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https://www.readbyqxmd.com/read/28213624/oligometastatic-colorectal-cancer-is-single-site-bony-colorectal-metastasis-a-treatable-condition
#1
Noel Cassar, Adrian Ben Cresswell, Brendan Moran
INTRODUCTION: A potentially resectable bony metastasis in the context of oligometastatic colorectal cancer is uncommon. Bony metastases are usually considered a late event with poor prognosis and generally associated with liver and/or lung metastases. INDEX CASE: A previously healthy 33-year-old gentleman, with no family history of colorectal cancer, presented with rectal bleeding and at colonoscopy had a biopsy-proven adenocarcinoma of the rectum, 7 cm from the anal verge...
February 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28212258/factors-influencing-difficulty-of-laparoscopic-abdominoperineal-resection-for-ultra-low-rectal-cancer
#2
Qiken Li, Dechuan Li, Lai Jiang, Pengnian Qiu, Zhixuan Fu, Lilong Tang, Weiping Chen
PURPOSE: Our current study was conducted to identify patients' anatomic, pathologic, and clinical factors to predict difficulty of performing laparoscopic abdominoperineal resection for ultra-low rectal cancer. MATERIALS AND METHODS: Records of 117 consecutive patients with rectal cancer 2 to 5 cm from the anal verge were retrospectively reviewed. Using univariate and multivariate linear or logistic regression models, standardized operative time and blood loss, as well as postoperative morbidity were utilized as endpoints to screen patients' multiple variables to predict operative difficulty...
February 16, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28209745/platinum-fluoropyrimidine-and-paclitaxel-based-chemotherapy-in-the-treatment-of-advanced-anal-cancer-patients
#3
Francesco Sclafani, Federica Morano, David Cunningham, Chiara Baratelli, Eleftheria Kalaitzaki, David Watkins, Naureen Starling, Ian Chau, Sheela Rao
BACKGROUND: Although treatment of localized anal cancer (AC) is well established, very little evidence is available to inform the management of advanced tumors, and the prognosis of these patients remains poor. We have analyzed treatment pathways and outcomes of a single-institution series of advanced AC patients in order to provide insight into the management of this rare condition. MATERIALS AND METHODS: Inclusion criteria included epidermoid histology, inoperable locally recurrent or metastatic disease, and availability of full medical records...
February 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28209297/anal-cancer-leading-the-way
#4
Angelita Habr-Gama, Guilherme Pagin São Julião, Rodrigo Oliva Perez
No abstract text is available yet for this article.
February 10, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28209296/best-time-to-assess-complete-clinical-response-after-chemoradiotherapy-in-squamous-cell-carcinoma-of-the-anus-act-ii-a-post-hoc-analysis-of-randomised-controlled-phase-3-trial
#5
Robert Glynne-Jones, David Sebag-Montefiore, Helen M Meadows, David Cunningham, Rubina Begum, Fawzi Adab, Kim Benstead, Robert J Harte, Jill Stewart, Sandy Beare, Allan Hackshaw, Latha Kadalayil
BACKGROUND: Guidelines for anal cancer recommend assessment of response at 6-12 weeks after starting treatment. Using data from the ACT II trial, we determined the optimum timepoint to assess clinical tumour response after chemoradiotherapy. METHODS: The previously reported ACT II trial was a phase 3 randomised trial of patients of any age with newly diagnosed, histologically confirmed, squamous cell carcinoma of the anus without metastatic disease from 59 centres in the UK...
February 10, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28206939/the-ferguson-operating-anoscope-for-resection-of-t1-rectal-cancer
#6
Kristin C Turza, Thomas Brien, Steven Porbunderwala, Christopher M Bell, Shauna Lorenzo-Rivero, Richard A Moore, Eric C Nelson, J Daniel Stanley
The Ferguson Operating Anoscope (FOA) is a surgical instrument, which can facilitate transanal excision of appropriate rectal tumors within 15 cm of the anal verge. Previous work showed low recurrence (4.3%) for favorable T1 tumors (no lymphovascular invasion, well/moderate differentiation, negative margins). This follow-up study evaluates outcomes in rectal cancer excised with FOA at a tertiary care center. T1 rectal cancer patients were identified in a prospectively maintained database. Tumor pathology and patient characteristics were reviewed...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28203173/squamous-cell-carcinoma-of-the-anal-transitional-zone-after-ileal-pouch-surgery-for-ulcerative-colitis-systematic-review-and-treatment-perspectives
#7
Gianluca Pellino, Christos Kontovounisios, Diana Tait, John Nicholls, Paris P Tekkis
BACKGROUND: Few cases of pouch-related cancers have been reported in ulcerative colitis (UC), and squamous cell carcinoma (SCC) is very rare. METHOD: A systematic review of the literature was performed to identify all unequivocal cases of pouch-related SCC in UC patients. RESULTS: Eight cases of SCC developing after ileal pouch-anal anastomosis (IPAA) have been observed since 1978. Two arose from the pouch mucosa and 6 from below. The pooled cumulative incidence of SCC is below 0...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28194687/fecal-incontinence-and-radiation-dose-on-anal-sphincter-in-patients-with-locally-advanced-rectal-cancer-larc-treated-with-preoperative-chemoradiotherapy-a-retrospective-single-institutional-study
#8
F Arias, C Eito, G Asín, I Mora, K Cambra, F Mañeru, B Ibáñez, L Arbea, A Viudez, I Hernández, J I Arrarás, M Errasti, M Barrado, M Campo, I Visus, S Flamarique, M A Ciga
BACKGROUND: The objective of the study is to determine the correlations among the variables of dose and the sphincter function (SF) in patients with locally advanced rectal cancer treated with preoperative capecitabine/radiotherapy followed by low anterior resection (LAR) + TME. METHODS: We retrospectively reviewed 92 consecutive patients with LARC treated at our center with LAR from 2006 and more than 2 years free from disease. We re-contoured the anal sphincters (AS) of patients with the help of the radiologist...
February 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28191793/lateral-decubitus-position-vs-lithotomy-position-which-is-the-best-way-to-minimize-patient-s-pain-perception-during-transrectal-prostate-biopsy
#9
Phil Hyun Song, Young Hwii Ko
INTRODUCTION: Considering the distinctive nature in terms of psychological stress and anal tone of position which is generally selected between lithotomy and left lateral decubitus (LLD), we postulated its effect on pain perception during biopsy, and investigated their association. MATERIALS AND METHODS: A prospective study for comparison of two biopsy positions which were perform in a different working day was conducted for 208 men (lithotomy position=86, LLD=122)...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28191723/perceptions-of-hpv-and-attitudes-towards-hpv-vaccination-amongst-men-who-have-sex-with-men-a-qualitative-analysis
#10
Tom Nadarzynski, Helen Smith, Daniel Richardson, Alex Pollard, Carrie Llewellyn
OBJECTIVES: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme. DESIGN: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. METHODS: Participants were recruited from community-based lesbian-gay-bisexual-transgender (LGBT) venues and organizations...
February 13, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28178892/trends-in-the-incidence-of-aids-defining-and-non-aids-defining-cancers-in-people-living-with-aids-a-population-based-study-from-s%C3%A3-o-paulo-brazil
#11
Luana F Tanaka, Maria do Rosário DO Latorre, Eliana B Gutierrez, Christian Heumann, Karl-Heinz Herbinger, Guenter Froeschl
People living with AIDS are at increased risk of developing certain cancers. Since the introduction of the highly active antiretroviral therapy (HAART), the incidence of AIDS-defining cancers (ADCs) has decreased in high-income countries. The objective of this study was to analyse trends in ADCs and non-AIDS-defining cancers (NADCs) in HIV-positive people with a diagnosis of AIDS, in comparison to the general population, in São Paulo, Brazil. A probabilistic record linkage between the 'Population-based Cancer Registry of São Paulo' and the AIDS notification database (SINAN) was conducted...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178116/genital-human-papillomavirus-infection-in-indian-hiv-seropositive-men-who-have-sex-with-men
#12
Anantharam Raghavendran, Alexandra L Hernandez, Shelly Lensing, Manu Gnanamony, Rajiv Karthik, Murgesan Sivasubramanian, Rajesh Kannangai, Priya Abraham, Dilip Mathai, Joel M Palefsky
BACKGROUND: The incidence of penile cancer in Indian men is high. Little is known about genital human papillomavirus (HPV) infection in Indian HIV-seropositive men who have sex with men (MSM), a population that may be at particularly high risk for genital HPV infection and, potentially, penile cancer. In this study, we assessed the prevalence and risk factors for genital HPV infection in this population. DESIGN AND METHODS: Three hundred HIV-seropositive MSM were recruited from 2 clinical sites in India...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28177987/quality-of-life-and-functional-outcome-after-transanal-abdominal-transanal-proctectomy-for-low-rectal-cancer
#13
COMPARATIVE STUDY
John H Marks, Jean F Salem, Elsa B Valsdottir, Shadi S Yarandi, Gerald J Marks
BACKGROUND: Transanal abdominal transanal proctectomy is a sphincter-preserving procedure designed to avoid colostomy in patients with cancer in the distal third of the rectum. Oncologic outcomes of this procedure have been established. However, data regarding patient satisfaction and quality of life are scant. OBJECTIVE: The purpose of this study was to evaluate the quality of life and functional outcomes of patients after transanal abdominal transanal proctectomy...
March 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28158501/third-european-evidence-based-consensus-on-diagnosis-and-management-of-ulcerative-colitis-part-1-definitions-diagnosis-extra-intestinal-manifestations-pregnancy-cancer-surveillance-surgery-and-ileo-anal-pouch-disorders
#14
Fernando Magro, Paolo Gionchetti, Rami Eliakim, Sandro Ardizzone, Alessandro Armuzzi, Manuel Barreiro-de Acosta, Johan Burisch, Krisztina B Gecse, Ailsa L Hart, Pieter Hindryckx, Cord Langner, Jimmy K Limdi, Gianluca Pellino, Edyta Zagórowicz, Tim Raine, Marcus Harbord, Florian Rieder
No abstract text is available yet for this article.
February 2, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28152894/engaging-managing-physicians-in-clinical-staging-prior-to-the-initiation-of-cancer-treatment
#15
Carol Huibregtse, Marija Bjegovich-Weidman, James L Weese
: 143 Background: Managing physicians (medical oncologist, radiation oncologist, surgeons) have a responsibility to clinically stage patients prior to the initiation of cancer treatment. Clinical staging not only directs the treatment plan, but identifies appropriate clinical trials and estimates prognosis. We sought to determine whether engagement of managing physicians would result in increased clinical staging for various types of cancer. METHODS: Baseline data on clinical staging for breast, colorectal (colon, rectal, anal, rectosigmoid junction)*, thoracic (lung esophageal)†, genitourinary (prostate, penis, testes)‡, and pancreatic primary cancers were obtained...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152683/hiv-testing-in-a-cancer-center-emergency-department
#16
Kelly W Merriman, Zeena Shelal, Hadil Bazerbashi, Patricia A Brock, Carmen E Gonzalez, Harrys A Torres, Terry Rice
: 225 Background: HIV is a cancer-associated virus classically associated with KS, NHL, and cervical cancer, but more recently with anal cancer, lung, and head and neck cancers. HIV testing and treatment are important for cancer patients for three reasons: 1) HIV treatment is associated with reduced transmission of a cancer-associated virus. 2) HIV treatment is associated with improved outcomes of cancer therapy in many cancers. 3) HIV testing optimizes quality of care, since testing is recommended by the Centers for Disease Control and Prevention (CDC) and the US Preventive Services Task Force (USPSTF)(A level recommendation) for patients between the ages of 15 and 65 years of age...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152526/egfr-inhibitors-in-patients-with-advanced-squamous-cell-anal-carcinomas-a-single-institution-experience
#17
Dae Won Kim, Jennifer Byer, Nishi Kothari, Amit Mahipal, Yound Doo Chang, Richard D Kim
BACKGROUND: Although squamous cell anal carcinomas are relatively rare, their incidence has been increasing steadily. Because of the limited data, treatment of metastatic disease is a major therapeutic challenge. In this study, we report the safety and efficacy of epidermal growth factor receptor (EGFR) inhibitors in patients with advanced squamous cell anal carcinomas. METHOD: A retrospective analysis was conducted using the Moffitt Cancer Tumor Registry from January 2009 to January 2014...
February 3, 2017: Oncology
https://www.readbyqxmd.com/read/28152518/diagnostic-performance-of-magnetic-resonance-imaging-and-3d-endoanal-ultrasound-in-detection-staging-and-assessment-post-treatment-in-anal-cancer
#18
Alfonso Reginelli, Vincenza Granata, Roberta Fusco, Francesco Granata, Daniela Rega, Luca Roberto, Gianluca Pellino, Antonio Rotondo, Francesco Selvaggi, Francesco Izzo, Antonella Petrillo, Roberto Grassi
We compared Magnetic Resonance Imaging (MRI) and 3D Endoanal Ultrasound (EAUS) imaging performance to confirm anal carcinoma and to monitor treatment response.58 patients with anal cancer were retrospectively enrolled. All patients underwent clinical examination, anoscopic examination; EAUS and contrast-enhanced MRI study before and after treatment. Four radiologists evaluated the presence of lesions, using a 4-point confidence scale, features of the lesion and nodes on EAUS images, T1-weighted (T1-W), T2-weighted (T2-W) and diffusion-weighted images (DWI) signal intensity (SI), the apparent diffusion coefficient (ADC) map for nodes and lesion, as well as enhancement pattern during dynamic MRI were assessed...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28150422/successful-restoration-of-fecal-continence-using-sacral-nerve-stimulation-following-chemoradiation-and-transanal-excision-of-an-anal-melanoma-with-partial-internal-anal-sphincter-resection-a-case-report
#19
Tyler Cameron Tolopka, Craig A Messick
OBJECTIVE: This case report provides evidence for our hypothesis that use of a sacral nerve stimulator may be considered in patients with fecal incontinence (FI) following chemoradiation and transanal operations in the setting of cancer including partial internal sphincter resections. MATERIALS AND METHODS: A 57-year-old female with a history of anal melanoma was treated with neoadjuvant chemoradiation followed by wide local, transanal tumor excision with partial internal anal sphincter resection that resulted in ≥2 full fecal incontinent episodes/week with gas, liquid, and solid stool leakage ≥10/day requiring pad changes...
February 1, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28142148/role-of-the-common-fragile-sites-in-cancers-with-a-human-papillomavirus-etiology
#20
Ge Gao, David I Smith
High-risk human papillomaviruses (HPVs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. They are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (OPSCC) observed in the United States and Europe. The model for how high-risk HPVs induce cancer formation comes from studies of cervical cancer which usually involves integration of the HPV into the human genome and subsequent changes due to induced chromosomal instability...
February 1, 2017: Cytogenetic and Genome Research
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