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Endocrine metabolism

Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase
The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity...
2018: Journal of Diabetes Research
Meng-Fei Li, Xiao-Meng Zhou, Xue-Lian Li
Purpose: To evaluate the effect of berberine (BBR) on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR). Methods: PubMed (in English), Medline (in English), Embase (in English), CNKI (in Chinese), WanFang DATA (in Chinese), and VIP (in Chinese) were searched for randomized controlled trials in human beings with the search terms including "polycystic ovary syndrome /PCOS" and "berberine/BBR/Huang liansu (in Chinese)/ Xiao bojian (in Chinese)" till July 2018...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Stefanie Krick, Eric Scott Helton, Samuel B Hutcheson, Scott Blumhof, Jaleesa M Garth, Rebecca S Denson, Rennan S Zaharias, Hannah Wickham, Jarrod W Barnes
The hexosamine biosynthetic pathway (HBP) generates the substrate for the O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins. The HBP also serves as a stress sensor and has been reported to be involved with nuclear factor of activated T-cells (NFAT) activation, which can contribute to multiple cellular processes including cell metabolism, proliferation, and inflammation. In our previously published report, Fibroblast Growth Factor (FGF) 23, an important endocrine pro-inflammatory mediator, was shown to activate the FGFR4/phospholipase Cγ (PLCγ)/nuclear factor of activated T-cells (NFAT) signaling in chronic inflammatory airway diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD)...
2018: Frontiers in Endocrinology
Jaume Pérez-Sánchez, Paula Simó-Mirabet, Fernando Naya-Català, Juan Antonio Martos-Sitcha, Erick Perera, Azucena Bermejo-Nogales, Laura Benedito-Palos, Josep Alvar Calduch-Giner
The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make this association variable throughout season and life cycle, and the present minireview aims to better define the nutritional and environmental regulation of the endocrine growth cascade over precisely defined groups of fishes, focusing on Mediterranean farmed fishes...
2018: Frontiers in Endocrinology
Sofia S Pereira, Marta Guimarães, Rui Almeida, Ana M Pereira, Carolina B Lobato, Bolette Hartmann, Linda Hilsted, Jens J Holst, Mário Nora, Mariana P Monteiro
BACKGROUND/OBJECTIVE: Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective bariatric intervention to treat morbid obesity and related disorders. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a new bariatric procedure devised with the purpose of simplifying the complexity of the BPD-DS technique while maintaining its efficacy. However, whether BPD-DS and SADI-S result in similar fasting and post-prandial hormone profiles has not yet been studied...
December 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Z Esmaeilinezhad, S Babajafari, Z Sohrabi, M-H Eskandari, S Amooee, R Barati-Boldaji
BACKGROUND AND AIMS: Polycystic Ovarian Syndrome is a common reproductive, endocrine, and metabolic disease in women. Pomegranate juice, known as a rich source of phytochemicals with high antioxidant activity, enriched with probiotic may improve PCOS. METHODS AND RESULTS: A randomized, controlled, triple-blinded, parallel trial study was performed in PCOS patients (n = 92). Three treatment groups (23 patients each) received 2 L of synbiotic pomegranate juice (SPJ), pomegranate juice (PJ), and synbiotic beverage (SB) weekly...
July 17, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Long Zhou, Han-Yi Song, Lin-Lin Gao, Li-Yu Yang, Shuai Mu, Qin Fu
MicroRNAs (miRNAs/miRs) are post‑transcriptional regulators that serve important roles in osteoclastogenesis and bone metabolism; however, the roles of miRNAs have not been completely clarified. The present study aimed to investigate the effects of miR‑100‑5p on the mechanism of liver‑bone endocrine metabolism. A miRNA microarray analysis was conducted to evaluate the miRNA expression profile during receptor activator of nuclear factor‑κB ligand‑stimulated osteoclastogenesis. Hematoxylin and eosin and tartrate‑resistant acid phosphatase staining were performed to analyze the trabecular bone microstructure and osteoclast differentiation...
December 6, 2018: International Journal of Molecular Medicine
Patricia Álvarez-Campos, Nathan J Kenny, Aida Verdes, Rosa Fernández, Marta Novo, Gonzalo Giribet, Ana Riesgo
Stolonization in syllid annelids is a unique mode of reproduction among animals. During the breeding season, a structure resembling the adult but containing only gametes, called stolon, is formed generally at the posterior end of the animal. When stolons mature, they detach from the adult and gametes are released into the water column. The process is synchronized within each species, and it has been reported to be under environmental and endogenous control, probably via endocrine regulation. To further understand reproduction in syllids and to elucidate the molecular toolkit underlying stolonization, we generated Illumina RNA-seq data from different tissues of reproductive and non-reproductive individuals of Syllis magdalena, and characterized gene expression during the stolonization process...
December 11, 2018: Genome Biology and Evolution
Xinyan Shi, Duo Peng, Yanfei Liu, Xiaofen Miao, Hui Ye, Jun Zhang
Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS). Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. We generated receiver operating characteristic (ROC) curves to assess the usefulness of AMH, AFC, the luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, and testosterone (T), to discriminate between the PCOS and control groups...
December 10, 2018: Laboratory Medicine
Lisa Lindheim, Maria Manti, Romina Fornes, Mina Bashir, Paulo Czarnewski, Oscar E Diaz, Maike Seifert, Lars Engstrand, Eduardo J Villablanca, Barbara Obermayer-Pietsch, Elisabet Stener-Victorin
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of unclear etiology in women and is characterized by androgen excess, insulin resistance, and mood disorders. The gut microbiome is known to influence conditions closely related with PCOS, and several recent studies have observed changes in the stool microbiome of women with PCOS. The mechanism by which the gut microbiome interacts with PCOS is still unknown. We used a mouse model to investigate if diet-induced maternal obesity and maternal DHT exposure, mimicking the lean and obese PCOS women, cause lasting changes in the gut microbiome of offspring...
December 1, 2018: Journal of the Endocrine Society
Sanjay Kalra, Abhay Sahoo, Sambit Das, K V S Hari Kumar, Anoj Kumar Baliarsinha, Binoy Mohanty, Jayabhanu Kanwar, Sunil Kota, Sudeep Satpathy, Muthukrishnan Jayaraman, S K Singh, S V Madhu, Mona Shah, Narendra Kotwal, Gagan Priya, Belinda George, Arundhati Dasgupta, Arun Kumar R Pande, Nikhil Latey, Puneet Dhamija, John Ayuk, David Torpy, Pankaj Shah, Mohammed Wali Naseri, Robin Maskey, Zafar A Latif, Noel Somasundaram, Ali Jawa, Kirtida Acharya
Sports and endocrinology are complex interrelated disciplines. Sports and exercise modulate endocrine and metabolic health, and are used to prevent and manage disease. Endocrine and metabolic function influence participation and performance in sports activity. The Bhubaneswar Declaration, released on the occasion of the Endocrine Society of India Conference, resolves to promote the science of sports endocrinology. The authors commit to optimize endocrine health in sports persons, encourage safe use of sports to promote health, and prevent misuse of endocrine interventions in sports...
November 2018: Indian Journal of Endocrinology and Metabolism
Waleed A Mohamed, Mona F Schaalan
The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young obese patients with type 2 diabetes were selected from the Pediatric Endocrine Metabolic Unit, Cairo University and were randomly divided among two age and sex-matched groups so as to receive either standard therapy without lactoferrin in one arm or to be treated with oral lactoferrin capsules (250 mg/day, p...
2018: Diabetology & Metabolic Syndrome
(no author information available yet)
OBJECTIVES: Bisphenol A (BPA) is an endocrine disruptor which has been shown to be a harmful compound for living organisms. It is the main component of the most commonly used plastic products such as plastic bottles, food cans and containers or dental fillings, and other medical aids. Recently, it has become a new environmental pollutant. The current knowledge about the BPA effects (including genotoxic one) on different cells is in many cases contradictory. Thus, the aim of the paper is to study the potential genotoxic effect of BPA...
October 10, 2018: Neuro Endocrinology Letters
Angel González-Márquez, Octavio Loera-Corral, Ericka Santacruz-Juárez, Saúl Tlécuitl-Beristain, Jorge García-Dávila, Gustavo Viniegra-González, Carmen Sánchez
Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer, which is considered an endocrine disrupting pollutant. Growth kinetics and esterases activity by biochemical tests and polyacrylamide gel electrophoresis were characterized for Fusarium culmorum grown in DEHP-supplemented (1000 mg/L) medium as the only carbon source and in control medium with glucose. Intermediate compounds of biodegraded DEHP were identified by GC-MS. F. culmorum degraded 92% of DEHP within 36 h. DEHP was degraded to butanol, hexanal, catechol and acetic acid...
December 7, 2018: Ecotoxicology and Environmental Safety
Y Kanjanapan, D Day, M O Butler, L Wang, A M Joshua, D Hogg, N B Leighl, A R Abdul Razak, A R Hansen, S Boujos, M Chappell, K Chow, B Sherwin, L-A Stayner, L Soultani, A Zambrana, L L Siu, P L Bedard, A Spreafico
BACKGROUND: Immunotherapy (IO) agents can cause late-onset immune-related adverse events (irAEs). In phase I trials, observation for dose-limiting toxicities (DLTs) is typically limited to the first cycle. The incidence of delayed-onset DLTs and their potential impact on dose determination have not been fully elucidated. PATIENTS AND METHODS: Consecutive patients enrolled in early phase IO trials at Princess Margaret Cancer Centre between August 2012 and September 2016 were retrospectively reviewed, applying trial-specific definitions for DLTs...
December 6, 2018: European Journal of Cancer
Ruairi C Robertson, Amee R Manges, B Brett Finlay, Andrew J Prendergast
The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which may contribute to lifelong and intergenerational deficits in growth and development. Here, we review the human microbiome in the first 1000 days - referring to the period from conception to 2 years of age - and using a developmental model, we examine the role of early microbial succession in growth and development...
October 24, 2018: Trends in Microbiology
Rita M Graze, Ruei-Ying Tzeng, Tiffany S Howard, Michelle N Arbeitman
BACKGROUND: The core functions of the insulin/insulin-like signaling and target of rapamycin (IIS/TOR) pathway are nutrient sensing, energy homeostasis, growth, and regulation of stress responses. This pathway is also known to interact directly and indirectly with the sex determination regulatory hierarchy. The IIS/TOR pathway plays a role in directing sexually dimorphic traits, including dimorphism of growth, metabolism, stress and behavior. Previous studies of sexually dimorphic gene expression in the adult head, which includes both nervous system and endocrine tissues, have revealed variation in sex-differential expression, depending in part on genotype and environment...
December 10, 2018: BMC Genomics
Ilaria Matarazzo, Elena Toniato, Iole Robuffo
Recently gut bacterial populations seem to be involved in many functions and in the pathogenesis of several medical conditions. Traditionally the intestinal microbiome has been recognized to play an important role in metabolizing food compounds in simpler chemical structures for the absorption of different nutrients, and in maintenance control on gastrointestinal pathogens species. Bacterial populations are implicated in a complicated network of interactions within the immune system, epithelial cells, local endocrine system, that affects the peripheral and the central nervous system, via blood circulation...
December 10, 2018: Current Topics in Medicinal Chemistry
(no author information available yet)
The American Psychological Association Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. Janice K. Kiecolt-Glaser is a recipient of the 2018 award "for her outstanding contributions to our understanding of the roles of psychological and social factors in endocrine, immune, and metabolic responses. In earlier work with Ronald Glaser, Janice K...
December 2018: American Psychologist
Hai-Ming Zhao, He-Biao Huang, Yu-Mei Luo, Chun-Qing Huang, Huan Du, Lei Xiang, Quan-Ying Cai, Yan-Wen Li, Hui Li, Ce-Hui Mo, Zhenli He
Di-n-butyl phthalate (DBP) as an endocrine disrupting chemical that tends to be accumulated in crops poses great risks to human health through the food chain. To identify the molecular mechanism underlying differences in their DBP accumulation, the root physiological and proteomic responses to DBP stress of two Brassica parachinensis cultivars, a high-DBP accumulator (Huaguan) and a low-DBP accumulator (Lvbao), were investigated. Root damage of greater severity and significantly greater (p<0.05) decreases in root protein content and root activity were detected in Lvbao than in Huaguan, suggesting that Lvbao had lower tolerance to DBP...
December 10, 2018: Journal of Agricultural and Food Chemistry
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