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https://www.readbyqxmd.com/read/29678261/mirtazapine
#1
REVIEW
Abdulrahman Al-Majed, Ahmed H Bakheit, Raed M Alharbi, Hatem A Abdel Aziz
Mirtazapine is one of antidepression which is used mainly in the treatment of depression, moreover, it is sometimes used in the treatment of anxiety disorders, insomnia, nausea, and vomiting, and to produce weight gain when desirable. The action of mirtazapine is an antagonist of certain adrenergic and serotonin receptors, and, furthermore, the drug is used strong as antihistamine, and it is occasionally defined as a noradrenergic and specific serotonergic antidepressant (NaSSA). The comprehensive profile of mirtazapine gives more detailed information about nomenclature, formulae, elemental analysis, and appearance...
2018: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/29509190/quantitative-mapping-of-rna-mediated-nuclear-estrogen-receptor-%C3%AE-interactome-in-human-breast-cancer-cells
#2
Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A Nyman, Alessandro Weisz, Roberta Tarallo
The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concert with ERβ to control key cellular functions, including gene transcription, RNA splicing and post-transcriptional mRNA regulation. These studies revealed an involvement of RNA in ERβ interactome assembly and functions...
March 6, 2018: Scientific Data
https://www.readbyqxmd.com/read/29484706/identification-of-a-novel-truncating-mutation-in-palb2-gene-by-a-multigene-sequencing-panel-for-mutational-screening-of-breast-cancer-risk-associated-and-related-genes
#3
Anna Guacci, Angela Cordella, Teresa Rocco, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Chiara Carlomagno, Stefano Pepe, Roberta Tarallo, Alessandro Weisz
BACKGROUND: Breast cancer (BC) is the most common neoplasm in women, with 5%-10% patients showing a familial predisposition, where germline mutations in BRCA1/BRCA2 genes are found in -20% of cases. Next-generation sequencing (NGS) is among the best available options for genetic screening, providing several benefits that include enhanced sensitivity and unbiased mutation detection. PALB2 (partner and localizer of BRCA2) is a cancer predisposing gene recently described that encodes a protein partner of BRCA2 involved in DNA double-strand break repair and cell cycle control...
February 27, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29431197/efficacy-and-safety-of-antidepressant-augmentation-of-continued-antipsychotic-treatment-in-patients-with-schizophrenia
#4
B Galling, J A Vernon, A K Pagsberg, A Wadhwa, E Grudnikoff, A J Seidman, M Tsoy-Podosenin, M Poyurovsky, J M Kane, C U Correll
OBJECTIVE: To evaluate the efficacy and safety of antidepressant augmentation of antipsychotics in schizophrenia. METHODS: Systematic literature search (PubMed/MEDLINE/PsycINFO/Cochrane Library) from database inception until 10/10/2017 for randomized, double-blind, efficacy-focused trials comparing adjunctive antidepressants vs. placebo in schizophrenia. RESULTS: In a random-effects meta-analysis (studies = 42, n = 1934, duration = 10...
March 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29323256/splicing-of-platelet-resident-pre-mrnas-upon-activation-by-physiological-stimuli-results-in-functionally-relevant-proteome-modifications
#5
Giovanni Nassa, Giorgio Giurato, Giovanni Cimmino, Francesca Rizzo, Maria Ravo, Annamaria Salvati, Tuula A Nyman, Yafeng Zhu, Mattias Vesterlund, Janne Lehtiö, Paolo Golino, Alessandro Weisz, Roberta Tarallo
Platelet activation triggers thrombus formation in physiological and pathological conditions, such as acute coronary syndromes. Current therapies still fail to prevent thrombotic events in numerous patients, indicating that the mechanisms modulating platelet response during activation need to be clarified. The evidence that platelets are capable of de novo protein synthesis in response to stimuli raised the issue of how megakaryocyte-derived mRNAs are regulated in these anucleate cell fragments. Proteogenomics was applied here to investigate this phenomeon in platelets activated in vitro with Collagen or Thrombin Receptor Activating Peptide...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29177683/a-temporal-and-spatial-monitoring-of-organotin-pollution-in-a-harborside-region-of-brazil-by-imposex-and-ecological-quality-ratio-using-leucozonia-nassa
#6
Mercia Barcellos da Costa, Gabriela Carvalho Zamprogno, Mariana Beatriz Paz Otegui, Letícia de Morais, Felipe Corteletti Pedruzzi, Gabriel Bautz Dalbem, Daniele Angeli da Silva, Allana Cristini Borges Resende
This study represents the first use of Leucozonia nassa (Mollusca-Gastropoda) in a program of long-term monitoring. Specimens of L. nassa were collected between 2006 and 2014 and analyzed for the occurrence of imposex in two areas in Southeastern Brazil, one control area and another characterized by the presence of many ports and marinas. Imposex was evaluated in nine sites based on the percentage of females exhibiting imposex (I%), relative penis length index and vas deferens sequence index, classical indices to evaluate tributyltin (TBT) impacts...
November 25, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29059283/ismart-a-toolkit-for-a-comprehensive-analysis-of-small-rna-seq-data
#7
Riccardo Panero, Antonio Rinaldi, Domenico Memoli, Giovanni Nassa, Maria Ravo, Francesca Rizzo, Roberta Tarallo, Luciano Milanesi, Alessandro Weisz, Giorgio Giurato
No abstract text is available yet for this article.
October 20, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29017520/the-nuclear-receptor-er%C3%AE-engages-ago2-in-regulation-of-gene-transcription-rna-splicing-and-risc-loading
#8
Roberta Tarallo, Giorgio Giurato, Giuseppina Bruno, Maria Ravo, Francesca Rizzo, Annamaria Salvati, Luca Ricciardi, Giovanna Marchese, Angela Cordella, Teresa Rocco, Valerio Gigantino, Biancamaria Pierri, Giovanni Cimmino, Luciano Milanesi, Concetta Ambrosino, Tuula A Nyman, Giovanni Nassa, Alessandro Weisz
BACKGROUND: The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. Estrogen receptor beta (ERβ) is endowed with oncosuppressive activities, antagonizing hormone-induced carcinogenesis and inhibiting growth and oncogenic functions in luminal-like breast cancers (BCs), where its expression correlates with a better prognosis of the disease...
October 6, 2017: Genome Biology
https://www.readbyqxmd.com/read/28707591/new-generation-non-ssri-antidepressants-therapeutic-drug-monitoring-and-pharmacological-interactions-part-1-snris-smss-saris
#9
REVIEW
Roberto Mandrioli, Michele Protti, Laura Mercolini
BACKGROUND: New-generation antidepressants (NGAs) are the latest additions to the clinician's arsenal in the fight against depression. After the introduction of selective serotonin reuptake inhibitors (SSRIs), a plethora of other groups followed, identified by their main mechanisms of activity: serotonin and norepinephrine reuptake inhibitors (SNRI); serotonin modulators and stimulators (SMS); serotonin antagonists and reuptake inhibitors (SARI); noradrenergic and selective serotonergic antidepressants (NaSSA); norepinephrine reuptake inhibitors (NeRI); serotonin, norepinephrine and dopamine reuptake inhibitors (SNDRI) or triple reuptake inhibitors (TRI); and melatonin and serotonin agonists (MaSA)...
2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28446416/-research-progress-of-depression-and-the-application-of-esketamine
#10
REVIEW
Fang-Bo Lin, De-Ren Hou, Qiu-Ping Tang
The pathogenesis and etiology of still remain unknown. Current evidence suggests that the occurrence of depression may be related to a reduced secretion of neurotransmitters, neuronal apoptosis, inflammation, intestinal flora and other factors. Although the commonly used antidepressants such as SSRIs, SNRIs, NaSSA, and SARIs produce some therapeutic effects, they fail to relieve the full spectrum of the symptoms of depression. In recent years, esketamine was found to produce a potent and a long-lasting antidepressant effect by acting on the NMDA receptors...
April 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28275829/endothelial-nitric-oxide-synthase-in-rat-brain-is-downregulated-by-sub-chronic-antidepressant-treatment
#11
Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Shunsuke Nakata, Jun-Ichi Iga, Shu-Ichi Ueno
BACKGROUND: Nitric oxide (NO) is a neurotransmitter that may be related to major depressive disorder (MDD) because the selective neuronal NO synthase (NOS) inhibitor, 7-nitroindazole, induces a dose-dependent antidepressant-like effect. NO modulates major neurotransmitters involved in the neurobiology of MDD, such as norepinephrine, serotonin, dopamine, and glutamate. In this study, we investigated the effects of antidepressants as NO modulators in acute and sub-chronic treatments. METHODS: Rats were injected with the SSRI paroxetine (PAR, 10 mg/kg), the SNRI milnacipran (MIL, 30 mg/kg), or the NaSSA mirtazapine (MIR, 10 mg/kg) for acute (1 h) or sub-chronic (3 weeks) treatment prior to analysis of nine brain regions (frontal cortex, temporal cortex, striatum, thalamus, hippocampus, midbrain, pons, cerebellum, and olfactory bulb)...
June 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28111205/carcinogenic-risk-and-bisphenol-a-exposure-a-focus-on-molecular-aspects-in-endoderm-derived-glands
#12
REVIEW
Danila Cuomo, Immacolata Porreca, Gilda Cobellis, Roberta Tarallo, Giovanni Nassa, Geppino Falco, Antonio Nardone, Francesca Rizzo, Massimo Mallardo, Concetta Ambrosino
Epidemiological and experimental evidence associates the exposure to Bisphenol A with the increase of cancer risk in several organs, including prostate. BPA targets different pathways involved in carcinogenicity including the Nuclear Receptors (i.e. estrogen and androgen receptors), stress regulated proteins and, finally, epigenetic changes. Here, we analyse BPA-dependent carcinogenesis in endoderm-derived glands, thyroid, liver, pancreas and prostate focusing on cell signalling, DNA damage repair pathways and epigenetic modifications...
December 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28057684/ismart-a-toolkit-for-a-comprehensive-analysis-of-small-rna-seq-data
#13
Riccardo Panero, Antonio Rinaldi, Domenico Memoli, Giovanni Nassa, Maria Ravo, Francesca Rizzo, Roberta Tarallo, Luciano Milanesi, Alessandro Weisz, Giorgio Giurato
Summary: The interest in investigating the biological roles of small non-coding RNAs (sncRNAs) is increasing, due to the pleiotropic effects of these molecules exert in many biological contexts. While several methods and tools are available to study microRNAs (miRNAs), only few focus on novel classes of sncRNAs, in particular PIWI-interacting RNAs (piRNAs). To overcome these limitations, we implemented iSmaRT ( i ntegrative Sm all R NA T ool-kit), an automated pipeline to analyze smallRNA-Seq data...
March 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28006796/a-new-generic-name-i-semigothograptus-i-for-i-gothograptus-i-i-meganassa-i-rickards%C3%A2-amp-palmer-2002-from-the-silurian-post-i-lundgreni-i-biozone-recovery-phase-and-comparative-morphology-of-retiolitids-from-the-lowermost-upper-homerian-upper-wenlock
#14
Anna Kozłowska
Gothograptus? meganassa Rickards & Palmer, 2002 is assigned to a new genus Semigothograptus. New, well preserved material from the dubius/nassa Biozone (upper Homerian, Silurian) of the Bartoszyce IG-1 drill core Poland is described. This provides a new phylogenetic perspective on the evolution of post-lundgreni Event retiolitines. Semigothograptus meganassa is considered to be a descendant of Gothograptus nassa, although one of the most significant differences between these forms is the position of the nema, and narrow finite tubarium ending in an appendix in G...
December 21, 2016: Zootaxa
https://www.readbyqxmd.com/read/27903024/-depressive-disorders-in-elder-patients-with-ckd
#15
REVIEW
Ute Hoffmann
Depressive disorders in patients with CKD are common und could be detected by simple screening-tests. The differential diagnosis includes uremic somatic symptoms. Besides the psychotherapy, medical treatment with SSRI or NaSSA are recommended in patients with CKD.
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27836391/diagnosing-and-treating-depression-in-epilepsy
#16
REVIEW
Christian E Elger, Samantha A Johnston, Christian Hoppe
At least one third of patients with active epilepsy suffer from significant impairment of their emotional well-being. A targeted examination for possible depression (irrespective of any social, financial or personal burdens) can identify patients who may benefit from medical attention and therapeutic support. Reliable screening instruments such as the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) are suitable for the timely identification of patients needing help. Neurologists should be capable of managing mild to moderate comorbid depression but referral to mental health specialists is mandatory in severe and difficult-to-treat depression, or if the patient is acutely suicidal...
January 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27764787/pdgfr-alpha-inhibits-melanoma-growth-via-cxcl10-ip-10-a-multi-omics-approach
#17
Daniela D'Arcangelo, Francesco Facchiano, Giovanni Nassa, Andrea Stancato, Annalisa Antonini, Stefania Rossi, Cinzia Senatore, Martina Cordella, Claudio Tabolacci, Annamaria Salvati, Roberta Tarallo, Alessandro Weisz, Angelo M Facchiano, Antonio Facchiano
Melanoma is the most aggressive skin-cancer, showing high mortality at advanced stages. Platelet Derived Growth Factor Receptor-alpha (PDGFR-alpha) potently inhibits melanoma- and endothelium-proliferation and its expression is significantly reduced in melanoma-biopsies, suggesting that melanoma progression eliminates cells expressing PDGFR-alpha. In the present study transient overexpression of PDGFR-alpha in endothelial (HUVEC) and melanoma (SKMel-28, A375, Preyer) human-cells shows strong anti-proliferative effects, with profound transcriptome and miRNome deregulation...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27731832/report-renovation-of-a-traditional-ergh-al-nassa-pill-hab-to-a-standard-pharmaceutical-molded-tablet
#18
Arman Zargaran, Saeid Daneshamouz, Gholamreza Kordafshari, Abdolali Mohagheghzadeh
The Ergh-al-Nassa pill (Hab) is a traditional combination suggested as one of the most effective preparations useful for treatment of sciatica. Although traditional preparations can be applied as new therapeutic drugs for investigations and clinical trials, they need to be reformulated to achieve pharmacopoeial standards for modern medicine. In this research, based on seven traditional Persian pharmacopeias for Ergh-al-NassaHab, nine different molded tablets were reformulated. Each formulation comprised the same amount of colchicum, ginger, aloe and yellow myrobalan fruit...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27429044/specific-patterns-of-piwi-interacting-small-noncoding-rna-expression-in-dysplastic-liver-nodules-and-hepatocellular-carcinoma
#19
Francesca Rizzo, Antonio Rinaldi, Giovanna Marchese, Elena Coviello, Assunta Sellitto, Angela Cordella, Giorgio Giurato, Giovanni Nassa, Maria Ravo, Roberta Tarallo, Luciano Milanesi, Anna Destro, Guido Torzilli, Massimo Roncalli, Luca Di Tommaso, Alessandro Weisz
Hepatocellular carcinoma (HCC) is the result of a stepwise process, often beginning with development within a cirrhotic liver of premalignant lesions, morphologically characterized by low- (LGDN) and high-grade (HGDN) dysplastic nodules. PIWI-interacting RNAs (piRNAs) are small noncoding RNAs (sncRNAs), 23-35 nucleotide-long, exerting epigenetic and post-transcriptional regulation of gene expression. Recently the PIWI-piRNA pathway, best characterized in germline cells, has been identified also in somatic tissues, including stem and cancer cells, where it influences key cellular processes...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27236113/expression-of-functional-tissue-factor-in-activated-t-lymphocytes-in-vitro-and-in-vivo-a-possible-contribution-of-immunity-to-thrombosis
#20
Raffaele De Palma, Plinio Cirillo, Giovanni Ciccarelli, Giusi Barra, Stefano Conte, Grazia Pellegrino, Giuseppe Pasquale, Giovanni Nassa, Francesco Pacifico, Antonio Leonardi, Luigi Insabato, Gaetano Calì, Paolo Golino, Giovanni Cimmino
OBJECTIVE: T-lymphocyte activation plays an important role in the pathophysiology of acute coronary syndromes (ACS). Plaques from ACS patients show a selective oligoclonal expansion of T-cells, indicating a specific, antigen-driven recruitment of T-lymphocytes within the unstable lesions. At present, however, it is not known whether T-cells may contribute directly to thrombosis by expressing functional tissue factor (TF). Accordingly, the aim of the present study was to investigate whether T-cells are able to express functional TF in their activated status...
September 1, 2016: International Journal of Cardiology
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