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https://www.readbyqxmd.com/read/30517639/difference-in-pathomechanism-between-crohn-s-disease-and-ulcerative-colitis-revealed-by-colon-transcriptome
#1
Lili Yang, Shijie Tang, Susan S Baker, Ingrid Arijs, Wensheng Liu, Razan Alkhouri, Ping Lan, Robert D Baker, Zhipeng Tang, Guang Ji, Paul Rutgeerts, Severine Vermeire, Ruixin Zhu, Lixin Zhu
Background: We aim to identify the differences in colonic mucosal transcriptome between Crohn's disease (CD) and ulcerative colitis (UC) for a better understanding of the molecular pathology. Methods: Differentially expressed genes (DEG) in the colonic mucosa of CD and UC were identified with a global gene expression microarray dataset generated from the colon biopsies of CD and UC patients and normal controls. The DEGs were then processed to identify altered pathways and modularized DEGs and pathways...
December 4, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30515708/management-of-ulcerative-colitis-in-the-elderly
#2
Manish P Shrestha, Sasha Taleban
The incidence rate of ulcerative colitis (UC) in older patients is rising. Diagnosis of UC may be difficult in older patients as several common gastrointestinal disorders can mimic UC in these patients. Compared with younger adults, left-sided colitis is more common in older-onset UC, while rectal bleeding, abdominal pain, and extraintestinal manifestations are less common. The disease course of older-onset UC may be similar to that of adult-onset UC. The management of UC in older patients includes medical and surgical options...
December 4, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30515402/peripheral-lymphocytes-of-patients-with-inflammatory-bowel-disease-have-altered-concentrations-of-key-apoptosis-players-preliminary-results
#3
Katarzyna Neubauer, Barbara Woźniak-Stolarska, Małgorzata Krzystek-Korpacka
Notwithstanding uncertain pathogenesis of inflammatory bowel disease (IBD), deregulation of adaptive immunity is paramount for the development of inflammation. Essential role in the resolution of inflammation is played by apoptosis, deregulated in lymphocytes isolated from inflamed intestine. Despite IBD being a systemic disease, little is known about apoptosis of peripheral lymphocytes. The concentrations of Bcl-2, cytochrome c, p53, and caspase-9 were determined (ELISA) in lymphocyte-enriched fractions of peripheral blood mononuclear cells (LE-PBMCs) from 64 individuals (42 with IBD) and related to IBD phenotype and activity, treatment, and inflammatory and hematological indices...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30515045/sulfasalazine-induced-interstitial-fibrosis
#4
Bugra Kerget, Omer Araz, Elif Yilmazel Ucar, Ozkan Aydin, Metin Akgun, Leyla Saglam
Sulfasalazine has been used in the treatment of inflammatory bowel disease for over 60 years. Although the drug is frequently associated with gastrointestinal adverse effects, pulmonary adverse effects are very rare. Herein, we report a case of interstitial fibrosis resulting from 4-month sulfasalazine therapy for ulcerative colitis in a patient under long-term follow-up in our clinic due to chronic obstructive pulmonary disease.
October 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/30514905/identification-of-55-000-replicated-dna-methylation-qtl
#5
Allan F McRae, Riccardo E Marioni, Sonia Shah, Jian Yang, Joseph E Powell, Sarah E Harris, Jude Gibson, Anjali K Henders, Lisa Bowdler, Jodie N Painter, Lee Murphy, Nicholas G Martin, John M Starr, Naomi R Wray, Ian J Deary, Peter M Visscher, Grant W Montgomery
DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many identified SNP associations with disease that are not found in coding regions. We replicated 52,916 cis and 2,025 trans DNA methylation quantitative trait loci (mQTL) using methylation from whole blood measured on Illumina HumanMethylation450 arrays in the Brisbane Systems Genetics Study (n = 614 from 177 families) and the Lothian Birth Cohorts of 1921 and 1936 (combined n = 1366)...
December 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30514356/factor-xiii-activity-in-patients-with-mild-to-moderate-ulcerative-colitis-and-active-bleeding-a-prospective-observational-study
#6
Karsten Bernerth, Ingolf Schiefke, Karin Liebscher, Susanne Raczynski, Tanja Kottmann, Niels Teich
OBJECTIVE: Coagulation factor XIII plays a key role in fibrin clot stabilization and epithelial healing. Under chronic inflammatory conditions involving bleeding and an activation of the coagulation cascade, the FXIIIa inversely correlate with disease activity. We assumed that FXIIIa could be a predictor of severity in patients with ulcerative colitis (UC). Here, we evaluated the course of plasma activity of FXIIIa in 49 patients with mild to moderate UC and active rectal bleeding. Patients with a partial Mayo bleeding subscore > 2 were eligible to participate in our prospective observational study in an outpatient setting...
December 4, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30514241/disseminated-cryptococcosis-in-crohn-s-disease-a-case-report
#7
Natthakit Chavapradit, Nasikarn Angkasekwinai
BACKGROUND: Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn's disease with gastrointestinal cryptococcosis that resembled exacerbation of Crohn's disease. CASE PRESENTATION: A 64-year-old woman with Crohn's disease (CD) was referred to Siriraj Hospital due to worsening of abdominal pain and watery diarrhea for 2 weeks...
December 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30513801/a-bronze-tomato-enriched-diet-affects-the-intestinal-microbiome-under-homeostatic-and-inflammatory-conditions
#8
Marina Liso, Stefania De Santis, Aurelia Scarano, Giulio Verna, Manuela Dicarlo, Vanessa Galleggiante, Pietro Campiglia, Mauro Mastronardi, Antonio Lippolis, Mirco Vacca, Anastasia Sobolewski, Grazia Serino, Eugenio Butelli, Maria De Angelis, Cathie Martin, Angelo Santino, Marcello Chieppa
Inflammatory bowel diseases (IBD) are debilitating chronic inflammatory disorders that develop as a result of a defective immune response toward intestinal bacteria. Intestinal dysbiosis is associated with the onset of IBD and has been reported to persist even in patients in deep remission. We investigated the possibility of a dietary-induced switch to the gut microbiota composition using Winnie mice as a model of spontaneous ulcerative colitis and chow enriched with 1% Bronze tomato. We used the near isogenic tomato line strategy to investigate the effects of a diet enriched in polyphenols administered to mild but established chronic intestinal inflammation...
December 2, 2018: Nutrients
https://www.readbyqxmd.com/read/30513523/microrna-15-activates-nf-%C3%AE%C2%BAb-pathway-via-down-regulating-expression-of-adenosine-a2-receptor-in-ulcerative-colitis
#9
Huixia Zhang, Wei Li
BACKGROUND/AIMS: The role of miR-15 in ulcerative colitis (UC) is unclear. In this study, we found that miR-15 downregulated the expression of adenosine A2a receptor (A2aAR) in the colonic tissues of patients with UC and in HT-29 human colonic epithelial cells. METHODS: The study population comprised patients with UC (n=23), irritable bowel syndrome (IBS, n=22), and healthy subjects (n = 20). The levels of miR-15, A2aAR, and protein in colon tissue biopsies were determined by real-time quantitative reverse transcription polymerase chain reaction, immunofluorescence staining, and Western blotting...
December 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30511275/fasciocutaneous-lotus-petal-flap-in-the-treatment-of-chronic-pouch-vaginal-fistula-in-ulcerative-colitis
#10
L Sofo, A E Potenza, D Cervelli, F Sacchetti, N Ursino
No abstract text is available yet for this article.
December 3, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/30510942/epstein-barr-virus-associated-hemophagocytic-syndrome-in-a-patient-with-ulcerative-colitis-during-treatment-with-azathioprine-a-case-report-and-review-of-literature
#11
Kazuya Miyaguchi, Minoru Yamaoka, Yoshikazu Tsuzuki, Keigo Ashitani, Hideki Ohgo, Yoshitaka Miyagawa, Keisuke Ishizawa, Hidekazu Kayano, Hidetomo Nakamoto, Hiroyuki Imaeda
A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospital. The patient experienced high-grade fevers, chills, and cough five d prior to presenting to the outpatient unit. At first, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndrome (EB-VAHS) upon fulfilling the diagnostic criteria after bone marrow aspiration...
November 26, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30508908/mesalazine-related-lung-disease-in-a-patient-with-ulcerative-colitis-a-case-report
#12
Po-Han Huang, Chia-Jung Kuo, Chang-Wei Lin, Yu-Ming Cheng, Han-Chung Hu, Chun-Yen Lin, Ming-Yao Su, Cheng-Tang Chiu
RATIONALE: Mesalazine is widely used to treat inflammatory bowel disease (IBD). However, discriminating between pulmonary manifestations of IBD and drug-related lung disease remains a challenge. There were few case reports of mesalazine-related organizing pneumonia so far. PATIENT CONCERNS: A 75-year-old female was diagnosed with ulcerative colitis and took mesalazine over a period of 2 years and 8 months. She presented with progressive shortness of breath for 3 days and visited our emergency department...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30506156/the-detection-of-the-cytomegalovirus-dna-in-the-colonic-mucosa-of-patients-with-ulcerative-colitis-is-associated-with-increased-long-term-risk-of-proctocolectomy-results-from-an-outpatient-ibd-clinic
#13
Wiebke Schenk, Tobias Klugmann, Annett Borkenhagen, Chris Klecker, Peter Dietel, Ralf Kirschner, Eckhardt Schneider, Tony Bruns, Andreas Stallmach, Niels Teich
PURPOSE: Cytomegalovirus (CMV) infection has been found to be associated with a reactivation of ulcerative colitis (UC) and with an impaired response to medical therapy. In the past, only limited data were available on the long-term outcome for UC patients with positive tissue CMV-PCR in the colonic mucosa. METHODS: Between January 2010 and April 2015, we performed a qualitative PCR screening for CMV DNA in one biopsy from most actively inflamed rectal mucosa (tCMV-PCR)...
November 30, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/30505842/patient-preference-and-physician-perceptions-of-patient-preference-for-oral-pharmaceutical-formulations-results-from-a-real-life-survey
#14
Lara MacKenzie-Smith, Paolo Marchi, Helen Thorne, Susan Timeus, Ryan Young, Perrine Le Calvé
Background: Pharmaceutical treatment prescribed according to patient preference for a formulation may have a positive impact on adherence to treatment and consequently on treatment outcomes. Aim: This study aimed at understanding patient preference for pharmaceutical formulations and attributes that trigger patient preference and physician perception of patient preference. Methods: Between August and September 2017, gastroenterologists and patients with mild to moderate ulcerative colitis from France, Germany, Spain, and the UK participated in an online survey...
November 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/30505840/annual-incidence-and-phenotypic-presentation-of-ibd-in-southern-new-zealand-an-18-year-epidemiological-analysis
#15
Kirsten J Coppell, Ciarán P-C Galts, Fokko Y Huizing, Joanna K Norton, Andrew R Gray, Kim Schultz, Catherine E Hobbs, Kristina Aluzaite, Michael Schultz
Background: The aim of this study was to describe the incidence of inflammatory bowel disease (IBD) and changes in demographic and phenotypic disease presentation in Otago, New Zealand. Methods: This study was conducted at Dunedin Hospital and the study period was 1996-2013. Otago residents diagnosed with IBD were identified retrospectively from hospital lists using ICD-10 codes. Diagnosis, and place and date of diagnosis, were confirmed using medical notes and histology reports...
November 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/30505839/drug-lag-for-inflammatory-bowel-disease-treatments-in-the-east-and-west
#16
Shinji Okabayashi, Taku Kobayashi, Toshifumi Hibi
Background: Inflammatory bowel disease (IBD), though historically common in the West, is now increasingly prevalent in industrializing countries. A simultaneous dramatic increase in IBD drug options has enabled most patients to achieve remission. Nevertheless, worldwide disparities in the approval of IBD drugs, or "drug lag", remain problematic. Summary: Drug lag for major IBD drugs before March 31, 2018 (12 for Crohn's disease [CD] and 13 for ulcerative colitis [UC]) was compared between that of the United States (US), European Union (EU), and Asia (Japan, China, South Korea, Taiwan, and the Philippines) to assess current trends...
November 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/30505838/a-simple-noninvasive-score-predicts-disease-activity-and-deep-remission-in-ulcerative-colitis
#17
Amr Shaaban Hanafy, Mohamed Hesham Monir, Hany Abdel Malak, Mohamed Desoky Aiad
Background: There is a need to use noninvasive markers in refining the management of ulcerative colitis to reduce the number of unnecessary colonoscopies, which facilitates the follow-up of activity and the response to treatment. Aim: Postulation of a sensitive, specific, simple and noninvasive score to monitor disease activity in ulcerative colitis. Methods: A case-control study was conducted: 168 patients with ulcerative colitis, 40 healthy individuals, and 60 patients for validation...
November 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/30505837/vaccinations-in-adult-patients-with-inflammatory-bowel-diseases-in-the-west
#18
REVIEW
Bharati Kochar, Hans H Herfarth
Background: Patients with moderate-severe inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are commonly treated with long-term immunosuppressive therapies involving immunomodulators such as thiopurines, biologics (anti-TNF and anti-adhesion molecules), or novel small molecules such as Janus kinase inhibitors. Summary: Some infections seen with immunosuppressive therapy in IBD are preventable with vaccines. IBD-specific immunosuppressive therapy is generally initiated by gastroenterologists...
November 2018: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/30504685/nitric-oxide-is-involved-in-activation-of-toll-like-receptor-4-signaling-through-tyrosine-nitration-of-src-homology-protein-tyrosine-phosphatase-2-in-murine-dextran-sulfate-induced-colitis
#19
Xin Tun, Keiji Yasukawa, Ken-Ichi Yamada
Ulcerative colitis is characterized by colonic mucosal bleeding and ulceration, often with repeated active and remission stages. One factor in ulcerative colitis development is increased susceptibility to commensal bacteria and lipopolysaccharide (LPS). LPS activates macrophages to release nitric oxide (NO) through Toll-like receptor 4 (TLR4) signaling. However, whether NO is beneficial or detrimental to colitis remains controversial. In this study, we investigated whether NO enhances the development of colitis in mice treated with dextran sulfate sodium (DSS) and inflammation in cells treated with low-dose LPS...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30502794/histiocytic-ulcerative-colitis-in-an-american-staffordshire-terrier
#20
F F Argenta, S O de Souza, L S Meirelles, G G M Snel, C De Lorenzo, J Ienes-Lima, F Horn, D Driemeier, S P Pavarini
A 9-year-old female American Staffordshire terrier was presented to a veterinary hospital with diarrhoea, severe prostration, hypothermia, dehydration and anaemia. The dog died 6 days after the first consultation. At necropsy examination the serosa of the large intestine showed a granular appearance and the mucosa was thickened, ulcerated and red, with prominent folding. Histological examination revealed marked inflammatory infiltration of macrophages into the mucosa and submucosa of the large intestine. These cells stained positively by the periodic acid-Schiff reaction...
November 2018: Journal of Comparative Pathology
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