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Multiple sclerosis cognitive

J E Meca-Lallana, J M Prieto-González, J Jimenez-Veiga, E Carreón-Guarnizo, I Jiménez-Martín, R Hernández-Clares, A Sistiaga-Berrondo, R Carles-Dies, E García-Molina, M Cerdán-Sánchez, E Costa-Arpín, I Croitoru, T Castillo-Triviño, F Iniesta-Martinez, E García-Pérez, J Olascoaga-Urtaza
OBJECTIVE: Although cognitive impairment (CI) is common in multiple sclerosis (MS), it is difficult to suspect in patients with low disability and there is a lack of brief and effective CI screening tools with a define cut-off point to be used during routine clinic visits. This study aims to validate the Electronic Screening Cognitive Impairment in Multiple Sclerosis (SCI-MS) test for CI among MS patients. METHODS: Cross-sectional, observational study that included adult patients, diagnosed with MS, Expanded Disability Status Scale (EDSS) score ≤6...
December 3, 2018: Multiple Sclerosis and related Disorders
Brian M Sandroff, Robert W Motl, Marcus Bamman, Gary R Cutter, Mark Bolding, John R Rinker, Glenn R Wylie, Helen Genova, John DeLuca
INTRODUCTION: This randomised controlled trial (RCT) examines treadmill walking exercise training effects on learning and memory performance, hippocampal volume, and hippocampal resting-state functional connectivity in persons with multiple sclerosis (MS) who have objective impairments in learning new information. METHODS AND ANALYSIS: Forty fully ambulatory persons with MS who demonstrate objective learning and memory impairments will be randomly assigned into either the intervention or active control study conditions...
December 14, 2018: BMJ Open
Laura Emilia Toader, Gabriela Camelia Roşu, Bogdan Cătălin, Ionica Pirici, Ion Cristian Gîlceavă, Valeria Carmen Albu, Anca Maria Istrate-Ofiţeru, Dafin Fior Mureşanu, Daniel Pirici
Multiple sclerosis (MS) is a complex chronic neurodegenerative disease that involves an abnormal autoimmune response directed against the brain, nerves and spinal cord; it is considered the most frequent cause of neurological disability, because MS-associated inflammatory lesions can affect a wide range of systems to a varying degree and may cause a plethora of neurological comorbidities and symptoms. The symptoms are quite variable from patient to patient and depend on the spatial distribution of the central nervous system (CNS) lesions, but usually involve sensory disturbances, cognitive deficits, unilateral vision loss, bladder dysfunction, ataxia, fatigue, double vision, weakness of the limbs and intestinal disorders...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Hitoshi Shinotoh, Hitoshi Shimada, Yasumasa Kokubo, Kenji Tagai, Fumitoshi Niwa, Soichiro Kitamura, Hironobu Endo, Maiko Ono, Yasuyuki Kimura, Shigeki Hirano, Maya Mimuro, Masanori Ichise, Naruhiko Sahara, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
OBJECTIVE: To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11 C]PBB3 as ligand. METHODS: This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs)...
December 7, 2018: Neurology
Audrey Mazancieux, Céline Souchay, Olivier Casez, Chris J A Moulin
Although a large range of literature on awareness and metacognition focuses on different neurological populations, little attention has been paid to Multiple Sclerosis (MS). This paper gathers literatures related to studies of anosognosia and the theoretical construct of metacognition which both offer a means to operationalize and measure awareness in MS. We focused on both a clinical concern, regarding the relationship between subjective and objective evolution of cognitive performance, and the theoretical issue of metacognitive processes implicated in disease awareness...
November 19, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
James S Krause, Clara E Dismuke-Greer, Melinda Jarnecke, Chao Li, Karla S Reed, Phillip Rumrill
OBJECTIVE: To identify demographic, educational, and disease-related characteristics associated with the odds of employment and earnings among participants with multiple sclerosis (MS). DESIGN: Cross-sectional using self-report assessment obtained by mail or online SETTING: Medical University in the southeastern United States. PARTICIPANT: Participants with MS (n = 1059) were enrolled from a specialty hospital in the southeastern United States...
December 6, 2018: Archives of Physical Medicine and Rehabilitation
Mark Howard, Christina Ramsenthaler
BACKGROUND: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concern among specialist palliative care services about patients continuing to drive despite having progressive incurable illnesses, comorbidities and medications to manage their symptoms. OBJECTIVES: To determine the quality of literature available about driving that would apply to palliative care patients, specifically in relation to road test or simulated driving scores and neurocognitive testing...
December 6, 2018: BMJ Supportive & Palliative Care
Bryan Dobbs, Natalie Pawlak, Milton Biagioni, Shashank Agarwal, Michael Shaw, Giuseppina Pilloni, Marom Bikson, Abhishek Datta, Leigh Charvet
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been shown to improve common symptoms of neurological disorders like depressed mood, fatigue, motor deficits and cognitive dysfunction. tDCS requires daily treatment sessions in order to be effective. We developed a remotely supervised tDCS (RS-tDCS) protocol for participants with multiple sclerosis (MS) to increase accessibility of tDCS, reducing clinician, patient, and caregiver burden...
December 7, 2018: Journal of Neuroengineering and Rehabilitation
Andreas Johnen, Paul-Christian Bürkner, Nils C Landmeyer, Björn Ambrosius, Pasquale Calabrese, Jeremias Motte, Nicole Hessler, Gisela Antony, Inke R König, Luisa Klotz, Muna-Miriam Hoshi, Lilian Aly, Sergiu Groppa, Felix Luessi, Friedemann Paul, Björn Tackenberg, Florian Then Bergh, Tania Kümpfel, Hayrettin Tumani, Martin Stangel, Frank Weber, Antonios Bayas, Brigitte Wildemann, Christoph Heesen, Uwe K Zettl, Frauke Zipp, Bernhard Hemmer, Sven G Meuth, Ralf Gold, Heinz Wiendl, Anke Salmen
BACKGROUND: Cognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI and progression after initial diagnosis. METHODS: Neuropsychological screening data from baseline and 1-year follow-up of a prospective multicenter cohort study (NationMS) involving 1123 patients with newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical and conventional MRI markers at baseline were predictive for CI and longitudinal cognitive changes...
December 4, 2018: Journal of Neurology
Anne Katrine Andreasen, Pernille Iversen, Lisbet Marstrand, Volkert Siersma, Hartwig Roman Siebner, Finn Sellebjerg
BACKGROUND: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course. METHODS: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC) and patients were further examined with a cognitive test battery, including Symbol Digit Modalities Test (SDMT), and 3 T MRI with subsequent quantitative analyses of 13 cortical regions of interest, deep grey matter and lesion volume...
December 4, 2018: Neurological Research
Matthew Fifolt, Emma V Richardson, Elizabeth Barstow, Robert W Motl
BACKGROUND: Bandura has identified knowledge and four core determinants (e.g., self-efficacy, outcomes expectations, goals, and facilitators/impediments) along with a threefold stepwise implementation model for guiding health promotion and disease prevention interventions. AIMS: This research explored the exercise behaviors of persons with multiple sclerosis (MS) through the articulated lens of social cognitive theory. METHODS: We conducted secondary analysis of qualitative data from 50 people with MS using deductive, thematic analysis...
December 4, 2018: Disability and Rehabilitation
Olga A Klein, Roshan das Nair, Joanne Ablewhite, Avril Drummond
BACKGROUND: People diagnosed with Multiple Sclerosis often have cognitive problems. However, it is unclear how cognitive impairment is currently assessed and managed in the UK. AIMS: To understand current clinical practice of assessment and management of cognitive impairment in people with MS and to highlight any national variation. METHODS: A survey was posted to 150 MS centres and large hospitals and an online version was shared via e-mail and on social media...
December 3, 2018: International Journal of Clinical Practice
Riley M Bove, Gillian Rush, Chao Zhao, William Rowles, Priya Garcha, John Morrissey, Adrian Schembri, Titi Alailima, Dawn Langdon, Katherine Possin, Adam Gazzaley, Anthony Feinstein, Joaquin Anguera
INTRODUCTION: Self-administered in-home digital therapeutics could expand access to cognitive rehabilitation for individuals with multiple sclerosis (MS), over half of whom experience cognitive impairment (CI). However, feasibility in an MS population must be clarified. This study was conducted to assess the feasibility of deploying a videogame-like digital treatment for CI in MS, including initial efficacy and barriers to adherence. METHODS: In this pilot study, 21 participants with MS completed an in-clinic baseline neurological evaluation...
November 30, 2018: Neurology and Therapy
Laura Weinkle, Christopher H Domen, Ian Shelton, Stefan Sillau, Kavita Nair, Enrique Alvarez
BACKGROUND: Studies suggest cannabis may improve symptoms like pain and muscle spasticity in patients with multiple sclerosis (PwMS). Despite cannabis' new-found legality and availability, few studies have explored the profile of PwMS cannabis users and characteristics of their use, particularly in a state where cannabis is legal both for recreational and medicinal use. The purpose of the current study was to evaluate cannabis use among PwMS at a large academic multiple sclerosis (MS) clinic, specifically: (1) prevalence, (2) products used (e...
November 20, 2018: Multiple Sclerosis and related Disorders
Rosario Megna, Bruno Alfano, Roberta Lanzillo, Teresa Costabile, Marco Comerci, Giovanni Vacca, Antonio Carotenuto, Marcello Moccia, Giuseppe Servillo, Anna Prinster, Vincenzo Brescia Morra, Mario Quarantelli
OBJECTIVE: Both normal gray matter atrophy and brain tissue relaxation rates, in addition to total lesion volume, have shown significant correlations with cognitive test scores in multiple sclerosis (MS). Aim of the study was to assess the relative contributions of macro- and microstructural changes of both normal and abnormal brain tissues, probed, respectively, by their volumes and relaxation rates, to the cognitive status and physical disability of MS patients. METHODS: MRI studies from 241 patients with relapsing-remitting MS were retrospectively analyzed by fully automated multiparametric relaxometric segmentation...
November 29, 2018: Journal of Neurology
Koji Sakai, Kei Yamada
In the recent 5 years (2014-2018), there has been growing interest in the use of machine learning (ML) techniques to explore image diagnosis and prognosis of therapeutic lesion changes within the area of neuroradiology. However, to date, the majority of research trend and current status have not been clearly illuminated in the neuroradiology field. More than 1000 papers have been published during the past 5 years on subject classification and prediction focused on multiple brain disorders. We provide a survey of 209 papers in this field with a focus on top ten active areas of research; i...
November 29, 2018: Japanese Journal of Radiology
Christian Veauthier, Sophie K Piper, Gunnar Gaede, Thomas Penzel, Friedemann Paul
Background: The first night effect (FNE) is a polysomnography (PSG) habituation effect in the first of several consecutive in-laboratory PSGs (I-PSGs). The FNE is caused by the discomfort provoked by electrodes and cables and the exposure to an unfamiliar environment. A reverse FNE (RFNE) with an improved sleep in the first night is characteristic of insomnia, presumably because the video PSG in the sleep laboratory leads to a decrease in the negatively toned cognitive activity. Therefore, two or more I-PSGs are required for an accurate diagnosis...
2018: Nature and Science of Sleep
Sarah J Donkers, Katherine Chan, Stephan Milosavljevic, Maureen Pakosh, Kristin E Musselman
Initiatives to increase physical activity (PA) are most effective when combined with behavior change strategies (BCS). However, this is not routinely done and perhaps can be attributed to health care professionals' (HCP) lack of confidence and understanding of how to best apply BCS. This review aimed to identify and synthesize the existing literature describing methods used to train HCP to deliver BCS for PA promotion for individuals living with neurological conditions. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
November 29, 2018: Translational Behavioral Medicine
Peter Rieckmann, Matthias Schwab, Dieter Pöhlau, Iris-Katharina Penner, Torsten Wagner, Elke Schel, Antonios Bayas
INTRODUCTION: Patient adherence is a key determinant of treatment success in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates patient self-injection of subcutaneous interferon β-1a (sc IFN β-1a) and allows quantitative measurement of adherence via its automated dosing log. We evaluated patient adherence and patient-reported cognitive and health-economic outcomes over 2 years in patients using RebiSmart® . METHODS: In this non-interventional, single-arm study, enrolled patients were 12-65 years of age, had relapsing-remitting MS or a single demyelinating event, and had been prescribed 44 or 22 μg sc IFN β-1a...
November 28, 2018: Advances in Therapy
Erdinç Dursun, Duygu Gezen-Ak
Alzheimer's disease (AD) is a progressive neurodegenerative disorder seen mostly in the elderly population. While to date AD research has focused on either neurochemical disruptions, genetic studies, or the pathological hallmarks, little has been done to establish a novel approach that would encompass all three aspects, one that would overcome the current barriers in AD research and determine the cause of AD and, eventually, discover a treatment. Meanwhile, there have been strong indications in recent years that vitamin D, a secosteroid hormone, and its receptors are fundamentally involved in neurodegenerative mechanisms...
November 27, 2018: Hormones: International Journal of Endocrinology and Metabolism
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