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Amanda C Kentner, Stephanie Scalia, Junyoung Shin, Mattia M Migliore, Alejandro N Rondón-Ortiz
Both basic and clinical research support the use of tactile stimulation to rescue several neurobiobehavioral consequences that follow early life stress including. Here, using a translational rodent model of the neonatal intensive care unit (NICU), we tested the individual prophylactic potential of a variety of sensory interventions including tactile (brushing pups with a paint brush to mimic maternal licking), auditory (a simulated lactating rat dam heart beat), and olfactory (a series of aroma therapy scents) stimulation...
July 30, 2018: Psychoneuroendocrinology
Yoshinori Aragane, Hideaki Higashino
BACKGROUND: Far-infrared is well known with various therapeutic benefits. Recently, we have developed a novel far-infrared bathing system called the Enseki sandbath. In this regard, we focused on physical nature of ceramic to radiate far-infrared rays when heated adequately. METHODS: A bathtub was filled with ceramic beads and was equipped with computerized system which enabled to supply hot water over the ceramic beads and to drain out when beads were sufficiently heated...
August 18, 2018: Photodermatology, Photoimmunology & Photomedicine
Danilo Iannetta, Calaine Erin Inglis, Christopher Fullerton, Louis Passfield, Juan M Murias
Exercising at the maximal lactate steady state (MLSS) results in increased but stable metabolic responses. We tested the hypothesis that even a slight increase above MLSS (10 W), by altering the metabolic steady-state, would reduce exercise performance capacity. Eleven trained men in our study performed: one ramp-incremental tests; two to four 30-min constant-load cycling exercise trials to determine the PO at MLSS (MLSSp ), and ten watts above MLSS (MLSSp+10 ), which were immediately followed by a time-to-exhaustion test; and a time-to-exhaustion test with no-prior exercise...
August 17, 2018: Scandinavian Journal of Medicine & Science in Sports
Hui Yang, Xia Li, Feng Xue, Qunli Xia, Xin Zhao, Dixin Wang, Lihong Chen, Hua Cao, Han Xu, Xiaoyan Shen, Weiru Yuan, Xiaoqing Zhao, Ruofei Shi, Jie Zheng
Human prolactin (PRL) is a well-known hormone for pituitary of lactation and reproduction, but it also has immunostimulatory effect in some inflammatory or autoimmune diseases including psoriasis, which has not been well elucidated. This study aimed to determine the relationship between PRL and psoriasis through clinical case-control studies, and explore the function of PRL in the pathogenesis of imiquimod (IMQ)-induced psoriasis-like mouse model. Serum from patients with psoriasis vulgaris (PsV), patients with erythrodermic psoriasis, and healthy controls (HCs) were collected for PRL test...
August 18, 2018: Experimental Dermatology
Ayako Kumagai, Tsutomu Sasaki, Kenta Matsuoka, Masayoshi Abe, Toshihide Tabata, Yumi Itoh, Hiroyuki Fuchino, Sartagul Wugangerile, Mika Suga, Tomoko Yamaguchi, Hidehisa Kawahara, Yasuo Nagaoka, Kenji Kawabata, Miho Kusuda Furue, Hiroshi Takemori
Dysfunction of mitochondrial activity is often associated with the onset and progress of neurodegenerative diseases. Membrane depolarization induced by Na+ influx increases intracellular Ca2+ levels in neurons, which upregulates mitochondrial activity. However, overlimit of Na+ influx and its prolonged retention ultimately cause excitotoxicity leading to neuronal cell death. To return the membrane potential to the normal level, Na+ /K+ -ATPase exchanges intracellular Na+ with extracellular K+ by consuming a large amount of ATP...
August 18, 2018: Synapse
Yue Zheng, Wen-Cheng Zhang, Ze-Yu Wu, Chuan-Xiang Fu, Ai-Ling Hui, Han Gao, Peng-Peng Chen, Biao Du, Hua-Wei Zhang
BACKGROUND: Macamides, the main active component contained in maca, have attracted increasing attention due to their various bioactivities. In this study, crude macamides extract (CME) and purified macamides extract (PME) were prepared by enzyme-assisted extraction and macroporous resin separation, and anti-fatigue effects of CME and PME were evaluated in a forced swimming model. RESULTS: The composition analysis results revealed that both CME and PME mainly contain 8 kinds of macamides...
August 17, 2018: Journal of the Science of Food and Agriculture
Phillip Weeks, Adam Sieg, Indranee Rajapreyar, Sriram Nathan, Marwan Jumean, Manish Patel, Rajko Radovancevic, Biswajit Kar, Igor Gregoric
Pump thrombosis remains a serious complication of implantable ventricular assist device therapy and is associated with increased risk of morbidity and mortality. Optimal management strategies remain controversial and are guided largely by limited literature and expert opinion. Medical management of pump thrombosis, including the use of direct thrombin inhibitors, has been associated with mixed results. The purpose of this study is to report the outcomes associated with bivalirudin therapy in LVAD patients with suspected pump thrombosis...
August 17, 2018: Journal of Thrombosis and Thrombolysis
Moumita Banerjee, Xiaoyu Cui, Zhichuan Li, Hui Yu, Liquan Cai, Xuelian Jia, Daheng He, Chi Wang, Tianyan Gao, Zijian Xie
We report here the identification of α1 Na/K-ATPase as a major regulator of the proto-oncogene Src kinase and the role of this regulation in control of Warburg effect and tumor growth. Specifically, we discovered Y260 in α1 Na/K-ATPase as a Src-specific phosphorylation and binding site and that Y260 phosphorylation is required for Src-mediated signal transduction in response to a number of stimuli including EGF. As such, it enables a dynamic control of aerobic glycolysis. However, such regulation appears to be lost or attenuated in human cancers as the expression of Na/K-ATPase α1 was significantly decreased in prostate, breast and kidney cancers, and further reduced in corresponding metastatic lesions in patient samples...
August 17, 2018: Scientific Reports
Kwesi Marshall, Sharon Howell, Asha Badaloo, Marvin Reid, Norma McFarlane-Anderson, Colin McKenzie
Patients with sickle cell disease (SCD) display puzzling inter-individual phenotypic heterogeneity, conceivably related to inherent differences in antioxidant protection, hemoglobin binding, bilirubin catabolism and methyl group handling. Therefore, we explored putative associations between clinically important phenotypic measures and functional polymorphisms within specific candidate genes encoding glutathione S-transferase, haptoglobin, uridine 5'-diphospho-glucuronosyltransferase 1A1, methyl tetrahydrofolate reductase, 5-methyltetrahydrofolate-homocysteine methyltransferase, and cystathionine beta-synthase...
August 2, 2018: Blood Cells, Molecules & Diseases
Yun-Dong Xie, Zi-Zhang Chen, Li-Hua Shao, Qiu-Tang Wang, Na Li, Wen-Fang Lu, Yan-Hong Xu, Yu-Qiong Gao, Li-Ying Guo, Hao-Le Liu, Yi-Ping Li, Guang-De Yang, Xiao-Li Bian
Oxidative stress has been regarded as the leading mechanism of the hepatotoxicity of clofibrate (CF). To achieve multifunctional novel hypolipidemic agents with hypolipidemia, antioxidant, and ameliorating liver injury, clofibric acid derivative hydroxytyrosol-clofibrate (CF-HT) was synthesized by molecular hybridization. CF-HT exhibited significant hypolipidemia, reducing serum triglyceride (TG), total cholesterol (TC), and malonaldehyde (MDA) by 30%, 33%, and 29% in hyperlipidemic mice induced by Triton WR 1339...
June 5, 2018: Bioorganic & Medicinal Chemistry Letters
Peng Li, Xiaoming Zhong, Juan Li, Hongyang Liu, Xiang Ma, Ruili He, Yanzhuo Zhao
Atherosclerosis is a chronic inflammatory disease involved in endothelial dysfunction. Pyroptosis is a pro-inflammatory form of cell death and plays pivotal roles in atherosclerosis. MicroRNAs (miRNAs) are implicated in atherosclerosis, however the mechanisms that underlie miR-30c-5p is required for endothelial cell pyroptosis remain elusive. In the present study, we probed the interaction of miR-30c-5p with forkhead box O3 (FOXO3) and investigated the effect of miR-30c-5p and FOXO3 on NLRP3 inflammasome and endothelial cell pyroptosis...
August 6, 2018: Biochemical and Biophysical Research Communications
Catherine Go, Youngjae J Chun, Jenna Kuhn, Yanfei Chen, Sung Kwon Cho, William C Clark, Bryan W Tillman
OBJECTIVE: Early hemorrhage control before the operating room is essential to reduce the significant mortality associated with traumatic injuries of the vena cava. Conventional approaches present logistical challenges on the battlefield or in the trauma bay. A retrievable stent graft would allow rapid hemorrhage control in the preoperative setting when endovascular expertise is not immediately available and without committing a patient to the limitations of current permanent stents. This study details a refined retrievable Rescue stent for percutaneous delivery that was examined in a porcine survival model of penetrating caval hemorrhage...
September 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Paulo N Martins, Amanda Rawson, Babak Movahedi, Isabel M A Brüggenwirth, Natasha H Dolgin, Ann-Britt Martins, Paria Mahboub, Adel Bozorgzadeh
OBJECTIVES: Elevation of transaminases has been used as a marker of hepatic ischemic injury and as a crucial parameter for liver graft assessment. However, analysis of serum transaminases has limitations regarding the quantitative assessment of liver necrosis and is not a reliable predictor of outcomes. MATERIALS AND METHODS: We retrospectively reviewed the medical records of all liver transplants (N = 238) performed at the UMass Memorial Medical Center from 2009 to 2013...
August 17, 2018: Experimental and Clinical Transplantation
Shilei Yang, Yongguo Dai, Zhihao Liu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Huijun Sun, Xiaodong Ma, Jinyong Peng, Kexin Liu
The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA. However, the molecular mechanism of the adverse event is not yet clear. In this study, iohexol injection was used as a model drug. The contrast agent acute kidney injury rat model, in vivo rat pharmacokinetic study, kidney slices and HK-2 cells were performed to elucidate the pharmacokinetic molecular mechanism of accumulation of metformin caused by contrast-induced nephropathy (CIN)...
July 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Khalil Ali Ahmad, Hong Ze, Jichao Chen, Farhan Ullah Khan, Chen Xuezhuo, Jinyi Xu, Ding Qilong
Antioxidant therapy is considered as promising strategy for treating oxidative stress-induced cardiovascular disease. Bis (β-elemene-13-yl) glutarate (BEG) is a novel β-elemene derivative. Herein, we examined the antioxidant activity of BEG on human umbilical vein endothelial cells (HUVECs) after injury with hydrogen peroxide (H2 O2 ) and investigated the mechanism involved. HUVECs were divided into the following groups: control group (untreated cells); treated groups (cells treated with 0.1, 1, 10 μmol/L of BEG); positive control group (cells treated with 0...
July 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jin-Seok Lee, Won-Yong Kim, Yoo-Jin Jeon, Sam-Keun Lee, Chang-Gue Son
An imbalance between excitatory and inhibitory neurotransmitters is known to induce neuronal excitotoxicity which is a major cause of neurodegenerative disorders. Excessive glutamate concentration leads to the neuronal death by increasing oxidative stress and affecting the apoptotic signaling pathway. We investigated the anti-excitotoxic effects and associated working mechanisms of 30% ethanol extract of Aquilariae Lignum (ALE) against hippocampal neuronal death by glutamate. HT22 cells were treated with glutamate (20 mM) for 24 h following pretreatment with ALE (5, 10, 25 μg/mL)...
July 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jon G Divine, Joseph F Clark, Angelo J Colosimo, John P Detherage, Michael A Donaworth, Kimberly A Hasselfeld, Aaron Himmler, Joseph T Rauch, Robert E Mangine
OBJECTIVE: This study was designed to identify changes in blood biomarkers that would indicate excessive muscle breakdown during the initial 10 days of preseason training in collegiate American football players and subsequently increase their risk of acute kidney injury (AKI). DESIGN: Prospective cohort study. SETTING: Preseason, heat acclimatization period. PARTICIPANTS: Twenty-five Division I American football players...
August 16, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Cornelia Voigt, Nigel Bennett
The eusocial Damaraland mole-rat (Fukomys damarensis) represents an extreme example of reproductive skew, in that reproduction is completely blocked in female subordinate group members. It is thought that in these animals normal GnRH secretion from the hypothalamus is disrupted. Prolactin, a peptide hormone secreted from the anterior pituitary gland, has been implicated in a wide variety of functions. Well documented in rodents is its role in mediating lactational infertility. Elevated circulating prolactin levels, such as during lactation, are associated with reduced GnRH release into the portal blood and with a reduction in the frequency and amplitude of LH pulses...
August 14, 2018: Journal of Chemical Neuroanatomy
Monica Maria Mion, Giada Bragato, Martina Zaninotto, Jhessica Alessandroni, Sergio Bernardini, Mario Plebani
AIM OF THE STUDY: Blood gas analysis (BGA) is essential for the diagnosis and management of acid-base imbalances. We evaluated and compared the analytical characteristics of the new GEM® Premier™ 5000 (GP5000) (Instrumentation Laboratory, Bedford, MA, United States) BGA point-of-care (POC) device with those of the GEM® Premier™ 4000 (GP4000) (Instrumentation Laboratory, Bedford, MA, United States) and RapidPoint® 405 (RP405) (Siemens Healthcare, Milan, Italy) POC analyzers. The effect of sample mixing on patient results was also studied...
August 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Eliane Campos Alves, Jacqueline de Almeida Gonçalves Sachett, Vanderson Souza Sampaio, José Diego de Brito Sousa, Sâmella Silva de Oliveira, Elizandra Freitas do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça da Silva, Ana Maria Moura da Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN)...
2018: PloS One
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