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Gökmen Karabağ, Halil İbrahim Tanrıverdi, Mehmet Sunay Yavuz, Abdülkadir Genç, Ufuk Akın, Selma Saraç
The reported rate of sex crimes, some of the most severe acts of violence that can be perpetrated against an individual, is increasing across all societies, regardless of gender or age of the victim. Sexual abuse has been defined, in part, as the involvement of a child in sexual activity for which they are incapable of giving consent, that they cannot fully comprehend, or for which they are developmentally immature. Molestation of the anorectal region is frequently encountered when the victim of sexual abuse is a male child...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Syed Shoeb Razvi, Hani Choudhry, Mohammed Nihal Hasan, Mohammed A Hassan, Said Salama Moselhy, Khalid Omer Abualnaja, Mazin A Zamzami, Taha Abduallah Kumosani, Abdulrahman Labeed Al-Malki, Majed A Halwani, Abdulkhaleg Ibrahim, Ali Hamiche, Christian Bronner, Tadao Asami, Mahmoud Alhosin
Natural polyamines such as putrescine, spermidine, and spermine are crucial in the cell proliferation and maintenance in all the eukaryotes. However, the requirement of polyamines in tumor cells is stepped up to maintain tumorigenicity. Many synthetic polyamine analogues have been designed recently to target the polyamine metabolism in tumors to induce apoptosis. N4 -Erucoyl spermidine (designed as N4 -Eru), a novel acylspermidine derivative, has been shown to exert selective inhibitory effects on both hematological and solid tumors, but its mechanisms of action are unknown...
2018: Epigenetics insights
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, José Trevino, Rays H Y Jiang, Muhammad Ayaz, Harshani R Lawrence, Perry Kennedy, Saïd M Sebti
Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy, underscoring the need to develop approaches that disable mutant KRas-driven tumors. Because targeting KRas directly has proven difficult, identifying vulnerabilities specific for mutant KRas tumors is an important alternative approach. Here we show that glycogen synthase kinase 3 (GSK3) is required for the in vitro and in vivo growth and survival of human mutant KRas-dependent tumors but is dispensable for mutant KRas-independent tumors...
December 4, 2018: Nature Communications
Alexander C Egbe, William R Miranda, Naser M Ammash, Nandan S Anavekar, Venkata R Missula, Srikanth Kothapalli, Arooj R Khan, Sameh M Said, Heidi M Connolly
BACKGROUND: Aortic dilation and aortic valve disease are known long-term complication of tetralogy of Fallot (TOF), but the risk of aortic dissection and the indications for prophylactic aortic surgery are unknown in this population. The purpose of this study was to: (1) determine the prevalence of significant aortic valve disease and/or significant aortic aneurysm (AVD-AA); (2) determine the incidence of progressive aortic dilation and aortic dissection in patients with TOF. METHODS: Retrospective review of adults with repaired TOF, and no prior aortic valve/aorta surgery, who had ≥2 measurements of the thoracic aorta >12 months apart, 1990-2017...
December 4, 2018: Heart: Official Journal of the British Cardiac Society
Cecily Begley, Natalie Sedlicka, Deirdre Daly
BACKGROUND: Respectful maternity care includes treating women with dignity, consulting them about preferences, gaining consent for treatment, respecting their wishes, and giving care based on evidence, not routines. In the absence of any documented evidence, this study aimed to ascertain maternity care-givers' perceptions of respectful care provided for childbearing women in Czech Republic. METHODS: Following ethical approval, an online quantitative survey with qualitative comments was completed by 52 respondents recruited from workshops on promoting normal birth, followed by snowball sampling...
December 4, 2018: Reproductive Health
Truls Gjestland
The new WHO Environmental Noise Guidelines for the European Region have recommendations for limiting noise exposure associated with adverse health effects. The limits are said to be based on a systematic review of existing evidence. This paper gives a systematic assessment of the presented evidence with respect to annoyance from aircraft noise. The new guidelines have been based on the results from a selection of existing aircraft noise studies. This paper demonstrates that a similar selection of other existing post-2000 studies will yield very different results...
December 2, 2018: International Journal of Environmental Research and Public Health
Alexander Savelyev, Alan M MacEachren
This paper investigates the feasibility, from a user perspective, of integrating a heterogeneous information network mining (HINM) technique into SensePlace3 (SP3), a web-based geovisual analytics environment. The core contribution of this paper is a user study that determines whether an analyst with minimal background can comprehend the network data modeling metaphors employed by the resulting system, whether they can employ said metaphors to explore spatial data, and whether they can interpret the results of such spatial analysis correctly...
2018: PloS One
Ozgur Yasar Celik, Kivanc Irak
In this study, it was aimed to investigate the effect of the date extract (Phoenix dactylifera) on certain biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index in nephrotoxicity induced by gentamicin. The rats used in the study were randomly selected and divided into 4 groups, each consisting of 8 rats: control group, date extract (DE) group, gentamicin (GEN) group, gentamicin+date extract (GEN+DE) group. Blood samples and kidney tissues were taken 24 hours after eight days of trial...
November 30, 2018: Cellular and Molecular Biology
Heba Shehta Said, Abdalbagi Basheer Benmahmod, Ramadan Hassan Ibrahim
Acinetobacter baumannii is an opportunistic pathogen that has been held responsible for a lot of infections worldwide. Infections caused by this pathogen are difficult to control because of the widespread of antimicrobial resistance mechanisms. The aim of the present study is to assess the prevalence of extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases among isolates of A. baumannii collected from different clinical sources in Mansoura University Hospitals, Egypt. Antimicrobial susceptibility testing has demonstrated elevated resistance level to β-lactams, quinolones and aminoglycosides...
December 3, 2018: World Journal of Microbiology & Biotechnology
Kyle Bruun, Erika Schermer, Anjali Sivendra, Emily Valaik, Reed B Wise, Rana Said, John R Bracht
Cardiovascular disease (CVD) is the number one cause of death globally, and new therapeutic techniques outside of traditional pharmaceutical and surgical interventions are currently being developed. At the forefront is stem cell-centered therapy, with adipose derived stem cells (ADSCs), an adult stem population, providing significant clinical promise. When introduced into damaged heart tissue, ADSCs promote cardiac regeneration by a variety of mechanisms including differentiation into new cardiomyocytes and secretion of paracrine factors acting on endogenous cardiac cells...
2018: American Journal of Stem Cells
Long Meng, Lei Guo, Yiwei Zhong, Zhe Wang, Kuiyuan Chen, Zhancheng Guo
Printed circuit boards (PCBs) comprise valuable metals, precious metals, and hazardous materials. Thus, they are considered both attractive secondary sources of metals and environmental pollutants. This study is based on the selective separation of Pb-Sn, Sn-Cu, and Cu-Zn alloys, where supergravity separation was used to concentrate precious metals (i.e., Ag, Au, and Pd) from PCBs in Cu-Zn alloy and final residue. The temperature and gravity coefficient were found to have great influence on the concentration of precious metals in said alloy and residue...
December 2018: Waste Management
Clara Gallego Cerveró, Julio Martín Ruiz, Laura Ruiz Sanchis, Concepción Ros Ros
BACKGROUND: Wind musicians suffer injuries resulting from muscle overuse and poor postural habits, often due to the lack of required physical fitness. For this reason, it is important to study and analyze the characteristics of their activity in order to select appropriate preventive exercises. METHODS: 10 clarinetists, who were experiencing joint pain due to instrumental practice, followed a specific program of physical activity, 3 times a week for 2 months. To assess postural changes after its implementation, the Langlade test and muscle pain scale were used at the beginning and the end of the program...
December 2018: Medical Problems of Performing Artists
Rachel Jodoin, Jean-Pierre Perreault
RNA G-quadruplexes (rG4) are stable non-canonical secondary structures composed of G-rich sequences. Many rG4 structures located in the 5'UTRs of mRNAs act as translation repressors due to their high stability which is thought to impede ribosomal scanning. That said, it is not known if these are mRNA-specific examples, or if they are indicative of a global expression regulation mechanism of the mRNAs involved in a common pathway based on structure folding recognition. Gene-ontology analysis of mRNAs bearing a predicted rG4 motif in their 5'UTRs revealed an enrichment for mRNAs associated with the colorectal cancer pathway...
2018: PloS One
Ryan M Antiel, Annie Janvier, Chris Feudtner, Kallie Blaine, Jessica Fry, Lori J Howell, Amy J Houtrow
BACKGROUND: Prenatal surgery for myelomeningocele (MMC) has been demonstrated to have benefits over postnatal surgery. Nevertheless, prenatal surgery requires a significant emotional, physical, and financial commitment from the entire family. METHODS: Mixed methods study of parents' perceptions regarding provider communication, treatment choices, and the family impact of having a child with MMC. RESULTS: Parents of children with MMC (n= 109) completed questionnaires...
November 18, 2018: Journal of Pediatric Rehabilitation Medicine
Graham Paul Martin, Sarah Chew, Mary Dixon-Woods
OBJECTIVES: To examine the experiences of clinical and managerial leaders in the English healthcare system charged with implementing policy goals of openness, particularly in relation to improving employee voice. DESIGN: Semi-structured qualitative interviews. SETTING: National Health Service, regulatory and third-sector organisations in England. PARTICIPANTS: Fifty-one interviewees, including senior leaders in healthcare organisations (38) and policymakers and representatives of other relevant regulatory, legal and third-sector organisations (13)...
December 3, 2018: Journal of the Royal Society of Medicine
Karen B Lasater, Douglas M Sloane, Matthew D McHugh, Linda H Aiken
OBJECTIVES: The purpose of this study is twofold: (1) to describe the quality of end-of-life care in US hospitals from the perspective of hospital nurses; and (2) to evaluate the relationship between the nurse practice environment and end-of-life care quality. DESIGN: Cross-sectional analysis of multiple linked secondary data sources. PARTICIPANTS AND SETTING: A total of 12,870 direct care registered nurses in 491 acute-care hospitals. MEASUREMENTS: Measures of end-of-life care quality and nurse practice environment were derived from the 2016 RN4CAST-US survey of nurses...
December 2, 2018: Journal of the American Geriatrics Society
Brian P Quinn, Aimee K Armstrong, Holly D Bauser-Heaton, Ryan Callahan, Howaida G El-Said, Susan R Foerster, Bryan H Goldstein, Andrea S Goodman, Todd M Gudausky, Jacqueline N Kreutzer, Ryan A Leahy, Christopher J Petit, Toby A Rockefeller, Shabana Shahanavaz, Sara M Trucco, Lisa Bergersen
To stratify diverse procedure types into categories with similar radiation exposure in cardiac catheterization for congenital heart disease. Radiation exposures for a comprehensive list of specific procedure types and stratification of outcomes based on radiation risk are not currently available. Data between January 2014 and December 2015 were collected on all cases performed at sites participating in C3PO-QI (Congenital Cardiac Catheterization Outcomes Project-Quality Improvement Initiative) and 9 centers were included...
November 30, 2018: Pediatric Cardiology
Min Sun Kim, Jihye Lee, Jin-Ah Sim, Jung Hye Kwon, Eun Joo Kang, Yu Jung Kim, Junglim Lee, Eun-Kee Song, Jung Hun Kang, Eun Mi Nam, Si-Young Kim, Hwan-Jung Yun, Kyung Hae Jung, June Dong Park, Young Ho Yun
Background: It is difficult to decide whether to inform the child of the incurable illness. We investigated attitudes of the general population and physicians toward prognosis disclosure to children and associated factors in Korea. Methods: Physicians working in one of 13 university hospitals or the National Cancer Center and members of the general public responded to the questionnaire. The questionnaire consisted of the age appropriate for informing children about the prognosis and the reason why children should not be informed...
December 3, 2018: Journal of Korean Medical Science
Hamed A El-Serehy, Hala S Abdallah, Fahad A Al-Misned, Saleh A Al-Farraj, Khaled A Al-Rasheid
Lake Timsah is considered as the biggest water body at Ismailia City with a surface area of 14 km2 . It is a saline shallow water basin lies approximately mid-way between the south city of Suez and the north city of Port Said at 30o 35'46.55"N and 32o 19'30.54″E. Because it receives water with high and low salinities, salinity stratification is producing in the Lake Timsah, with values of 14-40‰ for the surface water and over 40‰ for the bottom water. The temperature of the lake water decreased to below 19 °C in the winter and rose to above 29 °C in the summer; the concentration of dissolved oxygen ranged between 6...
November 2018: Saudi Journal of Biological Sciences
Leticia Coín-Aragüez, Francisco Javier Pavón, Alba Contreras, Adriana-Mariel Gentile, Said Lhamyani, Yolanda De Diego-Otero, Yolanda Casado, Wilfredo Oliva Olivera, Gabriel Olveira, Francisco J Tinahones, Lucía Pérez Costillas, Rajaa El Bekay
Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. An observational study was conducted in samples of patients consisting of non-obese and obese subjects, who were diagnosed with anxiety or mood disorders...
November 30, 2018: Scientific Reports
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