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Early attachment

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https://www.readbyqxmd.com/read/29149699/tetrahymena-cilia-cap-is-built-in-a-multi-step-process-a-study-by-atomic-force-microscopy
#1
Cecília Seixas, João Gonçalves, Luís Viseu Melo, Helena Soares
Cilia are complex and dynamic organelles that have motility and sensory functions. Defects in cilia biogenesis and function are at the origin of human ciliopathies. In motile cilia, a basal body organizes the axoneme composed of nine microtubule doublets surrounding a central pair of singlet microtubules. The distal ends of axonemal microtubules are attached to the membrane by microtubule-capping structures. Little is known about the early steps of cilium assembly. Although cilia grow and resorb from their distal tips, it remains poorly understood where and when the components of the caps are first assembled...
October 20, 2017: Protist
https://www.readbyqxmd.com/read/29149620/the-dopamine-d4-receptor-gene-birth-weight-maternal-depression-maternal-attention-and-the-prediction-of-disorganized-attachment-at-36-months-of-age-a-prospective-gene%C3%A3-environment-analysis
#2
Justin Graffi, Ellen Moss, Alexia Jolicoeur-Martineau, Gal Moss, Vanessa Lecompte, Katherine Pascuzzo, Vanessa Babineau, Cathryn Gordon-Green, Viara R Mileva-Seitz, Klaus Minde, Roberto Sassi, Meir Steiner, James L Kennedy, Helene Gaudreau, Robert Levitan, Michael J Meaney, Ashley Wazana
BACKGROUND: Efforts to understand the developmental pathways for disorganized attachment reflect the importance of disorganized attachment on the prediction of future psychopathology. The inconsistent findings on the prediction of disorganized attachment from the dopamine D4 receptor (DRD4) gene, birth weight, and maternal depression as well as the evidence supporting the contribution of early maternal care, suggest the importance of exploring a gene by environment model. METHODS: Our sample is from the Maternal Adversity, Vulnerability, and Neurodevelopment project; consisting of 655 mother-child dyads...
November 14, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29145330/pathologic-femoral-fracture-due-to-tenofovir-induced-fanconi-syndrome-in-patient-with-chronic-hepatitis-b-a-case-report
#3
You-Sung Suh, Dong-Il Chun, Sung-Woo Choi, Hwan-Woong Lee, Jae-Hwi Nho, Soon-Hyo Kwon, Jae-Ho Cho, Sung Hun Won
RATIONALE: We report a case of a hepatitis B virus (HBV)-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fracture. To our best knowledge, this is the first report in the English literature about pathologic femoral fracture due to tenofovir-induced Fanconi syndrome in patient with chronic hepatitis B (CHB). The present report describes detailed our experience with the diagnosis of pathologic femoral fracture due to tenofovir-induced Fanconi syndrome and treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143567/couple-relationship-quality-and-offspring-attachment-security-a-systematic-review-with-meta-analysis
#4
Evelyn S Tan, Jennifer E McIntosh, Emily J Kothe, Jessica E Opie, Craig A Olsson
This paper provides a meta-analytic examination of strength and direction of association between parents' couple relationship quality and early childhood attachment security (5 years and under). A comprehensive search of four EBSCOhost databases, Informit, Web of Science, and grey literature yielded 24 studies meeting eligibility criteria. Heterogeneity of the couple quality construct and measurement was marked. To disaggregate potentially differentially acting factors, we grouped homogeneous studies, creating two predictor variables defined as "positive dyadic adjustment" and "inter-parental conflict"...
November 16, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/29143536/time-for-a-new-zeitgeist-in-perinatal-mental-health
#5
Fiona Judd, Louise Kathryn Newman, Angela A Komiti
Perinatal depression, and to a lesser extent anxiety, has been the focus of interest for perinatal psychiatrists for several decades. Policy and substantial funding has supported this. We argue that it is now time to change this focus and to invest greater funding to support clinical and research effort in 'high-risk' caregivers and their infants. We define high-risk caregivers as those who are likely to have attachment and relationship difficulties with their infant as a result of their own developmental experiences, personality difficulties and/or trauma-related mental disorders, often complicated by substance abuse, depression and anxiety...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29140375/plasma-of-argon-increases-cell-attachment-and-bacterial-decontamination-on-different-implant-surfaces
#6
Luigi Canullo, Tullio Genova, Hom-Lay Wang, Stefano Carossa, Federico Mussano
PURPOSE: This in vitro study tested the effects of argon atmospheric pressure dielectric barrier discharge (APDBD) on different implant surfaces with regard to physical changes, bacterial decontamination, and osteoblast adhesion. MATERIALS AND METHODS: Seven hundred twenty disks with three different surface topographies-machined (MAC), titanium plasma-sprayed (TPS), and zirconia-blasted and acid-etched (ZRT)-were tested in this experiment. Bacterial adhesion tests were performed repeatedly on a simplified biofilm of Streptococcus mitis...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29138239/expanding-the-chondroitin-glycoproteome-of-caenorhabditis-elegans
#7
Fredrik Noborn, Alejandro Gomez Toledo, Waqas Nasir, Jonas Nilsson, Tabea Dierker, Lena Kjellén, Göran Larson
Chondroitin sulfate proteoglycans (CSPGs) are important structural components of connective tissues in essentially all metazoan organisms. In vertebrates, CSPGs are involved also in more specialized processes such as neurogenesis and growth factor signaling. In invertebrates, however, knowledge of CSPGs core proteins and proteoglycan-related functions is relatively limited, even for Caenorhabditis elegans. This nematode produces large amounts of non-sulfated chondroitin in addition to low-sulfated chondroitin sulfate chains...
November 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29135364/mothers-neural-and-behavioral-responses-to-their-infants-distress-cues-the-role-of-secure-base-script-knowledge
#8
Ashley M Groh, Katherine C Haydon
This research examined mothers' secure base script knowledge-reflected in the ability to generate narratives in which attachment-relevant problems are recognized, competent help is offered, and problems are resolved-and its significance for early-stage processing of infants' distress cues, using event-related potentials in an emotion oddball task. Mothers with lower secure base script knowledge exhibited (a) a heightened P3b response-reflective of greater allocation of cognitive resources-to their infants' distressed (but not happy) target facial expressions; (b) a larger P3b response to their infants' distressed (compared with happy) target facial expressions, which is indicative of allocating disproportional attentional resources to processing their infants' distress; and (c) poorer accuracy in identifying their infants' distressed target facial expressions...
November 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29133281/should-medical-assistance-in-dying-be-extended-to-incompetent-patients-with-dementia-research-protocol-of-a-survey-among-four-groups-of-stakeholders-from-quebec-canada
#9
Gina Bravo, Claudie Rodrigue, Vincent Thériault, Marcel Arcand, Jocelyn Downie, Marie-France Dubois, Sharon Kaasalainen, Cees M Hertogh, Sophie Pautex, Lieve Van den Block
BACKGROUND: Alzheimer's disease and related disorders affect a growing number of people worldwide. Quality of life is generally good in the early stages of these diseases. However, many individuals fear living through the advanced stages. Such fears are triggering requests for medical assistance in dying (MAiD) by patients with dementia. Legislation was recently passed in Canada and the province of Quebec allowing MAiD at the explicit request of a patient who meets a set of eligibility criteria, including competence...
November 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29131716/compassion-focused-therapy-as-an-intervention-for-adult-survivors-of-sexual-abuse
#10
Lisa McLean, Stanley R Steindl, Matthew Bambling
Child sexual abuse can have long-term negative impacts across psychological, physical, and interpersonal domains. Some of the common issues for survivors of sexual abuse include shame and self-blame, attachment-based difficulties, avoidant coping strategies, and reduced capacity for self-compassion. Compassion-focused therapy is a transdiagnostic intervention that specifically responds to these concerns. Compassion-focused therapy was originally developed for clients who experience high levels of shame and self-criticism and aims to strengthen the soothing and affiliative system through the cultivation of compassion...
November 13, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29127504/glycocalyx-in-atherosclerosis-relevant-endothelium-function-and-as-a-therapeutic-target
#11
REVIEW
Ronodeep Mitra, Gerard Leland O'Neil, Ian Chandler Harding, Ming Jie Cheng, Solomon Arko Mensah, Eno Essien Ebong
PURPOSE OF REVIEW: The cell surface-attached extracellular glycocalyx (GCX) layer is a major contributor to endothelial cell (EC) function and EC-dependent vascular health and is a first line of defense against vascular diseases including atherosclerosis. Here, we highlight our findings regarding three GCX-dependent EC functions, which are altered when GCX is shed and in atherosclerosis. We discuss why the GCX is a viable option for the prevention and treatment of atherosclerosis. RECENT FINDINGS: GCX regulated EC activities such as barrier and filtration function, active cell-to-cell communication, and vascular tone mediation contribute to function of the entire vascular wall...
November 10, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29125205/reconstructing-pectoral-appendicular-muscle-anatomy-in-fossil-fish-and-tetrapods-over-the-fins-to-limbs-transition
#12
Julia L Molnar, Rui Diogo, John R Hutchinson, Stephanie E Pierce
The question of how tetrapod limbs evolved from fins is one of the great puzzles of evolutionary biology. While palaeontologists, developmental biologists, and geneticists have made great strides in explaining the origin and early evolution of limb skeletal structures, that of the muscles remains largely unknown. The main reason is the lack of consensus about appendicular muscle homology between the closest living relatives of early tetrapods: lobe-finned fish and crown tetrapods. In the light of a recent study of these homologies, we re-examined osteological correlates of muscle attachment in the pectoral girdle, humerus, radius, and ulna of early tetrapods and their close relatives...
November 10, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29119744/cardiac-monitoring-and-the-use-of-a-systematic-approach-in-interpreting-electrocardiogram-rhythms
#13
Richard Hatchett
Attaching a patient to a cardiac monitor and obtaining a clear electrocardiogram (ECG) trace may now be considered basic nursing skills. In line with the UK professional standards and code of conduct, healthcare practitioners are required to practise effectively and preserve patients' safety. Therefore, healthcare practitioners undertaking cardiac monitoring are required to have a basic understanding of normal sinus rhythms and some of the common types of cardiac arrhythmia. This will enable prompt recognition of early warning signs of potential and actual clinical conditions, and the timely initiation of treatment...
November 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29117994/role-of-adenosine-1a-receptor-signaling-on-gfr-early-after-the-induction-of-sepsis
#14
Jonathan M Street, Erik H Koritzinsky, Tiffany R Bellomo, Xuzhen Hu, Peter S T Yuen, Robert A Star
Sepsis and acute kidney injury (AKI) synergistically increase morbidity and mortality in the ICU. How sepsis reduces GFR and causes AKI is poorly understood; one proposed mechanism includes tubuloglomerular feedback (TGF). When sodium reabsorption by the proximal tubules is reduced in normal animals, the macula densa senses increased luminal sodium chloride, then adenosine 1a receptor (A1aR) signaling triggers tubuloglomerular feedback, reducing GFR through afferent arteriole vasoconstriction. We measured GFR and systemic hemodynamics early during cecal ligation and puncture-induced sepsis in wild-type and A1aR knockout mice...
November 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29117427/impact-of-a-nursing-in-psychiatry-course-on-students-attitudes-toward-mental-health-disorders
#15
Goran Arbanas, Dina Bosnjak, Tamara Sabo
Negative attitudes toward patients with mental illnesses are not uncommon among health professionals, and lead to poorer quality and outcomes of care. Because attitudes are formed early in life, the current study aimed to investigate if teaching psychiatry in secondary school nursing students (i.e., adolescents) changes attitudes toward three prevalent psychiatric disorders: schizophrenia, posttraumatic stress disorder (PTSD), and depression. A pilot quasi-experimental study was conducted with 51 fourth-year students in secondary nursing school who completed a questionnaire regarding attitudes toward these disorders on the first and last day of their Nursing in Psychiatry course...
November 8, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29117102/mechanisms-of-entry-and-endosomal-pathway-of-african-swine-fever-virus
#16
REVIEW
Elena G. Sánchez, Daniel Pérez-Núñez, Yolanda Revilla
African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and presently spreading in Russia and neighboring countries, including Poland and recently, the Czech Republic. This uncontrolled dissemination is a world-wide threat, as no specific protection or vaccine is available. ASFV is a very complex icosahedral, enveloped virus about 200 nm in diameter, which infects several members of pigs. The virus enters host cells by receptor-mediated endocytosis that depends on energy, vacuolar pH and temperature...
November 8, 2017: Vaccines
https://www.readbyqxmd.com/read/29115666/potential-roles-of-metalloproteinases-of-endometrium-derived-exosomes-in-embryo-maternal-crosstalk-during-implantation
#17
REVIEW
Zeinab Latifi, Amir Fattahi, Ali Ranjbaran, Hamid Reza Nejabati, Kazuhiko Imakawa
During embryo implantation, crosstalk between the endometrial epithelium and the blastocyst, especially the trophoblasts, is a prerequisite for successful implantation. During this crosstalk, various molecular and functional changes occur to promote synchrony between the embryo and the endometrium as well as the uterine cavity microenvironment. In the past few years, growing evidence has shown that endometrium-derived exosomes play pivotal roles in the embryonic-maternal crosstalk during implantation, although the exact mechanism of this crosstalk has yet to be determined...
November 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29111823/surgical-results-in-ocriplasmin-candidates-with-symptomatic-vitreomacular-traction-syndrome
#18
Dario H Vasquez, Juan C Altamirano, Angel Casaus, Rodrigo A Del Valle, Roberto Gonzalez, Alejandro Gonzalez-De La Rosa, Jose Navarro-Partida, Martin A Vasquez, Arturo Santos
PURPOSE: To report surgical outcomes in a series of cases with symptomatic vitreomacular traction that met MIVI-TRUST (Microplasmin for intravitreous injection-traction release without surgical treatment) criteria for ocriplasmin use who underwent primary 25-gauge vitrectomy. MATERIALS AND METHODS: A single-center retrospective chart review study was performed in patients who underwent primary 25-gauge vitrectomy for symptomatic vitreomacular traction (VTM) from January 2013 through January 2016...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29108599/women-s-employment-trajectories-during-early-adulthood-in-urban-china-a-cohort-comparison
#19
Shengwei Sun, Feinian Chen
This study uses retrospective work history data from CGSS 2008 and employs group-based trajectory analysis to model the diverse employment trajectories of cohorts of urban Chinese women (born in the 1940s-1970s) during young adulthood (age 20-35). We identify ideal-types of urban women's employment trajectories and explore traits associated with each group type. In particular, we examine whether and how the timing of marriage and fertility as well as socioeconomic background help to distinguish patterns of women's labor force attachment in young adulthood...
November 2017: Social Science Research
https://www.readbyqxmd.com/read/29107054/selecting-the-correct-cellular-model-for-assessing-of-the-biological-response-of-collagen-based-biomaterials
#20
Natalia Davidenko, Samir Hamaia, Daniel V Bax, Jean-Daniel Malcor, Carlos F Schuster, Donald Gullberg, Richard W Farndale, Serena M Best, Ruth E Cameron
Accurate evaluation of the biological performance of biomaterials requires the correct assessment of their native-like cell ligation properties. However, cell attachment studies often overlook the details of the substrate-cell binding mechanisms, be they integrin-mediated or non-specific, and ignore the class- and species-specificities of the cell adhesion receptor involved. In this work we have used different collagen (Col) substrates (fibrillar collagens I, II and III and network-forming Col IV), containing different affinity cell-recognition motifs, to establish the influence of the receptor identity and species-specificity on collagen-cell interactive properties...
October 26, 2017: Acta Biomaterialia
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