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Su-Hsun Liu, I-Shiang Tzeng, Tsung-Han Hsieh, Yhu-Chering Huang
OBJECTIVES: Evidence on the association between herpes simplex virus (HSV) and excessive adiposity, such as obesity (body mass index ≥30 kg/m(2)) and abdominal obesity (waist circumference (WC) >102 or 88 cm), has been inconsistent. We sought to examine whether age-period-cohort (APC) effects could explain for the observed heterogeneities. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Adults aged 20-49 years with available serological data in the National Health and Nutrition Examination Survey (NHANES) in 1999-2012...
October 17, 2016: BMJ Open
Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Jun Wang, Yue Chen, Veenu Minhas, Charles Wood, Na He, Tiejun Zhang
Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Shanghai, China from January 2013 to December 2014 to explore epidemiologic features of HHV8 and HSV2 among MSM. Serum samples were collected and tested for HHV8 by immunofluoresence assay and HSV2 antibodies by ELISA...
October 21, 2016: Journal of Medical Virology
Barbara Van Der Pol
HSV-1 and HSV-2 are among the most common causes of sexually transmitted infections (stis) globally. these infections are strongly associated with increased risk of hiv acquisition and rare, but devastating, neonatal disease. available treatment options can reduce HSV transmission and improve quality of life. accurate diagnosis early in disease can improve patient management. Areas covered: This paper describes the clinical manifestations of HSV infection often used for clinical diagnostic purposes. The paper then describes the evolution of laboratory diagnostic assays...
October 8, 2016: Expert Review of Molecular Diagnostics
Allan Lieberman, Luke Curtis
We report the case of a 57 year-old woman who developed myelitis and acute HSV-2 reactivation following influenza vaccination. Over the next 5 years, she experienced a fluctuating course of improvement and regression for both myelitis and herpes.
September 26, 2016: Human Vaccines & Immunotherapeutics
Parichehr Ghalayani, Fateme Rashidi, Zahra Saberi
OBJECTIVES: Regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin G (IgG) antibodies against herpes simplex virus types 1 and 2 (HSV1 and HSV2), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with pemphigus vulgaris and healthy people. MATERIALS AND METHODS: In this cross-sectional study, 25 patients with pemphigus vulgaris and 27 healthy individuals comprised the experimental and control groups, respectively...
November 2015: Journal of Dentistry of Tehran University of Medical Sciences
Seok Joong Yun, Pildu Jeong, Ho Won Kang, Helen Ki Shinn, Ye-Hwan Kim, Chunri Yan, Young-Ki Choi, Dongho Kim, Dong Hee Ryu, Yun-Sok Ha, Tae-Hwan Kim, Tae Gyun Kwon, Jung Min Kim, Sang Heon Suh, Seon-Kyu Kim, Seon-Young Kim, Sang Tae Kim, Won Tae Kim, Ok-Jun Lee, Sung-Kwon Moon, Nam-Hyung Kim, Isaac Yi Kim, Jayoung Kim, Hee-Jae Cha, Yung-Hyun Choi, Eun-Jong Cha, Wun-Jae Kim
PURPOSE: Previously, we reported the presence of virus-encoded microRNAs (miRNAs) in the urine of prostate cancer (CaP) patients. In this study, we investigated the expression of two herpes virus-encoded miRNAs in prostate tissue. METHODS: A total of 175 tissue samples from noncancerous benign prostatic hyperplasia (BPH), 248 tissue samples from patients with CaP and BPH, and 50 samples from noncancerous surrounding tissues from these same patients were analyzed for the expression of two herpes virus-encoded miRNAs by real-time polymerase chain reaction (PCR) and immunocytochemistry using nanoparticles as molecular beacons...
June 2016: International Neurourology Journal
Andrea A Kim, Bharat S Parekh, Mamo Umuro, Tura Galgalo, Rebecca Bunnell, Ernest Makokha, Trudy Dobbs, Patrick Murithi, Nicholas Muraguri, Kevin M De Cock, Jonathan Mermin
INTRODUCTION: A recent infection testing algorithm (RITA) that can distinguish recent from long-standing HIV infection can be applied to nationally representative population-based surveys to characterize and identify risk factors for recent infection in a country. MATERIALS AND METHODS: We applied a RITA using the Limiting Antigen Avidity Enzyme Immunoassay (LAg) on stored HIV-positive samples from the 2007 Kenya AIDS Indicator Survey. The case definition for recent infection included testing recent on LAg and having no evidence of antiretroviral therapy use...
2016: PloS One
Thomas Köller, Daniel Kurze, Mirjam Lange, Martin Scherdin, Andreas Podbielski, Philipp Warnke
A fully automated multiplex real-time PCR assay--including a sample process control and a plasmid based positive control--for the detection and differentiation of herpes simplex virus 1 (HSV1), herpes simplex virus 2 (HSV2) and varicella-zoster virus (VZV) from cerebrospinal fluids (CSF) was developed on the BD Max platform. Performance was compared to an established accredited multiplex real time PCR protocol utilizing the easyMAG and the LightCycler 480/II, both very common devices in viral molecular diagnostics...
2016: PloS One
Mahmoud Huleihel, Elad Shufan, Leila Zeiri, Ahmad Salman
Of the eight members of the herpes family of viruses, HSV1, HSV2, and varicella zoster are the most common and are mainly involved in cutaneous disorders. These viruses usually are not life-threatening, but in some cases they might cause serious infections to the eyes and the brain that can lead to blindness and possibly death. An effective drug (acyclovir and its derivatives) is available against these viruses. Therefore, early detection and identification of these viral infections is highly important for an effective treatment...
2016: PloS One
Lyudmila Ivanova, Anna Buch, Katinka Döhner, Anja Pohlmann, Anne Binz, Ute Prank, Malte Sandbaumhüter, Rudolf Bauerfeind, Beate Sodeik
UNLABELLED: Herpes simplex virus (HSV) replicates in the skin and mucous membranes, and initiates lytic or latent infections in sensory neurons. Assembly of progeny virions depends on the essential large tegument protein pUL36 of 3,164 amino acid residues that links the capsids to the tegument proteins pUL37 and VP16. Of the 32 tryptophans of HSV-1-pUL36, the tryptophan-acidic motifs (1766)WD(1767) and (1862)WE(1863) are conserved in all HSV-1 and HSV-2 isolates. Here, we characterized the role of these motifs in the HSV life cycle since the rare tryptophans often have unique roles in protein function due to their large hydrophobic surface...
June 1, 2016: Journal of Virology
Katherine E Gallagher, Kathy Baisley, Heiner Grosskurth, Andrew Vallely, Saidi Kapiga, Judith Vandepitte, Anatoli Kamali, Silvia De Sanjosé, John Changalucha, Richard Hayes, Deborah Watson-Jones
OBJECTIVE: This study was performed to analyze the associations between cervical human papillomavirus (HPV) infection and human immunodeficiency virus (HIV) acquisition, using cervical samples from previous studies in Tanzania and Uganda. METHODS: A total of 161 adult women who acquired HIV infection during follow-up and 464 individually matched HIV-seronegative controls were selected from 5 cohorts of women working in bars and recreational facilities. Stored cervical samples were tested for 37 HPV genotypes, using a polymerase chain reaction assay (Roche Linear Array genotyping assay)...
July 1, 2016: Journal of Infectious Diseases
Elisa Crisci, Rada Ellegård, Sofia Nyström, Elin Rondahl, Lena Serrander, Tomas Bergström, Christopher Sjöwall, Kristina Eriksson, Marie Larsson
UNLABELLED: Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections globally, with a very high prevalence in many countries. During HSV-2 infection, viral particles become coated with complement proteins and antibodies, both present in genital fluids, which could influence the activation of immune responses. In genital mucosa, the primary target cells for HSV-2 infection are epithelial cells, but resident immune cells, such as dendritic cells (DCs), are also infected...
May 15, 2016: Journal of Virology
Benjamin Berger, Maximilian Pytlik, Tilman Hottenrott, Oliver Stich
PURPOSE: A 2012 report and subsequent case series described anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in patients during the acute phase and relapse of herpes simplex virus 1 (HSV1) encephalitis (HSV1E). However, the prevalence of this phenomenon is unknown and systematic studies on other viral infections of the nervous system are missing. MATERIALS AND METHODS: We retrospectively analyzed serial cerebrospinal fluid (CSF) and serum samples of consecutive patients treated for neurological HSV1, HSV2 and varicella zoster virus (VZV) infections in our tertiary care university hospital between 2003 and 2013 for the presence of antibodies directed against the NR1a subunit of the NMDAR using indirect immunofluorescence...
February 17, 2016: International Journal of Neuroscience
Charles Grose
No abstract text is available yet for this article.
February 23, 2016: Circulation
Kwame Owusu-Edusei, Chirag G Patel, Thomas L Gift
UNLABELLED: Background In this study, a previous study on the utilisation and cost of sexually transmissible infection (STI) tests was augmented by focusing on outpatient place of service for the most utilised tests. METHODS: Claims for eight STI tests [chlamydia, gonorrhoea, hepatitis B virus (HBV), HIV, human papillomavirus (HPV), herpes simplex virus type 2 (HSV2), syphilis and trichomoniasis] using the most utilised current procedural terminology (CPT) code for each STI from the 2012 MarketScan outpatient table were extracted...
April 2016: Sexual Health
N Lerolle, M Laanani, S Rivière, L Galicier, P Coppo, J-L Meynard, J-M Molina, E Azoulay, C Aumont, C Marzac, L Fardet, O Lambotte
Reactive haemophagocytic syndrome (HS) is a rare condition that occurs in patients with infections, haematological malignancies or autoimmune diseases. Although various microorganisms are thought to trigger HS, most of the literature data on this topic have been gathered in single-centre case series. Here, we sought to characterize infectious triggers in a large, multicentre cohort of patients with HS. Patients were included in the present study if HS was solely due to one or more infections. Detailed microbiological data were recorded...
March 2016: Clinical Microbiology and Infection
D Hanci, S Ulusoy, N B Muluk, C Cingi
OBJECTIVES: To investigate the role of viral infection in benign paroxysmal positional vertigo (BPPV). METHODS: In this retrospective study, 483 patients with BPPV were included in the study group. The control group consisted of 461 healthy subjects. In both groups, serologic analysis of viral agents (HSV1, HSV2, Herpes zoster, EBV, CMV, adenovirus, influenza, and parainfluenza virus) was performed. RESULTS: With the exception of influenza and parainfluenza, all viral serology values were higher in the BBPV group than the control group...
2015: B-ENT
Kening Wang, Kyle N Goodman, Daniel Y Li, Mark Raffeld, Mayra Chavez, Jeffrey I Cohen
UNLABELLED: A recent phase 3 trial with soluble herpes simplex virus 2 (HSV-2) glycoprotein D (gD2t) in adjuvant failed to show protection against genital herpes. We postulated that live attenuated HSV-2 would provide more HSV antigens for induction of virus-specific antibodies and cellular immunity than would gD2t. We previously reported an HSV-2 mutant, HSV2-gD27, in which the nectin-1 binding domain of gD2 is altered so that the virus is impaired for infecting neural cells, but not epithelial cells, in vitro and is impaired for infecting dorsal root ganglia in mice (K...
January 2016: Journal of Virology
Ricarda A Busse, Andreea Scacioc, Amanda M Schalk, Roswitha Krick, Michael Thumm, Karin Kühnel
Liposome flotation assays are a convenient tool to study protein-phosphoinositide interactions. Working with liposomes resembles physiological conditions more than protein-lipid overlay assays, which makes this method less prone to detect false positive interactions. However, liposome lipid composition must be well-considered in order to prevent nonspecific binding of the protein through electrostatic interactions with negatively charged lipids like phosphatidylserine. In this protocol we use the PROPPIN Hsv2 (homologous with swollen vacuole phenotype 2) as an example to demonstrate the influence of liposome lipid composition on binding and show how phosphoinositide binding specificities of a protein can be characterized with this method...
2016: Methods in Molecular Biology
Seok Joong Yun, Pildu Jeong, Ho Won Kang, Ye-Hwan Kim, Eun-Ah Kim, Chunri Yan, Young-Ki Choi, Dongho Kim, Jung Min Kim, Seon-Kyu Kim, Seon-Young Kim, Sang Tae Kim, Won Tae Kim, Ok-Jun Lee, Gou-Young Koh, Sung-Kwon Moon, Isaac Yi Kim, Jayoung Kim, Yung-Hyun Choi, Wun-Jae Kim
PURPOSE: MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of the study was to identify and validate urinary cell-free miRNAs that can segregate patients with PCa from those with BPH. METHODS: In total, 1,052 urine, 150 serum, and 150 prostate tissue samples from patients with PCa or BPH were used in the study. A urine-based miRNA microarray analysis suggested the presence of differentially expressed urinary miRNAs in patients with PCa, and these were further validated in three independent PCa cohorts, using a quantitative reverse transcriptionpolymerase chain reaction analysis...
June 2015: International Neurourology Journal
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