keyword
https://read.qxmd.com/read/38533280/evaluation-of-effect-of-montelukast-in-the-model-of-streptozotocin-induced-diabetic-nephropathy-in-rats
#21
JOURNAL ARTICLE
Dhananjay Kokate, Padmaja Marathe
BACKGROUND: Diabetic nephropathy is a progressive condition and a leading cause of end-stage renal disease. Oxidative stress and inflammation play an important role in its pathogenesis. In pre-clinical studies, Montelukast had shown renoprotective and anti-oxidant properties, hence the study was planned to evaluate the effect of Montelukast in a Streptozotocin (STZ) induced model of diabetic nephropathy. METHODS: 40 Wistar rats of either sex were randomly divided into four groups viz ...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#22
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533278/prevalence-of-congenital-hypothyroidism-in-india-mapping-and-critical-appraisal
#23
JOURNAL ARTICLE
Vijaya Sarathi, Siddu Nikith
No abstract text is available yet for this article.
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533277/heterophilic-interference-of-rheumatoid-factor-in-tsh-immunometric-assay-a-cross-sectional-observational-study
#24
JOURNAL ARTICLE
Shaikh N Nayeemuddin, Akash Panigrahi, Rana Bhattacharjee, Subhankar Chowdhury
INTRODUCTION: Considering the inherent vulnerability of immunoassays for heterophilic interference and the potential of Rheumatoid Factor (RF) to act as a heterophile-like antibody, we conducted this study to investigate if RF leads to any such heterophilic interference in seropositive rheumatoid arthritis (RA) patients. The study was done on the TSH assay as it is a noncompetitive, double antibody sandwich assay, which is known to be vulnerable to heterophilic interference. METHODS: In this cross-sectional observational study, eighty-four consecutive newly diagnosed RF-positive RA patients underwent TSH, Free T4, and anti-TPO estimation using the chemiluminescence technique (CLIA) on Siemens Immulite 1000 platform...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533276/primary-hyperparathyroidism-in-young-and-adolescents-alike-or-unlike-adult-hyperparathyroidism-a-series-from-south-india
#25
JOURNAL ARTICLE
Dhalapathy Sadacharan, Smitha S Rao, Shriraam Mahadevan, G Shanmugasundar, S Murthy, Shruti Chandrashekaran, Vijay Bhaskar Reddy, Bharath Ramji
BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrine condition but rare in the pediatric and adolescent populations. The presentations can be unique, accounting for significant morbidity in the case of untimely detection. AIM: To study surgically treated pediatric PHPT retrospectively. METHODS: Surgically treated children of PHPT up to 20 years of age between 2010 to 2022 were analyzed. All of them were operated on by an endocrine surgeon and team...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533275/fostering-excellence-in-endocrinology-research-the-inaugural-edition-of-the-yuvaratna-awards-of-the-endocrine-society-of-india
#26
JOURNAL ARTICLE
Lakshmi Nagendra, Sunetra Mondal
The Endocrine Society of India (ESI) has introduced a new award, the Yuvaratna Awards, for recognizing the best research conducted by recently graduated endocrinologists across the country. This research should be carried out independently and not as part of or as a continuation of work initiated during residency. Two distinct categories were established: one for individuals working in academic institutions and another for those employed in private hospitals. This distinction acknowledges the unique benefits and challenges faced in both settings...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533266/the-regulation-role-of-the-gut-islets-axis-in-diabetes
#27
REVIEW
Songtao Yang, Jie Cao, Chuan Sun, Li Yuan
The gut-islets axis is an important endocrine signaling axis that regulates the function of islets by modulating the gut micro-environment and its endocrine metabolism. The discovery of intestinal hormones, such as GLP-1 and GIP, has established a preliminary link between the gut and the islet, paving the way for the development of GLP-1 receptor agonists based on the regulation theory of the gut-islets axis for diabetes treatment. This discovery has created a new paradigm for diabetes management and rapidly made the regulation theory of the gut-islets axis a focal point of research attention...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38532900/roles-of-organokines-in-intervertebral-disc-homeostasis-and-degeneration
#28
REVIEW
Yuxin He, Sheng Liu, Hui Lin, Fan Ding, Zengwu Shao, Liming Xiong
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532510/care-management-and-use-of-ferrets-in-biomedical-research
#29
REVIEW
Ravindran Kumar Pramod, Pravin Kumar Atul, Mamta Pandey, S Anbazhagan, Suhas T Mhaske, R Barathidasan
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century...
March 26, 2024: Laboratory Animal Research
https://read.qxmd.com/read/38532489/real-world-association-between-systemic-corticosteroid-exposure-and-complications-in-us-patients-with-severe-asthma
#30
JOURNAL ARTICLE
Thomas B Casale, Thomas Corbridge, Guillaume Germain, François Laliberté, Sean D MacKnight, Julien Boudreau, Mei S Duh, Arijita Deb
BACKGROUND: Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. OBJECTIVE: Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma. METHODS: This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID: 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts: SCS use and non/burst-SCS use...
March 26, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38532282/glucocorticoid-induced-hyperglycemia-a-neglected-problem
#31
JOURNAL ARTICLE
Jung-Hwan Cho, Sunghwan Suh
Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-induced hyperglycemia (GIH), which is observed in over one-third of patients treated with glucocorticoids, is often neglected. To improve the clinical course and prognosis of diseases that necessitate glucocorticoid therapy, proper management of GIH is essential. The key pathophysiology of GIH includes systemic insulin resistance, which exacerbates hepatic steatosis and visceral obesity, as well as proteolysis and lipolysis of muscle and adipose tissue, coupled with β-cell dysfunction...
March 27, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38531915/predictive-value-of-clinical-risk-factors-for-bladder-dysfunction-in-syrian-patients-with-type-2-diabetes-mellitus
#32
JOURNAL ARTICLE
Younes A Khadour, Bashar M Ebrahem, Weaam Alhatem, Engo Ovone Yanne, Fater A Khadour
Diabetes mellitus (DM) is a prevalent disorder that affects the endocrine and metabolic systems. Among the various complications associated with DM, diabetic bladder dysfunction (DBD) is the most frequently occurring genitourinary complication. The presence of DBD can lead to complications that affect the upper urinary tract, significantly impacting the quality of life for individuals with DM. Therefore, it is crucial to identify early risk factors for DBD and predict its onset. Given the absence of studies involving bladder dysfunction in patients with type 2 diabetes mellitus (T2DM) in Syria, this study aims to examine the risk factors associated with bladder dysfunction in T2DM patients and develop a predictive model to identify DBD early...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531699/unveiling-the-cancer-risk-nexus-of-the-steatotic-liver
#33
REVIEW
Jieun Kim, Ekihiro Seki
Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers...
March 25, 2024: Trends in Endocrinology and Metabolism: TEM
https://read.qxmd.com/read/38531330/err%C3%AE-1-and-aromatase-expression-in-human-placental-tissues-from-term-deliveries-of-large-for-gestational-age-lga-newborns
#34
JOURNAL ARTICLE
Marcos Abdul Palligas, Cristina Patricia Nemer, Claudia Monica Cannizzaro, Maria Sonia Baquedano, Alicia Belgorosky, Nora Saraco
INTRODUCTION: Being born either large (LGA) or small for gestational age (SGA) has been associated with an increased risk of developing metabolic syndrome in adulthood. However, the mechanism underlying this early programming remained unclear. Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor with a high expression in human placenta, particularly ERRγ1. ERRγ has been proposed to play a central role in controlling genes involved in energy metabolism...
March 26, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38531185/memorial-william-e-o-brien-ph-d
#35
JOURNAL ARTICLE
Sarah H Elsea, Arthur L Beaudet
No abstract text is available yet for this article.
March 25, 2024: Molecular Genetics and Metabolism
https://read.qxmd.com/read/38531184/slc6a8-creatine-transporter-deficiency-can-be-detected-by-plasma-creatine-and-creatinine-concentrations
#36
JOURNAL ARTICLE
Karen Sanders, Dawn Peck, Gisele Bentz Pino, April Studinski Jones, Amy White, Dimitar Gavrilov, Dietrich Matern, Devin Oglesbee, Matthew Schultz, Silvia Tortorelli, Patricia L Hall
Creatine transporter deficiency has been described with normal or uninformative levels of creatine and creatinine in plasma, while urine has been the preferred specimen type for biochemical diagnosis. We report a cohort of untreated patients with creatine transporter deficiency and abnormal plasma creatine panel results, characterized mainly by markedly decreased plasma creatinine. We conclude that plasma should be considered a viable specimen type for the biochemical diagnosis of this disorder, and abnormal results should be followed up with further confirmatory testing...
March 24, 2024: Molecular Genetics and Metabolism
https://read.qxmd.com/read/38530966/response-to-the-letter-to-the-editor-osteonecrosis-of-the-jaws-in-patients-under-osteoporosis-treatment-nine-year-experience-report
#37
JOURNAL ARTICLE
Daniela Cia Penoni, João Vitor S Canellas, Flávia Sader, Gonçalo Sobreira Pimentel Neto, Anna Thereza Thomé Leão
None.
March 25, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38530965/osteonecrosis-of-the-jaws-in-patients-under-osteoporosis-treatment-a-nine-year-experience-report
#38
JOURNAL ARTICLE
Efsun Somay
None.
March 25, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38530964/hyperglycemia-induced-hemichorea-hemiballismus-syndrome-a-systematic-review
#39
JOURNAL ARTICLE
Mariana Costa Hoffmeister, Paola S G Bonavides, Vanessa Maurer Wiercinski, Viviane Alessio Baggio, Roberta de Pádua Borges, Gesner Francisco Xavier Junior, Clara K Maraschin, Beatriz D Schaan
Nonketotic hyperglycemia may occur as a cause of chorea in patients with chronic decompensated diabetes. Because it is rare and consequently poorly studied, diagnosis and treatment can be delayed. Therefore, our objective was to summarize clinical and radiological features, as well as treatments performed, from previously reported cases to facilitate adequate management in clinical practice. We searched MEDLINE/PubMed, EMBASE, Cochrane, CINAHL, Web of Science, Scopus, and LILACS databases for studies published before April 23, 2021...
March 25, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38530960/evaluation-of-screening-practices-for-primary-hyperaldosteronism-by-specialists-and-general-practitioners-an-observational-cross-sectional-study
#40
JOURNAL ARTICLE
Giselle Fernandes Taboada, Aline Barbosa Moraes, Leonardo Vieira
OBJECTIVE: Despite its recognized importance, primary hyperaldosteronism (PHA) remains an underdiagnosed condition in clinical practice. The objective of the present study was to evaluate PHA screening practices by general practitioners and specialists in endocrinology and cardiology. SUBJECTS AND METHODS: This cross-sectional, observational study invited physicians to respond voluntarily to an online survey. The survey collected the respondents' sociodemographic data and answers to five hypothetical clinical cases meeting Endocrine Society criteria for PHA screening...
March 15, 2024: Archives of Endocrinology and Metabolism
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