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Emily Reeve, Jennifer L Wolff, Maureen Skehan, Elizabeth A Bayliss, Sarah N Hilmer, Cynthia M Boyd
Importance: Use of harmful and/or unnecessary medications in older adults is prevalent. This can lead to avoidable harms such as adverse drug reactions, falls, hospitalization, and mortality. Primary care physicians report that patient resistance to discontinuing medication use is a significant barrier to deprescribing. Objective: To describe the attitudes of older adults toward deprescribing and to determine whether individual characteristics are associated with these attitudes...
October 15, 2018: JAMA Internal Medicine
Abdullah Hussain, Rohina Khizer Mufti, Maryam Shahid
OBJECTIVE: To find the frequency and determinants of patients preferring complementary and alternative medicine over registered medical doctors.. METHODS: This cross-sectional study was conducted at Services Hospital, Mayo Hospital and Jinnah Hospital in Lahore, Pakistan, from June 8 to August 20, 2017.A pre-tested self-administered questionnaire was used to collect data. SPSS 20 was used for data analysis. . RESULTS: Of the 385 subjects, 200(51...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Utaroh Motosugi, Alejandro Roldán-Alzate, Peter Bannas, Adnan Said, Sean Kelly, Ryan Zea, Oliver Wieben, Scott B Reeder
Purpose To assess the feasibility of four-dimensional (4D) flow MRI as a noninvasive imaging marker for stratifying the risk of variceal bleeding in patients with liver cirrhosis. Materials and Methods This study recruited participants scheduled for both liver MRI and gastroesophageal endoscopy. Risk of variceal bleeding was assessed at endoscopy by using a three-point scale: no varices, low risk, and high risk requiring treatment. Four-dimensional flow MRI was used to create angiograms for evaluating visibility of varices and to measure flow volumes in main portal vein (PV), superior mesenteric vein, splenic vein (SV), and azygos vein...
October 16, 2018: Radiology
Imen Ammous, Omar Hadj Said, Mejdi Boukari, Imen Zhioua, Khalil Errais, Raja Zhioua
Cranial nerves palsy associated with preeclampsia is reported in literature. Facial and abducens palsies were the most nerve disorders described. Only eleven cases have been reported in the literature. We report the case of a 27-years-old patient who presented abducens nerve palsy in immediately after the delivery of severe pre-eclampsia. No specific pathology was found. Symptoms of abducens nerve palsy have resolved spontaneously by controlling blood pressure after delivery.
January 2018: La Tunisie Médicale
Abby E Rudolph, April M Young, Jennifer R Havens
Geographic momentary assessments (GMA) collect real-time behavioral data in one's natural environment using a smartphone and could potentially increase the ecological validity of behavioral data. Several studies have evaluated the feasibility and acceptability of GMA among persons who use drugs (PWUD) and men who have sex with men (MSM), but fewer have discussed privacy, confidentiality, and safety concerns, particularly when illegal or stigmatized behavioral data were collected. This study explores perceptions regarding privacy, confidentiality, and safety of GMA research among PWUD and MSM recruited in three different settings (rural Appalachia, a mid-sized city in the South, and a mid-Atlantic city)...
October 15, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Livia E V M de Guerre, Said Sadiqi, Loek P H Leenen, Cumhur F Oner, Steven M van Gaalen
BACKGROUND: This study aims to analyze the incidence and outcomes of bicycle-related injuries in hospitalized patients in The Netherlands. METHODS: Bicycle accidents resulting in hospitalization in a level-I trauma center in The Netherlands between 2007 and 2017 were retrospectively identified. We subcategorized data of patients involved in a regular bicycle, race bike, off-road bike or e-bike accident. The primary outcomes were mortality rate and incidence of multitrauma...
October 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Michele Carbone, Ivano Amelio, El Bachir Affar, James Brugarolas, Lisa A Cannon-Albright, Lewis C Cantley, Webster K Cavenee, Zhijian Chen, Carlo M Croce, Alan D' Andrea, David Gandara, Carlotta Giorgi, Wei Jia, Qing Lan, Tak Wah Mak, James L Manley, Katsuhiko Mikoshiba, Jose N Onuchic, Harvey I Pass, Paolo Pinton, Carol Prives, Nathaniel Rothman, Said M Sebti, James Turkson, Xifeng Wu, Haining Yang, Herbert Yu, Gerry Melino
The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene-environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G × E interactions in cancer, and the expanded concept of G × E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment...
October 15, 2018: Cell Death and Differentiation
Alan Blum
No abstract text is available yet for this article.
October 15, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Hagar Rahel Haviv, Joanne Said, Ben Willem Mol
Infants born in the late preterm period and via non-labour caesarean section in the early term period are at increased risk of respiratory morbidity when compared to their term-born counterparts. The morbidity in these infants is less frequent and severe than in early preterm infants. Antenatal corticosteroids reduce respiratory morbidity in these populations; however, the magnitude of the reduction appears to be small and predominantly in the self-limiting condition of transient tachypnoea of the neonate. The smaller benefit, along with possible harmful effects of corticosteroids, raises a question about the role of antenatal corticosteroids in this population...
October 4, 2018: Seminars in Fetal & Neonatal Medicine
Raoul Borbé, Christine Pfäffle, Frank Eisele, Gerhard Längle
OBJECTIVE OF THE STUDY: General practitioners are mainly responsible for primary health care. Patients with mental disorders, in particular patients with complex or multiple needs, use these services infrequently in case of somatic complaints. Psychiatric outpatient clinics have to deal with these patients and have perhaps an additional role in diagnosing and treating somatic co-morbidities. This should be evaluated. METHODS: Physicians in outpatient clinics of the Centre of Psychiatry Suedwuerttemberg were asked about their attitude towards somatic co-morbidities, somatic co-treatment and prescribing somatic drugs...
October 15, 2018: Das Gesundheitswesen
Edison Eukun Sage, Nashriq Jailani, Azney Zuhaily Md Taib, Normah Mohd Noor, Md Ikram Mohd Said, Muntaz Abu Bakar, Mukram Mohamed Mackeen
The pulp and pericarp of mangosteen (Garcinia mangostana) fruit are popular food, beverage and health products whereby 60% of the fruit consist of the pericarp. The major metabolite in the previously neglected or less economically significant part of the fruit, the pericarp, is the prenylated xanthone α-mangostin. This highly bioactive secondary metabolite is typically isolated using solvent extraction methods that involve large volumes of halogenated solvents either via direct or indirect extraction. In this study, we compared the quantities of α-mangostin extracted using three different extraction methods based on the environmentally friendly solvents methanol and ethyl acetate...
2018: PloS One
Akihiro Shiina, Yasutaka Ojio, Aiko Sato, Naoya Sugiyama, Masaomi Iyo, Chiyo Fujii
Concern about mental health issues and the treatment of mentally disordered offenders attracts considerable public attention. This study aimed to gather the experiences and opinions of people who have experienced admission to a psychiatric ward in order to grasp their reaction to, and understanding of, the legislation behind the involuntary admission of psychiatric patients. A web-based questionnaire survey was conducted with a total of 379 participants, using a cross-sectional, exploratory design. The data were analyzed using a chi-squared test, Fisher's exact test, and a logistic regression analysis...
2018: PloS One
Ebrahim M Yimer, Kaleab Alemayehu Zewdie, Hailemichael Zeru Hishe
Diabetes is a multifactorial metabolic syndrome and is one of the shared long-lasting illnesses globally. It is linked to long-term microvascular and macrovascular complications that contribute to disability, compromised quality of life, and reduction in lifespan, which eventually leads to death. This disease is not only incurring significant economic burden but also adversely affects the patients, caregivers, communities, and the society at large. The interruption of diabetes progress and its complications is a primary focus of scientific communities...
2018: Journal of Diabetes Research
Fidel Vega, Maria S Millán, Nuria Garzón, Irene Altemir, Francisco Poyales, Jose Manuel Larrosa
The optical quality of a set of IOLs (modeling set: one monofocal and two bifocals) was assessed through focus by the area under the modulation transfer function (MTFa) metric and related to the visual acuity (VA) defocus curves of pseudophakic patients implanted with said IOLs. A non-linear relationship between the MTFa and clinical VA was obtained with an asymptotic limit found to be the best VA achievable by the patients. Two mathematical fitting functions between clinical VA and MTFa were derived with high correlation coefficients (R2 ≥0...
October 1, 2018: Biomedical Optics Express
Allison K Groves, Denise D Hallfors, Bonita J Iritani, Stuart Rennie, Fredrick S Odongo, Daniel Kwaro, Nyaguara Amek, Winnie K Luseno
Despite a pressing need for adolescent HIV research in sub-Saharan Africa, ethical guidance for conducting research among minor adolescents is lacking. One ethical issue is the degree to which parents should be involved in the research process. The existing discourse is predominantly speculative and focuses on negative consequences of parental involvement. We use empirical data to describe the perspectives of Kenyan adolescents on parental involvement in consent and disclosure of HIV test results within a research study context...
October 14, 2018: African Journal of AIDS Research: AJAR
R Ali, A El-Said, H El-Baz, A Settin
Type 2 diabetes mellitus (T2DM) has multigenetic and environmental interactive factors. Although diabetic neuropathies (DPN) are the most common, but at the same time, the least recognized and understood long-term complication of diabetes. This study aimed to investigate the association of IL-4 VNTR gene polymorphism with T2DM complicated with neuropathy in Egyptian subjects. This is a case control study including 102 T2DM Egyptian patients, plus 188 unrelated healthy individuals as controls. They were evaluated for variable number tandem repeat (VNTR); 70 base pair repeats located in the intron 3; of IL-4 gene using the PCR technique...
October 14, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Sajad Moradi, Elnaz Hosseini, Mohadese Abdoli, Solmaz Khani, Mohsen Shahlaei
Carbohydrate biopolymer of biocompatible biodegradable chitosan, currently become one of the most usable polymer in medical and pharmaceutical sciences. In this regard a large number of protein and peptide drugs are used as therapeutic agents which can be exposed to temperature stresses either in transporting or storage. These stresses can make the protein structure unstable, change the active structure and disrupt its therapeutic function that limits their using as successful drug. In order to overcome these disadvantages associated with protein drugs, different materials such as natural or synthetic polymers are used to make protein loaded biocompatible nano and microspheres...
January 1, 2019: Carbohydrate Polymers
Tariq F Al-Shaiji, Said M Yaiesh, Abdullatif E Al-Terki, Faisal M Alhajeri
INTRODUCTION: Erectile dysfunction affects over 50% of men 70 years and above, and penile prosthesis (PP) is its third-line treatment. Complications of PPs include infection, however, no formal guidelines exist for its management. METHODS: We performed a literature search and reviewed 53 recent published literatures of experiences with management of PP infections, prevention, and treatment. RESULTS: Acute infection can present early with pain and discharge and detection of early signs is of utmost importance...
October 15, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Sumaira Kanwal, Shazia Perveen, Hafiz Muhammad Arshad
OBJECTIVE: To find the causative mutation by linkage analysisof Charcot-Marie-Tooth disease while focussing on AMACR gene. METHODS: The case-control study was conducted from November 2016 to March 2017 in Kongju National University Korea.A family of 15 members with composite symptoms of peripheral neuropathy were enrolled. In addition, 50 healthy controls, which had no clinical features and family history of neuromuscular disorders, were also recruited. The family was selected for sequencing analysis by using capillary sequencing...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Cristina Belizna, Francesca Pregnolato, Sebastien Abad, Jaume Alijotas-Reig, Howard Amital, Zahir Amoura, Laura Andreoli, Emmanuel Andres, Achile Aouba, Sule Apras Bilgen, Laurent Arnaud, Boris Bienvenu, Viktoria Bitsadze, Patrick Blanco, Miri Blank, Maria Orietta Borghi, Antonia Caligaro, Elisabeta Candrea, Valentina Canti, Laurent Chiche, Jean Marie Chretien, Jan Willem Cohen Tervaert, Laura Damian, Teresa Delross, Emmanuelle Dernis, Katrien Devreese, Aleksandra Djokovic, Enrique Esteve-Valverde, Maria Favaro, Céline Fassot, Raquel Ferer-Oliveras, Alban Godon, Mohamed Hamidou, Milena Hasan, Daniel Henrion, Bernard Imbert, Pierre Yves Jeandel, Pascale Jeannin, Patrick Jego, Noemie Jourde-Chiche, Jamilya Khizroeva, Olivier Lambotte, Cédric Landron, Jose Omar Latino, Estibaliz Lazaro, Karina de Leeuw, Thomas Le Gallou, Kiliç Levent, Maarten Liimper, Laurent Loufrani, Romain Lubin, Nadine Magy-Bertrand, Guillaume Mahe, Alexander Makatsariya, Thierry Martin, Christian Muchardt, Gyorgy Nagy, Loukman Omarjee, Pieter Van Paasen, Gilles Pernod, Florence Perrinet, Gilberto Pires da Rosa, Marc Antoine Pistorius, Amelia Ruffati, Fatma Said, Patrick Saulnier, Damien Sene, Loic Sentilhes, Ova Shovman, Jean Sibilia, Crina Sinescu, Natasa Stanisavljevic, Ljudmila Stojanovitch, Lai Shan Tam, Angela Tincani, Fréderic Tollis, Sebastian Udry, Marie Noelle Ungeheuer, Mathilde Versini, Ricard Cervera, Pier Luigi Meroni
The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%-21% at 5 years in thrombotic APS and 20-28% in obstetrical APS (Cervera et al., 2009, 2015 [2,3]). Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects (Pericleous et al., 2016; Andrade and Tektonidou, 2016; Belizna, 2015; Erkan et al., 2014; Erkan and Lockshin, 2012; De Carolis et al., 2015; Mekinian et al., 2015; Merashli et al., 2015; Galli, 2014; Lopez-Pedrera et al...
October 11, 2018: Autoimmunity Reviews
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