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mesenchymal stem cells in liver disease

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https://www.readbyqxmd.com/read/30106103/antifibrotic-potential-of-bone-marrow%C3%A2-derived-mesenchymal-stem-cells-in-biliary-atresia-mice
#1
Jun Lei, Yong Chai, Juhua Xiao, Huakun Hu, Zhiqiang Liu, Yu Xiao, Lijun Yi, Jinshi Huang, Tianxin Xiang, Shouhua Zhang
Biliary atresia (BA) is a rare and severe disease that affects infants where a fibroinflammatory process destroys the bile ducts, leading to fibrosis and biliary cirrhosis, and mortality if untreated. Bone marrow‑derived mesenchymal stem cells (BMMSCs) have been considered as a promising therapy in fibrotic diseases. The aim of the present was to investigate the anti‑fibrotic roles of BMMSC transplantation in a BA mouse model. Mouse BA models were established by Rhesus rotavirus administration to neonatal mice...
August 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30103680/mesenchymal-stem-cell-transplantation-improves-chronic-colitis-associated-complications-through-inhibiting-the-activity-of-toll-like-receptor-4-in-mice
#2
Guo Chao Niu, Lei Liu, Libo Zheng, Hong Zhang, David Q Shih, Xiaolan Zhang
BACKGROUND: A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potential role in the therapy of IBD. This study was designed to investigate the effect and mechanism of MSCs on chronic colitis-associated hepatobiliary complications using mouse chronic colitis models induced by dextran sulfate sodium (DSS). METHODS: DSS-induced mouse chronic colitis models were established and treated with MSCs...
August 13, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30093947/effects-of-human-amnion-derived-mesenchymal-stem-cells-and-conditioned-medium-in-rats-with-sclerosing-cholangitis
#3
Ryo Sugiura, Shunsuke Ohnishi, Masatsugu Ohara, Marin Ishikawa, Shuichi Miyamoto, Reizo Onishi, Koji Yamamoto, Kazumichi Kawakubo, Masaki Kuwatani, Naoya Sakamoto
Mesenchymal stem cells (MSCs) represent a valuable cell source in regenerative medicine, and large numbers of MSCs can be isolated from the amnion noninvasively. Sclerosing cholangitis is a chronic cholestatic disease and characterized by progressive biliary destruction leading to cirrhosis. Many factors are involved in the development of sclerosing cholangitis; however, effective medical therapy is not established. We investigated the effects of human amnion-derived MSCs (hAMSCs) and conditioned medium (CM) obtained from hAMSC cultures in rats with sclerosing cholangitis...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30088333/loss-of-periostin-occurs-in-aging-adipose-tissue-of-mice-and-its-genetic-ablation-impairs-adipose-tissue-lipid-metabolism
#4
Antonia Graja, Francisco Garcia-Carrizo, Anne-Marie Jank, Sabrina Gohlke, Thomas H Ambrosi, Wenke Jonas, Siegfried Ussar, Matthias Kern, Annette Schürmann, Krasimira Aleksandrova, Matthias Blüher, Tim J Schulz
Remodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well-known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue-resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix-modifying proteins, have been described...
August 7, 2018: Aging Cell
https://www.readbyqxmd.com/read/30029699/in-atp7b-mice-modeling-wilson-s-disease-liver-repopulation-with-bone-marrowderived-myofibroblasts-or-inflammatory-cells-and-not-hepatocytes-is-deleterious
#5
Yogeshwar Sharma, Jinghua Liu, Kathleen E Kristian, Antonia Follenzi, Sanjeev Gupta
Background: In Wilson's disease, ATP7B mutations impair copper excretion with liver or brain damage. Healthy transplanted hepatocytes repopulate liver, excrete copper and reverse hepatic damage in animal models of Wilson's disease. In Fah-/- mice with tyrosinemia and alpha-1 antitrypsin mutant mice, liver disease is resolved by expansions of healthy hepatocytes derived from transplanted healthy bone marrow stem cells. This potential of stem cells has not been defined for Wilson's disease. Methods: In diseased Atp7b-/- mice we reconstituted bone marrow with donor cells expressing green fluorescent protein reporter from healthy transgenic mice...
July 20, 2018: Gene Expression
https://www.readbyqxmd.com/read/30019838/effects-of-fgf21-secreting-adipose-derived-stem-cells-in-thioacetamide-induced-hepatic-fibrosis
#6
Hwansu Kang, Eunhui Seo, Jong-Moon Park, Na-Young Han, Hookeun Lee, Hee-Sook Jun
Mesenchymal stem cells (MSCs) have been investigated to treat liver diseases, but the efficiency of MSCs to treat chronic liver diseases is conflicting. FGF21 can reduce inflammation and fibrosis. We established FGF21-secreting adipose derived stem cells (FGF21_ADSCs) to enhance the effects of ADSCs and transplanted them into thioacetamide (TAA)-induced liver fibrosis mice via the tail vein. Transplantation of FGF21_ADSCs significantly improved liver fibrosis by decreasing serum hyaluronic acid and reducing the expression of fibrosis-related factors such as α-smooth muscle actin (α-SMA), collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) compared with the Empty_ADSCs by inhibition of p-JNK, NF-κB and p-Smad2/3 signalling...
July 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30016629/the-assessment-of-multipotent-cell-transplantation-in-acute-on-chronic-liver-failure-a-systematic-review-and-meta-analysis
#7
REVIEW
Ran Xue, Qinghua Meng, Juan Li, Jing Wu, Qinwei Yao, Hongwei Yu, Yueke Zhu
Acute-on-chronic liver failure (ACLF) is a serious life-threatening disease with high prevalence. Liver transplantation is the only efficient clinical treatment for ACLF. Because of the rapid progression and lack of liver donors, it is urgent to find an effective and safe therapeutic approach to ACLF. Recent studies showed that multipotent cell transplantation could improve the patients' liver function and enhance their preoperative condition. Cells such as mesenchymal stem cells, bone marrow mononuclear cells and autologous peripheral blood stem cells, which addressed in this study have all been used in multipotent cell transplantation for liver diseases...
June 23, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/30014965/laminin-521-promotes-quiescence-in-isolated-stellate-cells-from-rat-liver
#8
Friederike Rohn, Claus Kordes, Mirco Castoldi, Silke Götze, Gereon Poschmann, Kai Stühler, Diran Herebian, Amelie S Benk, Fania Geiger, Tingyu Zhang, Joachim P Spatz, Dieter Häussinger
The laminin α5 protein chain is an element of basement membranes and important to maintain stem cells. Hepatic stellate cells (HSC) are liver-resident mesenchymal stem cells, which reside in a quiescent state on a basement membrane-like structure in the space of Dissé. In the present study, laminin α5 chain was detected in the space of Dissé of normal rat liver. Since HSC are critical for liver regeneration and can contribute to fibrosis in chronic liver diseases, the effect of laminins on HSC maintenance was investigated...
October 2018: Biomaterials
https://www.readbyqxmd.com/read/29937494/comparative-analysis-between-the-in-vivo-biodistribution-and-therapeutic-efficacy-of-adipose-derived-mesenchymal-stromal-cells-administered-intraperitoneally-in-experimental-colitis
#9
Mercedes Lopez-Santalla, Pablo Mancheño-Corvo, Amelia Escolano, Ramon Menta, Olga Delarosa, Juan M Redondo, Juan A Bueren, Wilfried Dalemans, Eleuterio Lombardo, Marina I Garin
Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory diseases. The immunomodulatory effect of MSCs takes place both by direct cell-to-cell contact and by means of soluble factors that leads to an increased accumulation of regulatory immune cells at the sites of inflammation. Similar efficacy of MSCs has been described regardless of the route of administration used, the inflammation conditions and the major histocompatibility complex context. These observations raise the question of whether the migration of the MSCs to the inflamed tissues is a pre-requisite to achieve their beneficial effect...
June 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29930465/taking-advantage-of-the-potential-of-mesenchymal-stromal-cells-in-liver-regeneration-cells-and-extracellular-vesicles-as-therapeutic-strategies
#10
REVIEW
Esteban Juan Fiore, Luciana María Domínguez, Juan Bayo, Mariana Gabriela García, Guillermo Daniel Mazzolini
Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells (MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise, it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles (EVs)...
June 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29916543/differentiation-of-umbilical-cord-mesenchymal-stem-cells-into-hepatocytes-in-comparison-with-bone-marrow-mesenchymal-stem-cells
#11
Ya-Bin Yu, Yan Song, Ya Chen, Feng Zhang, Fu-Zhen Qi
Mesenchymal stem cells (MSCs) are considered to be an ideal source for the cell therapy of end‑stage liver diseases. Umbilical cord (UC)‑MSCs can be obtained via a non‑invasive procedure and can be easily cultured, making them potentially superior candidates for cell transplantation when compared with MSCs from other sources. In the present study, UC‑MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)‑MSCs for their hepatic differentiation potential. UC‑MSCs showed significantly higher proliferation than BM‑MSCs...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29898789/co-stimulation-of-lpar-1-and-s1pr-1-3-increases-the-transplantation-efficacy-of-human-mesenchymal-stem-cells-in-drug-induced-and-alcoholic-liver-diseases
#12
Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li, Jia Xiao
BACKGROUND: One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of this study was to delineate the mechanistic involvement of lysophosphatidic acid receptors (LPARs) and sphingosine-1-phosphate receptors (S1PRs) in the regulation of anti-stress and transplantation efficacy of stem cells. METHODS: Human adipose-derived mesenchymal stem cells (hADMSCs) were treated with chemical toxin or ethanol to induce cell stress...
June 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29864400/assessment-of-the-hepatocytic-differentiation-ability-of-human-skin-derived-abcb5-stem-cells
#13
Lysann Tietze, Sandra Winkler, Madlen Hempel, Mark Andreas Kluth, Nils Tappenbeck, Christoph Ganss, Steven Dooley, Bruno Christ
The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. Cell therapy approaches using human hepatocytes or stem cell-derived hepatocyte-like cells may be a therapeutic option out of this dilemma. ABCB5-positive mesenchymal stromal cells from human skin featured promising potential to treat immune-mediated diseases. Since most of chronic liver diseases involve exaggerating immune mechanisms, it was the aim to demonstrate in this study, whether ABCB5+ stem cells may serve as a resource to generate hepatocytic cells for application in liver cell transplantation...
June 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29861744/mesenchymal-stem-cells-enhance-liver-regeneration-via-improving-lipid-accumulation-and-hippo-signaling
#14
Yang Liu, Faji Yang, Jun Li, Jinglin Wang, Xun Wang, Yuheng Zhang, Xianwen Yuan, Wei Zhu, Xiaolei Shi
The liver has the potential to regenerate after injury. It is a challenge to improve liver regeneration (LR) after liver resection in clinical practice. Bone morrow-derived mesenchymal stem cells (MSCs) have shown to have a role in various liver diseases. To explore the effects of MSCs on LR, we established a model of 70% partial hepatectomy (PHx). Results revealed that infusion of MSCs could improve LR through enhancing cell proliferation and cell growth during the first 2 days after PHx, and MSCs could also restore liver synthesis function...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29844633/therapeutic-potential-effect-of-bone-marrow-derived-mesenchymal-stem-cells-on-chronic-liver-disease-in-murine-schistosomiasis-mansoni
#15
Mohamed H Hegab, Somia H Abd-Allah, Maha S Badawey, Ayman A Saleh, Ashraf S Metwally, Ghada M Fathy, Soad M Nada, Sara A Abdel-Rahman, Amira A Saleh, Amal Fawzy, Mohammed Abu El-Magd
Some reports have shown that mesenchymal stem cells (MSCs) therapy could ameliorate chemically-induced hepatic fibrosis. This research assesses the therapeutic action of bone marrow mesenchymal stem cells (BM-MSCs) on chronic diseased liver in Schistosoma mansoni infected mice. All infected female mice divided into three groups, one group (15 mice) treated with oral praziquantel (PZQ), second group (15 mice) received intravenous injection of BM-MSCs and third group (15 mice) treated with both MSCs + PZQ...
June 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29787987/modulation-of-autophagy-as-new-approach-in-mesenchymal-stem-cell-based-therapy
#16
REVIEW
Jelena Jakovljevic, C Randall Harrell, Crissy Fellabaum, Aleksandar Arsenijevic, Nemanja Jovicic, Vladislav Volarevic
Due to their trophic and immunoregulatory characteristics mesenchymal stem cells (MSCs) have tremendous potential for use in a variety of clinical applications. Challenges in MSCs' clinical applications include low survival of transplanted cells and low grafting efficiency requiring use of a high number of MSCs to achieve therapeutic benefits. Accordingly, new approaches are urgently needed in order to overcome these limitations. Recent evidence indicates that modulation of autophagy in MSCs prior to their transplantation enhances survival and viability of engrafted MSCs and promotes their pro-angiogenic and immunomodulatory characteristics...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29766824/adipose-derived-mesenchymal-stem-cells-in-the-treatment-of-obesity-a-systematic-review-of-longitudinal-studies-on-preclinical-evidence
#17
Fatima Saleh, Leila Itani, Simona Calugi, Riccardo Dalle Grave, Marwan El Ghoch
BACKGROUND: Obesity is an increasing global health problem, but its treatment is not yet optimal, especially in the long term. For this reason, preclinical studies have been conducted relating to a new therapeutic strategy for obesity based on adipose-derived mesenchymal stem cells (AD-MSCs). The aim of our systematic review is to summarize these findings deriving from the animal model in order to establish whether there is sufficient evidence to justify going forward to clinical studies...
2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29727380/human-mesenchymal-stem-cells-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure-a-systematic-review-with-meta-analysis
#18
Bin Chen, Yong-Hong Wang, Jin-Qin Qian, Dong-Bo Wu, En-Qiang Chen, Hong Tang
BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) is a condition with high mortality. New strategies are urgently required. The present review aims to provide a comprehensive understanding of the efficacy and safety of mesenchymal stem cells (MSC) treatment in patients with ACLF associated with hepatitis B virus infection. MATERIALS AND METHODS: The MEDLINE, Embase, and Cochrane Library databases were searched for the relevant publications. If appropriate, a meta-analysis was carried out for the following outcomes: survival rate, model for end-stage liver disease score, and liver function...
May 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29691598/hepatocyte-transplantation-and-advancements-in-alternative-cell-sources-for-liver-based-regenerative-medicine
#19
REVIEW
Charlotte A Lee, Siddharth Sinha, Emer Fitzpatrick, Anil Dhawan
Human hepatocyte transplantation has been actively perused as an alternative to liver replacement for acute liver failure and liver-based metabolic defects. Current challenges in this field include a limited cell source, reduced cell viability following cryopreservation and poor engraftment of cells into the recipient liver with consequent limited life span. As a result, alternative stem cell sources such as pluripotent stem cells, fibroblasts, hepatic progenitor cells, amniotic epithelial cells and mesenchymal stem/stromal cells (MSCs) can be used to generate induced hepatocyte like cells (HLC) with each technique exhibiting advantages and disadvantages...
June 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29686702/mesenchymal-stem-cell-transplantation-for-liver-cell-failure-a-new-direction-and-option
#20
REVIEW
Yantian Cao, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, Fangfang Shen
Background and Aims: Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. We aimed to assess clinical advantages of MSCT in patients with LF. Methods: Clinical researches reporting MSCT in LF patients were searched and included. Results: Nine articles ( n = 476) related with LF patients were enrolled. After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month ( P < 0...
2018: Gastroenterology Research and Practice
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