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Stefan Pilz, Armin Zittermann, Rima Obeid, Andreas Hahn, Pawel Pludowski, Christian Trummer, Elisabeth Lerchbaum, Faustino R Pérez-López, Spyridon N Karras, Winfried März
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the "active vitamin D hormone" calcitriol support the important role of vitamin D in this setting...
October 12, 2018: International Journal of Environmental Research and Public Health
Angelika Terbuch, Jan B Adiprasito, Verena Stiegelbauer, Maximilian Seles, Christiane Klec, Georg P Pichler, Margit Resel, Florian Posch, Anna L Lembeck, Herbert Stöger, Joanna Szkandera, Karl Pummer, Thomas Bauernhofer, Georg C Hutterer, Armin Gerger, Michael Stotz, Martin Pichler
Metastatic testicular germ cell tumors (TGCTs) are a potentially curable disease by administration of risk-adapted cytotoxic chemotherapy. Nevertheless, a disease-relapse after curative chemotherapy needs more intensive salvage chemotherapy and significantly worsens the prognosis of TGCT patients. Circulating tumor markers (β-subunit of human chorionic gonadotropin (β-HCG), alpha-Fetoprotein (AFP), and Lactate Dehydrogenase (LDH)) are frequently used for monitoring disease recurrence in TGCT patients, though they lack diagnostic sensitivity and specificity...
October 12, 2018: International Journal of Molecular Sciences
Bruno Garcia Montagnini, Karine Vandressa Pernoncine, Lorena Ireno Borges, Nathalia Orlandini Costa, Estefânia Gastadello Moreira, Janete Aparecida Anselmo-Franci, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
Triclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study...
October 12, 2018: Toxicology
Matthew Heath, Andrea Petrella, Jonathan Blazevic, David Lim, Andre Pelletier, Glen Belfry
A single-bout of aerobic or resistance training facilitates executive function and is a benefit thought to be specific to exercise durations greater than 20minutes. We sought to determine whether an executive benefit is observed for a session as brief as 10-minutes, and whether distinct and participant-specific exercise intensities - and associated metabolic costs - influence the magnitude of the benefit. Participants completed exercise sessions - via cycle ergometer - at moderate (80% of lactate threshold [LT]), heavy (15% of the difference between LT and VO2 peak ) and very-heavy (50% of the difference between LT and VO2 peak ) intensities determined via an incremental ramp test to volitional exhaustion...
October 12, 2018: Neuropsychologia
Yu-Lin Pan, Rui Xin, Sheng-Yuan Wang, Yue Wang, Lin Zhang, Cui-Ping Yu, Yong-Hui Wu
Nickel (Ni) is widely present in the occupational environment and causes various adverse effects on the human body. Apoptosis induced by Ni2+ may be a key mechanism underlying its toxic effect. In the present study, we investigated the effect of Ni-smelting fumes on cell viability, mitochondrial damage, and apoptosis-related proteins in NIH/3T3 cells. The effects of Ni-smelting fumes at concentrations of 0, 25, 50, and 100 μg/mL were tested. Treatment with Ni-smelting fumes for 24 h and 48 h significantly decreased cell viability and lactate dehydrogenase activity in a dose- and time-dependent manner compared with the blank control group...
October 12, 2018: Archives of Biochemistry and Biophysics
Emmanuel Bugarin-Estrada, Andrés Gómez-De León, Yadith Karina López-García, Erik Alejandro Díaz-Chuc, José Manuel Priesca-Marín, Guillermo J Ruiz-Argüelles, José Carlos Jaime-Pérez, David Gómez-Almaguer
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a hematologic disease that can be fatal if not treated early. We aimed to describe the clinical characteristics of Mexican patients with idiopathic TTP. STUDY DESIGN AND METHODS: We conducted a retrospective study, including all adult patients diagnosed with idiopathic TTP from 2011 to 2017 in two Mexican centers. We further compared our results with the published literature. RESULTS: Twenty patients were included; 70% were female, with a median age of 38...
October 15, 2018: Journal of Clinical Apheresis
Yahua Xu, Ce Qi, Renqiang Yu, Xiangyu Wang, Qin Zhou, Jin Sun, Qingzhe Jin, Xingguo Wang
Data on the total fatty acid (FA) profile and position-specific triacylglycerides (TAGs) in preterm infants' maternal milk are essential for establishing the recommended requirement of FA in preterm infants in China. We aimed to determine the composition and positional distribution of FAs in preterm infants' maternal milk in China and further investigate the effect of maternal background on the FA composition. Breast milk samples (4, 11, 30, 60, and 90 (all ±3) days post-partum) were collected from 59 healthy women delivering preterm infants...
October 15, 2018: Food & Function
Ji-Jie Liu, Ce Guo, Bo Wang, Meng-Xing Shi, Yang Yang, Zhen Yu, Xiu-Hong Meng, De-Xiang Xu
Although use of fenvalerate has increased dramatically over the past decade, little is known about their potential adverse effects on growth and development. The purpose of this study was to examine the effects of maternal fenvalerate exposure during pregnancy on growth and neurobehavioral development in the offspring. Pregnant mice were orally administered to fenvalerate (0.2, 2.0, and 20 mg/kg) daily throughout pregnancy. The tests of growth and neurobehavioral development were performed during lactation period...
2018: PloS One
Mai M Hasan, Sally M Shalaby, Jehan El-Gendy, Eman M A Abdelghany
AIM: A growing interest to understand the signaling pathways mediating obesity-induced muscle atrophy is given. Metformin (Met) was reported to possess positive effects on preventing muscle damage and promoting muscle mass maintenance. The aim of the present study to investigate pathways involved in Met effect on obesity induced muscle atrophy. METHODS: Thirty adult male albino rats were assigned into two groups: normal chew diet fed group as control group (C; n = 10) and high-fat-diet (HFD) fed group ( n = 20)...
October 15, 2018: Journal of Cellular Biochemistry
Luciele Guerra Minuzzi, Luis Rama, Matheus Uba Chupel, Fátima Rosado, Gabriel Keine Kuga, Rafael Calais Gaspar, Vitor Rosetto Muñoz, José Rodrigo Pauli, Artur Paiva, Ana Maria Teixeira
The purpose of this study was to investigate the impact of a training season (approximately 7 months) on physiological and salivary immune-endocrine markers in master athletes. Nine male master athletes were evaluated at the beginning of the season (M1) and a week after the main official competition at the end of the sports season (M2). The controlled variables included Maximal oxygen consumption, anthropometric, physiological, and salivary immune-endocrine markers. Master athletes presented a reduced percentage of fat mass and increased lean body mass at the end of the season...
October 15, 2018: Journal of Cellular Biochemistry
Nordin M J Hanssen, Coen D A Stehouwer, Casper G Schalkwijk
PURPOSE OF REVIEW: Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments. Accumulation of methylglyoxal, a highly reactive glucose metabolite and a major precursor in the formation of advanced glycation end products, may link the hemodynamic, inflammatory, metabolic, and structural changes that drive diabetic CKD. Therefore, methylglyoxal may serve as a potential therapeutic target to prevent diabetic CKD...
October 12, 2018: Current Opinion in Nephrology and Hypertension
Eunji Ko, Jung Min Youn, Hyung Sun Park, Myeongjin Song, Kyung Hee Koh, Choon Hak Lim
BACKGROUND: Sepsis is a medical emergency during which early detection is closely associated with mortality. In sepsis, red blood cell (RBC) abnormalities have been reported. However, it is not known how early RBC abnormalities are expressed compared with various clinical manifestations used in sepsis-related organ failure assessment (SOFA). OBJECTIVE: Therefore, using a lipopolysaccharide (LPS)-induced sepsis model we investigated the clinical significance of RBC abnormalities as an early indicator in the detection of septic injury compared with clinical variables...
October 4, 2018: Clinical Hemorheology and Microcirculation
Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun
Acute myocardial infarction (AMI) is a disease associated with inflammation. T lymphocytes are involved by secreting cytokines and inflammatory factors. In our previous study, it was found that the T lymphocytes exhibited certain functional changes, the onset of which was induced by modulating calcium‑sensing receptor (CaSR) in AMI. In the present study, western blotting was used to verified the expression of T lymphocyte CaSR and pathway proteins, including phosphorylated extracellular signal‑regulated kinase (P‑ERK)1/2 and phosphorylated c‑Jun N‑terminal kinase (P‑JNK), and used cytometric bead array to detect the secretion of interleukin (IL)‑4, IL‑6, IL‑10 and tumor necrosis factor (TNF)‑α in AMI onset, the results demonstrated that they were all increased...
October 10, 2018: International Journal of Molecular Medicine
Jen Jen Chen, Elizabeth Gendy, Sharon Leu, Frank Zaldivar, Pietro Gallassetti, Elieze Nussbaum, Dan Cooper, Shlomit Random-Aizik
Post-exercise leucocytosis has been found in children and adults in response to exercise. When normalized to the work performed, children demonstrate a lower lactate response to exercise than in adults. This study examines the association between leukocyte and lactate response in children following exercise. 148 healthy children participated in this study. Each subject performed a ramp exercise on a cycle ergometer followed by ten 2-minute bouts of constant work rate separated by 1-minute rest intervals. Lactate, leukocyte and leukocyte subtype levels were taken pre- and post-exercise...
2018: Eur J Sports Exerc Sci
Zhiyao Lu, Valeriy Cherepakhin, Talya Kapenstein, Travis J Williams
Conversion of vegetable-derived triglycerides to fatty acid methyl esters (FAMEs) is a popular approach to the generation of biodiesel fuels and the basis of a growing industry. Drawbacks of the strategy are that (a) the glycerol backbone of the triglyceride is discarded as waste, and (2) most available natural triglycerides in the U.S. are multi-unsaturated or fully saturated, giving inferior fuel performance and causing engine problems. Here we show that catalysis by iridium complex 1 can address both of these problems through selective reduction of triglycerides high in polyunsaturation...
May 7, 2018: ACS Sustainable Chemistry & Engineering
Augustinas Vizbaras, Ieva Šimonytė, Arūnas Miasojedovas, Augustinas Trinkūnas, Tadas Bučiūnas, Mindaugas Greibus, Greta Naujokaitė, Nicolas Torcheboeuf, Serge Droz, Dmitri Boiko, Žilvinas Dambrauskas, Antanas Gulbinas, Kristijonas Vizbaras
The infrared spectral region beyond 1.7 μm is of utmost interest for biomedical applications due to strong overtone and combination absorption bands in a variety of important biomolecules such as lactates, urea, glucose, albumin, etc. In this article, we report on recent progress in widely tunable swept-wavelength lasers based on type-I GaSb gain-chip technology, setting a new state-of-the-art in the 1.7 - 2.5 μm range laser sources. We provide an application example for the spectroscopic sensing of several biomolecules in a cuvette as well as an experimental demonstration of a non-invasive in-vivo sensing of human serum albumin through the skin...
October 1, 2018: Biomedical Optics Express
Víctor Cerezuela-Espejo, Javier Courel-Ibáñez, Ricardo Morán-Navarro, Alejandro Martínez-Cava, Jesús G Pallarés
The aims of this study were (1) to establish the best fit between ventilatory and lactate exercise performance parameters in running and (2) to explore novel alternatives to estimate the maximal aerobic speed (MAS) in well-trained runners. Twenty-two trained male athletes ( <mml:math xmlns:mml=""> <mml:mover> <mml:mrow> <mml:mtext>V</mml:mtext> </mml:mrow> <mml:mo>˙</mml:mo> </mml:mover> </mml:math> O2max 60.2 ± 4...
2018: Frontiers in Physiology
Tingting Sun, Lihua Zhang, Xinxin Li, Fengfei Chen, Yanchuan Li, Xiaohui Ma, Feng Yu
Aim: To investigate the protective effect of dantonic in ischemic myocardial damage by evaluating the expression of circulating microvesicles (MVs) and microRNA-1 (miR-1) in two animal models. Methods: Two animal models of myocardial ischemia were established that were isoproterenol-induced myocardial ischemia (ISO-AMI) rat model and the acute myocardial infarction rat model induced by ligation of the left anterior descending coronary artery (LAD-AMI) of rat. To investigate the protective effect of dantonic, we observed the myocardial infarction size, creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) activities, cardiac troponin I (cTnI) level in serum, and the plasma levels of miR-1 and MVs...
2018: Frontiers in Physiology
Elizabeth Hilliard, Ardith Brunt
In response to suboptimal breastfeeding rates, North Dakota added a provision to SB 2344 (public indecency legislation) creating an Infant Friendly business designation for employers providing specified lactation accommodations to employees. However, there has been no evaluation of this designation to determine effectiveness. The purpose of this article is to examine the impact of the Infant Friendly business designation in North Dakota on breastfeeding continuation rates within the context of the social ecological model (SEM)...
October 15, 2018: Health Promotion Practice
David Macutkiewicz, Caroline Sunderland
Team sports, such as field hockey, incorporate high-intensity repeated sprints, interspersed with low-intensity running, which can result in acidosis. The aim of the present study was to examine the effect of acute sodium bicarbonate (SB) supplementation on team sport running and skill performance. Eight elite female field hockey players (age 23 ± 5 years, body mass 62.6 ± 8.4 kg, height 1.66 ± 0.05 m) completed three Field Hockey Skill Tests (FHST) interspersed with four sets of the Loughborough Intermittent Shuttle Test (LIST)...
September 2018: Physiological Reports
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