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Vahid Kia, Mahdi Paryan, Yousef Mortazavi, Alireza Biglari, Samira Mohammadi-Yeganeh
Breast cancer is one of the most prevalent cancers in women. Triple-negative breast cancer consists 15% to 20% of breast cancer cases and has a poor prognosis. Cancerous transformation has several causes one of which is dysregulation of microRNAs (miRNAs) expression. Exosomes can transfer miRNAs to neighboring and distant cells. Thus, exosomal miRNAs can transfer cancerous phenotype to distant cells. We used gene expression omnibus (GEO) datasets and miRNA target prediction tools to find overexpressed miRNA in breast cancer cells and their target genes, respectively...
October 18, 2018: Journal of Cellular Biochemistry
Helen Frost, Pauline Campbell, Margaret Maxwell, Ronan E O'Carroll, Stephan U Dombrowski, Brian Williams, Helen Cheyne, Emma Coles, Alex Pollock
BACKGROUND: The challenge of addressing unhealthy lifestyle choice is of global concern. Motivational Interviewing has been widely implemented to help people change their behaviour, but it is unclear for whom it is most beneficial. This overview aims to appraise and synthesise the review evidence for the effectiveness of Motivational Interviewing on health behaviour of adults in health and social care settings. METHODS: A systematic review of reviews. Methods were pre-specified and documented in a protocol (PROSPERO-CRD42016049278)...
2018: PloS One
Zhenxia Jiang, Cuizhen Xiu, Jun Yang, Xijiang Zhang, Minghua Liu, Xinlong Chen, Dianchang Liu
BACKGROUND: In China, the mode of HIV transmission and the types and routes of drug use have changed in the past decade. HIV testing amongst drug users needs further improvement. METHODS: Interviewer-administered questionnaires were used for data collection amongst 600 heterosexual drug users from the community and a municipal detention centre, where criminal suspects are supervised. Descriptive statistics, univariate analysis and multilevel logistic regression analysis were used to identify the factors associated with HIV testing amongst heterosexual drug users...
2018: PloS One
Sandesh Parajuli, Robert R Redfield, Neetika Garg, Fahad Aziz, Maha Mohamed, Brad C Astor, Weixong Zhong, Arjang Djamali, Didier A Mandelbrot
BACKGROUND: Limited information exists about outcomes of HLA DSA negative (DSA-) microvascular inflammation (MVI). METHODS: We report our experience with 25 DSA- patients with MVI compared to 155 DSA+ patients who met Banff 2013 criteria for ABMR. We also compared outcomes to 228 DSA+ patients whose biopsies were negative for rejection, and served as a negative control. RESULTS: There were no significant differences in the baseline characteristics between the DSA- MVI and DSA+ ABMR groups...
October 17, 2018: Transplantation
I R Weir, G D Marshall, J I Schneider, J A Sherer, E M Lord, B Gyawali, M K Paasche-Orlow, E J Benjamin, L Trinquart
Background: Multiple features in the presentation of randomized controlled trial (RCT) results are known to influence comprehension and interpretation. We aimed to compare interpretation of cancer RCTs with time-to-event outcomes when the reported treatment effect measure is the hazard ratio (HR), difference in restricted mean survival times (RMSTD), or both (HR+RMSTD). We also assessed the prevalence of misinterpretation of the HR. Patients and methods: We performed a randomized experiment...
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Hao Su, Pei Bao, Kang-Yu Chen, Ji Yan, Jian Xu, Fei Yu, Dong-Mei Yang
Background: The influence of different right ventricular lead locations on ventricular arrhythmias (VTA) in patients with a cardiac resynchronization therapy (CRT) is not clear. This study aimed to evaluate the influence on VTA in patients with a CRT when right ventricular lead was positioned at the right ventricular middle septum (RVMS) and the right ventricular apical (RVA). Methods: A total of 352 patients implanted with a CRT-defibrillator (CRT-D) between May 2012 and July 2016 in the Department of Cardiology of Anhui Provincial Hospital were included...
October 20, 2018: Chinese Medical Journal
Ivan A Kruglov, Alexander G Kvashnin, Alexander F Goncharov, Artem R Oganov, Sergey S Lobanov, Nicholas Holtgrewe, Shuqing Jiang, Vitali B Prakapenka, Eran Greenberg, Alexey V Yanilkin
Hydrogen-rich hydrides attract great attention due to recent theoretical ( 1 ) and then experimental discovery of record high-temperature superconductivity in H3 S [ T c = 203 K at 155 GPa ( 2 )]. Here we search for stable uranium hydrides at pressures up to 500 GPa using ab initio evolutionary crystal structure prediction. Chemistry of the U-H system turned out to be extremely rich, with 14 new compounds, including hydrogen-rich UH5 , UH6 , U2 H13 , UH7 , UH8 , U2 H17 , and UH9 . Their crystal structures are based on either common face-centered cubic or hexagonal close-packed uranium sublattice and unusual H8 cubic clusters...
October 2018: Science Advances
Hedwig Eisenbarth, Sandy Krammer, Bethany G Edwards, Kent A Kiehl, Craig Neumann
Valid measurement of psychopathic traits in females using the Psychopathy Checklist Revised (PCL-R) continues to be an under researched topic. Previous latent variable and other psychometric studies have raised questions concerning the structure and predictive effects of psychopathic traits in females. New cross-cultural research finds good support for a four-factor model of psychopathy in females and the predictive effects of the psychopathy factors (Declercq, Carter, & Neumann, 2015; Neumann, Hare, & Pardini, 2015)...
July 15, 2018: Personality and Individual Differences
Saeed Ghasemi, Diba Eghbali Koohi, Mohammad Sadegh Bakhshi Emmamzadehhashemi, Shahriyar Shahbazi Khamas, Mohammad Moazen, Amin Khabbaz Hashemi, Gholamreza Amin, Fereshteh Golfakhrabadi, Zahra Yousefi, Fatemeh Yousefbeyk
The leaves of seventeen cultivars of olive growing in the north of Iran were investigated for total phenol content and antioxidant activity. The identification and quantification of main phenolic compounds were performed by reverse phase high performance liquid chromatography with diode array detector. The cultivars Kalamon, Gordal, and Coratina contained the highest concentration of phenolic compounds (190.65 ± 0.03, 184.72 ± 0.001, and 155.91 ± 0.06 mg GAE/g extract, respectively). The maximum radical scavenging activities were found in Gordal, Coratina, and Kalamon extracts (IC50 20...
November 2018: Journal of Food Science and Technology
Yunjian Xu, Suwen Zhu, Fang Liu, Wei Wang, Xuewen Wang, Guomin Han, Beijiu Cheng
Maize can form symbiotic relationships with arbuscular mycorrhiza (AM) fungus to increase productivity and resistance, but the miRNAs in maize responsible for this process have not been discovered. In this study, 155 known and 28 novel miRNAs were identified by performing high-throughput sequencing of sRNA in maize roots colonized by AM fungi. Similar to the profiles in other AM-capable plants, a large proportion of identified maize miRNAs were 24 nt in length. Fourteen and two miRNAs were significantly down- and up-regulated in response to AM fungus Glomus intraradices inoculation, respectively, suggesting potential roles of these miRNAs in AM symbiosis...
October 16, 2018: International Journal of Molecular Sciences
Anselm A Derda, Angelika Pfanne, Christian Bär, Katharina Schimmel, Peter J Kennel, Ke Xiao, P Christian Schulze, Johann Bauersachs, Thomas Thum
INTRODUCTION: Amyloidosis is caused by dysregulation of protein folding resulting in systemic or organ specific amyloid aggregation. When affecting the heart, amyloidosis can cause severe heart failure, which is associated with a high morbidity and mortality. Different subtypes of cardiac amyloidosis exist e.g. transthyretin cardiac amyloidosis and senile cardiac amyloidosis. Today, diagnostics is primarily based on cardiac biopsies and no clinically used circulating blood-based biomarkers existing...
2018: PloS One
Xiaochun Yi, Huixiang Liu, Yuhua Ou, Meilan Liu, Liqiong Zhu, Hui Chen, Jianping Zhang
OBJECTIVE: Despite a growing association between inflammation and preterm labor, the underlying mechanisms explaining the development of preterm labor after infection are still poorly understood. Here, we use RNA-sequencing to characterize the transcriptome changes of placenta tissue in a preterm labor mouse model. MATERIALS AND METHODS: On day 15.5 of gestation, BALB/c mice received intrauterine injection of LPS to mimic preterm labor. A comprehensive catalogue of genes were got using RNA-sequences and followed by bioinformatics analysis...
October 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
Tomonari Harada, Masaru Obokata, Koji Kurosawa, Hidemi Sorimachi, Kuniko Yoshida, Hideki Ishida, Kyoko Ito, Tetsuya Ogawa, Yoshitaka Ando, Masahiko Kurabayashi, Kazuaki Negishi
Hemodialysis patients have conditions that increase cardiac output (CO), including arteriovenous fistula, fluid retention, vasodilator use, and anemia. We sought to determine the relationships between these factors and CO and to evaluate the effects of the high-output states on ventricular morphology, function, and myocardial energetics in hemodialysis patients, using noninvasive load-insensitive indices. Cardiovascular function was assessed in hemodialysis patients with high output [ejection fraction ≥ 50%, cardiac index (CI) > 3...
October 16, 2018: International Journal of Cardiovascular Imaging
Liubov S Arbeeva, Heidi A Hanson, Konstantin G Arbeev, Alexander M Kulminski, Eric Stallard, Svetlana V Ukraintseva, Deqing Wu, Robert M Boudreau, Michael A Province, Ken R Smith, Anatoliy I Yashin
The Family Longevity Selection Score (FLoSS) was used to select families for the Long Life Family Study (LLFS) but has never been validated in other populations. The goal of this paper is to validate how well the FLoSS-based selection procedure works in an independent dataset. In this paper, we computed FLoSS using the lifespan data of 234,155 individuals from a large comprehensive genealogically-based resource, the Utah Population Database (UPDB), born between 1779 and 1910 with mortality follow-up through 2012-2013...
2018: Frontiers in Public Health
Zehra Jamil, Syeda Sadia Fatima, Amna Afzal Saeed
OBJECTIVE: To explore the potentials of technology-assisted assessment for learning using Kahoot software in teaching session. METHODS: This cross-sectional study was conducted at Aga Khan University, Karachi, to investigate the usefulness of formative assessment based on the use of Kahoot, a quiz-based learning platform, in undergraduate setting.Six lectures were offered to undergraduate medical students with integration of assessment for learning (AfL) activities...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Suman Srinivasa, Kathleen V Fitch, Martin Torriani, Markella V Zanni, Christopher Defilippi, Robert Christenson, Patrick Maehler, Sara E Looby, Janet Lo, Steven K Grinspoon
OBJECTIVE: Persons living with HIV (PLWH) well-treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk. DESIGNS/METHODS: 155 HIV-infected and 70 non-HIV-infected individuals were well-phenotyped for body composition. Adipose depots were assessed via single-slice abdominal CT...
October 15, 2018: AIDS
J Wen, A Helmbrecht, M A Elliot, J Thomson, M E Persia
An experiment was conducted to evaluate the total Trp requirement of first cycle laying hens from 41 to 60 wk of age. In total, 270 Hy-Line W36 laying hens were randomly allocated to six treatments with 15 replicate groups of three birds for each experimental unit. A Trp-deficient basal diet was formulated with corn, corn gluten meal, and soybean meal with determined Trp, Lys, and crude protein concentrations of 0.096%, 0.873%, and 15.0%, respectively. Synthetic L-Trp was supplemented to the basal diet in 0...
October 15, 2018: Poultry Science
I A Franzini, F M Yamamoto, F Bolfi, S R Antonini, V S Nunes-Nogueira
OBJECTIVE: We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. METHODS: We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, EMBASE, LILACS and CENTRAL databases...
September 24, 2018: European Journal of Endocrinology
Lei Pang, Qiang Li, Yanqing Zhang, Bin Deng, Fan Wu, Jijun Wang, Keyan Wu, Yanbing Ding, Duonan Yu
BACKGROUND: Transcribed ultraconserved regions (T-UCRs) are a subset of long noncoding RNAs. It has been reported that T-UCRs are dysregulated in cancers and play an important role in the development and progression of malignancies. uc.160 was found to be a suppressive factor of cancer development, but its role has not been fully elucidated. METHODS: The uc.160 expression was examined in gastric cancer tissues and established cell lines by quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
2018: American Journal of Translational Research
Rani Sauriasari, Mia Yuliana Pratiwi
Background: Several clinical studies have shown increased level of urinary TGF-β1 in diabetic nephropathy patients and its correlation with urine albumin-to-creatinine ratio (UACR), but other studies showed different results. Because of this contradiction, this study aims to analyze the correlation between urinary TGF-β1 concentration and UACR, and also estimated glomerular filtration rate (eGFR) in type 2 diabetes mellitus (DM) patients by controlling some confounding factors. Methods: This was a cross-sectional study, and the samples were obtained using consecutive sampling technique...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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