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https://www.readbyqxmd.com/read/28319287/iatrogenic-thyrotoxicosis-and-the-role-of-therapeutic-plasma-exchange
#1
Kabeer K Shah, Michael M Mbughuni, Edwin A Burgstaler, Darci R Block, Jeffrey L Winters
Thyroid storm or severe thyrotoxicosis results from extreme thyroid hormone elevation. Therapy includes medical management to prevent hormone production, release, recycling, and peripheral conversion while stabilizing adrenergic tone. Thyroid dysfunction is the usual cause but it can be due to excessive thyroid hormone ingestion. Therapeutic plasma exchange (TPE) has been used to rapidly remove protein-bound thyroid hormone. American Society for Apheresis guidelines make a weak recommendation to perform TPE in selected patients in the treatment of thyrotoxicosis based on low quality evidence...
March 20, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28318255/excited-state-decay-paths-in-tetraphenylethene-derivatives
#2
Yuan-Jun Gao, Xue-Ping Chang, Xiang-Yang Liu, Quan-Song Li, Ganglong Cui, Walter Thiel
The photophysical properties of tetraphenylethene (TPE) compounds may differ widely depending on the substitution pattern, for example with regard to the fluorescence quantum yield phi_f and the propensity to exhibit aggregation-induced emission (AIE). We report combined electronic structure calculations and nonadiabatic dynamics simulations to study the excited-state decay mechanisms of two TPE derivatives with four methyl substituents, either in meta-position (TPE-4mM, phi_f = 0.1%) or in ortho-position (TPE-4oM, phi_f = 64...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28317372/a-pillararene-based-aie-active-supramolecular-system-for-simultaneous-detection-and-removal-of-mercury-ii-in-water
#3
Hong-Bo Cheng, Ziyan Li, Yao-Dong Huang, Lei Liu, Hai-Chen Wu
Supramolecular polymers are polymers based on monomeric units held together with directional and reversible noncovalent interactions. Compared with traditional polymers, they possess better processability and better recycling properties, owing to their reversible monomer-to-polymer transition. Herein, we report the construction of a new supramolecular system through self assembly of a thymine-substituted copillar[5]arene 1 and a tetraphenylethylene (TPE) derivative 2 in the presence of Hg2+. Copillar[5]arene 1 can coordinate with Hg2+ tightly through T-Hg2+-T pairings...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28304106/therapeutic-plasma-exchange-versus-double-plasma-molecular-absorption-system-in-hepatitis-b-virus-infected-acute-on-chronic-liver-failure-treated-by-entercavir-a-prospective-study
#4
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Jing Yang, Li-Hong Yang, Ying Xu, Jin-Hui Yang
BACKGROUND: Therapeutic plasma exchange (TPE) and double plasma molecular absorption system (DPMAS) were two extracorporeal liver support systems. Few studies compared their efficacy profile. OBJECTIVE: This study was to compare the efficacy of TPE and DPMAS on acute-on-chronic liver failure (ACLF) caused by hepatitis B virus (HBV-ACLF). METHODS: 60 HBV-ACLF patients were enrolled and prospectively studied. All patients received entecavir therapy, and were assigned to TPE group (n = 33) and DPMAS group (n = 27)...
March 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28295573/therapeutic-plasma-exchange-for-perioperative-management-of-patients-with-congenital-factor-xi-deficiency
#5
Mohamed S Alsammak, Aneel A Ashrani, Jeffrey L Winters, Rajiv K Pruthi
BACKGROUND: Factor XI (FXI) deficiency (hemophilia C [HEM-C]) is a bleeding disorder with unpredictable severity that correlates poorly with FXI coagulation activity (FXI:C). It poses a perioperative hemostatic management challenge. For US patients with severe disease, fresh frozen plasma (FFP) or, in current use, thawed plasma is the most readily available option but comes with risk of volume overload. We report our experience of using therapeutic plasma exchange (TPE) as an alternative perioperative management strategy...
March 15, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28294561/pyridinium-substituted-tetraphenylethylene-entailing-alkyne-moiety-enhancement-of-photosensitizing-efficiency-and-antimicrobial-activity
#6
Xue You, Huili Ma, Yuancheng Wang, Guanxin Zhang, Qian Peng, Libing Liu, Shu Wang, Deqing Zhang
Apart from sensing and imaging, luminogens with aggregation-induced emission are also interesting for photosensitizing. In this paper, we report the photosensitizing behavior and bacteria-killing performance of a new pyridinium substituted tetraphenylethylene with an alkyne group (TPE-A-Py+). Interestingly, TPE-A-Py+ exhibits higher photosensitizing efficiency than TPE-Py+ (without alkyne group) with I- as the counter anion. This is well explained by the fact that the energy gap between the excited singlet state (S1) and triplet state (T1) is lower for TPE-A-Py+ in comparison with that of TPE-Py+ on the basis of theoretical calculations...
March 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28266045/outcomes-in-necrotizing-soft-tissue-infections-treated-with-therapeutic-plasma-exchange
#7
Nabiha Huq Saifee, Heather L Evans, Amalia S Magaret, John R Hess, Meghan Delaney, Grant E O'Keefe, Tam N Pham, Hugh Foy, Eileen Bulger, Monica B Pagano
BACKGROUND: Treatment of necrotizing soft tissue infections (NSTIs) includes prompt surgical debridement and antibiotics, but despite standard care, the morbidity and mortality remain high. Since therapeutic plasma exchange (TPE) has been considered for treatment of severe sepsis, this study evaluates the efficacy of TPE for patients with NSTI. STUDY DESIGN AND METHODS: This is a retrospective study of patients with diagnosis of NSTI who received treatment with and without TPE over an 11-year period...
March 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28265596/a-fluorescent-light-up-aggregation-induced-emission-probe-for-screening-gefitinib-sensitive-non-small-cell-lung-carcinoma
#8
Yi Hu, Leilei Shi, Yue Su, Chuan Zhang, Xin Jin, Xinyuan Zhu
Fluorescent light-up probes with aggregation-induced emission (AIE) characteristics have been focused on recently. In this report, a new fluorescent probe, namely, DEVD-TPE, which consisted of the substrate peptide Asp-Glu-Val-Asp (DEVD) and the AIE reporter group tetraphenylethene (TPE), was developed for detecting caspase-3 in living cells. In a slightly alkaline solution, the DEVD-TPE probe displayed almost no fluorescence owing to the dynamic rotation of the phenyl rings in solution. However, DEVD-TPE exhibited significant fluorescence when it was cleaved by caspase-3, as well as when the reporter group TPE underwent aggregation...
March 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28265287/pernicious-anemia-associated-cobalamin-deficiency-and-thrombotic-microangiopathy-case-report-and-review-of-the-literature
#9
Farhanah Yousaf, Bruce Spinowitz, Chaim Charytan, Marilyn Galler
A 43-year-old Hispanic male without significant previous medical history was brought to emergency department for syncope following a blood draw to investigate a 40 lbs weight loss during the past 6 months associated with decreased appetite and progressive fatigue. The patient also reported a 1-month history of jaundice. On examination, he was hemodynamically stable and afebrile with pallor and diffuse jaundice but without skin rash or palpable purpura. Normal sensations and power in all extremities were evident on neurological exam...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28263990/human-treponema-pallidum-11q-j-isolate-belongs-to-subsp-endemicum-but-contains-two-loci-with-a-sequence-in-tp0548-and-tp0488-similar-to-subsp-pertenue-and-subsp-pallidum-respectively
#10
Lenka Mikalová, Michal Strouhal, Jan Oppelt, Philippe Alain Grange, Michel Janier, Nadjet Benhaddou, Nicolas Dupin, David Šmajs
BACKGROUND: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. METHODOLOGY/PRINCIPAL FINDINGS: The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28249613/a-new-prescription-model-for-regional-citrate-anticoagulation-in-therapeutic-plasma-exchanges
#11
Sébastien Kissling, Cécile Legallais, Menno Pruijm, Daniel Teta, Bruno Vogt, Michel Burnier, Eric Rondeau, Christophe Ridel
BACKGROUND: Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized treatment protocol has been proposed for therapeutic plasma exchange (TPE) so far. The objective of this study was to assess the determinants of blood citrate concentration needed and to develop an individualized RCA protocol useful for clinical practice. METHODS: The study population included 14 patients who underwent a total of 47 TPE sessions...
March 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28247959/therapeutic-plasma-exchange-in-chronic-dysimmune-peripheral-neuropathies-a-10-year-retrospective-study
#12
Philippe Codron, Maud Cousin, Jean-François Subra, Vivien Pautot, Franck Letournel, Christophe Verny, Julien Cassereau
INTRODUCTION: Therapeutic plasma exchange (TPE) can be proposed in the treatment of chronic dysimmune peripheral neuropathies (CDPN). Actual guidelines are however based on few studies, and indications and protocols still remain to be clarified. We conducted a 10-year retrospective study in order to assess the effectiveness and tolerance of TPE in CDPN. METHODS: All patients treated for CDPN with TPE from October 2006 to March 2016 in the university hospital of Angers were included...
March 1, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28244730/construction-of-supramolecular-nanoassembly-for-responsive-antibacterial-elimination-and-effective-bacterial-detection
#13
Qiaoying Li, Yuanhao Wu, Hongguang Lu, Xinshi Wu, Shuai Chen, Nan Song, Ying-Wei Yang, Hui Gao
There is an urgent need for developing novel strategies for bacterial detection and inhibition. Herein, a multifunctional nanomaterial based on mesoporous silica nanoparticles (MSNs) is designed, loaded with amoxicillin (AMO), and surface-coated with 1,2-ethanediamine (EDA)-modified polyglycerol methacrylate (PGEDA), cucurbit[7]uril (CB[7]), and tetraphenylethylene carboxylate derivatives (TPE-(COOH)4) by layer-by-layer (LbL) self-assembly technique. When bacteria contacts with this nanoassembly, the binding of anionic bacterial surface toward the cationic PGEDA layer of this material can reduce or break the interactions between PGEDA layer and TPE-(COOH)4 layer, leading to attenuated TPE-(COOH)4 emission due to the weakening of aggregation-induced emission (AIE) effect...
February 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28230060/flower-like-superstructures-of-aie-active-tetraphenylethylene-through-solvophobic-controlled-self-assembly
#14
Mina Salimimarand, Duong Duc La, Mohammad Al Kobaisi, Sheshanath V Bhosale
The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of amphiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE) derivatives and studied their self-assembly with solvophobic control. Interestingly, both TPE derivatives form a 3D flower-shape supramolecular structure from THF/water solutions at varying water fractions...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225341/patterns-of-drug-resistance-among-patients-with-tuberculous-pleural-effusion-in-greece
#15
V Anastasakos, V Skouras, C Moschos, S Tsikrika, S Karabela, I Marinou, E Vogiatzakis, K Konstantinou, A Papavasiliou, I Kalomenidis
SETTING: Data on the relationship between pleural tuberculosis (TB) and anti-tuberculosis drug resistance are scarce. OBJECTIVE: To determine the patterns of drug resistance among pleural Mycobacterium tuberculosis isolates in Greece and the incidence of tuberculous pleural effusion (TPE) among patients with multidrug-resistant (MDR) or extensively drug-resistant (XDR) pulmonary TB. DESIGN: Drug susceptibility testing (DST) results recorded in the database of the National Reference Centre for Tuberculosis in Athens, Greece, over a 9-year period (2003-2011) were reviewed...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225213/a-dual-organic-transistor-based-tactile-perception-system-with-signal-processing-functionality
#16
Yaping Zang, Hongguang Shen, Dazhen Huang, Chong-An Di, Daoben Zhu
Organic-device-based tactile-perception systems can open up new opportunities for the next generation of intelligent products. To meet the critical requirements of artificial perception systems, the efficient construction of organic smart elements with integrated sensing and signal processing functionalities is highly desired, but remains a challenge. This study presents a dual-organic-transistor-based tactile-perception element (DOT-TPE) with biomimetic functionality by the construction of organic synaptic transistors with integrated sensing transistors...
February 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28217826/in-vivo-comparison-of-two-navigation-systems-for-abdominal-percutaneous-needle-intervention
#17
Deqiang Xiao, Yong Li, Huoling Luo, Yanfang Zhang, Xuejun Guo, Huimin Zheng, Qingmao Hu, Fucang Jia
PURPOSE: To compare the accuracy of a Kinect-Optical navigation system with an electromagnetic (EM) navigation system for percutaneous liver needle intervention. MATERIALS AND METHODS: Five beagles with nine artificial tumors were used for validation. The Veran IG4 EM navigation system and a custom-made Kinect-Optical navigation system were used. Needle insertions into each tumor were conducted with these two guidance methods. The target positioning error (TPE) and the time cost of the puncture procedures were evaluated...
February 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28208261/construction-of-aiegens-based-bioprobe-with-two-fluorescent-signals-for-enhanced-monitor-of-extracellular-and-intracellular-telomerase-activity
#18
Yuan Zhuang, Chunli Shang, Xiaoding Lou, Fan Xia
Detections of telomerase activity in vitro and in living cells are of great importance for clinical diagnosis of cancer. In this work, an AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity is designed. After addition of telomerase, two positively charged AIEgens (Silole-R and TPE-H) bind to quencher group labeled primer (QP) and the extension repeated units, leading enhancement of two telomerase-triggered fluorescent signals. Furthermore, by combination the wider linear range in vitro and lower background in living cells imaging, the bioprobe is used to detect telomerase extracted from various cell lines (MCF-7, HeLa, E-J, and HLF), 50 bladder cancer patients' urine samples, 10 normal people's urine samples, and also applied in mapping telomerase activity inside living cells (MCF-7, HeLa, MDA-MB-231, and HT1080)...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28198995/tropical-pulmonary-eosinophilia-effect-of-addition-of-corticosteroids-after-failure-of-diethylcarbamazine-therapy
#19
Manu Madan, Pawan Gupta, Richa Mittal, Sunil K Chhabra
Successful response in diethylcarbamazine (DEC) therapy in tropical pulmonary eosinophilia (TPE) is not universal with a 20-40% failure rates in chronic cases. Corticosteroids have been used in such patients. However, their role in management remains ill-defined. A patient of TPE with incomplete clinical, haematological and physiological response to a standard 3 weeks DEC therapy received additional corticosteroids for the next two cycles, after which complete remission occurred. However, there was a relapse two months later with evidence of a chronic state requiring further treatment with corticosteroids with good response...
2017: Adv Respir Med
https://www.readbyqxmd.com/read/28194065/adverse-events-during-apheresis-procedures-audit-at-a-tertiary-hospital
#20
Kanchan Dogra, Parag Fulzele, Diptiranjan Rout, Rahul Chaurasia, Poonam Coshic, Kabita Chatterjee
Apheretic platelets are better quality blood components which reduce donor exposure and chances of TTIs to transfusion recipients when compared to the whole blood derived components. Though safe, these apheretic donations are associated with donor adverse events. We evaluated the incidence of such adverse events associated with the modern apheresis procedures that would provide an insight as well as help formulating preventive steps to avoid frequent occurrences of such events. This prospective audit-based observational study was conducted over 1 year...
March 2017: Indian Journal of Hematology & Blood Transfusion
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