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https://www.readbyqxmd.com/read/28436106/therapeutic-plasma-exchange-as-part-of-multimodal-treatment-of-acquired-hemophilia-in-a-patient-with-concurrent-acute-intracerebral-bleed-and-pulmonary-embolism
#1
Geoffrey D Wool, David Chapel, Angela Treml, Jonathan L Miller
BACKGROUND: Autoantibodies against Factor VIII (FVIII) define the rare but life-threatening bleeding disorder acquired hemophilia A (AHA). Correction of FVIII deficiency and eradication of the factor inhibitor are the ultimate therapeutic goals in this disorder. Bypassing agents such as recombinant factor VIIa (rFVIIa) or FVIII inhibitor bypassing agent are often used to control coagulopathy before the inhibitor is eradicated. Bypassing agents carry a risk of thrombosis, however. CASE REPORT: We report a patient with newly diagnosed AHA and thalamic bleed who additionally had active atrial fibrillation and developed a segmental pulmonary embolism, limiting tolerable rFVIIa dosage...
April 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28417834/adaptive-changes-in-the-perception-of-fast-and-slow-movement-at-different-head-positions
#2
Roberto Panichi, Chiara Occhigrossi, Aldo Ferraresi, Mario Faralli, Marco Lucertini, Vito E Pettorossi
BACKGROUND: This paper examines the subjective sense of orientation during asymmetric body rotations in normal subjects. METHODS: Self-motion perception was investigated in 10 healthy individuals during asymmetric whole-body rotation with different head orientations. Both on-vertical axis and off-vertical axis rotations were employed. Subjects tracked a remembered earth-fixed visual target while rotating in the dark for four cycles of asymmetric rotation (two half-sinusoidal cycles of the same amplitude, but of different duration)...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28415098/p569diastolic-dyssynchrony-is-associated-with-exercise-intolerance-in-hypertensive-patients-with-left-ventricular-hypertrophy
#3
I H Jung, H S Seo, M J Kim
Background: Left ventricular hypertrophy (LVH) is associated with intra-ventricular dyssynchrony at systolic phase during exercise in hypertensive patients. However, dypsnea on exertion is much more correlated with diastolic phase. We investigated whether LVH is associated with diastolic dyssynchrony during exercise in patients with hypertension. Methods: Ninety hypertensive patients with exertional dyspnea and 30 control individuals were enrolled. Exercise stress echocardiography was performed using a symptom limited, multistage supine bicycle test...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28414461/a-tetraphenylethene-naphthyridine-based-aiegen-tpen-with-dual-mechanochromic-and-chemosensing-properties
#4
Shahida Umar, Ajay Kumar Jha, Deepak Purohit, Atul Goel
Synthesis of new tetraphenylethene (TPE) conjugates via an innocuous route led to the revelation of a unique TPE-based aggregation-induced emissive fluorogen 3 (TPEN), which showed an interesting mechanochromic property when the emission was changed from blue to green upon grinding and green to blue upon fuming. The mechanochromic property of TPEN has been explored to prepare ink-free rewritable paper for security documentation. A detailed photophysical investigation of the TPE-naphthyridine scaffold led to the discovery of its high sensitivity to silver ions (Ag(+)) over other metal ions with a detection limit of 0...
April 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28411139/the-quidam-study-hydroquinidine-therapy-in-the-management-of-brugada-syndrome-patients-at-high-arrhythmic-risk
#5
Antoine Andorin, Jean-Baptiste Gourraud, Jacques Mansourati, Swanny Fouchard, Hervé le Marec, Philippe Maury, Philippe Mabo, Jean-Sylvain Hermida, Jean-Claude Deharo, Beatrice Delasalle, Simon Esnault, Nicolas Sadoul, Jean-Marc Davy, Antoine Leenhardt, Didier Klug, Pascal Defaye, Dominique Babuty, Frédéric Sacher, Vincent Probst
BACKGROUND: Although the implantable cardiac defibrillator (ICD) remains the main therapy in Brugada syndrome (BrS), it does not reduce life-threatening ventricular arrhythmia. Based on pathophysiological mechanisms, hydroquinidine (HQ) has been suggested for the effective prevention of arrhythmia. OBJECTIVE: To provide evidence-based data supporting HQ use to prevent life threatening ventricular arrhythmia in high-risk patients with BrS. METHODS: We performed a prospective multicentre randomised (HQ vs...
April 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28409011/utility-of-t-wave-amplitude-as-a-non-invasive-risk-marker-of-sudden-cardiac-death-in-hypertrophic-cardiomyopathy
#6
Alan Sugrue, Ammar M Killu, Christopher V DeSimone, Anwar A Chahal, Josh C Vogt, Vaclav Kremen, JoJo Hai, David O Hodge, Nancy G Acker, Jeffrey B Geske, Michael J Ackerman, Steve R Ommen, Grace Lin, Peter A Noseworthy, Peter A Brady
OBJECTIVE: Sudden cardiac arrest (SCA) is the most devastating outcome in hypertrophic cardiomyopathy (HCM). We evaluated repolarisation features on the surface electrocardiogram (ECG) to identify the potential risk factors for SCA. METHODS: Data was collected from 52 patients with HCM who underwent implantable cardioverter defibrillator (ICD) implantation. Leads V2 and V5 from the ECG closest to the time of ICD implant were utilised for measuring the Tpeak-Tend interval (Tpe), QTc, Tpe/QTc, T-wave duration and T-wave amplitude...
2017: Open Heart
https://www.readbyqxmd.com/read/28386154/the-exploration-of-peptide-biomarkers-in-malignant-pleural-effusion-of-lung-cancer-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#7
Jing Xu, Bin Xu, Chuanhao Tang, Xiaoyan Li, Haifeng Qin, Weixia Wang, Hong Wang, Zhongyuan Wang, Liangliang Li, Zhihua Li, Hongjun Gao, Kun He, Xiaoqing Liu
Background. Diagnoses of malignant pleural effusion (MPE) are a crucial problem in clinics. In our study, we compared the peptide profiles of MPE and tuberculosis pleural effusion (TPE) to investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in diagnosis of MPE. Material and Methods. The 46 MPE and 32 TPE were randomly assigned to training set and validation set. Peptides were isolated by weak cation exchange magnetic beads and peaks in the m/z range of 800-10000 Da were analyzed...
2017: Disease Markers
https://www.readbyqxmd.com/read/28383580/a-selective-and-light-up-fluorescent-probe-for-%C3%AE-galactosidase-activity-detection-and-imaging-in-living-cells-based-on-an-aie-tetraphenylethylene-derivative
#8
Guoyu Jiang, Guanjie Zeng, Wenping Zhu, Yongdong Li, Xiaobiao Dong, Guanxin Zhang, Xiaolin Fan, Jianguo Wang, Yongquan Wu, Ben Zhong Tang
An aggregation induced emission (AIE) based bioimaging probe, TPE-Gal, was designed for light-up imaging of β-galactosidase in living cells. The applicability of TPE-Gal in imaging endogenous β-galactosidase activity was confirmed in OVCAR-3 cells.
April 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28370959/therapeutic-plasma-exchange-normalizes-insulin-mediated-response-in-a-child-with-type-1-diabetes-and-insulin-autoimmune-syndrome
#9
Erin F Sharwood, Ian P Hughes, Carel J Pretorius, Peter Trnka, Jane Peake, Tony Huynh
BACKGROUND: Insulin autoimmune syndrome (IAS), characterized by glycemic dysregulation and life-threatening hypoglycemia, can occur in patients with type 1 diabetes (T1D). Diagnostic confirmation is complex but important in order to ensure timely initiation of definitive therapy. AIMS: We aimed to quantitate the degree of immunoglobulin-insulin complex (IIC) formation and its effects on glycemic control in a patient with T1D and IAS compared with T1D and non-T1D controls and before and after therapeutic plasma exchange (TPE)...
March 29, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28370705/ratiometric-hg2-ag-probes-with-orange-red-white-blue-fluorescence-response-constructed-by-integrating-vibration-induced-emission-with-an-aie-motif
#10
Yiru Li, Yang Liu, Haitao Zhou, Wei Chen, Ju Mei, Jianhua Su
Two novel ratiometric fluorometric probes 6a and 6b have been successfully designed and synthesized for the detection of Hg2+ and Ag+, respectively. Each of these probes is comprised of a 9,14-diphenyl-9,14-dihydrodibenzo[a,c]phenazine (DPAC) skeleton, a tetraphenylethylene (TPE) unit, and two thymine/adenine groups. In this proof-of-concept work, the DPAC unit featured with vibration-induced emission (VIE) characteristics serves as a dual-emission chromogen, while the TPE moiety which is noted for its aggregation-induced emission (AIE) properties functions mainly as a signal amplifier...
March 29, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28366590/increasing-use-of-therapeutic-apheresis-as-a-liver-saving-modality
#11
Hyun-Ji Lee, Kyung-Hwa Shin, Duyeal Song, Sun-Min Lee, Chulhun L Chang, Chong Woo Chu, Je Ho Ryu, Tae Bum Lee, Yong-Mok Park, Kwang Ho Yang, Byung Hyun Choi, Hyung-Hoi Kim
INTRODUCTION: Therapeutic plasma exchange (TPE) is used for temporary support of liver function in patients presenting with early graft dysfunction after liver transplantation (LT) or liver surgery. We analyzed the effect of therapeutic apheresis on patients with liver disease. METHODS: Between January 2011 and August 2016, 93 apheresis procedures were performed for 26 patients at our institution. Anti-ABO isoagglutination immunoglobulin (Ig) M titer was checked using a type A and type B 3% red blood cell (RBC) suspension in saline with two-fold serial dilutions of patient serum...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28356722/from-therapeutic-patient-education-principles-to-educative-attitude-the-perceptions-of-health-care-professionals-a-pragmatic-approach-for-defining-competencies-and-resources
#12
Benoit Pétré, Remi Gagnayre, Vincent De Andrade, Olivier Ziegler, Michèle Guillaume
Educative attitude is an essential, if implicit, aspect of training to acquire competency in therapeutic patient education (TPE). With multiple (or nonexistent) definitions in the literature, however, the concept needs clarification. The primary aim of this study was to analyze the representations and transformations experienced by health care professionals in the course of TPE training in order to characterize educative attitude. We conducted an exploratory qualitative study using several narrative research-based tools with participants of two TPE continuing education courses...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28355072/spontaneous-amino-yne-click-polymerization-a-powerful-tool-toward-regio-and-stereospecific-poly-%C3%AE-aminoacrylate-s
#13
Benzhao He, Huifang Su, Tianwen Bai, Yongwei Wu, Shiwu Li, Meng Gao, Rongrong Hu, Zujin Zhao, Anjun Qin, Jun Ling, Ben Zhong Tang
Efficient synthesis of poly(enamine)s has been a great challenge because of their poor stability, poor solubility, and low molecular weights. In this work, a spontaneous amino-yne click polymerization for the efficient preparation of poly(enamine)s was established, which could proceed with 100% atom efficiency under very mild conditions without any external catalyst. Through systematic optimization of the reaction conditions, several soluble and thermally stable poly(β-aminoacrylate)s with high molecular weights (Mw up to 64400) and well-defined structures were obtained in excellent yields (up to 99%)...
April 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28350958/photo-controlled-sirna-delivery-and-biomarker-triggered-aiegen-emission-by-upconversion-nayf4-yb-3-tm-3-sio2-nanoparticles-for-inducing-and-monitoring-stem-cell-differentiation
#14
Jinming Li, Chris Wai Tung Leung, Dexter Siu Hong Wong, Jianbin Xu, Rui Li, Yueyue Zhao, Chris Yu Yee Yung, Engui Zhao, Benzhong Tang, Liming Bian
Controlling differentiation of stem cell and monitoring the cell differentiation has attracted much research interest since the discovery of stem cells. In this regard, a novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by encapsulating the photoactivated caged compound (DMNPE/siRNA) and combining a MMP13 cleavaged imaging peptide-tetrapheny-lethene (TPE) unit conjugated with the mesoporous silica coated upconversion nanoparticles (UCNPs) for the remote control of cell differentiation and simultaneously for real-time monitoring of differentiation...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28340760/tetraphenylethene-derivative-modified-dna-oligonucleotide-for-in-situ-potassium-ion-detection-and-imaging-in-living-cells
#15
Danqing Lu, Lei He, Yaya Wang, Mengyi Xiong, Miaomiao Hu, Hao Liang, Shuangyan Huan, Xiao-Bing Zhang, Weihong Tan
The monitoring of K(+) is very important and emergency because of their unique relationship in various disease diagnosis and treatment. G-quadruplex analogue is a classical recognition unit for K(+) detection and has been widely applied in K(+) relevant research. Common fluorescent dyes were employed for design of G-quadruplex structure-based K(+) probes which suffered from the aggregation-caused quenching effect, and possibly limited the biological applications in living systems. Herein, we report an aggregation-induced emission (AIE) effect-based fluorescent probe for cellular K(+) analysis and imaging...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28339886/optimal-method-of-measuring-the-t-peak-to-t-end-interval-for-risk-stratification-in-primary-prevention
#16
Todd M Rosenthal, Daniel Masvidal, Freddy M Abi Samra, Michael L Bernard, Sammy Khatib, Glenn M Polin, Paul A Rogers, Joel Q Xue, Daniel P Morin
Aims: Several published investigations demonstrated that a longer T-peak to T-end interval (Tpe) implies increased risk for ventricular tachyarrhythmia (VT/VF) and mortality. Tpe has been measured using diverse methods. We aimed to determine the optimal Tpe measurement method for screening purposes. Methods and results: We evaluated 305 patients with LVEF ≤ 35% and an implantable cardioverter-defibrillator implanted for primary prevention. Tpe was measured using seven different methods described in the literature, including six manual methods and the automated algorithm '12SL', and was corrected for heart rate...
February 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339843/availability-and-cost-of-extracorporeal-treatments-for-poisonings-and-other-emergency-indications-a-worldwide-survey
#17
Josée Bouchard, Valery Lavergne, Darren M Roberts, Monique Cormier, Genevieve Morissette, Marc Ghannoum
Background: Extracorporeal treatments (ECTRs) are used for different conditions, including replacement of organ function and poisoning. Current recommendations for ECTRs in various poisonings suggest that intermittent haemodialysis (IHD) is the most efficient technique. However, the practicality of these recommendations is poorly defined in view of limited information on availability and cost worldwide. Methods: A survey invitation to an Internet-based questionnaire was emailed between January 2014 and March 2015 to members of international societies to determine the availability, time to initiation and cost of ECTRs (including filters, dialysate, catheter, anticoagulant and nursing/physician salary)...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28338291/versatile-polymer-nanoparticles-as-two-photon-triggered-photosensitizers-for-simultaneous-cellular-deep-tissue-imaging-and-photodynamic-therapy
#18
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth, Pengfei Wang
Clinical applications of current photodynamic therapy (PDT) photosensitizers (PSs) are often limited by their absorption in the UV-vis range that possesses limited tissue penetration ability, leading to ineffective therapeutic response for deep-seated tumors. Alternatively, two-photon excited PS (TPE-PS) using NIR light triggered is one the most promising candidates for PDT improvement. Herein, multimodal polymer nanoparticles (PNPs) from polythiophene derivative as two-photon fluorescence imaging as well as two-photon-excited PDT agent are developed...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28337499/organic-nanostructure-based-probes-for-two-photon-imaging-of-mitochondria-and-microbes-with-emission-between-430-nm-and-640-nm
#19
Xinglong Yang, Nuoxin Wang, Lingmin Zhang, Luru Dai, Huawu Shao, Xingyu Jiang
Multi-photon excitation and versatile fluorescent probes are in high need for biological imaging, since one probe can satisfy many needs as a biosensor. Herein we synthesize a series of two-photon excited probes based on tetraphenylethene (TPE) structures (TPE-Acr, TPE-Py, and TPE-Quino), which can image both mammalian cells and bacteria based on aggregation-induced emission (AIE) without washing them. Because of cationic moieties, the fluorescent molecules can aggregate into nanoscale fluorescent organic nanoscale dots to image mitochondria and bacteria with tunable emissions using both one-photon and two-photon excitation...
March 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28332834/multicomponent-platinum-ii-cages-with-tunable-emission-and-amino-acid-sensing
#20
Mingming Zhang, Manik Lal Saha, Ming Wang, Zhixuan Zhou, Bo Song, Chenjie Lu, Xuzhou Yan, Xiaopeng Li, Feihe Huang, Shouchun Yin, Peter J Stang
The syntheses, characterization, and emission properties of three tetragonal prismatic cages, 4a-4c, constructed from eight 90° Pt(II) acceptors, four linear dipyridyl ligands, and two tetraphenylethene (TPE)-based sodium benzoate ligands, are described. These cages are emissive in dilute solutions due to the metal-coordination-induced partial restriction of intramolecular rotation of their TPE units, while the dipyridyl moieties, which act as the pillars as well as the solvents, strongly influence these emissions...
March 31, 2017: Journal of the American Chemical Society
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