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https://www.readbyqxmd.com/read/30039504/utility-of-the-virtual-liver-parenchymal-perfusion-area-using-a-commercially-available-workstation-in-transarterial-chemoembolization-for-hepatocellular-carcinoma
#1
Mitsuhiro Kinoshita, Katsuya Takechi, Yuta Arai, Ryozo Shirono, Yoshihiro Nagao, Shoichi Izumi, Takuya Akagawa, Shiori Noda, Shoichiro Takao, Chikara Ogawa, Daisuke Suwa, Katsuyoshi Tamaki, Naoto Uyama, Yoko Akagawa, Kyosuke Osaki, Norio Ohnishi, Hayato Tani
PURPOSE: To evaluate the accuracy of the virtual liver parenchymal perfusion area using a commercially available workstation and liver analysis software in conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This method was retrospectively applied to 29 treated HCCs in 23 patients. The virtual embolic area (VEA) was estimated based on cone beam computed tomography during hepatic arteriography using a commercially available workstation and liver analysis software by two observer groups (group A: experts; group B: semi-experts)...
July 23, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29935812/microvessel-density-and-angiogenesis-in-primary-hepatic-malignancies-differential-expression-of-cd31-and-vegfr-2-in-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#2
Hans Bösmüller, Vanessa Pfefferle, Zeid Bittar, Veit Scheble, Marius Horger, Bence Sipos, Falko Fend
BACKGROUND: Microvessel density is an indicator of tumor-driven neoangiogenesis. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have distinct vascular patterns, which are also reflected in their imaging characteristics. Since a significant proportion of HCC are treated without biopsy confirmation, it is essential to discriminate HCC and ICC radiologically. The aim of our study was therefore to compare microvessel density and expression of VEGFR-2 in HCC and ICC, since these data may ultimately help us to better understand their imaging characteristics...
June 19, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29879746/interobserver-agreement-for-contrast-enhanced-ultrasound-ceus-based-standardized-algorithms-for-the-diagnosis-of-hepatocellular-carcinoma-in-high-risk-patients
#3
Barbara Schellhaas, Lukas Pfeifer, Christian Kielisch, Ruediger Stephan Goertz, Markus F Neurath, Deike Strobel
OBJECTIVES:  This pilot study aimed at assessing interobserver agreement with two contrast-enhanced ultrasound (CEUS) algorithms for the diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. METHODS:  Focal liver lesions in 55 high-risk patients were assessed independently by three blinded observers with two standardized CEUS algorithms: ESCULAP (Erlanger Synopsis of Contrast-Enhanced Ultrasound for Liver Lesion Assessment in Patients at risk) and ACR-CEUS-LI-RADSv...
June 7, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29859792/differential-association-between-circulating-lymphocyte-populations-with-outcome-after-radiation-therapy-in-subtypes-of-liver-cancer
#4
Clemens Grassberger, Theodore S Hong, Tai Hato, Beow Y Yeap, Jennifer Y Wo, Mark Tracy, Thomas Bortfeld, John A Wolfgang, Christine E Eyler, Lipika Goyal, Jeffrey W Clark, Christopher H Crane, Eugene J Koay, Mark Cobbold, Thomas F DeLaney, Rakesh K Jain, Andrew X Zhu, Dan G Duda
PURPOSE: Irradiation may have significant immunomodulatory effects that impact tumor response and could potentiate immunotherapeutic approaches. The purposes of this study were to prospectively investigate circulating lymphoid cell population fractions during hypofractionated proton therapy (HPT) in blood samples of liver cancer patients and to explore their association with survival. METHODS AND MATERIALS: We collected serial blood samples before treatment and at days 8 and 15 of HPT from 43 patients with liver cancer-22 with hepatocellular carcinoma (HCC) and 21 with intrahepatic cholangiocarcinoma (ICC)-enrolled in a phase 2 clinical trial...
August 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29778232/nuclear-bap1-loss-is-common-in-intrahepatic-cholangiocarcinoma-and-a-subtype-of-hepatocellular-carcinoma-but-rare-in-pancreatic-ductal-adenocarcinoma
#5
Asmaa Mosbeh, Khalil Halfawy, Wael S Abdel-Mageed, Dina Sweed, Mohamed H Abdel-Rahman
Deletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the same tumors by genotyping. We identified high frequency 4/8 (50%) of BAP1 loss in intrahepatic cholangicarcinoma (ICC)...
August 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29755690/prognostic-value-of-line-1-methylation-level-in-321-patients-with-primary-liver-cancer-including-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#6
Tatsunori Miyata, Yo-Ichi Yamashita, Yoshifumi Baba, Kazuto Harada, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Mototsugu Shimokawa, Hideo Baba
Background: The methylation level of long interspersed nucleotide element-1 (LINE-1) is a good surrogate marker of the global DNA methylation level. The relationship between LINE-1 methylation level and prognosis in primary liver cancer (PLC) patients remains unclear. Results: LINE-1 methylation levels were significantly lower in HCC and cHCC-CC tissues, but not in ICC tissues, than those in noncancerous liver parenchyma (HCC: p < 0.0001; cHCC-CC: p < 0.001; and ICC: p = 0...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29746696/detection-of-albumin-expression-by-rna-in-situ-hybridization-is-a-sensitive-and-specific-method-for-identification-of-hepatocellular-carcinomas-and-intrahepatic-cholangiocarcinomas
#7
Fan Lin, Jianhui Shi, Hanlin L Wang, Xiao-Jun Ma, Robert Monroe, Yuling Luo, Zongming Chen, Haiyan Liu
Objectives: Inconsistent data on detection of albumin expression by ribonucleic acid (RNA) in situ hybridization have been reported. We investigated the utility of RNAscope (Advanced Cell Diagnostics, Hayward, CA) in detection of albumin in hepatocellular carcinomas (HCCs), intrahepatic cholangiocarcinomas (ICCs), and carcinomas from various organs using manual and automated staining. Methods: RNAscope for albumin detection was performed on 482 cases on tissue microarray sections and on 22 cases of ICC, including 14 surgical resection and eight core biopsy specimens...
May 31, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29667093/the-predictive-value-of-staging-systems-and-inflammation-scores-for-patients-with-combined-hepatocellular-cholangiocarcinoma-after-surgical-resection-a-retrospective-study
#8
Chaobin He, Yize Mao, Jun Wang, Yunda Song, Xin Huang, Xiaojun Lin, Shengping Li
BACKGROUND: Combined hepatocellular cholangiocarcinoma (cHCC-CC) is a rare form of primary liver tumor. A specific staging system for predicting survival in patients with cHCC-CC is not available. The aim of the present study was to evaluate the ability of staging systems and inflammation-based scores to predict overall survival (OS) and progression-free survival (PFS) of patients with cHCC-CC after surgical resection. METHODS: The data from 99 patients with cHCC-CC after surgical resection from June 2000 and January 2017 were retrospectively collected...
July 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29643652/utility-of-cytokeratin7-immunocytochemistry-in-the-cytopathological-diagnosis-of-fibrolamellar-hepatocellular-carcinoma
#9
Rashi Garg, Radhika Srinivasan, Pranab Dey, Priya Singh, Nalini Gupta, Arvind Rajwanshi
Objective: To distinguish fibrolamellar hepatocellular carcinoma (FL-HCC) variant from the conventional hepatocellular carcinoma (HCC) by cytology, immunocytochemistry, and morphometry. Study Design: Retrospective detailed cytomorphological, immunocytochemical, and morphometric analysis was performed in 6 cases of FL-HCC reported on fine needle aspiration. Cell block immunocytochemistry (CB-ICC) for CK7 and CD68 was performed in four cases. Morphometry was carried out with Cell A software...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643204/l1-retrotransposition-is-a-common-feature-of-mammalian-hepatocarcinogenesis
#10
Stephanie N Schauer, Patricia E Carreira, Ruchi Shukla, Daniel J Gerhardt, Patricia Gerdes, Francisco J Sanchez-Luque, Paola Nicoli, Michaela Kindlova, Serena Ghisletti, Alexandre Dos Santos, Delphine Rapoud, Didier Samuel, Jamila Faivre, Adam D Ewing, Sandra R Richardson, Geoffrey J Faulkner
The retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is a continuing source of germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of cancer, and L1 mutagenesis has been described in numerous human malignancies. We previously employed retrotransposon capture sequencing (RC-seq) to analyze hepatocellular carcinoma (HCC) samples from patients infected with hepatitis B or hepatitis C virus and identified L1 variants responsible for activating oncogenic pathways. Here, we have applied RC-seq and whole-genome sequencing (WGS) to an Abcb4 (Mdr2) -/- mouse model of hepatic carcinogenesis and demonstrated for the first time that L1 mobilization occurs in murine tumors...
May 2018: Genome Research
https://www.readbyqxmd.com/read/29545603/notch2-controls-hepatocyte-derived-cholangiocarcinoma-formation-in-mice
#11
Jingxiao Wang, Mingjie Dong, Zhong Xu, Xinhua Song, Shanshan Zhang, Yu Qiao, Li Che, John Gordan, Kaiwen Hu, Yan Liu, Diego F Calvisi, Xin Chen
Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with poor clinical outcome. Studies have shown that a subset of human ICCs may originate from mature hepatocytes. However, the mechanisms driving the trans-differentiation of hepatocytes into malignant cholangiocytes remain poorly defined. We adopted lineage tracing techniques and an established murine hepatocyte-derived ICC model by hydrodynamic injection of activated forms of AKT (myr-AKT) and Yap (YapS127A) proto-oncogenes...
June 2018: Oncogene
https://www.readbyqxmd.com/read/29526953/budd-chiari-syndrome-and-esophageal-achalasia-a-case-of-unrecognized-intrahepatic-cholangiocarcinoma-invading-multiple-organs
#12
Keisuke Kakisaka, Kei Endo, Ryo Sugimoto, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver cancer, although its occurrence is relatively rare. Budd-Chiari syndrome (BCS) is characterized by outflow obstruction from the liver, with hepatocellular carcinoma being the most common cause of malignant BCS. In this case report, we describe the occurrence of an unrecognized ICC that induced BCS and esophageal achalasia.
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29520041/tobacco-alcohol-use-and-risk-of-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma-the-liver-cancer-pooling-project
#13
Jessica L Petrick, Peter T Campbell, Jill Koshiol, Jake E Thistle, Gabriella Andreotti, Laura E Beane-Freeman, Julie E Buring, Andrew T Chan, Dawn Q Chong, Michele M Doody, Susan M Gapstur, John Michael Gaziano, Edward Giovannucci, Barry I Graubard, I-Min Lee, Linda M Liao, Martha S Linet, Julie R Palmer, Jenny N Poynter, Mark P Purdue, Kim Robien, Lynn Rosenberg, Catherine Schairer, Howard D Sesso, Rashmi Sinha, Meir J Stampfer, Marcia Stefanick, Jean Wactawski-Wende, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Neal D Freedman, Katherine A McGlynn
BACKGROUND: While tobacco and alcohol are established risk factors for hepatocellular carcinoma (HCC), the most common type of primary liver cancer, it is unknown whether they also increase the risk of intrahepatic cholangiocarcinoma (ICC). Thus, we examined the association between tobacco and alcohol use by primary liver cancer type. METHODS: The Liver Cancer Pooling Project is a consortium of 14 US-based prospective cohort studies that includes data from 1,518,741 individuals (HCC n = 1423, ICC n = 410)...
April 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29514406/liver-transplantation-for-intrahepatic-cholangiocarcinoma
#14
David D Lee, Kristopher P Croome, Kaitlyn R Musto, Jose Melendez, Ghassan Tranesh, Raouf Nakhleh, C Burcin Taner, Justin H Nguyen, Tushar Patel, Denise M Harnois
Although hepatocellular carcinoma (HCC) has become a common indication for liver transplantation (LT), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) are historically contraindicated due to their aggressive behavior. On the basis of recent experiences, some groups have proposed a clinical trial investigating the role of LT for patients with early cholangiocarcinoma (CCA), defined as a single lesion ≤ 2 cm. The purpose of this study is to assess the clinicopathologic features and outcomes following LT for patients who were initially diagnosed with HCC and subsequently found to have either ICC or cHCC-CCA on explant...
May 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29491686/intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-for-predicting-histological-grade-of-hepatocellular-carcinoma-comparison-with-conventional-diffusion-weighted-imaging
#15
Shao-Cheng Zhu, Yue-Hua Liu, Yi Wei, Lin-Lin Li, She-Wei Dou, Ting-Yi Sun, Da-Peng Shi
AIM: To compare intravoxel incoherent motion (IVIM)-derived parameters with conventional diffusion-weighted imaging (DWI) parameters in predicting the histological grade of hepatocellular carcinoma (HCC) and to evaluate the correlation between the parameters and the histological grades. METHODS: A retrospective study was performed. Sixty-two patients with surgically confirmed HCCs underwent diffusion-weighted magnetic resonance imaging with twelve b values (10-1200 s/mm2 )...
February 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29487707/intrahepatic-cholangiocarcinoma-in-the-setting-of-hbv-related-cirrhosis-differentiation-with-hepatocellular-carcinoma-by-using-intravoxel-incoherent-motion-diffusion-weighted-mr-imaging
#16
Yi Wei, Feifei Gao, Dandan Zheng, Zixing Huang, Min Wang, Fubi Hu, Chenyang Chen, Ting Duan, Jie Chen, Likun Cao, Bin Song
Accurate preoperative differentiation of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) in the setting of cirrhotic liver is of great clinical significance because the treatment and prognosis of these entities differ markedly. Through a retrospectively research, we sought to determine the diagnostic performances of intravoxel incoherent motion (IVIM) and diffusion weighted imaging (DWI) parameters in the differentiating of ICC and HCC. According to the results, we found that apparent diffusion coefficient (ADC) derived from mono-exponential model and true ADC (ADCslow ) derived from bi-exponential model can be used to distinguish the ICC and HCC, and ADCslow entailed the higher diagnostic performance than ADC...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29486800/mri-features-of-combined-hepatocellular-cholangiocarcinoma-versus-mass-forming-intrahepatic-cholangiocarcinoma
#17
Jennifer Sammon, Sandra Fischer, Ravi Menezes, Hooman Hosseini-Nik, Sara Lewis, Bachir Taouli, Kartik Jhaveri
BACKGROUND: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare primary liver tumor, which has overlapping imaging features with mass forming intra-hepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC). Previous studies reported imaging features more closely resemble ICC and the aim of our study was to examine the differential MRI features of cHCC-CC and ICC with emphasis on enhancement pattern observations of gadolinium enhanced MRI. METHODS: Institutional review board approval with consent waiver was obtained for this retrospective bi-centric study...
February 27, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29473340/a-nomogram-incorporating-six-easily-obtained-parameters-to-discriminate-intrahepatic-cholangiocarcinoma-and-hepatocellular-carcinoma
#18
Mengmeng Wang, Yuzhen Gao, Huijuan Feng, Elisa Warner, Mingrui An, Jian'an Jia, Shipeng Chen, Meng Fang, Jun Ji, Xing Gu, Chunfang Gao
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are the most prevalent histologic types of primary liver cancer (PLC). Although ICC and HCC share similar risk factors and clinical manifestations, ICC usually bears poorer prognosis than HCC. Confidently discriminating ICC and HCC before surgery is beneficial to both treatment and prognosis. Given the lack of effective differential diagnosis biomarkers and methods, construction of models based on available clinicopathological characteristics is in need...
March 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29467557/esophageal-metastasis-of-stem-cell-subtype-hepatocholangiocarcinoma-rare-presentation-of-a-rare-tumor
#19
Maëva Salimon, Nicolas Chapelle, Tamara Matysiak-Budnik, Jean-François Mosnier, Eric Frampas, Yann Touchefeu
Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable cHCC-ICC with stem-cell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29452147/combination-of-kras-activation-and-pten-deletion-contributes-to-murine-hepatopancreatic-ductal-malignancy
#20
Yun-Kai Lin, Zheng Fang, Tian-Yi Jiang, Zheng-Hua Wan, Yu-Fei Pan, Yun-Han Ma, Yuan-Yuan Shi, Ye-Xiong Tan, Li-Wei Dong, Yong-Jie Zhang, Hong-Yang Wang
Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma...
May 1, 2018: Cancer Letters
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