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https://www.readbyqxmd.com/read/28746988/the-association-between-clinical-outcome-and-cd8-lymphocytic-infiltration-in-advanced-stages-of-colorectal-cancer-differs-by-latent-virus-infection-in-the-tumour-tissue
#1
Britta Kleist, Marius Bagdonas, Prakash Oommen, Irina Schoenhardt, Janina Levermann, Micaela Poetsch
AIMS: In near future, an immunoscore based on the quantification of lymphocytic populations can be expected as fundamental supplement of colorectal cancer (CRC) classification. This study explored, whether latent viral infection has an influence on prognostic relevant host immunity in CRC. METHODS AND RESULTS: CD8+ lymphocytic infiltration in three tumour compartments of 121 CRC was compared with clinical data and occurrence of latent infection with HSV1, HSV2, CMV, EBV, HPV16, and HPV18 in the tumour tissue, which was determined by PCR...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28688377/no-role-of-herpes-simplex-virus-type-2-hsv-2-infection-on-hiv-progression-in-na%C3%A3-ve-hiv-patients
#2
Minoo Mohraz, Arezoo Aghakhani, Saeedeh Moayedi-Nia, Mohammad Banifazl, Alireza Janbakhsh, Setareh Mamishi, Afsaneh Karami, Anahita Bavand, Pegah Mirzapour, Amitis Ramezani
Background: Herpes simplex virus type 2 (HSV-2) is a common infection in human immunodeficiency virus (HIV) patients and may accelerate HIV progression by rising HIV viral load and decreasing CD4 count. However, the available data regarding the influence of HSV-2 seropositivity on HIV progression in HIV individuals are inconclusive. Therefore, we aimed to determine HSV-2 seroprevalence in naïve HIV patients and normal controls and also investigate the relation of HIV viral load and CD4 count with HSV-2 seropositivity...
July 9, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28683784/decreasing-seroprevalence-of-herpes-simplex-virus-type-1-and-type-2-in-germany-leaves-many-people-susceptible-to-genital-infection-time-to-raise-awareness-and-enhance-control
#3
Gerit Korr, Michael Thamm, Irina Czogiel, Christina Poethko-Mueller, Viviane Bremer, Klaus Jansen
BACKGROUND: Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are scarce. A previous study found higher HSV1/2 seroprevalences in women in East Germany than in women in West Germany. We assessed changes in the HSV1/2 seroprevalences over time and investigated determinants associated with HSV1/2 seropositivity to guide prevention and control...
July 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28566076/-evaluation-of-viral-etiology-in-central-nervous-system-infections-from-a-university-hospital-point-of-view-in-izmir-based-on-seven-years-data
#4
Ayşın Zeytinoğlu, Selda Erensoy, Rüçhan Sertöz, İmre Altuğlu, Candan Çiçek, Münevver Kayın, Hadiye Şirin, Şafak Taner
The serious diseases of the central nervous system (CNS); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. Nucleic acid testing (NAT) is the tool of choice for viral diagnosis in CNS infections. In this study, viral etiological agents found in cerebrospinal fluid (CSF) samples sent to our university hospital virology laboratory for laboratory diagnosis of CNS infections were retrospectively evaluated and results were compared with other reports from our country...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28491117/herpes-virus-seroepidemiology-in-the-adult-swedish-population
#5
Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim, Fredrik Elgh
BACKGROUND: Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex type 1 (HSV1), Herpes simplex type 2 (HSV2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV) and Human herpes virus type 6 (HHV6) in an adult Swedish population (35-95 years of age). METHODS: Presence of antibodies against the respective viruses in serum from individuals in the Betula study was determined with an enzyme-linked immunosorbent assay (ELISA)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28468588/a-herpes-simplex-virus-type-2-encoded-microrna-promotes-tumor-cell-metastasis-by-targeting-suppressor-of-cytokine-signaling-2-in-lung-cancer
#6
Xudong Wang, Shupeng Liu, Zhenhua Zhou, Hongli Yan, Jianru Xiao
Certain viruses use microRNAs to regulate the expression of their own genes, host genes, or both. A number of microRNAs expressed by herpes simplex virus type 2 have been confirmed by previous studies. However, whether these microRNAs play a role in the metastasis of lung cancers and how these viral microRNAs precisely regulated the tumor biological process in lung cancer bone metastasis remain obscure. We recently identified the high expression of an acutely and latently expressed viral microRNA, Hsv2-miR-H9-5p, encoded by herpes simplex virus type 2 latency-associated transcript through microarray and quantitative polymerase chain reaction analyses which compared the expression of microRNAs in bone metastasis from lung cancer with primary lung cancers...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28282487/establishment-of-multiplex-solid-phase-strip-pcr-test-for-detection-of-24-ocular-infectious-disease-pathogens
#7
Satoko Nakano, Sunao Sugita, Yasuhiro Tomaru, Ayumi Hono, Takako Nakamuro, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Masayo Takahashi, Norio Shimizu
Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens. Methods: A new multiplex strip PCR was established to detect 24 common ocular infectious disease pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus (HHV) 6, HHV7, HHV8, human T-cell lymphotropic virus (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28242091/-dermatoses-and-herpes-superinfection-a-retrospective-study-of-34%C3%A2-cases
#8
V Seta, F Fichel, J-F Méritet, S Bouam, N Franck, M-F Avril, N Dupin
BACKGROUND: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated. AIM: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department. PATIENTS AND METHODS: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis...
March 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28178213/neurotrophic-factors-ngf-gdnf-and-ntn-selectively-modulate-hsv1-and-hsv2-lytic-infection-and-reactivation-in-primary-adult-sensory-and-autonomic-neurons
#9
Andy A Yanez, Telvin Harrell, Heather J Sriranganathan, Angela M Ives, Andrea S Bertke
Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for survival, some populations cease expression of NGF receptors postnatally, and the viruses preferentially establish latency in different populations of sensory neurons responsive to other neurotrophic factors (NTFs)...
February 7, 2017: Pathogens
https://www.readbyqxmd.com/read/28150409/bizarre-cell-dysplasia-of-the-cervix
#10
Ondrej Ondič, Radoslav Ferko, Jana Kašpírková, Marián Švajdler, Boris Rýchly, Peter Talarčík, Jiří Bouda, Michal Michal
AIM: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD). METHODS: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28043100/erratum-increased-expression-of-herpes-virus-encoded-hsv1-mir-h18-and-hsv2-mir-h9-5p-in-cancer-containing-prostate-tissue-compared-to-that-in-benign-prostate-hyperplasia-tissue
#11
Seok Joong Yun, Pildu Jeong, Ho Won Kang, Helen Ki Shinn, Ye-Hwan Kim, Chunri Yan, Young-Ki Choi, Dongho Kim, Dong Hee Ryu, Yun-Sok Ha, Tae-Hwan Kim, Tae Gyun Kwon, Jung Min Kim, Sang Heon Suh, Seon-Kyu Kim, Seon-Young Kim, Sang Tae Kim, Won Tae Kim, Ok-Jun Lee, Sung-Kwon Moon, Nam-Hyung Kim, Isaac Yi Kim, Jayoung Kim, Hee-Jae Cha, Yung-Hyun Choi, Eun-Jong Cha, Wun-Jae Kim
[This corrects the article on p. 122 in vol. 20, PMID: 27377944.].
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27986552/combining-different-types-of-multifunctional-liposomes-loaded-with-ammonium-bicarbonate-to-fabricate-microneedle-arrays-as-a-vaginal-mucosal-vaccine-adjuvant-dual-delivery-system-vadds
#12
Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang, Ting Wang
To develop effective mucosal vaccines, two types of multifunctional liposomes, the mannosylated lipid A-liposomes (MLLs) with a size of 200nm and the stealth lipid A-liposomes (SLLs) of 50nm, both loaded with a model antigen and NH4HCO3, were fabricated together into microneedles, forming the proSLL/MLL-constituted microneedle array (proSMMA), which upon rehydration dissolved rapidly recovering the initial MLLs and SLLs. Mice vaccinated with proSMMAs by vaginal mucosa patching other than conventional intradermal administration established robust antigen-specific humoral and cellular immunity at both systemic and mucosal levels, especially, in the reproductive and intestinal ducts...
December 13, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27966015/oral-shedding-of-human-herpesviruses-in-patients-undergoing-radiotherapy-chemotherapy-treatment-for-head-and-neck-squamous-cell-carcinoma
#13
Michelle Palmieri, Victor Adriano de Oliveira Martins, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Bruna Baraldi Romano, Clarisse Martins Machado, Claudio Sergio Pannuti, Thaís Bianca Brandão, Ana Carolina Prado Ribeiro, Luciana Corrêa, Paulo Henrique Braz-Silva
OBJECTIVE: Opportunistic infections may affect the oral mucosa of patients undergoing radio/chemotherapy through exacerbation of oral mucositis. The aim of this study is to evaluate the oral shedding of all eight human herpesviruses and its possible association with oral mucositis. MATERIALS AND METHODS: In this prospective cohort study, we analyzed oral rinse samples, collected weekly, from 20 patients during radiotherapy treatment. Serologic status to HSV1 and HSV2, EBV, CMV, and VZV in three different periods was performed by ELISA assay...
December 14, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27921084/the-prevalence-of-herpes-simplex-virus-type-1-and-2-infection-in-iran-a-meta-analysis
#14
REVIEW
Mina Malary, Ghasem Abedi, Zeinab Hamzehgardeshi, Mahdi Afshari, Mahmood Moosazadeh
BACKGROUND: Seroepidemiologic studies indicate a high prevalence of herpes simplex virus (HSV) infection. This infection leads to ophthalmic, dermatologic, oral, neurologic, vaginal and cervical problems. Different studies have been carried out to estimate the HSV seroprevalence in Iran. Combining the results of these studies would be useful for health policy-making. OBJECTIVE: This study aims to estimate the pooled prevalence of HSV infection using meta-analysis...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27798014/associations-between-excessive-adiposity-and-seroprevalence-of-herpes-simplex-virus-type-1-and-type-2-among-us-adults-a-population-based-age-period-cohort-analysis
#15
Su-Hsun Liu, I-Shiang Tzeng, Tsung-Han Hsieh, Yhu-Chering Huang
OBJECTIVES: Evidence on the association between herpes simplex virus (HSV) and excessive adiposity, such as obesity (body mass index ≥30 kg/m(2)) and abdominal obesity (waist circumference (WC) >102 or 88 cm), has been inconsistent. We sought to examine whether age-period-cohort (APC) effects could explain for the observed heterogeneities. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Adults aged 20-49 years with available serological data in the National Health and Nutrition Examination Survey (NHANES) in 1999-2012...
October 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27769110/high-seroprevalence-of-human-herpesvirus-8-and-herpes-simplex-virus-2-infections-in-men-who-have-sex-with-men-in-shanghai-china
#16
Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Jun Wang, Yue Chen, Veenu Minhas, Charles Wood, Na He, Tiejun Zhang
Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Shanghai, China from January 2013 to December 2014 to explore epidemiologic features of HHV8 and HSV2 among MSM. Serum samples were collected and tested for HHV8 by immunofluoresence assay and HSV2 antibodies by ELISA...
May 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/27687862/type-specific-detection-of-herpes-simplex-virus-type-1-and-type-2-using-the-cobas%C3%A2-hsv-1-and-2-test-on-the-cobas%C3%A2-4800-platform
#17
Barbara Van Der Pol
HSV-1 and HSV-2 are among the most common causes of sexually transmitted infections (stis) globally. these infections are strongly associated with increased risk of hiv acquisition and rare, but devastating, neonatal disease. available treatment options can reduce HSV transmission and improve quality of life. accurate diagnosis early in disease can improve patient management. Areas covered: This paper describes the clinical manifestations of HSV infection often used for clinical diagnostic purposes. The paper then describes the evolution of laboratory diagnostic assays...
November 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27668461/hsv2-reactivation-and-myelitis-following-influenza-vaccination
#18
Allan Lieberman, Luke Curtis
We report the case of a 57 year-old woman who developed transverse myelitis and acute HSV-2 reactivation following influenza vaccination. Over the next 5 years, she experienced a fluctuating course of improvement and regression for both myelitis and herpes.
March 4, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27507994/assessment-of-igg-antibodies-against-hsv1-hsv2-cmv-and-ebv-in-patients-with-pemphigus-vulgaris-versus-healthy-people
#19
Parichehr Ghalayani, Fateme Rashidi, Zahra Saberi
OBJECTIVES: Regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin G (IgG) antibodies against herpes simplex virus types 1 and 2 (HSV1 and HSV2), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with pemphigus vulgaris and healthy people. MATERIALS AND METHODS: In this cross-sectional study, 25 patients with pemphigus vulgaris and 27 healthy individuals comprised the experimental and control groups, respectively...
November 2015: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27377944/increased-expression-of-herpes-virus-encoded-hsv1-mir-h18-and-hsv2-mir-h9-5p-in-cancer-containing-prostate-tissue-compared-to-that-in-benign-prostate-hyperplasia-tissue
#20
Seok Joong Yun, Pildu Jeong, Ho Won Kang, Helen Ki Shinn, Ye-Hwan Kim, Chunri Yan, Young-Ki Choi, Dongho Kim, Dong Hee Ryu, Yun-Sok Ha, Tae-Hwan Kim, Tae Gyun Kwon, Jung Min Kim, Sang Heon Suh, Seon-Kyu Kim, Seon-Young Kim, Sang Tae Kim, Won Tae Kim, Ok-Jun Lee, Sung-Kwon Moon, Nam-Hyung Kim, Isaac Yi Kim, Jayoung Kim, Hee-Jae Cha, Yung-Hyun Choi, Eun-Jong Cha, Wun-Jae Kim
PURPOSE: Previously, we reported the presence of virus-encoded microRNAs (miRNAs) in the urine of prostate cancer (CaP) patients. In this study, we investigated the expression of two herpes virus-encoded miRNAs in prostate tissue. METHODS: A total of 175 tissue samples from noncancerous benign prostatic hyperplasia (BPH), 248 tissue samples from patients with CaP and BPH, and 50 samples from noncancerous surrounding tissues from these same patients were analyzed for the expression of two herpes virus-encoded miRNAs by real-time polymerase chain reaction (PCR) and immunocytochemistry using nanoparticles as molecular beacons...
June 2016: International Neurourology Journal
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