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Esomeprazole and preeclampsia

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https://www.readbyqxmd.com/read/30055127/esomeprazole-to-treat-women-with-preterm-preeclampsia-a-randomised-placebo-controlled-trial
#1
Catherine A Cluver, Natalie J Hannan, Erika van Papendorp, Richard Hiscock, Sally Beard, Ben W Mol, Gerhard B Theron, David R Hall, Eric H Decloed, Marietjie Stander, Kim T Adams, Megan Rensburg, Pawel Schubert, Susan P Walker, Stephen Tong
BACKGROUND: Preterm preeclampsia has high rates of fetal death or disability. There is no treatment to slow the disease, except delivery. Preclinical studies have identified proton pump inhibitors as a possible treatment. OBJECTIVE: To examine whether esomeprazole could prolong pregnancy in women diagnosed with preterm preeclampsia STUDY DESIGN: We performed a double blind, randomised controlled trial at Tygerberg Hospital in South Africa. Women with preterm preeclampsia (gestational age 26 weeks+0 days to 31 weeks+6 days) were randomly assigned to 40 mg daily esomeprazole or placebo...
July 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29758543/magnesium-sulfate-versus-esomeprazole-impact-on-the-neonates-of-preeclamptic-rats
#2
COMPARATIVE STUDY
Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman
OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29466360/combining-metformin-and-esomeprazole-is-additive-in-reducing-sflt-1-secretion-and-decreasing-endothelial-dysfunction-implications-for-treating-preeclampsia
#3
Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan
INTRODUCTION: The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multiorgan injury. We recently identified metformin and esomeprazole as potential treatments for preeclampsia. Both reduce placental and endothelial secretion of sFlt-1 and soluble endoglin, and reduce endothelial dysfunction...
2018: PloS One
https://www.readbyqxmd.com/read/28716993/low-soluble-fms-like-tyrosine-kinase-1-endoglin-and-endothelin-1-levels-in-women-with-confirmed-or-suspected-preeclampsia-using-proton-pump-inhibitors
#4
Langeza Saleh, Raaho Samantar, Ingrid M Garrelds, Anton H van den Meiracker, Willy Visser, A H Jan Danser
Patients with preeclampsia display elevated placenta-derived sFlt-1 (soluble Fms-like tyrosine kinase-1) and endoglin levels and decreased placental growth factor levels. Proton pump inhibitors (PPIs) decrease trophoblast sFlt-1 and endoglin secretion in vitro. PPIs are used during pregnancy to combat reflux disease. Here, we investigated whether PPIs affect sFlt-1 in women with confirmed/suspected preeclampsia, making use of a prospective cohort study involving 430 women. Of these women, 40 took PPIs (6 esomeprazole, 32 omeprazole, and 2 pantoprazole) for 8 to 45 (median 29) days before sFlt-1 measurement...
September 2017: Hypertension
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