and their products have been shown protective effects on autoimmune diseases, including IBD. In this experiment, 96 male BALB/c mice aged 6-8 weeks were randomly divided into two large groups: prevention group and therapy group. The changes on the various indicators of colitis were detected to demonstrate that T. spiralis serine protease inhibitors can relieve the inflammatory severity of TNBS-induced colitis and to explore possible immunological mechanisms...
August 13, 2018: Clinical and Experimental Immunology
Henry H Nguyen, Robert Bechara, William G Paterson, Lawrence C Hookey
Background and aims:  Rectal bleeding affects ~15 % of the general population and is a common reason for referral to gastroenterologists by primary care physicians. Direct to procedure flexible sigmoidoscopy is an appealing modality to investigate rectal bleeding due its diagnostic yield, safety profile, and accessibility. Patients referred on a routine basis for direct to procedure clinic by primary care physicians with the sole complaint of rectal bleeding have not previously been studied...
August 2018: Endoscopy International Open
Simon Ghaly, Nadeem O Kaakoush, Frances Lloyd, Lavinia Gordon, Cynthia Forest, Ian C Lawrance, Prue H Hart
Reduced sunlight exposure has been associated with an increased incidence of Crohn's disease and ulcerative colitis. The effect of ultraviolet radiation (UVR) on the faecal microbiome and susceptibility to colitis has not been explored. C57Bl/6 female mice were fed three different vitamin D-containing diets for 24 days before half of the mice in each group were UV-irradiated (1 kJ/m²) for each of four days, followed by twice-weekly irradiation of shaved dorsal skin for 35 days. Faecal DNA was extracted and high-throughput sequencing of the 16S RNA gene performed...
August 11, 2018: Nutrients
T G J de Meij, E F J de Groot, C F W Peeters, N K H de Boer, C M F Kneepkens, A Eck, M A Benninga, P H M Savelkoul, A A van Bodegraven, A E Budding
BACKGROUND & AIMS: Intestinal microbiota is considered to play a crucial role in the aetiology of inflammatory bowel disease (IBD). We aimed to describe faecal microbiota composition and dynamics in a large cohort of children with de novo (naïve) IBD, in comparison to healthy paediatric controls (HC). METHODS: In this prospective study, performed at two tertiary centres, faecal samples from newly diagnosed, treatment-naïve paediatric IBD patients were collected prior to bowel cleansing for colonoscopy (t0) and 1, 3 and 6 weeks and 3 months after initiation of therapy...
2018: PloS One
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