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https://www.readbyqxmd.com/read/30517695/sleep-and-breathing-disturbances-in-patients-with-chronic-obstructive-pulmonary-disease-traveling-to-altitude-a-randomized-trial
#1
Tsogyal D Latshang, René P M Tardent, Michael Furian, Deborah Flueck, Sebastian D Segitz, Séverine Mueller-Mottet, Malcolm Kohler, Silvia Ulrich, Konrad E Bloch
Study Objectives: Patients with chronic obstructive pulmonary disease (COPD) have impaired pulmonary gas exchange near sea level. The purpose of the current study was to investigate whether exposure to hypobaric hypoxia during a stay at altitude affects nocturnal oxygen saturation, breathing pattern, and sleep in patients with moderate to severe COPD. Methods: Thirty-two patients with COPD, median age 67 years, FEV1 59% predicted, PaO2 68 mmHg, living below 800 m, underwent polysomnography and questionnaire evaluations in Zurich (490 m), and in Swiss Alpine villages at 1650 and 2590 m, for two nights each, in random order...
December 4, 2018: Sleep
https://www.readbyqxmd.com/read/30505377/atrial-fibrillation-and-objective-sleep-quality-by-slow-wave-sleep
#2
Younghoon Kwon, Sneha Gadi, Neil R Shah, Christopher Stout, Jacob N Blackwell, Yeilim Cho, Ryan J Koene, Nishaki Mehta, Sula Mazimba, Andrew E Darby, John D Ferguson, Kenneth C Bilchick
Background: Self-reported poor sleep quality has been suggested in patients with AF. Slow wave sleep (SWS) is considered the most restorative sleep stage and represents an important objective measure of sleep quality. The aim of this study was to compare quantity of SWS between patients with and without AF. Methods and Results: We included patients with and without a documented history of AF by reviewing clinically indicated polysomnography data from a single sleep center...
August 2018: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/30498381/the-first-night-effect-in-multiple-sclerosis-patients-undergoing-home-based-polysomnography
#3
Christian Veauthier, Sophie K Piper, Gunnar Gaede, Thomas Penzel, Friedemann Paul
Background: The first night effect (FNE) is a polysomnography (PSG) habituation effect in the first of several consecutive in-laboratory PSGs (I-PSGs). The FNE is caused by the discomfort provoked by electrodes and cables and the exposure to an unfamiliar environment. A reverse FNE (RFNE) with an improved sleep in the first night is characteristic of insomnia, presumably because the video PSG in the sleep laboratory leads to a decrease in the negatively toned cognitive activity. Therefore, two or more I-PSGs are required for an accurate diagnosis...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/30483046/complexity-of-wake-electroencephalography-correlates-with-slow-wave-activity-after-sleep-onset
#4
Fengzhen Hou, Zhinan Yu, Chung-Kang Peng, Albert Yang, Chunyong Wu, Yan Ma
Sleep electroencephalography (EEG) provides an opportunity to study sleep scientifically, whose chaotic, dynamic, complex, and dissipative nature implies that non-linear approaches could uncover some mechanism of sleep. Based on well-established complexity theories, one hypothesis in sleep medicine is that lower complexity of brain waves at pre-sleep state can facilitate sleep initiation and further improve sleep quality. However, this has never been studied with solid data. In this study, EEG collected from healthy subjects was used to investigate the association between pre-sleep EEG complexity and sleep quality...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30482491/effectiveness-of-a-voice-smoke-alarm-using-the-child-s-name-for-sleeping-children-a-randomized-trial
#5
Gary A Smith, Thitphalak Chounthirath, Mark Splaingard
OBJECTIVES: To test maternal voice alarm effectiveness under residential conditions and determine whether personalizing the maternal voice alarm message with the child's first name improves effectiveness. STUDY DESIGN: Using a randomized, nonblinded, repeated measures design, we compared 3 maternal voice smoke alarms with respect to their ability to awaken 176 children 5-12 years old from stage 4 slow-wave sleep and prompt their performance of an escape procedure...
October 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30476269/heart-rate-variability-rebound-following-exposure-to-persistent-and-repetitive-sleep-restriction
#6
Huan Yang, Monika Haack, Rammy Dang, Shiva Gautam, Norah S Simpson, Janet M Mullington
While it is well established that slow wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during 4 blocks of repetitive sleep restriction and sequential nights of recovery sleep. Twenty-one healthy participants completed the 22-day in-hospital protocol. Following 3 nights of 8h sleep, they were assigned to a repetitive sleep restriction condition...
November 17, 2018: Sleep
https://www.readbyqxmd.com/read/30473798/necessity-of-the-sleep-wake-cycle-for-synaptic-homeostasis-system-level-analysis-of-plasticity-in-the-corticothalamic-system
#7
S Assadzadeh, P A Robinson
Neural field theory is used to study the system-level effects of plasticity in the corticothalamic system, where arousal states are represented parametrically by the connection strengths of the system, among other physiologically based parameters. It is found that the plasticity dynamics have no fixed points or closed cycles in the parameter space of the connection strengths, but parameter subregions exist where flows have opposite signs. Remarkably, these subregions coincide with previously identified regions that correspond to wake and slow-wave sleep, thus demonstrating state dependence of the sign of synaptic modification...
October 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30471995/hypothalamic-neurons-that-regulate-feeding-can-influence-sleep-wake-states-based-on-homeostatic-need
#8
Nitsan Goldstein, Brian J Levine, Kelsey A Loy, William L Duke, Olivia S Meyerson, Adam A Jamnik, Matthew E Carter
Eating and sleeping represent two mutually exclusive behaviors that satisfy distinct homeostatic needs. Because an animal cannot eat and sleep at the same time, brain systems that regulate energy homeostasis are likely to influence sleep/wake behavior. Indeed, previous studies indicate that animals adjust sleep cycles around periods of food need and availability. Furthermore, hormones that affect energy homeostasis also affect sleep/wake states: the orexigenic hormone ghrelin promotes wakefulness, and the anorexigenic hormones leptin and insulin increase the duration of slow-wave sleep...
November 6, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/30469495/the-benefits-of-closed-loop-transcranial-alternating-current-stimulation-on-subjective-sleep-quality
#9
Charles S H Robinson, Natalie B Bryant, Joshua W Maxwell, Aaron P Jones, Bradley Robert, Melanie Lamphere, Angela Combs, Hussein M Al Azzawi, Benjamin C Gibson, Joseph L Sanguinetti, Nicholas A Ketz, Praveen K Pilly, Vincent P Clark
BACKGROUND: Poor sleep quality is a common complaint, affecting over one third of people in the United States. While sleep quality is thought to be related to slow-wave sleep (SWS), there has been little investigation to address whether modulating slow-wave oscillations (SWOs) that characterize SWS could impact sleep quality. Here we examined whether closed-loop transcranial alternating current stimulation (CL-tACS) applied during sleep impacts sleep quality and efficiency. METHODS: CL-tACS was used in 21 participants delivered at the same frequency and in phase with endogenous SWOs during sleep...
November 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/30464744/training-on-an-appetitive-delay-conditioning-task-enhances-oscillatory-waves-during-sleep-in-the-cortical-and-amygdalar-network
#10
Shweta Tripathi, Pankaj Taneja, Sushil K Jha
Oscillating waves during sleep play an essential role in memory consolidation. The cortical slow wave activity (SWA) and sigma waves during NREM sleep and theta waves during REM sleep increase after a variety of memory tasks including declarative, procedural and associative learning tasks. These oscillatory waves during sleep help to promote neural dialog between circuitries, which possibly plays a causal role in memory consolidation. However, the role of sleep-associated oscillating waves in a complex appetitive-conditioning paradigm is not clear...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30462347/intra-cortical-activity-during-avian-non-rem-and-rem-sleep-variant-and-invariant-traits-between-birds-and-mammals
#11
Jacqueline van der Meij, Dolores Martinez-Gonzalez, Gabriël J L Beckers, Niels C Rattenborg
Several mammalian-based theories propose that the varying patterns of neuronal activity occurring in wakefulness and sleep reflect different modes of information processing. Neocortical slow-waves, hippocampal sharp-wave ripples, and thalamocortical spindles occurring during mammalian non-rapid eye-movement (NREM) sleep are proposed to play a role in systems level memory consolidation. Birds show similar NREM and REM (rapid eye-movement) sleep stages to mammals, however, it is unclear whether all neurophysiological rhythms implicated in mammalian memory consolidation are also present...
November 21, 2018: Sleep
https://www.readbyqxmd.com/read/30450286/cognition-in-schizophrenia-improves-with-treatment-of-severe-obstructive-sleep-apnoea-a-pilot-study
#12
Hannah Myles, Nicholas Myles, Ching Li Chai Coetzer, Robert Adams, Madhu Chandratilleke, Dennis Liu, Jeremy Mercer, Andrew Vakulin, Andrew Vincent, Gary Wittert, Cherrie Galletly
Previous studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence...
March 2019: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/30446718/cued-reactivation-during-slow-wave-sleep-induces-brain-connectivity-changes-related-to-memory-stabilization
#13
Ruud M W J Berkers, Matthias Ekman, Eelco V van Dongen, Atsuko Takashima, Markus Barth, Ken A Paller, Guillén Fernández
Memory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be 'replayed' during subsequent slow-wave sleep. Such memory replay is thought to contribute to the functional reorganization of neural memory traces. In particular, memory replay may facilitate the exchange of information across brain regions by inducing a reconfiguration of connectivity across the brain. Memory reactivation can be induced by external cues through a procedure known as "targeted memory reactivation"...
November 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30441041/chaotic-analysis-of-hippocampal-and-cortical-sleep-eeg-during-various-vigilance-states
#14
Prawesh Dahal, Taikang Ning, J Harry Blaise
In this paper, we investigate the hippocampal and cortical sleep EEG of adult rats at different sleep stages by employing Lyapunov exponent and third-order cumulant measures to quantify and compare the chaotic and nonlinear behavior of EEG obtained during vigilance states of quiet- waking, slow-wave sleep, and rapid eye movement (REM) sleep. Lyapunov exponent was computed to characterize the EEG for chaos and third-order cumulant was used to measure the deviations from Gaussianity of the signal. Our results show positive Lyapunov exponents for all EEG states indicating a Iow- dimensional chaos for both REM and non-REM system...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30440557/effect-of-vigilance-changes-on-the-incidence-of-high-frequency-oscillations-in-the-epileptic-brain
#15
Amir F Al-Bakri, Farid Yaghouby, Walter Besio, Lei Ding, Pradeep Modur, Sridhar Sunderam
Recent studies show that the rate of cortical high frequency oscillations (HFOs) differentiates epileptogenic tissue in individuals with epilepsy. However, HFO occurrence can vary widely with vigilance state. In this study we attempt to characterize this variation, which has implications for the choice of a suitable diagnostic baseline for spatiotemporal analysis of HFO activity. We analyzed simultaneous recordings of the scalp electroencephalogram (EEG) and the electrocorticogram (ECoG) to examine the correlation of HFO activity with vigilance state...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30440436/the-neurophysiological-effect-of-acoustic-stimulation-with-real-time-sleep-spindle-detection
#16
Jinyoung Choi, Sangjun Han, Kyungho Won, Sung Chan Jun
Sleep spindle is a salient brain activity found in the sigma frequency range (11-16 Hz) during sleep stage 2. It has been demonstrated that sleep spindle is related to memory consolidation, neurodegenerative disease, and mental disorders. Slow wave activity (0.5-4 Hz) is the most prominent EEG activity during sleep and appears as a large, spontaneous synchronization of cortical neurons. The role of slow wave activity has been proposed to regulate synaptic strength and memory consolidation. Many studies have investigated the effect of acoustic stimuli during the sleep slow wave...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30430534/what-is-the-interest-of-the-electroencephalogram-in-the-syndromic-diagnosis
#17
Ines Kammoun, Héla Mnif, Fatma Kamoun Feki, Kaouthar Masmoudi, Chahnez Triki
INTRODUCTION: The identification of the epileptic syndrome is a challenge particularly in childhood epilepsies. In fact, the diagnosis may need several years to be fulfilled. OBSERVATION: Our patient presented at the age of 3 years 6 months atypical absence. His electroencephalogram (EEG) showed generalized spikes and waves andpolyspikes and waves. At age 6, he has developed other types of seizures: slow fall of the head, shoulders jerks,slow fall to the side and loss of consciousness...
August 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30429612/the-hippocampus-is-crucial-for-forming-non-hippocampal-long-term-memory-during-sleep
#18
Anuck Sawangjit, Carlos N Oyanedel, Niels Niethard, Carolina Salazar, Jan Born, Marion Inostroza
There is a long-standing division in memory research between hippocampus-dependent memory and non-hippocampus-dependent memory, as only the latter can be acquired and retrieved in the absence of normal hippocampal function1,2 . Consolidation of hippocampus-dependent memory, in particular, is strongly supported by sleep3-5 . Here we show that the formation of long-term representations in a rat model of non-hippocampus-dependent memory depends not only on sleep but also on activation of a hippocampus-dependent mechanism during sleep...
November 14, 2018: Nature
https://www.readbyqxmd.com/read/30399547/electrographic-spikes-are-common-in-wildtype-mice
#19
Hannah Purtell, Sameer C Dhamne, Sarika Gurnani, Elizabeth Bainbridge, Meera E Modi, Stephen H T Lammers, Chloe E Super, Mustafa Q Hameed, Ervin L Johnson, Mustafa Sahin, Alexander Rotenberg
High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is known about epileptiform spikes in WT mice. We thus characterize and quantify epileptiform discharges in WT mice for the first time. Thirty-six male WT C57 mice with 24-h wireless telemetry video-EEG recordings were manually scored by blinded reviewers to mark individual spikes and spike trains...
November 3, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30391634/development-of-propagated-discharge-and-behavioral-arrest-in-hippocampal-and-amygdala-kindled-animals
#20
Jabir Mohamed, Brian W Scott, Olivier David, W McIntyre Burnham
Patients with focal temporal lobe seizures often experience transient episodes of impaired awareness with behavioral arrest, but the precise mechanism remains unknown. The Network Inhibition Hypothesis attributes these deficits to a loss of cholinergic input to the cortex. This is presumed to result from increased activation of inhibitory regions that suppress subcortical arousal, giving rise to cortical delta wave activity. Recently, this hypothesis has been tested in animal experiments, where triggering dorsal hippocampal seizures is associated with behavioral arrest...
October 24, 2018: Epilepsy Research
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