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Pancreatitis and nutrition

M Matejcic, F Lesueur, C Biessy, A L Renault, N Mebirouk, S Yammine, P Keski-Rahkonen, K Li, B Hémon, E Weiderpass, V Rebours, M C Boutron-Ruault, F Carbonnel, R Kaaks, V Katzke, T Kuhn, H Boeing, A Trichopoulou, D Palli, C Agnoli, S Panico, R Tumino, C Sacerdote, J R Quirós, E J Duell, M Porta, M J Sánchez, M D Chirlaque, A Barricarte, P Amiano, W Ye, P H Peeters, K T Khaw, A Perez-Cornago, T J Key, H B Bueno-de-Mesquita, E Riboli, P Vineis, I Romieu, M J Gunter, V Chajès
There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from 375 incident pancreatic cancer cases and 375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors...
August 15, 2018: International Journal of Cancer. Journal International du Cancer
Zhouxiang Jin, Zhaohong Wang, Jisheng Wang
GOALS: The aim of this study was to determine a potential strategy to prevent acute pancreatitis (AP) from deteriorating in obese patients. BACKGROUND: Nutritional support plays a critical role in the treatment of AP. Early enteral nutrition (EEN) is considered to be able to protect mucosa of AP patients and alleviate inflammatory reactions. Obesity worsen AP prognosis. However, little is known about the effects of EEN in obese patients. STUDY: Prospective randomized control trial...
August 13, 2018: Journal of Clinical Gastroenterology
Velibor Čabarkapa, Mirjana Djerić, Milena Mitrović, Sunčica Kojić-Damjanov, Ivana Isakov, Bojan Vuković, Djordje Popović
In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determining the correlation of the level of FE-1 with certain anthropometric parameters, certain indicators of metabolic regulation of diabetes, and certain nutritive markers of PED...
February 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Julia B Greer, Phil Greer, Bimaljit S Sandhu, Samer Alkaade, C Mel Wilcox, Michelle A Anderson, Stuart Sherman, Timothy B Gardner, Michele D Lewis, Nalini M Guda, Thiruvengadam Muniraj, Darwin Conwell, Gregory A Cote, Christopher E Forsmark, Peter A Banks, Gong Tang, Kim Stello, Andres Gelrud, Randall E Brand, Adam Slivka, David C Whitcomb, Dhiraj Yadav
BACKGROUND: Chronic pancreatitis (CP) patients frequently experience malabsorption and maldigestion, leading to micronutrient and macronutrient deficiencies. Comorbid diabetes and lifestyle habits, such as alcohol consumption, may impact nutrition status. METHODS: We compared micronutrient antioxidant, bone metabolism, serum protein, and inflammatory marker levels in 301 CP patients and 266 controls with no known pancreatic disease. We analyzed serum prealbumin and retinol binding protein; vitamins A, D, E, and B12; osteocalcin; tumor necrosis factor-α; and C-reactive protein (CRP)...
August 13, 2018: Nutrition in Clinical Practice
Jean-Frederic Colombel, Andrea Shin, Peter R Gibson
DESCRIPTION: The purpose of this clinical practice update review is to describe key principles in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients with inflammatory bowel disease (IBD). METHODS: The evidence and best practices summarized in this manuscript are based on relevant scientific publications, systematic reviews, and expert opinion where applicable. BEST PRACTICE ADVICE 1: A stepwise approach to rule-out ongoing inflammatory activity should be followed in IBD patients with persistent GI symptoms (measurement of fecal calprotectin, endoscopy with biopsy, cross-sectional imaging)...
August 9, 2018: Clinical Gastroenterology and Hepatology
Mitsuru Tashiro, Suguru Yamada, Fuminori Sonohara, Hideki Takami, Masaya Suenaga, Masamichi Hayashi, Yukiko Niwa, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Tsutomu Fujii, Yasuhiro Kodera
BACKGROUND: The association between neoadjuvant therapy (NAT) and nutritional status in pancreatic cancer (PC) is unknown. OBJECTIVE: The aim of this study was to assess the impact of NAT on nutritional status. METHODS: Overall, 161 patients who underwent pancreatoduodenectomy for PC between August 2010 and March 2017 were enrolled and were divided into two groups: the neoadjuvant group (NAG; n = 67) and the control group (CG; n = 94)...
August 10, 2018: Annals of Surgical Oncology
M Brunner, R Grützmann, G F Weber
The majority of patients with ductal pancreatic adenocarcinoma are already in a locally advanced or metastatic stage at the time of diagnosis and require palliative therapy. Interventional and operative measures are available for the restoration of biliary outflow in bile duct obstruction and the continuity of the upper intestinal lumen in duodenal or gastric outlet obstruction. In the presence of tumor-related pain, pain therapy according to the World Health Organization (WHO) scheme or a truncus coeliacus blockade, in cachexia a nutritional therapy and in thromboembolic events an anticoagulant therapy are used...
August 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
U Herbers, C Trautwein, F Tacke, A Koch
Acute pancreatitis is a potentially life-threatening disease, which is morphologically classified into interstitial edematous or necrotizing pancreatitis. According to the revised Atlanta classification, mild, moderate and severe clinical courses are differentiated regarding local and systemic complications as well as concomitant organ failure. In the initial disease phase, the therapeutic measures are focused on (aggressive) volume replacement, early enteral nutrition and adequate analgesia. Characteristic in the course of severe acute pancreatitis are abdominal necroses, which require individualized and interdisciplinary treatment with antibiotic therapy, drainage and definitive necrosectomy...
August 9, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
David Gomez-Pastrana, Chinedu Nwokoro, Mike McLean, Sarah Brown, Nanna Christiansen, Caroline S Pao
INTRODUCTION: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has been shown to improve the nutritional status and lung function of cystic fibrosis patients with the G551D mutation in clinical trials. The objective of this study was to describe the real-world progress of children receiving ivacaftor. METHODS: We describe the real-world progress of four children with cystic fibrosis and the F508del/G551D genotype comparing data during ivacaftor treatment with baseline and with the year before commencing treatment...
August 6, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Jorrit Jv de Vries, Anne B Chang, Catherine M Bonifant, Elizabeth Shevill, Julie M Marchant
BACKGROUND: People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines...
August 9, 2018: Cochrane Database of Systematic Reviews
Trey Richardson, Stella Aslibekyan, Ambika P Ashraf
OBJECTIVE: Severe hypertriglyceridemia (HTG) (i.e., plasma triglycerides [TGs] >1,000 mg/dL) in children is a rare but pernicious and understudied condition. Our objective was to evaluate the etiology, characteristics, and sequelae of severe pediatric HTG. METHODS: This was a retrospective electronic medical record review of pediatric patients with severe HTG at a tertiary referral Children's hospital over a 17-year period. RESULTS: There were a total of 124 patients with severe HTG...
August 7, 2018: Endocrine Practice
Christopher S King, A Whitney Brown, Shambhu Aryal, Kareem Ahmad, Scott Donaldson
Cystic fibrosis (CF) is a multi-organ, genetic disease resulting from dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR). The primary clinical manifestations are bronchiectasis, chronic pulmonary infections with recurrent exacerbations, and pancreatic insufficiency. Advances in CF care have led to improved survival with over half of those affected being adults. As a result, adult pulmonary and critical care physicians will increasingly be involved in the care of these patients. Patients with CF are at risk for numerous conditions that require intensive care unit admission including respiratory failure, massive hemoptysis, pneumothorax, hepatic failure, and bowel obstruction...
August 2, 2018: Chest
Eileen Viviana Fonseca Sepúlveda, Rafael Guerrero-Lozano
OBJECTIVE: To describe the epidemiology and clinical features of acute pancreatitis and recurrent acute pancreatitis in children. METHODS: Observational and retrospective study with an analytical component. Patients were classified into two groups: Acute pancreatitis and recurrent pancreatitis. The relationship with each parameter obtained was analyzed using the chi-squared test, Student's t-test, or the Mann-Whitney U test. RESULTS: There were 130 patients with acute pancreatitis; recurrent pancreatitis was diagnosed in 23...
July 31, 2018: Jornal de Pediatria
Steven D Freedman, Colby Wyatt, John Stevens, Dhiren Patel, Robert Gallotto, Danica Grujic, Perry Brown
OBJECTIVES: Pancreatic insufficiency (PI) and malabsorption of fats lead to reduced caloric intake, inability to maintain weight, and increased gastrointestinal symptoms. Thus, Enteral Nutrition (EN) is used in patients with cystic fibrosis (CF) and poor nutritional status. The current study evaluated safety, tolerability and improvement of fatty acid (FA) status in Red Blood Cell (RBC) membranes, a marker of long term FA absorption, with an in-line digestive cartridge (RELiZORB) that hydrolyzes fat in enteral formula...
August 1, 2018: Journal of Pediatric Gastroenterology and Nutrition
L Amas Gómez, F Zubia Olaskoaga
OBJECTIVE: To determine whether the implementation of a protocol for the management of patients with acute pancreatitis (AP) in an Intensive Care Unit (ICU) improves the clinical outcomes. DESIGN: A retrospective, before-after observational case series study was carried out. STUDY PERIOD: 1 January 2001 to 31 December 2016, divided in 2 periods (pre-protocol 2001-2007, post-protocol 2008-2016). SCOPE: An ICU with 48 beds and a recruitment population of 700,000 inhabitants...
July 30, 2018: Medicina Intensiva
A D Hintaran, M N Chenault, B P M Verhaegh, P L M Reijven, A A M Masclee, Y C A Keulemans
INTRODUCTION: Chronic pancreatitis (CP) is a progressive inflammatory disorder causing irreversible destruction of pancreatic tissue, leading to malnutrition. A previous study has found that currently used screening methods (periodic recording of body weight and faecal and serological markers) fall short in identifying and curbing malnutrition. Moreover, data is lacking regarding change in nutritional status over time. The aim of our study is to investigate changes in nutritional status in CP patients over time and to determine whether a more extensive set of measurements would be beneficial for nutritional screening of these patients...
August 30, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Norifumi Harimoto, Hiroki Hoshino, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichirou Araki, Ken Shirabe
BACKGROUND/AIM: Recently, skeletal muscle quality was important in patients with malignant tumors to predict the surgical outcome. The relationship between postoperative complications of Clavien-Dindo grade III or more and prognosis in patients who have undergone hepatic resection for hepatic malignancies were investigated. PATIENTS AND METHODS: Patient data were retrospectively collected for 146 consecutive patients who underwent curative hepatic resection in the Department of Hepatobiliary and Pancreatic Surgery, Gunma University, Japan, for hepatic malignancy...
August 2018: Anticancer Research
Stephanie Young, Michael L Sung, Jennifer A Lee, Louis A DiFronzo, Victoria V O'Connor
BACKGROUND: In a single trial, perioperative pasireotide demonstrated reduction in postoperative pancreatic fistula (POPF) following pancreatectomy, yet recent studies question the efficacy of this drug. METHODS: All patients who underwent pancreatic resection between January 2014 and August 2017 at a single institution were prospectively followed. Starting in February 2016, pasireotide was administered to all pancreatectomies. Pancreaticoduodenectomy (PD) patients were additionally risk-stratified using a validated clinical risk score...
July 28, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Pierre-Yves Boelle, Dominique Debray, Loic Guillot, Annick Clement, Harriet Corvol
Cystic fibrosis (CF)-related liver disease (CFLD) is a common symptom in patients with CF. However, its prevalence, risk factors, and evolution are unclear. We analyzed a large database of patients with CF to investigate the incidence of CFLD, its related risk factors, and the use and effect of ursodeoxycholic acid (UDCA) treatment. We retrospectively analyzed 3,328 CF patients with pancreatic insufficiency born after 1985 and recruited into the French CF Modifier Gene Study since 2004. We determined liver status, age at CFLD and severe CFLD onset, sex, CFTR genotype, history of meconium ileus, treatment with UDCA, and respiratory and nutritional status...
July 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Kateřina Vaňková, Ivana Marková, Jana Jašprová, Aleš Dvořák, Iva Subhanová, Jaroslav Zelenka, Iva Novosádová, Jan Rasl, Tomáš Vomastek, Roman Sobotka, Lucie Muchová, Libor Vítek
Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment with antioxidant activity) are among those molecules which are purportedly responsible for these effects. Therefore, the aim of our study was to assess both the antiproliferative and antioxidative effects of chlorophylls (chlorophyll a / b , chlorophyllin, and pheophytin a ) in experimental pancreatic cancer...
2018: Oxidative Medicine and Cellular Longevity
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