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Anna Colpo, Tiziana Tison, Maria Teresa Gervasi, Cinzia Vio, Maria Vicarioto, Giustina De Silvestro, Piero Marson
INTRODUCTION: Despite prophylaxis, a small proportion of RhD-negative women may develop anti-D antibodies after a sensitizing event occurring during pregnancy or delivery of a D-positive baby. Intrauterine transfusion (IUT) is the treatment of choice in case of fetal anemia, but it cannot be performed early during pregnancy. Combined treatment with therapeutic plasma-exchange (TPE) and intravenous immunoglobulin (IVIG) can avoid or delay IUT. Immunoadsorption (IA) could represent a more effective treatment in selected cases...
June 6, 2017: Transfusion and Apheresis Science
P Coppo
Daily therapeutic plasma exchange (TPE) transformed the historically fatal prognosis of acquired, anti-ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura (TTP), leading to the current overall survival rates of >80%. However, relapses occur in up to 40% of patients and refractory disease with fatal outcomes still occurs, typically within the first days of management. In this context, the introduction of rituximab has been the second major breakthrough in TTP management. Rituximab is now routinely recommended during the acute phase, typically in patients with a suboptimal response to treatment, and increasingly as frontline therapy, with high response rates in the following weeks...
June 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Yuanyuan Zhao, Xu Zhang, Zhipeng Li, Shuaidong Huo, Ke Zhang, Juntao Gao, Hao Wang, Xing-Jie Liang
Simultaneous precise localization and activity evaluation of a biomolecule in a single living cell is through an enzyme-specific signal-amplification process, which involves the localized, site-specific self-assembly, and activation of a presignaling molecule. The inactive presignaling tetraphenylethylene (TPE)-peptide derivative, TPE-YpYY, is nondetectable and highly biocompatible and these small molecules rapidly diffuse into living cells. Upon safely arriving at an active site, and accessing the catalytic pocket of an enzyme, TPE-YpYY immediately and quantitatively accumulates in situ in response to enzymatic activity, forms an enzyme anchor TPE-YYY nanoassembly, displays aggregation-induced emission behavior, and finally lights up the active enzyme, indicating its activity, and allowing its status in living cells to be tracked...
June 22, 2017: Advanced Materials
Yu-Qing Niu, Tao He, Jun Song, Si-Ping Chen, Xiang-Yu Liu, Zhi-Gang Chen, Ying-Jie Yu, Shi-Guo Chen
A multi-block fluorescent amphiphilic polyurethane copolymer (TPE-PU), self-assembling into hairy, water-soluble micelles, is used as a subcellular microfilament probe in living cells.
June 21, 2017: Chemical Communications: Chem Comm
Si-Si Zhao, Li Chen, Lei Wang, Zhigang Xie
Two fluorescent coordination polymers have been designed and synthesized from a tetraphenylethene (TPE) derivative. These polymers, which can be potentially utilized as mechanical sensors, exhibit reversible mechanochromic luminescence with color changes visible to the naked-eye from blue to green-yellow by grinding or soaking in N,N-dimethylformamide (DMF) under UV irradiation.
June 15, 2017: Chemical Communications: Chem Comm
Tao Yu, Depei Ou, Zhiyong Yang, Qiuyi Huang, Zhu Mao, Junru Chen, Yi Zhang, Siwei Liu, Jiarui Xu, Martin R Bryce, Zhenguo Chi
This study probes the effect of intramolecular rotations on aggregation-induced emission (AIE) and leads to a kind of supramolecular mechanoluminescent material. Two hydrogen-bonded organic frameworks (HOFs), namely HOFTPE3N and HOFTPE4N, have been constructed from nitro-substituted tetraphenylethene (TPE) building blocks, namely tris(4-nitrophenyl)phenylethene (TPE3N) and tetrakis(4-nitrophenyl)ethene (TPE4N). Using single-crystal X-ray diffraction analysis, two types of pores are observed in the HOFTPE4N supramolecular structure...
February 1, 2017: Chemical Science
Dan Pan, Fengyan Luo, Xianjun Liu, Wei Liu, Wen Chen, Feng Liu, Yong-Qing Kuang, Jian-Hui Jiang
In recent years, many activatable fluorescent probes have been developed for hNQO1 detection. However, most of the reported fluorescent probes are susceptible to the interferences of endogenous fluorescence and have the drawback of inadequate penetration depth. Very recently, researchers have reported a two-photon excitation (TPE) fluorescent probe for hNQO1 detection. Nevertheless, this probe only exhibits a compromised signal-to-background ratio, and has not been applied to image hNQO1 in living tissues. Herein, a novel TPE fluorescent probe, trimethyl locked quinone caged Acedan (Q3CA-P), has been developed for hNQO1 detection and imaging in living cells and tissues...
June 13, 2017: Analyst
Casey N Gashti, Daniel C Andreoli, Dipal Patel
Therapeutic plasma exchange (TPE) has long been utilized to manage a variety of immune-mediated diseases. The basic principle relies on removal of circulating pathogenic substances from the bloodstream. Methods of plasma separation include centrifuge (cTPE) and membrane (mTPE). Although mTPE has existed for a few decades, recent advances in developing highly permeable filters that are compatible with currently existing dialysis machines has opened a new frontier. Published data in the area of technical and clinical experience with mTPE is lacking...
June 13, 2017: Journal of Clinical Apheresis
Andrea M McGonigle, Aaron A R Tobian, Jennifer L Zink, Karen E King
Thyroid storm is a potentially lethal complication of hyperthyroidism with increased thyroid hormones and exaggerated symptoms of thyrotoxicosis. First-line therapy includes methimazole (MMI) or propylthiouracil (PTU) to block production of thyroid hormones as a bridge toward definitive surgical treatment. Untreated thyroid storm has a mortality rate of up to 30%; this is particularly alarming when patients cannot tolerate or fail pharmacotherapy, especially if they cannot undergo thyroidectomy. Therapeutic plasma exchange (TPE) is an ASFA category III indication for thyroid storm, meaning the optimum role of this therapy is not established, and there are a limited number of cases in the literature...
June 13, 2017: Journal of Clinical Apheresis
Annelies Tonnelier, Jeroen de Filette, Ann De Becker, Sophie Deweer, Brigitte Velkeniers
INTRODUCTION: Amiodarone, used for the management of tachyarrhythmias, is associated with both hypothyroidism and thyrotoxicosis. Total thyroidectomy is an effective procedure for promptly reducing circulating thyroid hormone levels. It has been proposed in patients who have severe amiodarone-induced thyrotoxicosis (AIT) or are refractory to medical therapy, or when such therapy is contraindicated. Therapeutic plasma exchange (TPE) may be considered as a pretreatment for restoring a euthyroid state preoperatively, thereby reducing a patient's symptoms and the potential perioperative risk associated with thyrotoxicosis...
April 2017: European Thyroid Journal
Hongye Huang, Dazhuang Xu, Meiying Liu, Ruming Jiang, Liucheng Mao, Qiang Huang, Qing Wan, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Aggregation-induced emission (AIE) phenomenon has attracted great attention recently and been extensively explored for biomedical applications. Nevertheless, the direct utilization of AIE-active dyes for biomedical applications has demonstrated to be enormous challenge owing to the hydrophobic nature of these AIE-active dyes. In this work, we reported the fabrication of amphiphilic AIE-active copolymers through the specific host-guest interaction between β cyclodextrin (β-CD) and an adamantine terminating tetraphenylethene derivative (TPE-Ad)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Timea Nagy-Simon, Andra-Sorina Tatar, Ana-Maria Craciun, Adriana Vulpoi, Maria-Ancuta Jurj, Adrian Florea, Ciprian Tomuleasa, Ioana Berindan-Neagoe, Simion Astilean, Sanda Boca
In this Research Article, we propose a new class of contrast agents for the detection and multimodal imaging of CD19(+) cancer lymphoblasts. The agents are based on NIR responsive hollow gold-silver nanospheres conjugated with antiCD19 monoclonal antibodies and marked with Nile Blue (NB) SERS active molecules (HNS-NB-PEG-antiCD19). Proof of concept experiments on specificity of the complex for the investigated cells was achieved by transmission electron microscopy (TEM). The microspectroscopic investigations via dark field (DF), surface-enhanced Raman spectroscopy (SERS), and two-photon excited fluorescence lifetime imaging microscopy (TPE-FLIM) corroborate with TEM and demonstrate successful and preferential internalization of the antibody-nanocomplex...
June 15, 2017: ACS Applied Materials & Interfaces
Steven A Mann, Lance A Williams, Marisa B Marques, Huy P Pham
INTRODUCTION: Daily laboratory testing (DLT) is an important cause of iatrogenic anemia. Therapeutic plasma exchanges (TPE) represent another source of blood loss. This study investigated the contributions of DLT and TPE to changes in hemoglobin of inpatients with myasthenia gravis (MG) exacerbation. STUDY DESIGN AND METHODS: All admissions for MG that included TPE between 2008 and 2012 were identified. The DLT- and TPE-related blood losses per patient were estimated based on the number of laboratory tests and TPE procedures...
June 2, 2017: Journal of Clinical Apheresis
Jinye Niu, Jilin Fan, Xu Wang, Yongsheng Xiao, Xilei Xie, Xiaoyun Jiao, Chuanzhi Sun, Bo Tang
Biological sensors with simultaneous turn-on signals of fluorescence (FL) and chemiluminescence (CL) triggered by one single species are supposed to integrate spatiotemporally resolved FL imaging with dynamic CL sensing into one luminescent assay. Efficiently increased accuracy can be expected based on complementary information simultaneously obtained from two independent modes, which is crucial in disease detection and diagnosis. However, very few examples can be found to date because of the key challenges in the rational design of sensing structures...
June 15, 2017: Analytical Chemistry
Baolong Zhou, Xiang Hu, Guang Zeng, Shiwu Li, Zhenhai Wen, Long Chen
Two redox-active radical (TEMPO) built-in porous organic frameworks (POFs), which feature hierarchical porous structures, were synthesized via a facile bottom-up strategy and were studied as cathode materials for lithium-sulphur (Li-S) batteries. The sulphur loading in these two POFs can reach up to 61% benefitting from their large pore volume. For the existence of highly densed docking sites of TEMPO, sulphur could be covalently restrained within the porous networks and efficiently inhibited the shuttle effect, therefore significantly improving the cycling performance...
May 29, 2017: ChemSusChem
Kristine M Fischenich, Katie Boncella, Jackson T Lewis, Travis S Bailey, Tammy L Haut Donahue
Understanding how human meniscal tissue responds to loading regimes mimetic of daily life as well as how it compares to larger animal models is critical in the development of a functionally accurate synthetic surrogate. Seven human and 8 ovine cadaveric meniscal specimens were regionally sectioned into cylinders 5mm in diameter and 3 mm thick along with 10 polystyrene-b-polyethylene oxide block copolymer-based thermoplastic elastomer (TPE) hydrogels. Samples were compressed to 12% strain at 1 Hz for 5000 cycles, unloaded for 24 hours, and then retested...
May 27, 2017: Journal of Biomedical Materials Research. Part A
Can Wang, Zhiyang Liu, Mengshu Li, Yujun Xie, Bingshi Li, Shuo Wang, Shan Xue, Qian Peng, Bin Chen, Zujin Zhao, Qianqian Li, Ziyi Ge, Zhen Li
As a promising option out of all of the well-recognized candidates that have been developed to solve the coming energy crisis, polymer solar cells (PSCs) are a kind of competitive clean energy source. However, as a convenient and efficient method to improve the efficiency of PSCs, the inherent mechanism of the interfacial modification was still not so clear, and interfacial materials constructed with new units were limited to a large degree. Here we present a new kind of interfacial material consisting of AIE units for the first time, with an efficiency of 8...
May 1, 2017: Chemical Science
Shixin Zhou, Yijun Xia, Yinan Liu, Qihua He, Bo Song
Understanding the enrichment and intracellular trafficking of substances is centrally important to the biological systems. Here, employing an amphiphilic molecule (denoted by TPE-11) bearing tetraphenylethene moiety, known for aggregation induced emission property, we demonstrated its localization shifting in Hela cells after prolonged incubation. Through a set of delicately designed experiments, we found that one type of cytoskeleton, i.e., microtubule, is responsible for the intracellular transportation regardless of the sources of fluorogens, via endocytosis pathways or not...
May 31, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Sandra Vanessa Pirela, John Martin, Dhimiter Bello, Philip Demokritou
Toner formulations used by laser printers (LP) and photocopiers (PC), collectively called "toner-based printing equipment" (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE...
May 19, 2017: Critical Reviews in Toxicology
Kevin Singh, Ahmed Jamal Nadeem, Behzad Doratotaj
Thrombotic microangiopathy (TMA) occurring after acute pancreatitis is rarely described. Without prompt intervention, TMA can be, and often is, lethal, so prompt recognition is important. Here, we present a case of a 61-year-old woman with a history of alcohol misuse who presented with epigastric pain, nausea and vomiting after binge drinking. Elevated serum lipase and imaging were suggestive of acute-on-chronic pancreatitis. Although the patient's symptoms of acute pancreatitis subsided, her anaemia, thrombocytopenia and acute kidney injury worsened...
May 15, 2017: BMJ Case Reports
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