Read by QxMD icon Read


Osman Yeşilbaş, Hasan Serdar Kıhtır, Hamdi Murat Yıldırım, Nevin Hatipoğlu, Esra Şevketoğlu
BACKGROUND: Leptospirosis is a zoonotic infectious disease caused by pathogenic spirochetes of the genus Leptospira. Although it is usually asymptomatic and self-limited, severe potentially fatal illness accompanied by multi-organ failure may occur. CASE REPORT: Here we report an unusual case of severe leptospirosis successfully treated with continuous venovenous hemofiltration (CVVHF) and therapeutic plasma exchange (TPE). The patient presented with pericardial tamponade, renal failure and macrophage activation syndrome, and later suffered prolonged jaundice and sclerosing cholangitis during hospitalization in the pediatric intensive care unit (PICU)...
September 2016: Balkan Medical Journal
Youri van Berkel, Michael Ludwig, Joanna A E van Wijk, Arend Bökenkamp
BACKGROUND: Dent disease is a rare X-linked recessive proximal tubulopathy caused by mutations in CLCN5 (Dent-1) or OCRL (Dent-2). As a rule, total protein excretion (TPE) is low in tubular proteinuria compared with glomerular disease. Several authors have reported nephrotic-range proteinuria (NP) and glomerulosclerosis in Dent disease. Therefore, we aimed to analyze protein excretion in patients with documented CLCN5 or OCRL mutations in a systematic literature review. DESIGN: PubMed and Embase were searched for cases with documented CLCN5 or OCRL mutations and (semi-)quantitative data on protein excretion...
October 18, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Wen-Shuo Kuo, Chia-Yuan Chang, Hua-Han Chen, Chih-Li Lilian Hsu, Jiu-Yao Wang, Hui-Fang Kao, Lawrence Chao-Shan Chou, Yi-Chun Chen, Shean-Jen Chen, Wen-Tsan Chang, Shih-Wen Tseng, Ping-Ching Wu, Ying-Chih Pu
A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both gram-positive and -negative bacteria, with ultra-low energy and an extremely short photoexcitation time generated by TPE...
October 18, 2016: ACS Applied Materials & Interfaces
Mehmet Bosnak, Seher Erdogan, E Habibe Aktekin, Ali Bay
We report two children who were diagnosed as having primary hemophagocytic syndrome and who successfully underwent therapeutic plasma exchange (TPE). The first patient was a 6-month-old girl diagnosed with HLH who was admitted to the pediatric intensive care unit. The patient's clinical condition worsened on the 9th day of the HLH-2004 treatment protocol. Her ferritin level was found 50.000 ng/mL, and TPE was performed for 9 sessions, after which her clinical condition and laboratory findings improved. The patient is still on the HLH-2004 protocol and waits for a suitable stem cell transplantation donor...
September 28, 2016: Transfusion and Apheresis Science
Luke McKenzie, Igor Sazanovich, Elizabeth Baggaley, Mickaële Bonneau, Véronique Guerchais, Gareth Williams, Julia Weinstein, Helen E Bryant
Photodynamic therapy (PDT) uses photosensitizers (PS) which only become cytotoxic upon light-irradiation. Transition metal complexes are highly promising PS due to long excited state lifetimes, and photostability. However, these complexes usually absorb higher-energy UV/Visible light, whilst the optimal tissue transparency is in the lower-energy NIR region. Two-photon excitation (TPE) can overcome this dichotomy, with simultaneous absorption of two lower-energy NIR-photons populating the same PS-active excited state as one higher-energy photon...
October 14, 2016: Chemistry: a European Journal
Yan-Song Zheng, Hai-Tao Feng, Jun Luo, Jia-Bin Xiong, Wen-Fang Feng, Desuo Yang
Tetraphenylethylene (TPE) and its derivatives are the most typical and most widely studied organic compounds with aggregation-induced emission (AIE) characteristics. Due to their propeller-like structures, V-like clefts exist between the aryl rings, making them promising as host compounds. However, such possibility is seldom explored. Here, we reported for the first time that TPE derivatives (TPE-Pys) bearing two or four pyridine rings at the para-position of the phenyl rings could selectively include triangular (Δ-like) m-phthalic acid from a mixture of o-, m- and p-phthalic acids due to their shape complementary to offer host-guest cocrystals, which showed redder emission than TPE-Pys themselves...
October 14, 2016: Chemistry: a European Journal
Manik Lal Saha, Xuzhou Yan, Peter J Stang
Over the past couple of decades, coordination-driven self-assembly has evolved as a broad multidisciplinary domain that not only covers the syntheses of aesthetically pleasing supramolecular architectures but also emerges as a method to form new optical materials, chemical sensors, theranostic agents, and compounds with light-harvesting and emissive properties. The majority of these applications depend upon investigations that reveal the photophysical nature and electronic structure of supramolecular coordination complexes (SCCs), including two-dimensional (2D) metallacycles and three-dimensional (3D) metallacages...
October 13, 2016: Accounts of Chemical Research
A N Aggarwal, R Agarwal, I S Sehgal, S Dhooria, D Behera
OBJECTIVE: To determine the diagnostic accuracy of pleural fluid adenosine deaminase (ADA) in diagnosing tuberculous pleural effusion (TPE) among Indian patients using systematic review and meta-analysis. DESIGN: The PubMed, Embase, IndMED and Cochrane databases and other relevant publications were searched to identify Indian studies evaluating the sensitivity and specificity of ADA in diagnosing TPE. Pooled diagnostic accuracy measures and 95% confidence intervals (95%CI) were generated using a bivariate random-effects model, and examined using forest plots and hierarchical summary receiver operating characteristic (HSROC) curves...
October 2016: International Journal of Tuberculosis and Lung Disease
Cui Su, Zhenhu Liang, Xiaoli Li, Duan Li, Yongwang Li, Mauro Ursino
OBJECTIVE: Multiscale permutation entropy (MSPE) is becoming an interesting tool to explore neurophysiological mechanisms in recent years. In this study, six MSPE measures were proposed for on-line depth of anesthesia (DoA) monitoring to quantify the anesthetic effect on the real-time EEG recordings. The performance of these measures in describing the transient characters of simulated neural populations and clinical anesthesia EEG were evaluated and compared. METHODS: Six MSPE algorithms-derived from Shannon permutation entropy (SPE), Renyi permutation entropy (RPE) and Tsallis permutation entropy (TPE) combined with the decomposition procedures of coarse-graining (CG) method and moving average (MA) analysis-were studied...
2016: PloS One
Tao Li, Jauhar Ali, Manuel Marcaida, Olivyn Angeles, Neil Johann Franje, Jastin Edrian Revilleza, Emmali Manalo, Edilberto Redoña, Jianlong Xu, Zhikang Li
Multi-Environment Trials (MET) are conventionally used to evaluate varietal performance prior to national yield trials, but the accuracy of MET is constrained by the number of test environments. A modeling approach was innovated to evaluate varietal performance in a large number of environments using the rice model ORYZA (v3). Modeled yields representing genotype by environment interactions were used to classify the target population of environments (TPE) and analyze varietal yield and yield stability. Eight Green Super Rice (GSR) and three check varieties were evaluated across 3796 environments and 14 seasons in Southern Asia...
2016: PloS One
W H Nijhof, M M Jansen, G J Jager, C H Slump, M J C M Rutten
AIM: To investigate the feasibility of using a low-concentration test bolus in abdominal aorta computed tomography (CT) angiography (CTA). MATERIALS AND METHODS: In 10 patients referred for CTA of the abdominal aorta with a body mass index (BMI) ≤28 kg/m(2), a standard test bolus of 10 ml contrast medium (CM; 350 mg iodine/ml) was compared with a low-concentration test bolus (5 ml CM; 350 mg iodine/ml; 1:1 diluted with saline) in terms of time to peak enhancement (tPE) and peak enhancement (PE)...
October 5, 2016: Clinical Radiology
Jason Brazelton, Robert A Oster, Brandi McCleskey, Jessica Fuller, Jill Adamski, Marisa B Marques
Thrombotic thrombocytopenic purpura (TTP) has >90% mortality without therapeutic plasma exchange (TPE). Despite TPE, approximately 10% of patients still die, presumably from cardiac ischemia. We sought clinical or laboratory parameters associated with death by reviewing the records of all patients hospitalized with acquired TTP in our institution for 10 years, and collect demographics and results for hemoglobin, platelet count, creatinine, lactate dehydrogenase, transaminases, total bilirubin, creatinine kinase (CK), CK-MB, and troponin I...
September 26, 2016: Journal of Clinical Apheresis
Yizhong Shen, Adam J Shuhendler, Deju Ye, Jing-Juan Xu, Hong-Yuan Chen
Two-photon excitation (TPE) nanoparticle-based photosensitizers (PSs) that combine the advantages of TPE and nanotechnology have emerged as attractive therapeutic agents for near-infrared red (NIR) light excited photodynamic therapy (PDT) for cancer treatment. TPE PDT is characterized by nonlinear absorption of two relatively low-energy photons of NIR light with the resulting emission of high-energy visible light. This high-energy light can sensitize oxygen to produce cytotoxic reactive oxygen species (ROS) and singlet oxygen ((1)O2) which can kill cancer cells...
October 5, 2016: Chemical Society Reviews
Jie Li, Kangjie Shi, Markus Drechsler, Ben Zhong Tang, Jianbin Huang, Yun Yan
Binding of Zn(2+) to the coordinating supramolecular vesicle based on an aggregation induced emission amphiphile TPE-BPA immediately triggers the formation of charged vesicles. This induces vesicle fission and fluorescence reduction, suggesting a looser molecular packing in the charged vesicle membrane. Since cancer cells are highly charged, this indicates that the quick fission of cancer cells may have electrical charge origin.
October 13, 2016: Chemical Communications: Chem Comm
Hui Zhou, Jiesheng Li, Ming Hui Chua, Hong Yan, Qun Ye, Jing Song, Ting Ting Lin, Ben Zhong Tang, Jianwei Xu
Mono-TPE modified POSS molecules, in which the flexible spacers between TPE and POSS moieties control their self-assembly and aggregation, exhibit a unique unadulterated monomer emission in organic solvents as well as an AIE emission in THF/water.
October 13, 2016: Chemical Communications: Chem Comm
Qiu-Yan Li, Zheng Ma, Wen-Qiang Zhang, Jia-Long Xu, Wei Wei, Han Lu, Xinsheng Zhao, Xiao-Jun Wang
AIE-active luminogen tetraphenylethene (TPE) was incorporated into a UiO-isoreticular zirconium metal-organic framework via the strategy of mixed dicarboxylate struts, and the resulting functionalized MOF shows a strong blue-green emission and selective sensing of nitroaromatic explosives 2,4,6-trinitrophenol (TNP) and 2,4-dinitrophenol (DNP) through fluorescence quenching. Moreover, the luminescent MOF exhibits efficient photocatalytic activity for aerobic cross-dehydrogenative coupling reactions mediated by visible light...
September 13, 2016: Chemical Communications: Chem Comm
Fei Wu, Jianlin Liu, Gang Wang, Qunliang Song, Linna Zhu
Three tetrapheynlethylene derivatives (N,N-di(4-methoxyphenyl)aminophenyl-substituted tetraphenylethylene; TPE-4DPA) with different methoxy positions (pp-, pm-, and po-) have been synthesized and characterized. The methoxy groups can control the oxidation potential of the materials, and the electronic properties of the derivatives were affected by the position of the methoxy substituents. These compounds were synthesized in a facile and cost-effective way, and were applied as hole-transport materials in perovskite solar cells...
October 5, 2016: Chemistry: a European Journal
Petar Kes, Michiel Etienne Janssens, Nikolina Bašić-Jukić, Milića Kljak
BACKGROUND: Therapeutic plasma exchange (TPE) can be performed either on a membrane-based system (mTPE) or on a device that separates blood components by centrifugation (cTPE). The number of studies in this field is limited. This randomized study is the first that offers data on the membrane-based Diapact device (B. Braun Medical, Inc.) for TPE procedures and compares it to the centrifuge-based Spectra Optia (Terumo BCT, Inc.). STUDY DESIGN AND METHODS: Twenty-seven patients were enrolled in this randomized prospective head-to-head study comparing the mTPE and cTPE systems...
October 5, 2016: Transfusion
Xue Pan, Anyuan Zhong, Yufei Xing, Minhua Shi, Bin Qian, Tong Zhou, Yongjing Chen, Xueguang Zhang
Soluble and membrane-bound programmed death ligand-1 (sPD-L1 and mPD-L1, respectively) have been demonstrated to participate in the immune suppression of non-small cell lung cancer. However, the contribution of sPD-L1 and mPD-L1 to immune regulation and disease progression in patients with pleural effusions remains unknown. The present study evaluated the levels of sPD-L1 and membrane-bound PD-1/PD-L1 in the peripheral blood and pleural effusions of patients with tuberculous pleural effusion (TPE), malignant pleural effusion (MPE) and non-tuberculous non-malignant pleural effusion (n-TB n-M)...
October 2016: Experimental and Therapeutic Medicine
Jeffrey T Guptill, Vern C Juel, Janice M Massey, Amanda C Anderson, Manisha Chopra, John S Yi, Ehsanollah Esfandiari, Tim Buchanan, Bryan Smith, Paul Atherfold, Emma Jones, James F Howard
An integrated understanding of therapeutic plasma exchange (TPE) effects on immunoglobulins, autoantibodies, and natural or acquired (vaccine) protective antibodies in patients with autoimmune myasthenia gravis (MG) is lacking. Prior studies measured TPE effects in healthy volunteers or heterogeneous autoimmune disease populations. We prospectively profiled plasma IgA, IgM, IgG, IgG subclasses (IgG1-4), acetylcholine receptor autoantibodies (AChR+), and protective antibodies in patients with AChR + MG receiving TPE for an exacerbation...
August 11, 2016: Autoimmunity
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"