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Emily L Fargo, Frank D'Amico, Aaron Pickering, Kathleen Fowler, Ronald Campbell, Megan Baumgartner
BACKGROUND:  Sepsis is a serious medical condition that can lead to organ dysfunction and death. Research shows that each hour delay in antibiotic administration increases mortality. The Surviving Sepsis Campaign Bundles created standards to assist in the timely treatment of patients with suspected sepsis to improve outcomes and reduce mortality. OBJECTIVE:  This article determines if the use of an electronic physician order-set decreases time to antibiotic ordering for patients with sepsis in the emergency department (ED)...
October 2018: Applied Clinical Informatics
Alexandre R Carvalho, Solange Guizilini, Gustavo M Murai, Isis Begot, Isadora S Rocco, Nelson A Hossne, Eduardo G Chamlian, João Manoel T Santos, Ricardo A Macedo, Gustavo C O Lisboa, Alberto C Nasciutti, Carlos Eduardo R Santos, João Paulo M Figueiredo, Walter J Gomes
OBJECTIVE: To evaluate the sequential changes of hemodynamic and metabolic parameters in patients who underwent aorta no-touch off-pump coronary artery bypass surgery (OPCAB). METHODS: Prospective study involving twenty-seven consecutive patients who underwent aorta no-touch OPCAB. The FloTrac/PreSep/Vigileo™ system (Edwards Lifesciences) was used to continuously record heart rate (HR), mean arterial blood pressure (MABP), central venous pressure (CVP), continuous cardiac index (FCI), stroke volume (SV), stroke volume variation (SVV), and central venous oxygen saturation (ScvO2)...
September 2018: Brazilian Journal of Cardiovascular Surgery
Rennan H R Moreira, Rodrigo F DE Oliveira, Jorge Y P Palencia, Marina A G Lemes, Marilane D Silva, Cesar A P Garbossa, Márvio L T DE Abreu, Giselle B DE Moura, Rony A Ferreira
The objective of this trial was to evaluate the behavioral patterns and performance of lactating sows and their litters under the effect of artificial vocalization. Twenty-eight sows and their litters were distributed in a completely randomized design in a 2x2 factorial scheme (artificial vocalization x lactation week). The behavior of the animals was monitored during 24 hours on the 7th and 15th days of lactation, analyzing the number, interval, and frequency of nursings. The body condition and performance of the sows were also evaluated...
October 2018: Anais da Academia Brasileira de Ciências
Alessandra N Bazzano, Kaitlin Storck Potts, Afework Mulugeta
Maternal and child feeding behaviors are often rooted in family and sociocultural context, making these an important point of inquiry for improving nutrition and health over the life course. The present study explored the practice of fasting during religious periods in relation to eating patterns of pregnant and lactating women and young children in four regions of Ethiopia, a nation which has experienced rapid economic growth and marked improvement in health and nutrition outcomes over the last two decades...
2018: PloS One
Valerie L Flax, John Chapola, Lemekeza Mokiwa, Innocent Mofolo, Henry Swira, Mina C Hosseinipour, Suzanne Maman
Based on formative research, HIV-positive women in Lilongwe District, Malawi receive little infant and young child feeding (IYCF) counseling postpartum and want more support for IYCF from their husbands. To address these gaps, we implemented a behavior change communication intervention promoting IYCF in village savings and loan associations (VSLAs) that included HIV-positive and HIV-negative women. The intervention consisted of 15 IYCF learning sessions facilitated by VSLA volunteers during regular VSLA meetings and included four sessions to which husbands were invited...
December 5, 2018: Maternal & Child Nutrition
S Stalder, X Sidler, M Hässig
At present, the usage of antimicrobial agents in organic dairy farming is a subject of controversial public debate because of its impact on animals, humans and the environment. This study shows how farms can be successfully managed without using antimicrobials for udder diseases. Thereby, animal welfare and targeted low bulk tank somatic cell counts should not be neglected. The operating data analysed in this study was collected during feeding and milking time on 18 swiss dairy farms that have not been treating diseased udders with antibiotics for at least 3 years...
December 2018: Schweizer Archiv Für Tierheilkunde
Zheng Guo, Yinyu Yang, Wei Zhang, Jia Shen, Lei Jiang, Xindi Yu, Wei Wang
PURPOSE: Extracorporeal membrane oxygenation (ECMO) provides cardiorespiratory support during cardiopulmonary resuscitation unresponsive to conventional methods. Here, we analyzed the extracorporeal cardiopulmonary resuscitation (ECPR) results of children in a cardiac arrest setting after cardiac surgery. METHODS: Of 3119 cases of pediatric open-heart surgery, 31 required postoperative ECMO. Among the 31 patients, 11experienced cardiac arrest and ECPR in the early postoperative period...
December 4, 2018: Artificial Organs
Nawal El Menyiy, Noori Al-Waili, Asmae El Ghouizi, Wail Al-Waili, Badiaa Lyoussi
BACKGROUND/OBJECTIVES: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats. MATERIALS AND METHODS: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg...
December 2018: Nutrition Research and Practice
Miriam Sanderson, Marc Chikhani, Esme Blyth, Sally Wood, Iain K Moppett, Tricia McKeever, Mark Jr Simmonds
Background: Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients with sepsis in Nottingham. Methods: Data were collected prospectively from adult patients with sepsis in Nottingham University Hospitals NHS Trust as part of an on-going quality improvement project between November 2011 and March 2014...
November 2018: Journal of the Intensive Care Society
Wei Gao, Yong Zhang, Haibin Ni, Jialiu Zhang, Dandan Zhou, Liping Yin, Feng Zhang, Hao Chen, Beibei Zhang, Wei Li
OBJECTIVE: To evaluate the prognostic value of the difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock following early resuscitation. METHODS: This prospective study was conducted among the patients with septic shock treated in our department during the period from May, 2017 to May, 2018. Peripheral venous, peripheral arterial and central venous blood samples were collected simultaneously and analyzed immediately at bedside after 6-h bundle treatment...
November 30, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Miaoting Yang, Zhijuan Chen, Chunxin Xiao, Waijiao Tang, Beijie Zhou
OBJECTIVE: To investigate the effects of sera from rats fed with Huganqingzhi tablets (HGT) on endoplasmic reticulum (ER) stress in a steatotic hepatocyte model of free fatty acids (FFAs)-induced nonalcoholic fatty liver disease (NAFLD) and explore the possible mechanism. METHODS: FFAs prepared by mixing oleic acid and palmitic acid at the ratio of 2:1. HepG2 cells were treated with the sera from rats fed with low-, moderate-or high-dose HGT (HGT sera) or sera of rats fed with fenofibrate (fenofibrate sera), followed by treatment with 1 mmol/L FFAs for 24 h to induce hepatic steatosis...
November 30, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Rosette Megnekou, Jean Claude Djontu, Benderli C Nana, Jude D Bigoga, Maurice Fotso, Balotin Fogang, Rose F G Leke
BACKGROUND: Plasmodium falciparum infected erythrocytes sequestering in placental tissue release Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected in peripheral blood using monoclonal antibody-based rapid diagnostic tests (RDTs). Nevertheless, studies to evaluate the reliability of RDTs in detecting placental malaria compared with microscopy of placental tissue impression smear (PTIS) as the gold standard are scarce. METHODS: Between August 2013 and January 2015, Giemsa-stained blood smears for peripheral blood smear (Pbs), placental intervillous space (IVS) blood smear and placental tissue impression smear (PTIS)] were prepared from HIV-negative women during delivery at the Marie Reine Medical Health Centre in Yaoundé, Cameroon...
December 4, 2018: Malaria Journal
Daohua Shi, Di Zhao, Peiguang Niu, Yanting Zhu, Jintuo Zhou, Huajiao Chen
BACKGROUND: Autophagy occurs in cells that undergoing nutrient deprivation. Glycolysis rapidly supplies energy for the proliferation of cancer cells. Cardamonin inhibits proliferation and enhances autophagy by mTORC1 suppression in ovarian cancer cells. Here, we investigate the relationship between cardamonin-triggered autophagy and glycolysis inhibition via mTORC1 suppression. METHODS: Treated with indicated compounds, ATP content and the activity of hexokinase (HK) and lactate dehydrogenase (LDH) were analyzed by the assay kits...
December 4, 2018: BMC Complementary and Alternative Medicine
Gokhan Zengin, Marcello Locatelli, Claudio Ferrante, Luigi Menghini, Giustino Orlando, Luigi Brunetti, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Lidia Leporini, Muhammad Zakariyyah Aumeeruddy, Mohamad Fawzi Mahomoodally
This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2 O2 )-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-α and interleukin (IL)-6 gene expression in rat colon specimens...
December 5, 2018: International Journal of Environmental Health Research
Matylda Czosnykowska-Łukacka, Barbara Królak-Olejnik, Magdalena Orczyk-Pawiłowicz
Human milk (HM) is the first dietary exposure in infancy and the best nutritional option for growth and healthy development of the newborn and infant. The concentrations of macronutrients, namely proteins, carbohydrates and lipids, change during lactation stages. HM has been studied extensively in the first 6 months of lactation, but there are limited data regarding milk composition beyond 1 or 2 years postpartum. The aim of our study was to describe longitudinal changes in HM macronutrient concentrations during the prolonged lactation of healthy mothers from the 1st to the 48th month...
December 3, 2018: Nutrients
Karolina A Chodkowska, Anna Ciecierska, Kinga Majchrzak, Piotr Ostaszewski, Tomasz Sadkowski
Gamma-oryzanol (GO) is a popular supplement for performance horses, dogs, and humans. Previous studies indicated that GO supplementation decreases creatine kinase activity and lactate level after exercise and may affect oxidative stress in Thoroughbred horses. GO may change genes expression in equine satellite cells (ESC). The purpose of this study was to evaluate the effect of GO on miRNA, gene expression, oxidative stress, and cell damage and viability in differentiating ESC pretreated with hydrogen peroxide (H₂O₂)...
December 2, 2018: Nutrients
I Garcia-Ispierto, F De Rensis, J A Pérez-Salas, J M Nunes, B Pradés, B Serrano-Pérez, F López-Gatius
This study compares the fertility effects of inducing ovulation using the GnRH analogue, dephereline, versus natural GnRH at the end of a 5-day progesterone(P4)-based protocol for fixed-time artificial insemination (FTAI) in in heat-stressed and non-heat stressed lactating dairy cows. Cows were given GnRH (GnRH group, n = 369) or dephereline (DEPH group, n = 379) and were inseminated 14-20 h later. Dephereline treatment increased corpus luteum (CL) size on Day 7 post-AI compared with GnRH (P < ...
November 28, 2018: Research in Veterinary Science
Chloe M Barrera, Jennifer F Kawwass, Sheree L Boulet, Jennifer M Nelson, Cria G Perrine
BACKGROUND: About 15% of women aged 15-44 in the US experience infertility. Factors associated with infertility and fertility treatments may also be associated with lactation difficulties. Limited data exist examining the impact of infertility or mode of conception on breastfeeding outcomes. OBJECTIVE: The objectives of this study were to report breastfeeding outcomes (initiation and duration at 8 weeks) among women who conceived spontaneously compared to women who conceived using fertility treatments (assisted reproductive technology, intrauterine insemination, or fertility-enhancing drugs)...
December 1, 2018: American Journal of Obstetrics and Gynecology
Guifang Guo, Xiuxing Chen, Wenzhuo He, Haohua Wang, Yixing Wang, Pili Hu, Yuming Rong, Lei Fan, Liangping Xia
PURPOSE: To establish three novel prognostic nomograms with inflammatory factors for advanced colorectal cancer (ACRC), right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) according to real world data. MATERIALS AND METHODS: ACRC patients receiving medicine therapy from January 1st, 2005 to September 31th, 2015 in Sun Yat-sen University Cancer Center were enrolled. Inflammatory indicators such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were analyzed for establishing nomograms predicting overall survival (OS)...
2018: PloS One
Abdelgawad A Fahmi, Mariam Abdur-Rahman, Asmaa F Aboul-Naser, Manal A Hamed, Howida I Abd-Alla, Mohamed I Nasr
CONTEXT: Stomach ulcers are the common gastrointestinal disorders worldwide. OBJECTIVE: This study aimed to investigate the therapeutic impact of Pulicaria crispa aerial part ethanol extract against gastric ulcer in rats. MATERIALS AND METHODS: Ulcer was induced by one oral dose of ethanol (0.5 ml/100g body weight) on 24 hours empty stomach, then the plant extract (500 mg/kg b.wt.) was orally administered daily for one week. Ranitidine (100mg/kg b...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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