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Thomas C Randall, Catherine Sauvaget, Richard Muwonge, Edward L Trimble, Jose Jeronimo
Treatment of preinvasive lesions is critical to the success of secondary prevention of cervical cancer. In many settings, however, excision or ablation of preinvasive lesions can prove challenging. Thermal ablation (TA) is a form of treatment for cervical precancer that may present fewer logistical challenges in resource limited settings. In 2013, Dolman and colleagues wrote a meta-analysis of publications reporting cure rates from TA. This included only one article from a low or middle-income country (LMIC)...
October 17, 2018: Preventive Medicine
Sunil V Patel, Lisa Zhang, Basheer Elsolh, Daid Yu, A Sami Chadi
AIM: Minimally Invasive Trans anal Total Mesorectal Excision (TaTME) is a new approach in treating rectal cancer. "Spin" can be defined as "reporting strategies to highlight that the experimental treatment is beneficial" despite limitations in study design. The aim of this study was to assess Spin within TaTME publications. METHODS: EMBASE and MEDLINE (2009 - 2017) were searched for publications assessing TaTME in rectal cancer. All publications, published between 2009 - 2017 were eligible for inclusion...
October 20, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Tyler Marshall, Elizabeth N Kinnard, Myles Hancock, Susanne King-Jones, Karin Olson, Adam Abba-Aji, Katherine Rittenbach, Sunita Vohra
INTRODUCTION: Opioid use disorder (OUD) is characterised by the fifth Edition of the Diagnostic and Statistics Manual as a problematic pattern of opioid use (eg, fentanyl, heroin, oxycodone) that leads to clinically significant impairment. OUD diagnoses have risen substantially over the last decade, and treatment services have struggled to meet the demand. Evidence suggests when patients with chronic illnesses are matched with their treatment preferences and engaged in shared decision-making (SDM), health outcomes may improve...
October 17, 2018: BMJ Open
Peter H Kilmarx, Flora Katz, Myat Htoo Razak, John Palen, Laura W Cheever, Roger I Glass
Faced with a critical shortage of physicians in Africa, which hampered the efforts of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), the Medical Education Partnership Initiative (MEPI) was established in 2010 to increase the number of medical graduates, the quality of their education, and their retention in Africa. To summarize the accomplishments of the initiative, lessons learned, and remaining challenges, the authors conducted a narrative review of MEPI-from the perspectives of the U.S. government funding agencies and implementing agencies-by reviewing reports from grantee institutions and conducting a search of scientific publications about MEPI...
October 16, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Denita Biyanda Utami, Ardi Findyartini
BACKGROUND: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional changes are one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. The aim of this report is to perform a critical appraisal to analyze whether plant-based diet reduces the HbA1c level compared to conventional diet...
July 2018: Acta Medica Indonesiana
German O Gallucci, Adam Hamilton, Wenjie Zhou, Daniel Buser, Stephen Chen
OBJECTIVES: To systematically review the evidence for the clinical outcome of fixed implant prostheses treated with different combinations of implant placement and loading protocols in partially edentulous patients. MATERIALS AND METHODS: An electronic search was performed in Medline, Embase, and Central to identify studies investigating the outcome of implants subjected to immediate placement + immediate restoration/loading (Type 1A), immediate placement + early loading (Type 1B), immediate placement + conventional loading (Type 1C), early placement + immediate restoration/loading (Type 2-3A), early placement + early loading (Type 2-3B), early placement + conventional loading (Type 2-3C), late placement + immediate restoration/loading (Type 4A), late placement + early loading (Type 4B), late placement + conventional loading (Type 4C) with implant-supported fixed dental prostheses (IFDPs) in partially edentulous patients...
October 2018: Clinical Oral Implants Research
Julia-Gabriela Wittneben, Daniel Wismeijer, Urs Brägger, Tim Joda, Samir Abou-Ayash
OBJECTIVES: The aim of this systematic review and meta-analysis was to summarize the existing evidence on patient-reported aesthetic outcome measures (PROMs) of implant-supported, relative to tooth-supported fixed dental prostheses. MATERIAL AND METHODS: In April 2017, two reviewers independently searched the Medline (PubMed), EMBASE, and Cochrane electronic databases, focusing on studies including patient-reported aesthetic outcomes of implant- and tooth-supported fixed dental prostheses (FDPs)...
October 2018: Clinical Oral Implants Research
Dale R Calder, Henry H C Choong
An account is given of the names of families, genera, and species of hydroids established by C.M. Fraser of Canada, excluding those from Allan Hancock Pacific Expeditions and the Allan Hancock Caribbean Sea Expedition. The names of four families, 11 genera, and 101 species are attributed to him in this work, complementing those of another two genera and 164 species described by Fraser in various Allan Hancock publications. Information is provided on type localities of his new species, on locations and kinds of type material in existence, where known, and on the current taxonomic status of families, genera, and species described by him in works reviewed herein...
October 1, 2018: Zootaxa
Jorge L Cavalcante Neto, Cristina C de Oliveira, Ana L Greco, Antonio R Zamunér, Roberta C Moreira, Eloisa Tudella
INTRODUCTION: Although virtual reality (VR) is an increasingly popular approach within studies that propose interventions for children with developmental coordination disorder (DCD), evidence on the effectiveness of VR remains debatable. The aim of this study was to synthesise evidence on the effectiveness of VR interventions for motor performance improvement in children with DCD. EVIDENCE ACQUISITION: Searches were conducted in the MEDLINE/PubMed, Scopus, Web of Science and ERIC databases to select studies published from 1 January 2006 to 30 November 2017...
October 4, 2018: European Journal of Physical and Rehabilitation Medicine
Hans-Werner Hense
Cancer is one of the most relevant chronic diseases in the German population, but not all neoplastic entities are eligible for early cancer detection (ECD) programs. In 1971, ECDs were introduced as population-wide screenings for the first time in the catalogue of benefits of the West German statutory health insurance funds. However, the implementation at that time was rarely systematic. Concurrently, a discussion on the perspectives of ECD arose in the former German Democratic Republic, where a structured program was not prepared in the country until the late 1980s...
October 11, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Evanson Zondani Sambala, Aaron Mdolo, Richard Banda, Arthur Phiri, Alison B Wiyeh, Charles Shey Wiysonge
INTRODUCTION: Measures of epidemiological burdens are an important contribution to estimating disease severity and determining the at-risk populations for seasonal influenza. In the absence of these data, it is extremely difficult for policy-makers to decide on how to distribute limited resources. This systematic review will synthesise the literature on reported burden of seasonal influenza (eg, morbidity and mortality) in sub-Saharan Africa. METHOD AND ANALYSIS: We will include published epidemiological studies that capture the burden estimation of seasonal influenza between 1 January 2000 and 31 August 2018...
October 10, 2018: BMJ Open
Marcela Baraúna Magno, Aline Borburema Neves, Daniele Masterson Ferreira, Matheus Melo Pithon, Lucianne Cople Maia
BACKGROUND/AIMS: Traumatic dental injuries (TDI) are a public health concern with high prevalence and recurrence rate. The aim of this study was to perform a systematic review and meta-analysis to determine whether previous dental trauma is a predictive factor for new episodes of TDI (recurrence or first episodes). MATERIALS AND METHODS: Electronic searches were performed with no language or date restrictions. According to the PECOS strategy, cohort studies that investigated subjects with and without previous TDI, and its association with new TDI episodes, as primary or secondary outcomes, were included...
October 11, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Herdiana Herdiana, Jana Fitria Kartika Sari, Maxine Whittaker
INTRODUCTION: Vector Borne Diseases (VBDs) have a major impact on public health and socio-economic development. Inter-sectoral collaboration was recommended as one of the key elements of Integrated Vector Management (IVM), however limited evidence measures the effect and contribution of intersectoral approaches including but not only IVM. This systematic review aims to assess the existing evidence on all forms of inter-sectoral collaboration in VBD control and prevention, identify any gaps and develop a framework from a global perspective...
2018: PloS One
Bin Wang, Peng Zhao
BACKGROUND: This study aimed to show the world research productivity in the field of back pain and to help researchers follow the scientific development and promote the cooperation in this field. METHODS: Web of Science (WoS) database was searched from 1995 to 2016 without other restrictions. The keywords were as follows: "lumbar NEAR pain," "back pain," "dorsalgia," "backache," "lumbago," "back NEAR disorder," and "discitis...
October 2018: Medicine (Baltimore)
Georgina MacArthur, Deborah M Caldwell, James Redmore, Sarah H Watkins, Ruth Kipping, James White, Catherine Chittleborough, Rebecca Langford, Vanessa Er, Raghu Lingam, Keryn Pasch, David Gunnell, Matthew Hickman, Rona Campbell
BACKGROUND: Engagement in multiple risk behaviours can have adverse consequences for health during childhood, during adolescence, and later in life, yet little is known about the impact of different types of interventions that target multiple risk behaviours in children and young people, or the differential impact of universal versus targeted approaches. Findings from systematic reviews have been mixed, and effects of these interventions have not been quantitatively estimated. OBJECTIVES: To examine the effects of interventions implemented up to 18 years of age for the primary or secondary prevention of multiple risk behaviours among young people...
October 5, 2018: Cochrane Database of Systematic Reviews
Melissa Bersanelli, Francesco Leonardi, Sebastiano Buti
Background: In the past few years, new drugs made their appearance in the first-line setting of treatment for metastatic renal cell carcinoma (mRCC), and cabozantinib is one among them. The present systematic review aims to point out any evidence published to date about first-line treatment with cabozantinib for mRCC patients, describing their outcome in all end points explored by the literature. Methods: PRISMA guidelines were followed. A systematic assessment of literature and peer- reviewed presentations was performed by searching PubMed and major oncology meeting resources, from the database inception until June 25, 2018...
2018: Cancer Management and Research
Kari White, Katelin Adams, Kristine Hopkins
OBJECTIVES: To compare pregnancy options counseling and referral practices at state- and Title X-funded family planning organizations in Texas after enforcement of a policy restricting abortion referrals for providers participating in state-funded programs, which differed from Title X guidelines to provide referrals for services upon request. STUDY DESIGN: Between November 2014 and February 2015, we conducted in-depth interviews with administrators at publicly funded family planning organizations in Texas about how they integrated primary care and family planning services, including pregnancy options counseling and referrals for unplanned pregnancies...
October 1, 2018: Contraception
Vibhu Paudyal, Scott Cunningham, Kathrine Gibson Smith, Katie MacLure, Cristin Ryan, Maria Cordina
BACKGROUND: The accessibility of services within community pharmacies provides an ideal opportunity to manage minor ailments, yet over £1.1 billion is spent by the National Health Service (NHS) in the United Kingdom (UK) in managing minor ailments in high cost settings. There is a need to review the evidence base around clinical effectiveness of pharmacy-based management of minor ailments since the absence of such may lead to under-utilisation of pharmacy services and non-implementation of available pharmacy service models...
2018: PloS One
Chellan Kumarasamy, Arikketh Devi, Rama Jayaraj
BACKGROUND: Head and neck cancers form a significant share of all cancer incidences worldwide. Though treatment modalities exist, post-treatment recurrence and survival rates in recurrent patients continue to be high. MiRNAs offer an effective method of estimating the probability of recurrence and survival of HNC patients, thereby allowing for effective treatment and better survival rates. METHODS: The systematic review protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P) 2015 statement...
October 2, 2018: Systematic Reviews
Martin Feller, Marieke Snel, Elisavet Moutzouri, Douglas C Bauer, Maria de Montmollin, Drahomir Aujesky, Ian Ford, Jacobijn Gussekloo, Patricia M Kearney, Simon Mooijaart, Terry Quinn, David Stott, Rudi Westendorp, Nicolas Rodondi, Olaf M Dekkers
Importance: The benefit of thyroid hormone therapy for subclinical hypothyroidism is uncertain. New evidence from recent large randomized clinical trials warrants an update of previous meta-analyses. Objective: To conduct a meta-analysis of the association of thyroid hormone therapy with quality of life and thyroid-related symptoms in adults with subclinical hypothyroidism. Data Sources: PubMed, EMBASE,, Web of Science, Cochrane Library, CENTRAL, Emcare, and Academic Search Premier from inception until July 4, 2018...
October 2, 2018: JAMA: the Journal of the American Medical Association
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