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chronic thromboembolism

Tobias Tritschler, Noémie Kraaijpoel, Grégoire Le Gal, Philip S Wells
Importance: Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially fatal disease. Objective: To summarize the advances in diagnosis and treatment of VTE of the past 5 years. Evidence Review: A systematic search was conducted in EMBASE Classic, EMBASE, Ovid MEDLINE, and other nonindexed citations using broad terms for diagnosis and treatment of VTE to find systematic reviews and meta-analyses, randomized trials, and prospective cohort studies published between January 1, 2013, and July 31, 2018...
October 16, 2018: JAMA: the Journal of the American Medical Association
Tawfik Addi, Laetitia Dou, Stéphane Burtey
Patients with chronic kidney disease (CKD) display an elevated risk of thrombosis. Thrombosis occurs in cardiovascular events, such as venous thromboembolism, stroke, and acute coronary syndrome, and is a cause of hemodialysis vascular access dysfunction. CKD leads to the accumulation of uremic toxins, which exerts toxic effects on blood and the vessel wall. Some uremic toxins result from tryptophan metabolization in the gut through the indolic and the kynurenine pathways. An increasing number of studies are highlighting the link between such uremic toxins and thrombosis in CKD...
October 12, 2018: Toxins
M A Cherniavskiĭ, A G Edemskiĭ, Iu A Kudaev, A M Cherniavskiĭ
Analysed herein are the results of pulmonary endarterectomy (PEA) performed in a total of 169 patients presenting with chronic thromboembolic pulmonary hypertension (CTEPH) at the National Medical Research Centre named after Academician E.N. Meshalkin over the period from 2004 to 2014. Pulmonary endarterectomy was carried out according to the standard technique in the conditions of assisted circulation with the use of hypothermia and circulatory arrest. The duration of follow up of patients after surgical treatment amounted to 10 years...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Fan Ma, Kaiyu Zhou, Yimin Hua, Xiaoliang Liu, Hongyu Duan, Yifei Li, Chuan Wang
RATIONALE: Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and determining the underlying etiologies is essential for treatment. Venous thromboembolism, a well-known complication in nephrotic syndrome (NS), always occurrs during the treatment in course of the disease. However, CTEPH as the first manifestation of NS has not been reported till now. PATIENT CONCERNS: A 12-year-old boy initially complained of hemoptysis, cough and shortness of breath with exertion, any symptoms regarding NS such as edema were not presented...
October 2018: Medicine (Baltimore)
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
Christian Schoenfeld, Jan B Hinrichs, Karen M Olsson, Martin-Alexander Kuettner, Julius Renne, Till Kaireit, Christoph Czerner, Frank Wacker, Marius M Hoeper, Bernhard C Meyer, Jens Vogel-Claussen
OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with balloon pulmonary angioplasty (BPA) in inoperable patients. Sensitive non-invasive imaging methods are missing to detect treatment response after a single BPA treatment session. Therefore, the aim of this study was to measure treatment response after a single BPA session using cardio-pulmonary MRI. MATERIALS AND METHODS: Overall, 29 patients with CTEPH were examined with cardio-pulmonary MRI before and 62 days after their initial BPA session...
October 11, 2018: European Radiology
Lillian Benck, Evan Kransdorf, Jignesh Patel
PURPOSE OF REVIEW: Chagas cardiomyopathy is an emerging form of non-ischemic cardiomyopathy in the USA. This review aims to summarize current concepts in pathophysiology, disease transmission, medical therapy, and heart transplantation for patients with chronic Chagas cardiomyopathy. RECENT FINDINGS: The incidence of Chagas cardiomyopathy is increasing in the USA, driven mainly by immigration from countries where Chagas disease is endemic. Chagas cardiomyopathy is a chronic, progressive myocarditis, with hallmark features of biventricular dysfunction, ventricular arrhythmias, thromboembolic complications, and a high risk of mortality...
October 11, 2018: Current Cardiology Reports
Erzsébet Horváth-Puhó, Marit M Suttorp, Henrik Frederiksen, Tiny Hoekstra, Olaf M Dekkers, Lars Pedersen, Suzanne C Cannegieter, Friedo W Dekker, Henrik Toft Sørensen
Introduction: Erythropoiesis-stimulating agent (ESA) treatment has been associated with an increased risk of venous thromboembolism (VTE) in patients with solid tumors and with an increased risk of cardiovascular events in patients with chronic kidney disease. The ESA-related risk in patients with hematological neoplasms remains unclear. We, therefore, aimed to assess the ESA-related risk of VTE, myocardial infarction (MI), and stroke in patients with multiple myeloma (MM) and myelodysplastic syndrome (MDS)...
2018: Clinical Epidemiology
Jason Han, Hao Xiang, William E Ridley, Lloyd J Ridley
No abstract text is available yet for this article.
October 2018: Journal of Medical Imaging and Radiation Oncology
Jean Jacques Noubiap, Mazou N Temgoua, Ronni Tankeu, Joel Noutakdie Tochie, Ambroise Wonkam, Jean Joël Bigna
Background: Globally, sickle cell disease (SCD) is one of the most common haemoglobinopathy. Considered a public health problem, it leads to vessel occlusion, blood stasis and chronic activation of the coagulation system responsible for vaso-occlussive crises and venous thromboembolism (VTE) which may be fatal. Although contemporary observational studies suggest a relationship between SCD or sickle trait (SCT) and VTE, there is lack of a summary or meta-analysis data on this possible correlation...
2018: Thrombosis Journal
Ella Grilz, Florian Posch, Oliver Königsbrügge, Ilse Schwarzinger, Irene Marthe Lang, Christine Marosi, Ingrid Pabinger, Cihan Ay
Patients with cancer are at risk of developing venous and arterial thromboembolism (VTE and ATE). Elevated platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte ratios (NLR) have been suggested as potential biomarkers for cancer-associated chronic inflammation, VTE and mortality. We investigated the association between PLR and NLR with VTE, ATE and mortality in patients with cancer. Within a prospective cohort study, we followed-up patients with newly diagnosed or progressing cancer for objectively confirmed, symptomatic VTE, ATE and death...
October 8, 2018: Thrombosis and Haemostasis
Thomas P C Chu, Matthew J Grainge, Timothy R Card
BACKGROUND: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism. AIM: To determine when patients are at high risk of thromboembolic events, including after major surgery, and to guide timing of thromboprophylaxis. METHODS: Each IBD patient from Clinical Practice Research Datalink, linked with Hospital Episode Statistics, was matched to up to five non-IBD patients in this cohort study. We examined their risk of thromboembolism in hospital and within 6 weeks after leaving hospital, with or without undergoing major surgery, and while ambulant...
October 8, 2018: Alimentary Pharmacology & Therapeutics
Shun Kizawa, Takahide Ito, Kanako Akamatsu, Noboru Ichihara, Shimpei Nogi, Masatoshi Miyamura, Yumiko Kanzaki, Koichi Sohmiya, Masaaki Hoshiga
Patients with chronic kidney disease (CKD) experiencing atrial arrhythmia are hypothesized to have elevated CHADS2 and CHA2 DS2 -VASc scores, thereby predisposed to left atrial (LA) thrombus formation and subsequent thromboembolism. We examined possible association of LA thrombogenic milieu (TM) with CKD in patients with nonvalvular atrial fibrillation. A total of 581 patients (181 women; mean age, 67 years) who underwent transesophageal echocardiography were examined. Patients were divided into 4 groups based on the estimated glomerular filtration rate (eGFR) (ml/min/1...
September 13, 2018: American Journal of Cardiology
Manuel J Richter, Satenik Harutyunova, Tom Bollmann, Simon Classen, Henning Gall, Felix Gerhardt Md, Friedrich Grimminger, Jan Grimminger, Ekkehard Grünig, Stefan Guth, Michael Halank, Alexander Heine, Marius M Hoeper, Hans Klose, Tobias J Lange, Katrin Meyer, Claus Neurohr, Kai Nickolaus, Karen M Olsson, Christian F Opitz, Stephan Rosenkranz, Hans-Jürgen Seyfarth, Christian Warnke, Christoph Wiedenroth, Hossein A Ghofrani, Ralf Ewert
BACKGROUND: We examined safety and long-term outcomes of intravenous treprostinil administered via the implantable LENUS Pro pump in patients with severe pulmonary hypertension (PH). METHODS: Patients with PH undergoing pump implantation between December 2009 and October 2016 in German referral centers were retrospectively analyzed (end of follow-up: May 2017). The primary objective was to determine long-term safety of the implantable pump. Secondary end points were 3-year survival and prognostic relevance of pre-implantation hemodynamics...
October 2018: Journal of Heart and Lung Transplantation
Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Syunsuke Saga, Hidewo Amano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Tomoki Sasa, Jiro Sakamoto, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Hiroki Shiomi, Takao Kato, Takeru Makiyama, Koh Ono, Yukihito Sato, Takeshi Kimura
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT). Identifying high-risk patients for the development of PTS might be useful for its prevention. The COMMAND VTE Registry is a multicenter registry that enrolled 3027 consecutive patients with acute symptomatic venous thromboembolisms (VTEs) in Japan between January 2010 and August 2014. The current study population consisted of 1298 patients with lower extremities DVTs who completed 3-year follow-up for those who developed PTS and those without PTS...
October 6, 2018: Heart and Vessels
Maria Teresa La Rovere, Gian Domenico Pinna, Maurizio Pin, Claudio Bruschi, Giovanna Callegari, Ercole Zanotti, Andrea D'Armini, Nicolino Ambrosino
BACKGROUND: After undergoing a procedure of pulmonary endarterectomy (PEA), patients with chronic thromboembolic pulmonary hypertension (CTEPH) may still experience reduced exercise capacity. Data on effects of exercise training in these patients are scant. OBJECTIVES: To evaluate the effectiveness of exercise training after PEA for CTEPH and if the presence of "residual pulmonary hypertension" may affect the outcome. METHODS: Retrospective data analysis of CTEPH patients undergoing inpatient exercise training after PEA...
October 5, 2018: Respiration; International Review of Thoracic Diseases
Can Li, Jiuliang Zhao, Kun He, Yan Wu, Sheng Liu, Qian Wang, Yan Zhao
RATIONALE: Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of antiphospholipid syndrome (APS). Once diagnosed, the recommendation for the treatment of CTEPH is long-term anticoagulation and pulmonary thromboendarterectomy (PTE). However, cardiac surgeons apply PTE cautiously for these patients, as there is an increased risk of perioperative complications. Here, we present the curative case of a patient with severe APS-associated CTEPH treated with PTE. PATIENT CONCERNS: A 29-year-old man presented with chest pain, decreased exercise capacity, dyspnoea, and haemoptysis...
October 2018: Medicine (Baltimore)
Myung-Jin Cha, Youngjin Cho, Il-Young Oh, Eue-Keun Choi, Seil Oh
BACKGROUND: There is little evidence that focuses on the ethnic variability of clinical risk factors for thromboembolism (TE) in atrial fibrillation (AF). We aimed to investigate the effect of each traditional risk factor in the Korean AF population. Methods and Results:Medical records of 12,876 consecutive patients (aged >18 years) newly diagnosed and followed up with non-valvular AF from 2000 to 2013 were reviewed. TE events, including ischemic stroke and systemic embolism, were investigated for risk factor validation...
October 4, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Suresh K Nayar, Anne M Kuwabara, José M Flores, Greg M Osgood, Dawn M LaPorte, Babar Shafiq
BACKGROUND: Venous thromboembolism (VTE) has been studied in lower extremity fractures but little is known of its relation with upper extremity (UE) fractures. As an often overlooked but serious complication, VTE may compromise patient outcomes. METHODS: Using data on inpatients (aged ≥ 18 years) at a level-I trauma center and patients in the National Surgical Quality Improvement Program database who sustained UE fractures (clavicle, humerus, or radius/ulna) and VTE in the same hospitalization between 2007 and 2014, the authors analyzed data on demographic characteristics, fracture type, VTE location (pulmonary embolism, lower extremity, or UE), VTE onset, polytrauma, operative or nonoperative management, comorbidities, and mortality...
September 2018: Journal of Hand Surgery Asian-Pacific Volume
Diana Alexandra Cherata, Ionut Donoiu, Oana Mirea, Rodica Diaconu, Octavian Istratoaie
Pulmonary embolism in the context of pancreatitis is a rare condition and even fewer cases of pulmonary embolism associated with pancreatic pseudocyst and chronic pancreatitis have been reported in the literature. We present the case of a patient diagnosed with chronic pancreatitis due to alcohol ingestion complicated with pancreatic pseudocyst, with no classic thrombogenic risk factors, who developed right atrial thrombus and massive bilateral pulmonary embolism. < Learning objective: Venous thromboembolism risk is present in acute pancreatitis or pancreatic cancer, but even chronic pancreatitis may promote thrombogenesis and trigger the development of a life-threatening condition such as pulmonary embolism...
August 2018: Journal of Cardiology Cases
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