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https://www.readbyqxmd.com/read/30505488/obstructive-sleep-apnea-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#1
Xue Yu, Zhiwei Huang, Yi Zhang, Zhihong Liu, Qin Luo, Zhihui Zhao, Qing Zhao, Liu Gao, Qi Jin, Lu Yan
Background: Due to its effects, like an exaggerated negative intrathoracic pressure, sympathetic activation, systemic inflammation, oxidative stress, and endothelial dysfunction, obstructive sleep apnea (OSA) has been involved as a cause in multiple cardiovascular diseases. These diseases include coronary artery disease, hypertension, heart failure, and pulmonary hypertension (PH). Furthermore, OSA often coexists with chronic thromboembolic pulmonary hypertension (CTEPH) in clinical practice...
October 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30504348/the-current-state-of-sickle-cell-trait-implications-for-reproductive-and-genetic-counseling
#2
REVIEW
Lydia H Pecker, Rakhi P Naik
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because of this high frequency, reproductive counseling is of paramount importance. In addition, unlike other carrier states, SCT seems to be a risk factor for several clinical complications, such as extreme exertional injury, chronic kidney disease, and venous thromboembolism...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504116/-percutaneous-balloon-angioplasty-for-treatment-of-chronic-thromboembolic-pulmonary-hypertension
#3
Fernando J Daghero, Juan P Casas, Pablo E Sarmiento, Roberto M A Colque, Miguel A Tibaldi, Eduardo Moreyra, Leandro Martínez Riera, Guillermo Pacheco
Chronic thromboembolic pulmonary hypertension is characterized by the presence of organized thrombotic material in the pulmonary arteries which causes elevation of the pulmonary vascular resistance, right heart failure, and death if not treated. Pulmonary thromboendarterectomy is the treatment of choice and can be curative when the obstruction is proximal. There are cases in which this therapy is not possible, and pulmonary angioplasty is a therapeutic alternative of growing interest. We present our experience with three patients diagnosed with chronic thromboembolic pulmonary hypertension in whom pulmonary endarterectomy was not possible and pulmonary angioplasty was performed...
2018: Medicina
https://www.readbyqxmd.com/read/30501851/frequency-of-pulmonary-hypertension-in-transthoracic-echocardiography-screening-is-not-increased-in-takayasu-arteritis-experience-from-a-single-center-in-turkey
#4
Melike Kalfa, Hakan Emmungil, Oktay Musayev, Özgül Soysal Gündüz, Zevcet Yılmaz, Vedat İnal, Servet Akar, Nurullah Akkoç, Fatoş Önen, Meral Kayıkçıoğlu, Gökhan Keser, Kenan Aksu
OBJECTIVE: Pulmonary hypertension (PH) may occur in Takayasu arteritis (TA), mostly due to pulmonary arteritis, but also due to left heart disease and/or chronic thromboembolism (CTE). Using transthoracic echocardiography (TTE), we investigated the frequency of PH caused by pulmonary arteritis. METHODS: This cross-sectional study included 70 patients with TA fulfilling the 1990 ACR criteria, 68 healthy controls, and 67 patients with systemic sclerosis (SSc) fulfilling the 1980 ACR criteria representing the disease control group...
December 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30499177/efficacy-of-different-hemodialysis-methods-on-dendritic-cell-marker-cd40-and-cd80-and-platelet-activation-marker-cd62p-and-p10-in-patients-with-chronic-renal-failure
#5
Xin-Fang Wang, Bei-Hao Zhang, Xiao-Qing Lu, Pei Wang
BACKGROUND: Chronic renal failure (CRF) has become a major public health concern, which increases the risk of stroke and systemic thromboembolism. Therefore, therapeutic strategies are in urgent requirement. This study was conducted for investigating efficacy of hemodialysis (HD), hemodiafiltration (HDF), and hemoperfusion (HP) in patients with CRF and the correlation with the presence of complications following HD therapy. METHODS: The therapeutic effect, living quality, biochemical indicators, and dry weight were detected before and after the treatment regimens...
November 29, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/30496427/magnetic-resonance-direct-thrombus-imaging-for-pre-operative-assessment-of-acute-thrombosis-in-chronic-thromboembolic-pulmonary-hypertension
#6
Frederikus A Klok, Diethard Pruefer, Andreas Rolf, Stavros V Konstantinides
No abstract text is available yet for this article.
November 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30487151/cardiovascular-thromboembolic-and-renal-outcomes-in-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-a-retrospective-cohort-study-using-routinely-collected-primary-care-data
#7
Alexander Tracy, Anuradhaa Subramanian, Nicola J Adderley, Paul Cockwell, Charles Ferro, Simon Ball, Lorraine Harper, Krishnarajah Nirantharakumar
BACKGROUND: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. METHODS: Using a large UK primary care database, we conducted an open retrospective matched cohort study of cardiovascular, venous thrombotic and renal outcomes in adult-onset and childhood-onset IgAV...
November 28, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30487130/the-current-state-of-sickle-cell-trait-implications-for-reproductive-and-genetic-counseling
#8
Lydia H Pecker, Rakhi P Naik
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because of this high frequency, reproductive counseling is of paramount importance. In addition, unlike other carrier states, SCT appears to be a risk factor for several clinical complications such as extreme exertional injury, chronic kidney disease, and venous thromboembolism...
November 28, 2018: Blood
https://www.readbyqxmd.com/read/30485890/coagulation-pathways-hemostasis-and-thrombosis-in-liver-failure
#9
Nicolas M Intagliata, Jessica P E Davis, Stephen H Caldwell
Achieving hemostasis, preventing and treating thrombosis, and laboratory measurement of the hemostatic pathways constitute the core elements of managing the critically ill patient with liver failure. Uncontrolled bleeding in acutely decompensated cirrhosis and acute-on-chronic liver failure is probably the most familiar clinical challenge to intensivists. Bleeding in these patients can be broadly divided into pressure-driven (portal hypertension-related) bleeding with only limited dependence on hemostatic pathways and intractable mucosal/wound bleeding, which is much more directly related to a severely disturbed hemostatic system with imbalances in the coagulation cascade and the fibrinolytic system...
October 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30485648/association-of-chorioamnionitis-and-its-duration-with-adverse-maternal-outcomes-by-mode-of-delivery-a-cohort-study
#10
Kartik K Venkatesh, Angelica Glover, Catherine J Vladutiu, David M Stamilio
OBJECTIVE: To investigate the association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery. DESIGN: A retrospective cohort study. SETTING: Data from the Consortium on Safe Labor Study (CSL) in the USA (2002-2008). POPULATION: Singleton deliveries at ≥23 weeks of gestation (221,274 assessed deliveries, 62,331 by cesarean). METHODS: The association of chorioamnionitis, and secondarily the duration of chorioamnionitis estimated from intrapartum antibiotic use, with adverse maternal outcomes was analyzed using logistic regression with generalized estimating equations, adjusting for age, parity, race, pre-gestational diabetes, chronic hypertension, gestational age at delivery, study site, and delivery year...
November 28, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30482666/association-between-venous-thromboembolism-events-and-fibrates-a-comparative-study
#11
Charles Dolladille, Xavier Humbert, Murielle Faucon, Claire Tournilhac, Marion Sassier, Sophie Fedrizzi, Paul Milliez, Véronique Lelong-Boulouard, Antoine Coquerel, Paolo Emilio Puddu, Jean-Jacques Parienti, Joachim Alexandre
AIM: Previous studies highlighted a significant association between fibrates and venous thromboembolism (VTE) events in dyslipidemia diabetic patients. Studies in non-diabetic patients are divergent. The present study investigated the association between VTE events and fibrates in diabetic and non-diabetic patients. METHODS: Two approaches were used: (1) a disproportionality analysis using the World health organization pharmacovigilance database VigiBase® was used to evaluate the reporting odds-ratio (ROR) of fibrates for VTE events...
October 5, 2018: Thérapie
https://www.readbyqxmd.com/read/30477764/subcutaneous-treprostinil-a-new-treatment-for-chronic-thromboembolic-pulmonary-hypertension
#12
Hossein-Ardeschir Ghofrani
No abstract text is available yet for this article.
November 23, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30477763/subcutaneous-treprostinil-for-the-treatment-of-severe-non-operable-chronic-thromboembolic-pulmonary-hypertension-ctreph-a-double-blind-phase-3-randomised-controlled-trial
#13
Roela Sadushi-Kolici, Pavel Jansa, Grzegorz Kopec, Adam Torbicki, Nika Skoro-Sajer, Ioana-Alexandra Campean, Michael Halank, Iveta Simkova, Kristof Karlocai, Regina Steringer-Mascherbauer, Miroslav Samarzija, Barbara Salobir, Walter Klepetko, Jaroslav Lindner, Irene M Lang
BACKGROUND: Treprostinil, a prostacyclin analogue, is effective for the treatment of pulmonary arterial hypertension. However, information is scarce regarding treprostinil for treatment of chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to examine the efficacy and safety of subcutaneous treprostinil in this setting. METHODS: In this 24-week, randomised, double-blind controlled trial, we enrolled patients with CTEPH, classified as non-operable, or with persistent or recurrent pulmonary hypertension after pulmonary endarterectomy, in six European expert centres in Austria, Czech Republic, Germany, and Poland...
November 23, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30472021/effectiveness-and-safety-of-non-vitamin-k-antagonist-oral-anticoagulants-in-atrial-fibrillation-patients-with-hypertrophic-cardiomyopathy-a-nationwide-cohort-study
#14
Hyunjean Jung, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
BACKGROUND: Chronic anticoagulation is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative to warfarin, but there are limited data to support their use in patients with HCM and AF. We sought to compare thromboembolic events, bleeding, and mortality between NOAC and warfarin in patients with HCM and AF. METHODS: From the Korean National Health Insurance Service (NHIS) database during the period from January 1, 2011 to December 31, 2016, we identified a warfarin-treated group of patients with HCM and AF (n = 955) who were compared with a 1:2 propensity-matched NOAC treated group (n = 1,504)...
November 22, 2018: Chest
https://www.readbyqxmd.com/read/30466848/contribution-of-cardiac-implantable-electronic-devices-to-thrombus-formation-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#15
Rohith Nayak, Timothy M Fernandes, William R Auger, G Victor Pretorius, Michael M Madani, Ulrika M Birgersdotter-Green
OBJECTIVES: This study aimed to identify the prevalence of cardiac implantable electronic devices (CIEDs) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and to describe the associated disease burden. BACKGROUND: CTEPH is a debilitating disease, now potentially curable with pulmonary thromboendarterectomy (PTE). The contribution of CIEDs to thrombosis in this patient population has not been previously studied. METHODS: The charts of 982 CTEPH patients, who underwent PTE between January 1, 2009, and December 31, 2015 at University of California-San Diego (UCSD) Medical Center, were reviewed for pacemakers or implantable cardioverter defibrillators (ICDs) implanted before surgery...
November 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30463686/-treatment-of-chronic-thromboembolic-pulmonary-hypertension-in-elderly-patients
#16
C Garcia-Alonso, B Gerardin, L Moisson, O Mercier, E Fadel, P Brenot
AIM OF THE STUDY: To establish efficacy and security of invasive treatments for chronic thromboembolic pulmonary hypertension (CTEPH) in elderly patients (≥80 years old): pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA). PATIENTS AND METHODS: Between 2014 and 2017, 549 CTEPH patients were addressed to our hospital for PEA (364 patients) or BPA (225). From this total, patients 80 years old and over were: 17 treated by PEA and 21 by BPA. Demographic characteristics as well as hemodynamic parameters, results and complications were compared for both groups (Young - Y - versus Old - O)...
December 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/30460973/pulmonary-thromboendarterectomy-in-a-combined-thrombophilia-patient
#17
Hakan Akbayrak, Hayrettin Tekumit
Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially correctable cause of secondary pulmonary hypertension. Surgical treatment remains the primary treatment for patients with CTEPH. Pulmonary thromboendarterectomy (PEA) with deep hypothermic circulatory arrest is the standard and recommended surgical technique for the treatment of these patients. The prevalence of CTEPH after an acute pulmonary thromboembolism (PTE) has been found in various studies to be between 0.6 and 8.8%. Mortality rates in elective PEA cases with CTEPH are reported to be between 1...
November 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/30460573/residual-high-intrapulmonary-shunt-fraction-limits-exercise-capacity-in-patients-treated-with-balloon-pulmonary-angioplasty
#18
Makoto Takei, Takashi Kawakami, Masaharu Kataoka, Ichiro Kuwahira, Keiichi Fukuda
Balloon pulmonary angioplasty (BPA) has emerged as a new treatment strategy for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Improvements in hemodynamic parameters after BPA have been reported, but some patients continue to suffer from reduced exercise tolerance even after the normalization of hemodynamic parameters following BPA. As the amelioration of hemodynamic parameters is reportedly achieved via BPA, we hypothesized that the limiting factors for exercise tolerance in these patients are related to respiratory function...
November 20, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/30451640/pulmonary-thromboendarterectomy-is-a-curative-resolution-for-chronic-thromboembolic-pulmonary-hypertension-associated-with-antiphospholipid-syndrome-a-retrospective-cohort-study
#19
C Li, J Zhao, S Liu, W Song, J Zhu, L Hua, Q Wang, M Li, X Zeng, Y Zhao
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening condition with poor prognosis in patients with antiphospholipid syndrome (APS). Pulmonary thromboendarterectomy (PTE) is the optimal surgical option for CTEPH. OBJECTIVES: This retrospective cohort study aimed to evaluate the efficacy and risk of PTE in patients with APS-associated CTEPH. METHODS: Consecutive patients with APS-associated CTEPH diagnosed between January 2012 and September 2017 at Peking Union Medical College Hospital were retrospectively evaluated...
December 2018: Lupus
https://www.readbyqxmd.com/read/30448112/prolonged-qrs-duration-as-a-predictor-of-right-ventricular-dysfunction-after-balloon-pulmonary-angioplasty
#20
Ryotaro Asano, Takeshi Ogo, Keiko Ohta-Ogo, Shigefumi Fukui, Akihiro Tsuji, Jin Ueda, Nao Konagai, Tetsuya Fukuda, Yoshiaki Morita, Teruo Noguchi, Kengo Kusano, Toshihisa Anzai, Hatsue Ishibashi-Ueda, Satoshi Yasuda
BACKGROUND: Balloon pulmonary angioplasty (BPA) has shown beneficial effects for chronic thromboembolic pulmonary hypertension (CTEPH). However, previous studies have shown less cardiac output improvement and symptoms remaining after BPA, implying poor right ventricular (RV) function recovery. Therefore, we investigated the residual RV dysfunction after BPA to reveal risk factors, clinical effects, and possible underlying histopathological mechanisms. METHODS AND RESULTS: We investigated 61 consecutive CTEPH patients who underwent cardiovascular magnetic resonance before and 3 and 12 months after BPA series...
November 10, 2018: International Journal of Cardiology
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