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Prostate cancer imrt

David Dearnaley, Clare L Griffin, Rebecca Lewis, Philip Mayles, Helen Mayles, Olivia F Naismith, Victoria Harris, Christopher D Scrase, John Staffurth, Isabel Syndikus, Anjali Zarkar, Daniel R Ford, Yvonne L Rimmer, Gail Horan, Vincent Khoo, John Frew, Ramachandran Venkitaraman, Emma Hall
PURPOSE: To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at multiple centers. METHODS AND MATERIALS: In this phase 2 noncomparative multicenter trial, 124 patients with locally advanced, high-risk prostate cancer were randomized between prostate-only IMRT (PO) (74 Gy/37 fractions) and prostate and pelvic lymph node IMRT (P&P; 74 Gy/37 fractions to prostate, 60 Gy/37 fractions to pelvis)...
December 6, 2018: International Journal of Radiation Oncology, Biology, Physics
Matthew Hoffmann, Jacqueline Pacey, Josie Goodworth, Andrea Laszcyzk, Richard Ford, Brendon Chick, Stuart Greenham, Justin Westhuyzen
Aim: To assess a class solution template for volumetric-modulated arc therapy (VMAT) for prostate cancer using plan analysis software. Background: VMAT is a development of intensity-modulated radiotherapy (IMRT) with potential advantages for the delivery of radiotherapy (RT) in prostate cancer. Class solutions are increasingly used for facilitating RT planning. Plan analysis software provides an objective tool for evaluating class solutions. Materials and methods: The class solution for VMAT was based on the current static field IMRT template...
January 2019: Reports of Practical Oncology and Radiotherapy
Dirk Bottke, Detlef Bartkowiak, Alessandra Siegmann, Reinhard Thamm, Dirk Böhmer, Volker Budach, Thomas Wiegel
BACKGROUND: For patients with recurrent prostate cancer after radical prostatectomy (RP), salvage radiotherapy (SRT) offers a second chance of cure. European guidelines (EAU) recommend SRT at a PSA < 0.5 ng/ml. We analyze the efficacy of SRT given according to this recommendation and investigate the predictive power of the post-SRT PSA nadir. METHODS: Between 1998 and 2013, 301 patients of two university hospitals received SRT at a PSA < 0.5 ng/ml (median 0...
November 28, 2018: Prostate Cancer and Prostatic Diseases
B A Jereczek-Fossa, A Maucieri, G Marvaso, S Gandini, C Fodor, D Zerini, G Riva, O Alessandro, A Surgo, S Volpe, G Fanetti, S Arculeo, M A Zerella, S Parisi, P Maisonneuve, A Vavassori, F Cattani, R Cambria, C Garibaldi, A Starzyńska, G Musi, O De Cobelli, M Ferro, F Nolè, D Ciardo, R Orecchia
To report toxicity and efficacy outcome of moderately hypofractionated image-guided external-beam radiotherapy in a large series of patients treated for prostate cancer (PCa). Between 10/2006 and 12/2015, 572 T1-T3N0M0 PCa patients received 70.2 Gy in 26 fractions at 2.7 Gy/fraction: 344 patients (60%) with three-dimensional conformal radiotherapy (3D-CRT) and 228 (40%) with intensity-modulated radiotherapy (IMRT). Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria and Houston definition (nadir + 2) were used for toxicity and biochemical failure evaluation, respectively...
November 27, 2018: Medical Oncology
Ben G L Vanneste, Florian Buettner, Michael Pinkawa, Philippe Lambin, Aswin L Hoffmann
Background and purpose: To evaluate spatial differences in dose distributions of the ano-rectal wall (ARW) using dose-surface maps (DSMs) between prostate cancer patients receiving intensity-modulated radiation therapy with and without implantable rectum spacer (IMRT+IRS; IMRT-IRS, respectively), and to correlate this with late gastro-intestinal (GI) toxicities using validated spatial and non-spatial normal-tissue complication probability (NTCP) models. Materials and methods: For 26 patients DSMs of the ARW were generated...
January 2019: Clinical and Translational Radiation Oncology
Jonathan Hayman, Knut H Hole, Therese Seierstad, Jamie Perin, Theodore L DeWeese, Phuoc T Tran, Wolfgang Lilleby
BACKGROUND: The recurrence patterns of high-risk, N1 prostate cancer after radiation therapy (RT) including the pelvic lymph nodes have not been fully investigated. MATERIAL AND METHODS: We have a prospective clinical study since 2004 that has followed 138 men with locally advanced prostate cancer (T1-T4N0-N1M0) treated with definitive RT encompassing the prostate and pelvic lymph nodes and long-term androgen deprivation therapy (ADT). Forty nine of the 52 patients that developed recurrence were imaged at biochemical failure to detect the site of recurrence...
November 13, 2018: Urologic Oncology
Arne Grün, Michael Kawgan-Kagan, David Kaul, Harun Badakhshi, Carmen Stromberger, Volker Budach, Dirk Böhmer
BACKGROUND AND PURPOSE: To evaluate the effect of changes in bladder volume during high-dose intensity-modulated-radiotherapy (IMRT) of prostate cancer on acute genitourinary (GU) toxicity and prospectively evaluate a simple biofeedback technique for reproducible bladder filling with the aim of reducing acute GU toxicity. METHODS: One hundred ninety-three patients were trained via a biofeedback mechanism to maintain a partially filled bladder with a reproducible volume of 200-300 cc at planning CT and subsequently at each fraction of radiotherapy...
November 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Yasushi Nakai, Nobumichi Tanaka, Satoshi Anai, Makito Miyake, Isao Asakawa, Yosuke Morizawa, Shunta Hori, Kazumasa Torimoto, Tomomi Fujii, Masatoshi Hasegawa, Kiyohide Fujimoto
Purpose: The aim of this study was to evaluate the chronological changes in lower urinary tract symptoms (LUTSs), disease-related quality of life (QOL), and health-related QOL (HR-QOL) of patients who received intensity-modulated radiotherapy (IMRT). Patients and methods: In 121 patients who had received IMRT and were followed up for >2 years, the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Expanded Prostate Cancer Index Composite (EPIC), and 8-Item Short-Form Health Survey (SF-8) were used before IMRT, at the halfway point in IMRT, immediately after IMRT, and 1-24 months after the completion of IMRT...
2018: Research and Reports in Urology
Hideya Yamazaki, Koji Masui, Gen Suzuki, Satoaki Nakamura, Norihiro Aibe, Daisuke Shimizu, Tatsuyuki Nishikawa, Haruumi Okabe, Ken Yoshida, Tadayuki Kotsuma, Eiichi Tanaka, Keisuke Otani, Yasuo Yoshioka, Kazuhiko Ogawa
We compared radiotherapy outcomes between 241 elderly patients aged ≥75 years and 867 younger controls (age <75 years) with clinically localized prostate cancer. The elderly group showed an equivalent actuarial seven-year biochemical failure-free survival rate (7y-bNED) (94.9%) to the younger control group (96.4%, p = 0.593). The incidence of late genitourinary (GU) and gastrointestinal (GI) toxicities grade ≥2 was also similar between the elderly and younger cohorts, while no grade ≥4 adverse events occurred...
November 8, 2018: Journal of Clinical Medicine
Natsuo Tomita, Norihito Soga, Yuji Ogura, Jun Furusawa, Hiroshi Tanaka, Yutaro Koide, Hiroyuki Tachibana, Takeshi Kodira
AIM: To investigate 10-year outcomes of high-dose image-guided intensity-modulated radiation therapy (IG-IMRT) combined with long-term androgen deprivation therapy (ADT) for Japanese patients with nonmetastatic prostate cancer. METHODS: A retrospective analysis was performed on 208 Japanese patients with T1-4N0M0 prostate cancer, who underwent definitive IG-IMRT from 2006 to 2010 at our single institution. The median dose was 78 Gy (74-78) and median ADT time was 32 months (6-151)...
November 8, 2018: Asia-Pacific Journal of Clinical Oncology
Anastassia Löser, Burkhard Beyer, Cedric Oliver Carl, Benjamin Löser, Yamini Nagaraj, Thorsten Frenzel, Cordula Petersen, Andreas Krüll, Markus Graefen, Rudolf Schwarz
PURPOSE: Combined high-dose-rate brachytherapy (HDR-BT) and external beam radiation therapy (EBRT) is a favorable treatment option in non-metastatic prostate cancer. However, reports on toxicity and outcome have mainly focused on younger patients. We aimed to determine toxicity and biochemical control rates after combined HDR-BT and EBRT in men ≥75 years. METHODS: From 1999 to 2015, 134 patients aged ≥75 years (median 76 years; 75-82 years) were identified...
November 2, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Scott O Quarrier, Jubin E Matloubieh, Guan Wu
OBJECTIVE: To present a robot-assisted surgical technique for overcoming challenges of a patient with prior pelvic surgeries and bowel in the radiation target. METHODS: A 72-year-old male required treatment for biochemically recurrent prostate cancer. In 2006, he presented with PSA 5.74 ng/ml, Gleason 3+3 prostate cancer. He underwent a robot-assisted radical prostatectomy for pT2aNx adenocarcinoma with negative margins. In 2008, he was found to have muscle invasive high-grade papillary urothelial carcinoma and underwent robot-assisted radical cystectomy and ileal conduit for pT2bN0 urothelial carcinoma...
October 29, 2018: Urology
Carola Hartel, Elena Nasonova, Martina C Fuss, Anna V Nikoghosyan, Juergen Debus, Sylvia Ritter
Background and purpose: Chromosomal aberrations in peripheral blood lymphocytes are a biomarker for radiation exposure and are associated with an increased risk for malignancies. To determine the long-term cytogenetic effect of radiotherapy, we analyzed the persistence of different aberration types up to 2.5 years after the treatment. Materials and methods: Cytogenetic damage was analyzed in lymphocytes from 14 patients that had undergone C-ion boost + IMRT treatment for prostate cancer...
November 2018: Clinical and Translational Radiation Oncology
Marcin Miszczyk, Wojciech Majewski
Background: The purpose of this study was to compare hematologic adverse effects and hematologic toxicity (HT) of pelvic irradiation in patients treated with conformal radiotherapy (CRT) and intensity modulated radiotherapy (IMRT) for radical treatment of prostate and bladder cancer. Methods: A group of 115 patients with prostate or bladder cancer treated with definitive radical radiotherapy was evaluated retrospectively. Blood test were taken before and after treatment comprising of following indices: white blood cells (WBC) hemoglobin (HGB), red blood cell (RBC), lymphocyte (LC), neutrophil (NC) and platelet (PLT) count...
October 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Shupeng Chen, An Qin, Dingyi Zhou, Di Yan
PURPOSE: Clinical implementation of magnetic resonance imaging (MRI)-only radiotherapy requires a method to derive synthetic CT image (S-CT) for dose calculation. This study investigated the feasibility of building a deep convolutional neural network for MRI based S-CT generation and evaluate the dosimetric accuracy on prostate IMRT planning. METHODS: A Paired CT and T2-weighted MR images were acquired from each of 51 prostate cancer patients. Fifteen pairs were randomly chosen as tested set and the remaining 36 pairs as training set...
October 20, 2018: Medical Physics
Tarun K Podder, Elisha T Fredman, Rodney J Ellis
Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety of radiation delivery machines, such as a linear accelerator (Linac), Cyberknife robotic system, Gamma knife, Tomotherapy and proton beam machine...
2018: Advances in Experimental Medicine and Biology
F Böckelmann, M Hammon, S Lettmaier, R Fietkau, C Bert, F Putz
OBJECTIVE: This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions. PATIENTS AND METHODS: A total of 17 prostate cancer patients were treated with intensity-modulated radiation therapy (IMRT) and interstitial brachytherapy (IBT). CT and MRI datasets were acquired back-to-back based on a 65 cm3 air-filled ERB and drinking instructions. After rigid co-registration of the imaging data, the CT-based planning target volume (PTV) used for treatment planning was retrospectively compared to an MRI-based adaptive PTV and the dose to the PB was determined in each case...
October 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Roman Paleny, Michael Bremer, Daniel Walacides, Silke Mainwaring, Kristina Weber, Christoph Henkenberens
PURPOSE: To compare relative and absolute dose-volume parameters (DV) of the rectum and their clinical correlation with acute and late radiation proctitis (RP) after radiotherapy (RT) for prostate cancer (PCa). PATIENTS AND METHODS: 366 patients received RT for PCa. In total, 49.2% received definitive RT, 20.2% received postoperative RT and 30.6% received salvage RT for biochemical recurrence. In 77.9% of patients, RT was delivered to the prostate or prostate bed, and additional whole pelvic RT was performed in 22...
September 6, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Hamid Abdollahi, Seied Rabi Mahdavi, Shayan Mostafaei, Bahram Mofid, Abolfazl Razzaghdoust, Afshin Saadipoor, Mohsen Bakhshandeh, Shahram Teimourian
PURPOSE: Rectal toxicity is one of the most common side effects in prostate cancer radiotherapy. Prediction of such effect is of particularly interest to personalize the treatment. This study's purpose is to investigate the performance of predictive radiomic models developed based on clinical, dosimetric parameters and radiomic features extracted from rectal wall magnetic resonance image (MRI). METHODS: This prospective study was conducted on 33 pathologically proven prostate cancer patients treated with intensity modulated radiation therapy (IMRT)...
September 4, 2018: Medical Physics
Daniel Bridges, Hidemasa Kawamura, Tatsuaki Kanai
PURPOSE: This observational study investigates the influence of interfractional motion on clinical target volume (CTV) coverage, planning target volume (PTV) margins, and rectum tissue sparing in carbon ion radiation therapy (CIRT). It reports dose coverage to target structures and organs at risk in the presence of interfractional motion, investigates rectal tissue sparing, and provides recommendations for lowering the rate of toxicity. We also propose probabilistic DVH based on cone-beam computed tomography (CBCT) table shifts from photon therapy for consideration in bone-matching CIRT treatment planning to represent probable dose to our CIRT patient population...
2018: PloS One
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