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Multiple sclerosis cognitive

Gustavo Noffs, Thushara Perera, Scott Camaron Kolbe, Camille Jessica Shanahan, Frederique Maria Christina Boonstra, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Adam Phillip Vogel
IMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased communication skills and quality of life. Advancements in technology now makes it possible to use quantitative acoustic assessment of speech as biomarkers of disease progression. OBSERVATIONS: Four domains of speech have been identified: articulation (slow articulation and imprecise consonants), voice (pitch and loudness instability), respiration (decreased phonatory time and expiratory pressure) and prosody (longer and frequent pauses, deficient loudness control)...
October 11, 2018: Autoimmunity Reviews
C Bakirtzis, E Konstantinopoulou, D W Langdon, E Grigoriadou, F Minti, I Nikolaidis, M K Boziki, T Tatsi, P Ioannidis, T Karapanayiotides, T Afrantou, G Hadjigeorgiou, N Grigoriadis
BACKGROUND: Studies have reported conflicting results regarding the potential benefit of prolonged release (PR) fampridine in other domains besides walking. Moreover, only a small number of studies have explored long- term effects of PR fampridine. The aim of this study was to assess cognitive function, quality of life, mood and fatigue in MS patients treated with fampridine after 6 and 12 months of treatment. METHODS: IGNITE was an observational, open label study...
October 4, 2018: Journal of the Neurological Sciences
Rosalind Kalb, Meghan Beier, Ralph Hb Benedict, Leigh Charvet, Kathleen Costello, Anthony Feinstein, Jeffrey Gingold, Yael Goverover, June Halper, Colleen Harris, Lori Kostich, Lauren Krupp, Ellen Lathi, Nicholas LaRocca, Ben Thrower, John DeLuca
PURPOSE: To promote understanding of cognitive impairment in multiple sclerosis (MS), recommend optimal screening, monitoring, and treatment strategies, and address barriers to optimal management. METHODS: The National MS Society ("Society") convened experts in cognitive dysfunction (clinicians, researchers, and lay people with MS) to review the published literature, reach consensus on optimal strategies for screening, monitoring, and treating cognitive changes, and propose strategies to address barriers to optimal care...
October 10, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Brian M Sandroff, Lara A Pilutti, Robert W Motl
BACKGROUND: Aerobic exercise training may improve cognitive performance among persons with multiple sclerosis (MS). This is largely based on evidence that cardiorespiratory fitness (as a cross-sectional surrogate for aerobic exercise training) is associated with cognitive processing speed. There may be a set of "other" variables (i.e., psychological symptoms) that influences the association between cardiorespiratory fitness and cognitive processing speed in MS, and such factors should be accounted for when designing optimized exercise rehabilitation interventions...
October 2, 2018: Multiple Sclerosis and related Disorders
Samuel L Battalio, Mari Glette, Kevin N Alschuler, Mark P Jensen
OBJECTIVE: This longitudinal study examined the unique relationship between anxiety, symptoms (pain intensity, sleep disturbance, fatigue severity), and function domains (self-reported cognitive function, physical function, satisfaction with social roles) in individuals with chronic physical conditions, independent of depressive symptoms. METHOD: Three surveys were mailed on an approximately yearly basis to community-dwelling adults with one of four chronic physical conditions (spinal cord injury, multiple sclerosis, muscular dystrophy, postpoliomyelitis syndrome)...
October 8, 2018: Rehabilitation Psychology
Bilal Sirhan, Lior Frid, Alon Kalron
The objective of the study was to investigate cognitive-motor interference of walking while texting in people with multiple sclerosis (PwMS). The study included 30 PwMS, mean disease duration 11.8 (SD = 6.8) years, and 15 healthy controls. The investigation included a cognitive assessment; texting assessment based on 100 typed characters; and gait assessment under two different conditions: normal walking and walking while texting. Outcome measures included the Symbol Digit Modalities Test to assess cognition...
October 8, 2018: Journal of Neural Transmission
Guillermo Borragán, Médhi Gilson, Anne Atas, Hichem Slama, Andreas Lysandropoulos, Melanie De Schepper, Philippe Peigneux
Patients with multiple sclerosis (MS) disease frequently experience fatigue as their most debilitating symptom. Fatigue in MS partially refers to a cognitive component, cognitive fatigue (CF), characterized by a faster and stronger than usual development of the subjective feeling of exhaustion that follows sustained cognitive demands. The feeling of CF might result from supplementary task-related brain activity following MS-related demyelination and neurodegeneration. Besides, CF in MS disease might also stem from disrupted sleep...
2018: Frontiers in Human Neuroscience
Rania S Nageeb, Noha A Hashim, Amal Fawzy
Background: Multiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients. Methods: This study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
P H R Silva, C T Spedo, C R Baldassarini, C D Benini, D A Ferreira, A A Barreira, R F Leoni
Delayed Information Processing Speed (IPS) often underlies attention deficits and is particularly evident in patients with traumatic brain injury, Parkinson's disease, depression, dementia, and multiple sclerosis. Therefore, it is of interest to determine the brain network that is responsible for such essential cognitive function to understand IPS deficits and to develop effective rehabilitation programs. We assessed brain functional connectivity and effective connectivity during the performance of an adapted version of the Symbol Digit Modalities Test...
October 4, 2018: NeuroImage
Elizabeth Bartlett, Michael Shaw, Colleen Schwarz, Charles Feinberg, Christine DeLorenzo, Lauren B Krupp, Leigh E Charvet
BACKGROUND AND PURPOSE: Pediatric-onset multiple sclerosis (POMS) is a demyelinating disorder with unique clinical challenges. A brief computer-administered cognitive screening battery measuring processing speed (Cogstate) and the Brief International Cognitive Assessment in MS (BICAMS) detect cognitive impairment in POMS. The neuroanatomic correlates of these deficits are incompletely understood. The purpose of this study is to define the neuroanatomic underpinnings of deficits identified with cognitive screening batteries in POMS...
October 4, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Lisa M McGinley, Osama N Kashlan, Elizabeth S Bruno, Kevin S Chen, John M Hayes, Samy R Kashlan, Julia Raykin, Karl Johe, Geoffrey G Murphy, Eva L Feldman
Stem cell transplantation offers a potentially transformative approach to treating neurodegenerative disorders. The safety of cellular therapies is established in multiple clinical trials, including our own in amyotrophic lateral sclerosis. To initiate similar trials in Alzheimer's disease, efficacious cell lines must be identified. Here, we completed a preclinical proof-of-concept study in the APP/PS1 murine model of Alzheimer's disease. Human neural stem cell transplantation targeted to the fimbria fornix significantly improved cognition in two hippocampal-dependent memory tasks at 4 and 16 weeks post-transplantation...
October 3, 2018: Scientific Reports
Imad Uthman, Mohammad Hassan A Noureldine, Guillermo Ruiz-Irastorza, Munther Khamashta
Antiphospholipid syndrome, also known as 'Hughes Syndrome', is an autoimmune disease characterised by a set of clinical manifestations, almost all of which are direct or indirect sequelae of a hypercoagulable state involving the venous, and to a lesser extent the arterial vasculature. The incidence and prevalence of antiphospholipid syndrome are estimated at approximately 5 de novo cases per 100 000 per year and 40-50 cases per 100 000 individuals, respectively. The clinical spectrum of antiphospholipid syndrome involves haematological (thrombocytopaenia, venous thrombosis), obstetrical (recurrent pregnancy loss), neurological (stroke, transient ischaemic attack, migraine, seizures, cognitive dysfunction, chorea, transverse myelitis, multiple sclerosis), cardiovascular (cardiac valve disease), dermatological (livedo reticularis and racemosa, skin ulceration and necrosis), renal (glomerulonephritis, renal thrombotic microangiopathy) and orthopaedic (avascular necrosis of bones, non-traumatic fractures) manifestations, among others...
October 3, 2018: Annals of the Rheumatic Diseases
K A Meijer, Q van Geest, A J C Eijlers, J J G Geurts, M M Schoonheim, H E Hulst
OBJECTIVE: Cognitive deficits, especially those of information processing speed (IPS), are common in multiple sclerosis (MS), however, the underlying neurobiological mechanisms remain poorly understood. In this study, we examined structural and functional brain changes separately, but also in an integrative manner, in relation to IPS performance. METHODS: IPS was measured using the symbol digit modalities test (SDMT) in 330 MS patients and 96 controls. Patients with IPS impairment (IPS-I, z-score < -1...
September 26, 2018: NeuroImage: Clinical
Mendel Friedman
Tryptophan is an essential plant-derived amino acid that is needed for the in vivo biosynthesis of proteins. After consumption, it is metabolically transformed to bioactive metabolites, including serotonin, melatonin, kynurenine, and the vitamin niacin (nicotinamide). This brief integrated overview surveys and interprets our current knowledge of the reported multiple analytical methods for free and protein-bound tryptophan in pure proteins, protein-containing foods, and in human fluids and tissues, the nutritional significance of l-tryptophan and its isomer d-tryptophan in fortified infant foods and corn tortillas as well the possible function of tryptophan in the diagnosis and mitigation of multiple human diseases...
2018: International Journal of Tryptophan Research: IJTR
S P Panda, R C Das, Kalpana Srivastava, Ashutosh Ratnam, Neha Sharma
AIM: To study the prevalence of psychiatric comorbidities in patients of multiple sclerosis and their association to the degree of disability. METHOD: Psychiatric symptoms were assessed in 90 patients of multiple sclerosis using GHQ-12, MMSE, HADS, Beck Depression Inventory and AUDIT. Neurological disability was assessed using Expanded Disability Status Scale. Correlations were determined between EDSS scores and psychiatric scale scores. RESULT: 61% of patients had significant psychological distress...
September 22, 2018: Neurologia i Neurochirurgia Polska
Patricia K Coyle, Bhupendra Khatri, Keith R Edwards, José E Meca-Lallana, Steve Cavalier, Pascal Rufi, Myriam Benamor, Karthinathan Thangavelu, Miqun Robinson, Ralf Gold
BACKGROUND: Patient-reported outcomes (PROs) can assist clinicians in understanding the impact of disease-modifying therapy (DMT) on the daily lives of patients with multiple sclerosis (MS). With an increased number of DMTs becoming available, patients are now switching treatments more frequently in clinical practice. The effects of switching DMTs on a patient's daily life and their disease course may be reflected in PROs. The global, multicenter, open-label, phase 4 Teri-PRO study (NCT01895335), which was conducted in routine clinical practice, previously showed statistically and clinically significant increases in patient-reported treatment satisfaction in patients switching to teriflunomide from other DMTs...
September 15, 2018: Multiple Sclerosis and related Disorders
A Carotenuto, T Costabile, M Moccia, F Falco, M R Scala, C V Russo, F Saccà, A De Rosa, R Lanzillo, V Brescia Morra
BACKGROUND: Both cognition and olfaction are impaired in multiple sclerosis (MS). However, little is known about the relationship between smell identification ability and measures of cognitive function in this disease. OBJECTIVE: To assess olfactory function in MS and to evaluate its relationship with cognitive and physical disability. METHODS: Fifty-five MS patients and 20 healthy controls (HCs) were tested. The University of Pennsylvania smell identification test (UPSIT) was administered to assess olfactory function...
September 22, 2018: Multiple Sclerosis and related Disorders
Anna M Barbarulo, Giacomo Lus, Elisabetta Signoriello, Luigi Trojano, Dario Grossi, Mariateresa Esposito, Teresa Costabile, Roberta Lanzillo, Francesco Saccà, Vincenzo Brescia Morra, Giovannina Conchiglia
Background: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a traditional neuromotor training on walking, balance, cognition and emotional functioning in MS patients. Methods: Sixty three MS patients were selected and assigned either to the Integrated Treatment Group (ITG; n = 32), receiving neuropsychological treatment (performed by ERICA software and paper-pencil tasks) complemented by conventional neuromotor rehabilitation, or to the Motor Treatment Group ( n = 31) receiving neuromotor rehabilitation only...
2018: Frontiers in Behavioral Neuroscience
Laura Clemens, Dawn Langdon
BACKGROUND: Almost half of people with multiple sclerosis (MS), with low levels of physical disability, are unemployed. It is likely that the impact of "invisible" symptoms of MS, such as cognition, are involved. Evidence also suggests that cognition is a mediating factor between physical disabilities and unemployment. METHODS: A systematic review was conducted to investigate the link between objective cognitive performance and unemployment in MS. The search was carried out in September 2017 using identical search terms across three search engines: PubMed, PSYCH Info and Web of Science...
September 15, 2018: Multiple Sclerosis and related Disorders
Y Forslin, Å Bergendal, F Hashim, J Martola, S Shams, M K Wiberg, S Fredrikson, T Granberg
BACKGROUND AND PURPOSE: Cortical lesions are common in multiple sclerosis and are included in the latest diagnostic criteria. The limited sensitivity of cortical MS lesions on conventional MR imaging can be improved by phase-sensitive inversion recovery. Synthetic MR imaging could provide phase-sensitive inversion recovery without additional scanning, but the use of synthetic phase-sensitive inversion recovery remains to be validated. We aimed to compare the ability and clinical value of detecting leukocortical lesions with conventional and synthetic phase-sensitive inversion recovery in MS...
September 27, 2018: AJNR. American Journal of Neuroradiology
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