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Multiple sclerosis cognitive

Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda Shoenfeld
Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. The etiopathogenesis of autoimmune disease is uncertain. Genetic factors as well as environmental factors appear to interplay, leading to a cascade of events resulting in disease onset...
August 14, 2018: Autoimmunity Reviews
Laura Zamarian, Margarete Delazer, Rainer Ehling, Marie-Theres Pertl, Gabriel Bsteh, Johanna Wenter, Susanne Glatzl, Christian Brenneis, Thomas Benke, Thomas Berger
BACKGROUND: People with multiple sclerosis (MS) have to face important decisions with regard to their medical treatment. OBJECTIVE: To evaluate whether a targeted cognitive training reduces framing effects and thus improves medical judgements. METHODS: This was a randomised, double-blind, cross-over study enrolling relapsing-remitting MS (RRMS) patients and healthy controls (HC). Participants were randomly assigned to training order A (first week: numerical training, second week: control training) or B (reverse order)...
August 17, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Felix P Bernhard, Jennifer Sartor, Kristina Bettecken, Markus A Hobert, Carina Arnold, Yvonne G Weber, Sven Poli, Nils G Margraf, Christian Schlenstedt, Clint Hansen, Walter Maetzler
BACKGROUND: Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more objective information. METHODS: In this prospective cross-sectional feasibility study performed over a four-month period, all patients referred to a normal neurology ward of a university hospital and aged between 40 and 89 years were asked to participate...
August 16, 2018: BMC Neurology
Shoji Yasuda, Hirohito Yano, Akio Kimura, Natsuko Suzui, Noriyuki Nakayama, Jun Shinoda, Toru Iwama
BACKGROUND: Tumefactive demyelinating lesion (TDL) is often reported as a rare variation of multiple sclerosis (MS). TDL is difficult to diagnose solely by magnetic resonance imaging (MRI) in patients with no history of MS. This is because the lesion often shows ring enhancement with perifocal brain edema on gadolinium MRI, thus mimicking glioblastoma multiforme (GBM). CASE DESCRIPTION: A 54-year-old healthy woman complained of headache 1 month before admission...
August 13, 2018: World Neurosurgery
Antonio Carotenuto, Sirio Cocozza, Mario Quarantelli, Giorgio Arcara, Roberta Lanzillo, Vincenzo Brescia Morra, Ilaria Cerillo, Enrico Tedeschi, Giuseppe Orefice, Valentina Bambini, Arturo Brunetti, Rosa Iodice
Recent studies showed that multiple sclerosis (MS) patients might experience communicative deficits, specifically in pragmatics (i.e., the ability to integrate the context-dependent aspects of language). A crucial region for pragmatics is the temporo-parietal junction, in particular the so-called Geschwind's area (GA), which is involved in high-level language processes, including the comprehension of narratives, metaphor, and irony. We evaluated the relationship between pragmatic abilities, measured through the Assessment of Pragmatic Abilities and Cognitive Substrates (APACS) test, and the functional connectivity (FC) of the bilateral GAs, assessed through a seed-based analysis of Resting-State fMRI in patients with MS...
August 11, 2018: Brain and Language
Laura Marie Schreck, Shane Paul Pawson Ryan, Patrick G Monaghan
Kalron et al. report people with Multiple Sclerosis (PwMS) who fall show a decreased cerebellar volume along with decreased overall cognition compared to non-fallers. While this paper focuses on cerebellar and cognitive alterations in PwMS, these findings may also be explained by additional factors such as aging and have the potential for broader impact in additional clinical populations who simultaneously experience cognitive and mobility dysfunction.
August 15, 2018: Journal of Neurophysiology
Gregory S Day, Alexander Rae-Grant, Melissa J Armstrong, Tamara Pringsheim, Stacey S Cofield, Ruth Ann Marrie
Background: Persons with multiple sclerosis (MS) may now choose from a broad array of approved disease-modifying treatments (DMTs). The priority that patients and practitioners assign to specific clinical outcomes is likely to influence the MS DMT selection process. Methods: We invited 9,126 participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry and 18 members of the American Academy of Neurology MS DMT guideline development panel to complete a brief survey prioritizing outcomes of importance to MS DMT selection...
June 2018: Neurology. Clinical Practice
Gillian Quinn, Laura Comber, Chris McGuigan, Rose Galvin, Susan Coote
OBJECTIVE: To investigate discriminative ability and clinical utility of the Timed Up and Go under single- and dual-task conditions between fallers and non-fallers in multiple sclerosis (MS). DESIGN: Prospective cohort study. SETTING: Neurology service in a tertiary hospital. SUBJECTS: Participants were 101 people with MS and Expanded Disability Status Scale score of 3-6.5. One participant withdrew after the baseline assessment, and hence the data were analysed for 100 participants...
August 14, 2018: Clinical Rehabilitation
Giancarlo Coghe, Giuseppe Fenu, Lorena Lorefice, Erica Zucca, Micaela Porta, Giuseppina Pilloni, Federica Corona, Jessica Frau, Maria Giovanna Marrosu, Massimiliano Pau, Eleonora Cocco
INTRODUCTION: Cognitive motor interference (CMI) is performance impairment due to simultaneuous task execution and is measured using the dual task cost (DTC). No pathological feature of MS has to date been associated with CMI. AIM: To assess the relationship between brain volumes and CMI, as measured using the DTC, in a cross-sectional study. METHODS: A group of persons with MS (pwMS) and an age- and sex-matched healthy control (HC) group underwent 3D gait analysis during using the dual task paradigm...
July 31, 2018: Multiple Sclerosis and related Disorders
Khwaja Salahuddin Siddiqi, Azamal Husen, Sayed Sartaj Sohrab, Mensur Osman Yassin
Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better efficacy and safety to deliver specific molecules into targeted cells as compared to conventional system for neurological disorders. Depending on their properties, various metal chelators, gold nanoparticles (NPs), micelles, quantum dots, polymeric NPs, liposomes, solid lipid NPs, microparticles, carbon nanotubes, and fullerenes have been utilized for various purposes including the improvement of drug delivery system, treatment response assessment, diagnosis at early stage, and management of neurological disorder by using neuro-engineering...
August 10, 2018: Nanoscale Research Letters
Carla Roberta Nunes Polachini, Roselia Maria Spanevello, Maria Rosa Chitolina Schetinger, Vera Maria Morsch
Multiple sclerosis (MS) commonly affects young adults and leads to a decreased quality of life due to different signs and symptoms that induce physical, cognitive, social, and psychological challenges. This disease, an autoimmune neurological disorder, is characterized by chronic inflammatory demyelination and axonal degeneration of the central nervous system (CNS). To date, its etiology is unknown. A large number of physiological functions are regulated by the cholinergic system because the acetylcholine (ACh) is released from cholinergic neurons and acts on other neurons, most of them not cholinergic in the brain, as well as in various nonneuronal cells, such as those of the immune system and blood; thus, it is considered an important modulatory pathway of both the central and peripheral nervous systems...
September 15, 2018: Journal of the Neurological Sciences
Elisabeth Solana, Eloy Martinez-Heras, Elena H Martinez-Lapiscina, Maria Sepulveda, Nuria Sola-Valls, Nuria Bargalló, Joan Berenguer, Yolanda Blanco, Magi Andorra, Irene Pulido-Valdeolivas, Irati Zubizarreta, Albert Saiz, Sara Llufriu
Patients with multiple sclerosis (MS) display reduced structural connectivity among brain regions, but the pathogenic mechanisms underlying network disruption are still unknown. We aimed to investigate the association between the loss of diffusion-based structural connectivity, measured with graph theory metrics, and magnetic resonance (MR) markers of microstructural damage. Moreover, we evaluated the cognitive consequences of connectivity changes. We analysed the frontoparietal network in 102 MS participants and 25 healthy volunteers (HV)...
2018: NeuroImage: Clinical
Hyun-Sik Yang, Lei Yu, Charles C White, Lori B Chibnik, Jasmeer P Chhatwal, Reisa A Sperling, David A Bennett, Julie A Schneider, Philip L De Jager
BACKGROUND: Transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy in older adults frequently coexists with Alzheimer's disease pathology and hippocampal sclerosis. It is unclear whether there is a link between APOE ε4 and TDP-43 proteinopathy, and the role of APOE ε4 in the association of TDP-43 proteinopathy with hippocampal sclerosis remains to be examined. We investigated the relationships of TDP-43 proteinopathy and hippocampal sclerosis with APOE ε4. METHODS: We used data from two community-based cohort studies of ageing and dementia: the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP)...
August 3, 2018: Lancet Neurology
Robert W Motl, Dorothy Pekmezi, Brooks C Wingo
There is an obvious disconnect between evidence of benefits and rates of participation in exercise and physical activity among people living with multiple sclerosis (MS). We propose that the problem with exercise behavior in MS (i.e. lack of broad or increasing participation by people with MS despite evidence of meaningful benefits) might be ameliorated through the inclusion of behavior change theory in the design of exercise programs and promotion efforts, as has been undertaken in other populations such as breast cancer survivors...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Sara Strzok, Sophie Cleanthous, Farrah Pompilus, Stefan J Cano, Patrick Marquis, Stanley Cohan, Myla D Goldman, Kiren Kresa-Reahl, Jennifer Petrillo, Carmen Castrillo-Viguera, Diego Cadavid, Shih-Yin Chen
Background and objective: The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a patient-reported outcome instrument that quantifies the progressive loss of walking ability from the patient perspective. However, previous psychometric analyses indicated floor and ceiling effects across the multiple sclerosis severity spectrum. This study aimed to address floor effects by creating a gait module that can be used in conjunction with the MSWS-12 for better measurement of treatment benefit in the higher functioning multiple sclerosis population...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Alon Kalron, Roy Aloni, Gilles Allali
Although falls, cognitive impairments and mood disorders are very common in people with MS (PwMS) the relationship between these conditions has received scant attention. Therefore, the purpose of the study was to investigate the specific involvement of depression and anxiety on cognition and falls in PwMS. The study included 122 PwMS (75 women) divided into four subgroups according to their manifestation of depression and anxiety assessed by the Hospital Anxiety and Depression Scale (HADS) (i.e. no depression/no anxiety, depression/no anxiety, no depression/anxiety and depression/anxiety)...
July 27, 2018: Multiple Sclerosis and related Disorders
Dorian A Lamis, Jameson K Hirsch, Kelley C Pugh, Raluca Topciu, Sheri A Nsamenang, Andrew Goodman, Paul R Duberstein
Multiple Sclerosis (MS), an autoimmune disorder marked by inflammation of the central nervous system, is associated with a myriad of symptoms. Individuals with MS are more likely to experience depressive symptoms, perhaps due to perceived cognitive impairments. Thus, we aimed to explore perceived stress and sleep deficits as potential mediators of the association between perceived cognitive deficits and depressive symptoms. We recruited a sample of 77 MS participants from an outpatient, university-based MS clinic in the United States...
July 26, 2018: Multiple Sclerosis and related Disorders
Viral Prakash Patel, Lingkai Shen, Jonathan Rose, Anthony Feinstein
BACKGROUND: One factor hindering the widespread use of cognitive testing for people with multiple sclerosis (pwMS) is the need for a tester to administer tests. OBJECTIVE: To undertake a proof of concept study assessing the feasibility of a fully automated speech recognition version of the Symbol Digit Modalities Test (auto-SDMT) in detecting abnormalities in processing speed in pwMS. METHODS: A sample of 50 pwMS and 32 matched healthy control (HC) subjects was tested with the auto-SDMT and the Brief International Cognitive Assessment for MS (BICAMS)...
August 6, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Weina Li, Jiuquan Zhang, Chaoyang Zhou, Wensheng Hou, Jun Hu, Hua Feng, Xiaolin Zheng
Purpose: Amyotrophic lateral sclerosis (ALS) is a motor neuro-degenerative disorder that also damages extra-motor neural pathways. A significant proportion of existing evidence describe alterations in the strengths of functional connectivity, whereas the changes in the density of these functional connections have not been explored. Therefore, our study seeks to identify ALS-induced alternations in the resting-state functional connectivity density (FCD). Methods: Two groups comprising of 38 ALS patients and 35 healthy participants (age and gender matched) were subjected to the resting-state functional magnetic resonance imaging (MRI) scanning...
2018: Frontiers in Aging Neuroscience
Magdalena Torbus-Paluszczak, Wojciech Bartman, Monika Adamczyk-Sowa
The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an accelerated aging and short life, whereas overexpression of Klotho in mice extends lifespan. Klotho participates in many metabolic pathways and is highly expressed in the kidneys, the choroid plexus and neurons. It plays a key role in the calcium-phosphate metabolism, remyelination, and cognitive processes. The present paper is a short review of the literature on the role of Klotho in neurodegenerative disorders, with special attention paid to multiple sclerosis...
July 30, 2018: Neurological Sciences
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