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https://www.readbyqxmd.com/read/29776418/the-impact-of-contour-variation-on-tumour-control-probability-in-anal-cancer
#1
Michael P Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway, Michael Jameson
BACKGROUND: While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour variation on tumour control probability (TCP) when using IMRT for AC. METHODS: Nine Australian centres contoured a single computed tomography dataset of a patient with AC. The same optimised template-based IMRT planning protocol was applied to each contour set to generate nine representative treatment plans and their corresponding dose volume histograms...
May 18, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29771796/a-population-based-cohort-analysis-of-chemoradiation-versus-radiation-alone-for-definitive-treatment-of-stage-i-anal-cancer-in-older-patients
#2
Michael Buckstein, Yotam Arens, Juan Wisnivesky, Michael Gaisa, Stephen Goldstone, Keith Sigel
BACKGROUND: Although the benefit of chemoradiation over radiation therapy alone has been shown in randomized trials for stage II to III squamous cell of the anus, this benefit is not clear for patients with stage I cancer. Nevertheless, most societal recommendations endorse chemoradiation for patients with stage I squamous cell carcinoma of the anus despite the lack of proven benefit and potential increase in toxicity. OBJECTIVE: The purpose of this study was to determine whether outcomes are improved with the addition of chemotherapy versus radiation alone for stage I squamous cell carcinoma of the anus...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29769057/patterns-of-care-for-anal-cancer-in-the-united-states-a-comparison-between-academic-and-community-cancer-centers
#3
Victor E Pricolo, Matteo Bonvini, Carlo F Abelli
BACKGROUND: Management of squamous cell carcinoma of the anus (SCCA) is becoming more relevant, as its incidence increases. The purpose of this study was to investigate possible differences in patient population and care delivery for SCCA between academic and community cancer programs in the United States. METHODS: A review of available data from the American College of Surgeons Committee on Cancer National Cancer DataBase focused on gender, age, race, type of health insurance, comorbidity score, distance traveled for care, stage at diagnosis, and therapy utilization (surgery, chemotherapy, and radiation therapy) as first course of treatment (FCT)...
May 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29759568/positron-emission-tomography-and-computed-tomographic-pet-ct-imaging-for-radiation-therapy-planning-in-anal-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Per Albertsson, Charlotte Alverbratt, Ann Liljegren, Emil Björkander, Annika Strandell, Ola Samuelsson, Stig Palm, Andreas Hallqvist
To improve the accuracy of chemoradiation therapy in anal cancer patients PET/CT is frequently used in the planning of radiation therapy. A systematic review was performed to assess impact on survival, quality of life, symptom score, change in target definition and treatment intention. Systematic literature searches were conducted in Medline, EMBASE, the Cochrane Library, and Centre for Reviews and Dissemination. Ten cross-sectional studies were identified. No data were available on survival or quality of life...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29757775/development-and-calibration-of-a-mathematical-model-of-anal-carcinogenesis-for-high-risk-hiv-infected-men
#5
Emily A Burger, Michael A Dyer, Stephen Sy, Joel M Palefsky, Alexandra De Pokomandy, François Coutlee, Michael J Silverberg, Jane J Kim
OBJECTIVES: Men who have sex with men (MSM) who are living with human immunodeficiency virus (HIV) are at highest risk for anal cancer. Our objective was to use empirical data to develop a comprehensive disease simulation model that reflects the most current understanding of anal carcinogenesis, which is uniquely positioned to evaluate future anal cancer screening strategies as well as provide insight on the unobservable course of the disease. SETTING: North America METHODS...
May 9, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29755775/rectal-and-anal-canal-neuroendocrine-tumours
#6
Teresa Raposo André, Margarida Brito, João Geraldes Freire, António Moreira
Neuroendocrine tumors (NETs) are rare, representing 0.5% of all newly diagnosed malignancies. Rectal and anal canal (AC) NETs account for less than 1% of all rectal and AC cancers. Review our institutional experience on NET of the rectum and AC, with emphasis on demographic, histological and treatment features and oncologic outcomes. The study group was identified from the Portuguese Regional South Oncological Registry. From 2000 to 2014, 22 patients with rectal or AC NETs were treated at our institution. Medical records were retrospectively reviewed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755663/the-ongoing-challenge-of-large-anal-cancers-prospective-long-term-outcomes-of-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy
#7
Ali Hosni, Kathy Han, Lisa W Le, Jolie Ringash, James Brierley, Rebecca Wong, Robert Dinniwell, Anthony Brade, Laura A Dawson, Bernard J Cummings, Monika K Krzyzanowska, Eric X Chen, David Hedley, Jennifer Knox, Alexandra M Easson, Patricia Lindsay, Tim Craig, John Kim
Purpose: Patterns of failure and long term outcomes were prospectively evaluated following tumor factors-stratified radiation dose for anal/perianal cancer. Methods: Between 2008-2013, patients with anal/perianal squamous cell carcinoma were accrued to an institutional REB-approved prospective study. All patients were treated with image-guided intensity-modulated radiation therapy (IG-IMRT). Radiation dose selection (27-36 Gy for elective target, and 45-63 Gy for gross target) was based on tumor clinico-pathologic features...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752845/perineal-closure-following-extralevator-abdominoperineal-excision-for-cancer-of-the-rectum
#8
Jenifer Barrie, Adam Haque, David Andrew Evans
AIM: Extralevator abdominoperineal resection (ELAP) may be complicated by perineal wound healing problems and herniation. We report a consecutive series of 38 such patients with selective use of a fasciocutaneous V-Y buttock advancement flap (BAF). METHOD: Data were collected on a series of patients undergoing ELAP for rectal malignancy between August 2011 and July 2017. Demographics, management and outcomes were recorded prospectively. Perineal wound problems were considered 'major' if they required packing, otherwise being classed as 'minor'...
May 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29750133/use-of-indirect-target-gating-in-magnetic-resonance-guided-liver-stereotactic-body-radiotherapy-case-report-of-an-oligometastatic-patient
#9
Luca Boldrini, Francesco Cellini, Stefania Manfrida, Giuditta Chiloiro, Stefania Teodoli, Davide Cusumano, Bruno Fionda, Gian Carlo Mattiucci, Anna Maria De Gaetano, Luigi Azario, Vincenzo Valentini
The case of a 73-year-old woman affected by anal canal cancer with concomitant liver metastases is presented here. The patient was addressed to stereotactic body radiotherapy (SBRT) on two hepatic secondary lesions after the first radiochemotherapy treatment of the primary tumor. A Tri-60-Co magnetic resonance hybrid radiotherapy unit was used for SBRT treatment delivery. Both liver lesions were not clearly visible on the setup magnetic resonance imaging (MRI) due to their limited dimensions (maximum diameter 13 mm); however, the presence of two cysts adjacent to the metastases allowed the use of an indirect target gating approach...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#10
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29742689/total-robotic-surgery-for-pancreaticoduodenectomy-combined-with-rectal-cancer-anterior-resection-a-case-report-and-literature-review
#11
QunGuang Jiang, TaiYuan Li, DongNing Liu, Cheng Tang
RATIONALE: Synchronous double malignancies, including carcinoma of the ampulla of Vater and rectal carcinoma, are generally uncommon occurrences in the gastrointestinal tract. PATIENT CONCERNS: The present study report a case of a 37-year-old man who was incidentally found to suffer from carcinoma of the ampulla of Vater and rectal carcinoma. DIAGNOSES: The duodenoscopy was performed and revealed an ulcerated and bulky ampulla of Vater, the biopsy from which revealed a moderate-differentiated adenocarcinoma, A local hospital colonoscopy confirmed a tumor located in rectal 7 cm from the anal margin and biopsy-confirmed poorly differentiated adenocarcinoma...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29735158/-psychological-impact-of-ostomy-on-the-quality-of-life-of-colorectal-cancer-patients-role-of-body-image-self-esteem-and-anxiety
#12
Laury Beaubrun En Famille Diant, Florence Sordes, Thierry Chaubard
Surgery accounts for an important part of the therapeutic arsenal of colorectal cancer treatment. In digestive cancers, ostomy devices induce the loss of anal function and control. This medical appliance generates changes affecting all aspects of patients' lives. This study explores, on the one hand, the psychological impact of colostomy on colorectal cancer patients' quality of life and on the other hand, it analyzes the correlational links between body image, self-esteem and anxiety during the stoma. Thirty-five patients with colorectal cancer participated in the study, divided into 2 subgroups: 23 were carriers of a definitive stoma and the 12 others with a temporary stoma...
May 4, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29733238/dose-response-relationships-of-the-sigmoid-for-urgency-syndrome-after-gynecological-radiotherapy
#13
Eleftheria Alevronta, Viktor Skokic, Ulrica Wilderäng, Gail Dunberger, Fei Sjöberg, Cecilia Bull, Karin Bergmark, Rebecka Jörnsten, Gunnar Steineck
PURPOSE: To find out what organs and doses are most relevant for 'radiation-induced urgency syndrome' in order to derive the corresponding dose-response relationships as an aid for avoiding the syndrome in the future. MATERIAL AND METHODS: From a larger group of gynecological cancer survivors followed-up 2-14 years, we identified 98 whom had undergone external beam radiation therapy but not brachytherapy and not having a stoma. Of those survivors, 24 developed urgency syndrome...
May 7, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29728940/systemic-therapies-for-advanced-squamous-cell-anal-cancer
#14
REVIEW
Francesco Sclafani, Sheela Rao
PURPOSE OF REVIEW: We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS: There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, ever-conducted, randomised trial in the first-line setting, investigation of immunotherapy in the refractory setting and use of comprehensive genomic profiling for a better molecular characterisation of this disease and the identification of novel potential targets...
May 4, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29722659/tolerability-of-adxs11-001-lm-llo-listeria-based-immunotherapy-with-mitomycin-fluorouracil-and-radiation-for-anal-cancer
#15
Howard Safran, Kara-Lynne Leonard, Kimberly Perez, Matthew Vrees, Adam Klipfel, Steven Schechter, Nicklas Oldenburg, Leslie Roth, Nishit Shah, Kayla Rosati, Lakshmi Rajdev, Kalyan Mantripragada, Iris Y Sheng, Peter Barth, Thomas A DiPetrillo
PURPOSE: To obtain safety and preliminary efficacy data of the combination of ADXS11-001, live attenuated Listeria monocytogenes bacterium, with mitomycin, 5-fluorouracil (5-FU), and intensity modulated radiation therapy in locally advanced anal cancer. PATIENTS AND METHODS: Eligibility included patients with previously untreated, nonmetastatic anal cancer with a primary tumor >4 cm or node-positive disease. Patients received 2 cycles of mitomycin and 5-FU concurrent with 54...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29720524/high-rate-of-infection-by-only-oncogenic-human-papillomavirus-in-amerindians
#16
Daniela Vargas-Robles, Magda Magris, Natalia Morales, Maurits N C de Koning, Iveth Rodríguez, Tahidid Nieves, Filipa Godoy-Vitorino, Gloria I Sánchez, Luis David Alcaraz, Larry J Forney, María-Eglée Pérez, Luis García-Briceño, Leen-Jan van Doorn, María Gloria Domínguez-Bello
Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, forming a gradient spanning urbanization. We hypothesized that, by virtue of their history, lifestyle, and isolation from the global society, remote Amerindian women have lower HPV diversity than do urban women (Amerindian or mestizo)...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29720242/anorectal-metastasis-from-breast-carcinoma-a-case-report-and-review-of-the-literature
#17
Hannes Ruymbeke, Luc Harlet, Barbara Stragier, Edwin Steenkiste, Merijn Ryckx, Francois Marolleau
BACKGROUND: Gastrointestinal metastasis from primary breast carcinoma is uncommon, anorectal involvement is extremely rare. CASE PRESENTATION: We present the case of a 65-year old woman who underwent treatment for an infiltrative lobular carcinoma of the left breast with bone metastases and who developed metastasis of the rectum and anal canal 4 years later. CONCLUSIONS: A patient with a history of breast cancer, especially lobular carcinoma, presenting with anorectal symptoms, should raise the suspicion of metastatic disease...
May 2, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29720197/the-prognostic-role-of-hemoglobin-levels-in-patients-undergoing-concurrent-chemo-radiation-for-anal-cancer
#18
Pierfrancesco Franco, Francesco Montagnani, Francesca Arcadipane, Chiara Casadei, Kalliopi Andrikou, Stefania Martini, Giuseppe Carlo Iorio, Mario Scartozzi, Massimiliano Mistrangelo, Lorenzo Fornaro, Paola Cassoni, Stefano Cascinu, Umberto Ricardi, Andrea Casadei Gardini
BACKGROUND: Concurrent chemo-radiation (CT-RT) is a standard therapy for squamous cell carcinoma of anal canal. Different clinical and biological factors may potentially affect outcome. We investigated the prognostic role of baseline hemoglobin (Hb) in a cohort of anal cancer patients submitted to CT-RT with 5-fluorouracil and mitomycin C. METHODS: Up to 161 patients with clinical stage T1-T4/N0-N3/M0 were treated. Response was assessed at 6 weeks and thereafter at 3, 6 and 12 months...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29718243/the-impact-of-age-at-time-of-ileal-pouch-anal-anastomosis-on-short-and-long-term-outcomes-in-adults
#19
Nicholas P McKenna, Kellie L Mathis, John H Pemberton, Amy L Lightner
Background: There is limited knowledge on ileal pouch anal anastomosis (IPAA) function when performed on patients older than age 50 years. The aim of this study was to determine if surgery on those older than age 50 years impacts short-term complications or long-term function. Methods: A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between 2002 and 2013 was conducted. Short-term postoperative complications and long-term function and quality of life were analyzed according to age at pouch formation (age >50 vs age ≤50 years)...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29717372/combined-repeat-laparoscopy-and-transanal-endolumenal-repair-hybrid-approach-in-the-early-management-of-postoperative-colorectal-anastomotic-leaks-technique-and-outcomes
#20
William Tzu-Liang Chen, Saurabh Bansal, Tao-Wei Ke, Sheng-Chi Chang, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, Abe Fingerhut
BACKGROUND: Few clear recommendations exist for the management of colorectal anastomotic leaks, often based on surgeon preferences or institutional protocols. The primary goal was to evaluate the feasibility and safety of the combined laparoscopic and transanal (hybrid) approach to treat postoperative colorectal anastomotic leaks. The secondary goals included comparison of outcomes following early (< 5 days after initial resection) versus late (≥ 5 days) detection of leaks...
May 1, 2018: Surgical Endoscopy
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