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Glycemic Variablity

Naohiko Yoshida, Teruki Miyake, Shin Yamamoto, Shinya Furukawa, Hidenori Senba, Sayaka Kanzaki, Mitsuhito Koizumi, Toru Ishihara, Osamu Yoshida, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
Objective Skeletal muscle is the main target organ for glycemic control, and the serum creatinine level is a convenient indicator of the skeletal muscle mass. This study aimed to assess the potential relationship between the serum creatinine level and the onset of impaired fasting glucose (IFG). Methods In this large, community-based, retrospective longitudinal cohort study, we examined the records of 7,905 Japanese participants (3,863 men, 4,042 women) of 18-80 years of age who underwent annual health checkups at a single center between April 2003 and August 2013...
October 17, 2018: Internal Medicine
Alan Carlos Nery Dos Santos, Jefferson Petto, Diego Passos Diogo, Candice Rocha Seixas, Lunara Horn de Souza, Wagner Santos Araújo, Ana Marice Teixeira Ladeia
BACKGROUND: The use of combined oral contraceptive (COC) has been related to changes in glycemic, lipid metabolism, increased oxidative stress, and systemic blood pressure, which could suggest a higher oxidation of low-density lipoprotein cholesterol (LDL-cholesterol) in women on use of COC. OBJECTIVE: To test the hypothesis that there is a difference in the plasma values of oxidized LDL among women who use and do not use COC, as well as to evaluate the correlation between it and the lipid profile and high-sensitivity C-reactive protein (hs-CRP)...
October 11, 2018: Arquivos Brasileiros de Cardiologia
Osama Hamdy, Mhd Wael Tasabehji, Taha Elseaidy, Shaheen Tomah, Sahar Ashrafzadeh, Adham Mottalib
PURPOSE OF REVIEW: The prevalence of combined obesity and diabetes has increased dramatically in the last few decades. Although medical and surgical weight management are variably effective in addressing this epidemic, it is essential to parallel these strategies with a hypocaloric diet comprising the appropriate macronutrient composition to induce weight loss, enhance glycemic control, and improve cardiovascular risk factors. This review reports the current evidence of the role of carbohydrates and fat-based diets for weight management in patients with combined type 2 diabetes (T2D) and obesity...
October 17, 2018: Current Diabetes Reports
Janice J Hwang, Lihong Jiang, Elizabeth Sanchez Rangel, Xiaoning Fan, Yuyan Ding, Wai Lam, Jessica Leventhal, Feng Dai, Douglas L Rothman, Graeme F Mason, Robert S Sherwin
The impact of glycemic variability on brain glucose transport kinetics amongst T1DM individuals remains unclear. 14 individuals with T1DM (age 35±4 years, BMI 26.0±1.4 kg/m2 , HbA1C 7.6±0.3) and 9 healthy control participants (age 32±4, BMI 23.1±0.8, HbA1C 5.0±0.1) wore a continuous glucose monitor (Dexcom) to measure hypoglycemia, hyperglycemia and glycemic variability for 5 days followed by 1 H magnetic resonance spectroscopy scanning in the occipital lobe to measure the change in intracerebral glucose levels during a 2-hour glucose clamp (target glucose 220 mg/dl)...
October 16, 2018: Diabetes
Nagma Zafar, Sathya S Krishnasamy, Jasmit Shah, Shesh N Rai, Daniel W Riggs, Aruni Bhatnagar, Timothy E O'Toole
Circulating angiogenic cells (CACs) of various described phenotypes participate in the regeneration of the damaged endothelium, but the abundance of these cells is highly influenced by external cues including diabetes. It is not entirely clear which CAC populations are most reflective of endothelial function nor which are impacted by diabetes. To answer these questions, we enrolled a human cohort with variable CVD risk and determined relationships between stratified levels of CACs and indices of diabetes and vascular function...
2018: PloS One
Emily Paprocki, Vincent Staggs, Susan Patton, Mark Clements
No abstract text is available yet for this article.
October 13, 2018: Journal of Diabetes Science and Technology
Kara Stoudt, Sanjay Chawla
Stress hyperglycemia is the transient increase in blood glucose as a result of complex hormonal changes that occur during critical illness. It has been described in the critically ill for nearly 200 years; patient harm, including increases in morbidity, mortality, and lengths of stay, has been associated with hyperglycemia, hypoglycemia, and glucose variability. However, there remains a contentious debate regarding the optimal glucose ranges for this population, most notably within the past 15 years. Recent landmark clinical trials have dramatically changed the treatment of stress hyperglycemia in the intensive care unit (ICU)...
October 11, 2018: Journal of Intensive Care Medicine
Ki-Ho Song, Jee-Sun Jeong, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Seung-Hyun Ko, Yu-Bae Ahn
AIMS: We aimed to investigate whether there are differences in the risk factors or markers for the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up...
October 9, 2018: Journal of Diabetes Investigation
Stefano Benedini, Roberto Codella, Andrea Caumo, Ileana Terruzzi, Livio Luzi
OBJECTIVES: The aim of this study was to investigate the acute effects of low-intensity exercise on the postprandial hormonal and metabolic milieu induced by breakfast consumption. METHODS: Exercise began 100min after the initiation of breakfast consumption and consisted of cycling at 40% of maximum oxygen uptake for 20min. Three different breakfasts were used to elicit the postprandial state: B1 = skimmed milk (125 mL) and 30g corn flakes; B2 = skimmed milk (220 mL), 200g apple, 30g cocoa cream-filled sponge cake; B3 = skimmed milk (125 mL), 50g bread, 150g apple, and 15g hazelnut and cocoa spread...
July 24, 2018: Nutrition
Sangeeta Dhir, Subhash Wangnoo, Viveka Kumar
Aim: The aim is to study the effect of glycemic level in Type 2 diabetes and cardiovascular risk factors on periodontal health. Materials and Method: Type 2 diabetic and nondiabetic patients in the age group of 35-80 years ( n = 1700) were recruited for the study. Periodontal examination included as follows: Probing depth, clinical attachment level (CAL), gingival recession, and bleeding on probing. Periodontitis was diagnosed based on the CAL levels and diabetes was diagnosed based on glycated hemoglobin (HbA1c) levels...
September 2018: Indian Journal of Endocrinology and Metabolism
Manjitpal Singh, Vimal Upreti, Yashpal Singh, Anand S Kannapur, Monish Nakra, Narendra Kotwal
Background: Evidence suggests a role of glycemic variability in intensive care unit (ICU) mortality. Objective: To assess effect of glycemic variability and ICU/in-hospital mortality. Design: Prospective, observational study. Setting: A 20-bedded medical/surgical ICU in a tertiary care hospital. Patients: Critically ill patients requiring life-support measures admitted to the ICU between November 1, 2015 and December 30, 2016 with hyperglycemia [random blood sugar (RBS) ≥200 mg%] and sequential organ failure assessment (SOFA) scores ≤9...
September 2018: Indian Journal of Endocrinology and Metabolism
Michelle L Litchman, Linda S Edelman, Gary W Donaldson
BACKGROUND: Successful diabetes management requires ongoing lifelong self-care and can require that individuals with diabetes become experts in translating care recommendations into real-life day-to-day diabetes self-care strategies. The diabetes online community comprises multiple websites that include social media sites, blogs, and discussion groups for people with diabetes to chat and exchange information. Online communities can provide disease-specific practical advice and emotional support, allow users to share experiences, and encourage self-advocacy and patient empowerment...
April 24, 2018: JMIR diabetes
Nobuyuki Takahashi, Daisuke Chujo, Hiroshi Kajio, Kohjiro Ueki
AIMS/INTRODUCTION: To evaluate the contribution of pancreatic alpha cell function to the dawn phenomenon, insulin sensitivity, hepatic glucose uptake (HGU), and glycemic variability in patients with type 1 diabetes. MATERIALS AND METHODS: In 40 patients with type 1 diabetes, arginine stimulation tests were performed, and the area under the curve of glucagon was measured using radioimmunoassays (AUCglc RIA ) and enzyme-linked immunosorbent assays (AUCglc ELISA )...
October 5, 2018: Journal of Diabetes Investigation
Mitchell Roslin, Bugra Tugertimur, Sharon Zarabi, Daniel Cottam
The majority of bariatric surgical stapling procedure concepts were developed prior to the understanding of obesity as an energy storage disease. Conventional treatments did not consider the impact of macronutrients on hormones and glucose variability. Current recommendations suggest diets low in glycemic load, with moderate protein and unsaturated fat. Roux-en-Y gastric bypass promotes glucose variability which can be harmful for health and encourage weight regain. Classic duodenal switch with short common channels may prevent absorption of measurable fat-soluble vitamins and frequently untested essential fatty acids...
October 4, 2018: Obesity Surgery
Chaima Rachdi, Rahma Damak, Feten Fekih Romdhane, Haroun Ouertani, Majda Cheour
AIM: Depression is prevalent in patients with type 2 diabetes. It may have a negative impact on the management of diabetes mellitus and could affect weight. The main aim of the investigation was to evaluate the effect of antidepressant treatment (sertraline) on anthropometric variables and glycemic control in depressed type 2 diabetic patients. METHODS: Thirty three type 2 diabetic outpatients depressed received open-label sertraline therapy for up to 12 weeks. Clinical outcome measures included the 17-item Hamilton depression rating...
October 1, 2018: Primary Care Diabetes
Mehri Jamilian, Niloufar Kazemi Sabzevar, Zatollah Asemi
Data on the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk of patients with polycystic ovary syndrome (PCOS) were collected. This investigation was conducted to evaluate the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. This randomized, double-blind, placebo-controlled trial was carried out on 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to receive 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n=30 each group) for 12 weeks...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
João P Magalhães, Pedro B Júdice, Rogério Ribeiro, Rita Andrade, João Raposo, Hélder Dores, Manuel Bicho, Luís B Sardinha
AIMS: To evaluate the impact of 1-year high intensity interval training (HIIT) combined with resistance training (RT) vs. continuous moderate intensity training (MCT) combined with RT on glycemic control, body composition, and cardiorespiratory fitness (CRF) in patients with type 2 diabetes. MATERIALS AND METHODS: A randomized controlled trial enrolled 96 participants with type 2 diabetes, for a 1-year supervised exercise intervention with three distinct groups (Control, HIIT with RT and MCT with RT)...
October 3, 2018: Diabetes, Obesity & Metabolism
Sven Delbeck, Thorsten Vahlsing, Steffen Leonhardt, Gerald Steiner, H Michael Heise
Diabetes mellitus is a widespread disease with greatly rising patient numbers expected in the future, not only for industrialized countries but also for regions in the developing world. There is a need for efficient therapy, which can be via self-monitoring of blood glucose levels to provide tight glycemic control for reducing the risks of severe health complications. Advancements in diabetes technology can nowadays offer different sensor approaches, even for continuous blood glucose monitoring. Non-invasive blood glucose assays have been promised for many years and various vibrational spectroscopy-based methods of the skin are candidates for achieving this goal...
October 3, 2018: Analytical and Bioanalytical Chemistry
Rafael Zapata-Lamana, Carlos Henríquez-Olguín, Carlos Burgos, Roberto Meneses-Valdés, Igor Cigarroa, Claudio Soto, Valentín E Fernández-Elías, Sonia García-Merino, Rodrigo Ramirez-Campillo, Antonio García-Hermoso, Hugo Cerda-Kohler
Introduction: Volume and intensity are major variables governing exercise training-mediated beneficial effects in both athletes and patients. Although polarized endurance training optimizes and maximizes physiological gains in highly trained individuals, its cardiometabolic protective-effects have not been established. The purpose of the present single site, randomized-controlled trial was to compare the effects of 12-weeks of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and polarized volume training (POL) programs on cardiometabolic risk factors in young overweight and obese women...
2018: Frontiers in Physiology
Juliano B Farinha, Thiago R Ramis, Alexandra F Vieira, Rodrigo C O Macedo, Josianne Rodrigues-Krause, Francesco P Boeno, Helena T Schroeder, Carlos Henrique Müller, Winston Boff, Maurício Krause, Paulo Ivo H De Bittencourt, Alvaro Reischak-Oliveira
AIMS: To investigate the effects of high-intensity interval training (HIIT) and/or strength training (ST) on inflammatory, oxidative stress (OS) and glycemic parameters in type 1 diabetes (T1DM) patients. METHODS: After a 4-week control period, volunteers were randomly assigned to 10-week HIIT, ST or ST + HIIT protocol, performed 3×/week. Blood biochemistry, anthropometric, strength and cardiopulmonary fitness variables were assessed. Outcomes were analyzed via generalized estimating equations (GEE), with Bonferroni post hoc analysis...
September 19, 2018: Journal of Diabetes and its Complications
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