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Pancreatitis and nutrition

María D Ballesteros Pomar, Elena González Arnaiz
Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. The absence of enteral stimulation affects both epithelial and GALT and the development of the microbiota. This situation modifies the immune system´s interaction, with a less competitive exclusion of more pathogenic bacteria, which can promote infections...
April 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
María D Ballesteros Pomar, Elena González Arnaiz
Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. The absence of enteral stimulation affects both epithelial and GALT and the development of the microbiota. This situation modifies the immune system´s interaction, with a less competitive exclusion of more pathogenic bacteria, which can promote infections...
April 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Fichtl Jakub, Skalický Tomáš, Vodička Josef, Třeška Vladislav, Tupý Radek, Hes Ondřej
INTRODUCTION: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively rare affliction representing less than 4% of cystic PC. Although the tumor is considered benign, metastasis, especially to the spleen, has been reported in approximately 0.5-4% patients. Despite R0 resection, vascular and perineural invasion is monitored in 20% of cases...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Amy Li, Rupen Shah, Xiaoxia Han, Akshay Sood, Christopher Steffes, David Kwon
BACKGROUND: It is unclear whether placement of operative enteral access (OEA) during pancreaticoduodenectomy (PD) correlates with decreased morbidity. METHODS: A retrospective chart review of patients undergoing PD with and without OEA placement between January 2016 and May 2018 was undertaken. Outcomes included length of stay (LOS), 30- and 90-day readmission, initiation of total parenteral nutrition (TPN), postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), and surgical site infection (SSI)...
November 28, 2018: American Journal of Surgery
Magda Gasull, José Pumarega, Hannu Kiviranta, Panu Rantakokko, Ole Raaschou-Nielsen, Ingvar A Bergdahl, Torkjel Manning Sandanger, Fernando Goñi, Lluís Cirera, Carolina Donat-Vargas, Juan Alguacil, Mar Iglesias, Anne Tjønneland, Kim Overvad, Francesca Romana Mancini, Marie-Christine Boutron-Ruault, Gianluca Severi, Theron Johnson, Tilman Kühn, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Domenico Palli, Valeria Pala, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Monique Verschuren, Roel Vermeulen, Charlotta Rylander, Therese Haugdahl Nøst, Miguel Rodríguez-Barranco, Amaia Molinuevo, María-Dolores Chirlaque, Eva Ardanaz, Malin Sund, Tim Key, Weimin Ye, Mazda Jenab, Dominique Michaud, Giuseppe Matullo, Federico Canzian, Rudolf Kaaks, Alexandra Nieters, Ute Nöthlings, Suzanne Jeurnink, Veronique Chajes, Marco Matejcic, Marc Gunter, Dagfinn Aune, Elio Riboli, Antoni Agudo, Carlos Alberto Gonzalez, Elisabete Weiderpass, Bas Bueno-de-Mesquita, Eric J Duell, Paolo Vineis, Miquel Porta
BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk...
November 23, 2018: Environmental Research
Pamela Vernocchi, Federica Del Chierico, Alessandra Russo, Fabio Majo, Martina Rossitto, Mariacristina Valerio, Luca Casadei, Antonietta La Storia, Francesca De Filippis, Cristiano Rizzo, Cesare Manetti, Paola Paci, Danilo Ercolini, Federico Marini, Ersilia Vita Fiscarelli, Bruno Dallapiccola, Vincenzina Lucidi, Alfredo Miccheli, Lorenza Putignani
BACKGROUND: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. OBJECTIVES: The aim of this study was to provide a predictive and functional model of the gut microbiota enterophenotype of pediatric patients affected by CF under clinical stability...
2018: PloS One
Nyanza K L M Timmers, Rebecca K Stellato, Cornelis K van der Ent, Roderick H J Houwen, Janna W Woestenenk
Pancreatic-insufficient children with cystic fibrosis (CF) receive age-group-specific vitamin D supplementation according to international CF nutritional guidelines. The potential advantageous immunomodulatory effect of serum 25-hydroxy vitamin D (25(OH)D) on pulmonary function (PF) is yet to be established and is complicated by CF-related vitamin D malabsorption. We aimed to assess whether current recommendations are optimal for preventing deficiencies and whether higher serum 25(OH)D levels have long-term beneficial effects on PF...
November 16, 2018: British Journal of Nutrition
Beatriz T Meneguetti, Marlon H Cardoso, Camila F Acosta Ribeiro, Mário R Felício, Ingrid B Pinto, Nuno C Santos, Cristiano Marcelo E Carvalho, Octávio L Franco
Obesity is a chronic multifactorial disease, characterized by an excessive accumulation of adipose tissue. It is usually the result of excessive food intake and/or low energy expenditure. Obesity can be triggered by lifestyle, nutritional, genetic, environmental, hormonal and psychological factors. Several strategies are used to treat obesity, including dietary reeducation, with balanced food intake, increased physical exercise, in order to promote energy expenditure and to overcome the insufficiency in weight reduction by other strategies, and the administration of drugs to treat obesity...
November 12, 2018: Pharmacology & Therapeutics
Sreenivasan Paruthiyil, Shin-Ichiro Hagiwara, Keshav Kundassery, Aditi Bhargava
BACKGROUND: Chronic stress is a major contributor in the development of metabolic syndrome and associated diseases, such as diabetes. High-fat diet (HFD) and sex are known modifiers of metabolic parameters. Peptide hormones corticotropin-releasing factor (CRF) and urocortins (UCN) mediate stress responses via activation and feedback to the hypothalamic-pituitary-adrenal (HPA) axis. UCN3 is a marker of pancreatic β-cell differentiation, and UCN2 is known to ameliorate glucose levels in mice rendered diabetic with HFD...
November 6, 2018: Biology of Sex Differences
Benjamin Myles Shandro, Rani Nagarajah, Andrew Poullis
Pancreatic exocrine insufficiency (PEI) occurs when the insufficient secretion or function of pancreatic enzymes leads to maldigestion, most commonly as a result of chronic pancreatitis and pancreatic cancer. The condition is associated with significant morbidity and reductions in quality of life, even in milder forms. The challenges in approaching this condition include the non-specific presentation of mild to moderate PEI, and the lack of a convenient, accurate diagnostic test in this cohort. Classical symptoms appear late in the disease, and the diagnosis should be considered before steatorrhoea develops...
October 25, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
Meera Kotagal, Joyce Slusher, Syed Ahmad, Lori A Aronson, John Brunner, Ranjit Chima, Deborah A Elder, Kenneth R Goldschneider, Lindsey Hornung, Tom K Lin, Stephen M Ogg, Joseph J Palermo, Kristin Rich, John Rose, Stephen Sekoulopoulos, Alexandra Szabova, Maisam Abu-El-Haija, Jaimie D Nathan
Total pancreatectomy with islet autotransplantation (TPIAT) is utilized to treat debilitating chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP) that has failed medical and endoscopic therapy. Retrospective review of TPIAT patients at a free-standing children's hospital was performed to evaluate perioperative outcomes. Twenty patients [median age 13; 65% female] underwent TPIAT (2015-2017). 95% had CP; 1 patient (5%) had ARP alone. Seventy-five percent had a pancreatitis-associated genetic mutation; 40% had pancreas divisum...
October 29, 2018: American Journal of Transplantation
Lv-Hui Sun, Jia-Qiang Huang, Jiang Deng, Xin Gen Lei
Selenium (Se) is an essential nutrient for humans and all food-producing animal species. Nutritional deficiencies of Se and (or) vitamin E induce exudative diathesis, nutritional pancreatic atrophy, and nutritional muscular dystrophy in chicks. Although these diseases are presumably associated with the need of Se for the synthesis of the 21st amino acid, selenocysteine (Sec, U) in selenoproteins, metabolic functions of the 25 selenoproteins identified in avian species remain largely unknown. This paper reviews regulations of the whole selenogenome and selected selenoproteins by different concentrations and chemical forms of dietary Se and (or) vitamin E in various affected tissues...
October 27, 2018: Poultry Science
Carolina Castro, Ana Couto, Alexandre F Diógenes, Geneviève Corraze, Stéphane Panserat, Cláudia R Serra, Aires Oliva-Teles
For an increased incorporation of plant ingredients in aquafeeds at the expense of fish meal (FM) and fish oil (FO), more knowledge is needed on the effects at the intestine level of dietary vegetable oils (VO) and carbohydrates (CH), and of possible interactions. For that purpose, in this study, the activities of digestive pancreatic enzymes (amylase, lipase, total alkaline proteases), gut microbiota, and histomorphology were assessed in gilthead sea bream (IBW 71.0 ± 1.5 g) fed four diets differing in lipid source (FO or a blend of VO) and carbohydrate content (0% or 20% gelatinized starch) for 81 days...
October 26, 2018: Fish Physiology and Biochemistry
Michal Shteinberg, Adi Ben Lulu, Damian G Downey, Zeev Blumenfeld, Christine Rousset-Jablonski, Marie Perceval, Alessandra Colombo, Nili Stein, Galit Livnat, Michal Gur, Lea Bentur, Huda Mussaffi, Hannah Blau, Ifat Sarouk, Adi Dagan, Eitan Kerem, Micha Aviram, Elie Picard, Stefano Aliberti, Antonio Álvarez, Javier Perez Miranda, Eva Polverino, Isabelle Durieu, J Stuart Elborn, Malena Cohen-Cymberknoh
OBJECTIVE: The causes of subfertility in women with CF though multifactorial are not well described. Our aim in this study was to determine the prevalence and factors associated with female subfertility among women with CF. METHODS: A retrospective multinational study from 11 CF centers in 5 countries (Israel, France, Spain, Italy, UK) including women with CF was undertaken. Sub/infertility was defined as not achieving a spontaneous pregnancy after one year of unprotected sexual intercourse...
October 23, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Harleen Kaur, Premkumar Nattanamai, Kathryn E Qualls
Hypertriglyceridemia and related pancreatitis due to the use of lipid emulsions such as propofol has been documented, but less is known about the additive adverse effects of propofol and clevidipine lipid emulsions in the literature. We report an unusual case, highlighting the trend of serum triglyceride and pancreatic enzymes (amylase/lipase) with the administration of propofol and clevidipine for a prolonged period in the neurocritical care setting. We present a case of a 27-year-old male who was admitted to the neuroscience intensive care unit (NSICU) for management of severe subarachnoid hemorrhage (SAH) with six-millimeter (mm) midline shift to the left from the rupture of anterior communicating artery aneurysm...
August 20, 2018: Curēus
Syuhei Kushiyama, Katsunobu Sakurai, Naoshi Kubo, Yutaka Tamamori, Takafumi Nishii, Akiko Tachimori, Toru Inoue, Kiyoshi Maeda
BACKGROUND/AIM: The relationship between the preoperative Geriatric Nutritional Risk Index (GNRI) and morbidity of patients with gastric cancer (GC) undergoing gastrectomy has not yet been reported. Our study aimed to investigate whether preoperative GNRI is associated with short-term outcomes in elderly patients with GC. PATIENTS AND METHODS: This study enrolled 348 elderly patients with GC who were more than 75 years old and underwent curative gastrectomy for GC at our Institution between January 2006 and December 2015...
November 2018: In Vivo
Ana Luiza Melo Dos Santos, Helen de Melo Santos, Marina Bettiol Nogueira, Hugo Tadashi Oshiro Távora, Maria de Lourdes Jaborandy Paim da Cunha, Renata Belém Pessoa de Melo Seixas, Luciana de Freitas Velloso Monte, Elisa de Carvalho
Purpose: The objective of this study was to describe the clinical phenotypes of children and adolescents with cystic fibrosis (CF); and to assess the role of pancreatic insufficiency and neonatal screening in diagnosis. Methods: A cross-sectional study was conducted, which included 77 patients attending a reference center of CF between 2014 and 2016. Epidemiological data, anthropometric measurements, and the presence of pulmonary, pancreatic, gastrointestinal and hepatobiliary manifestations were evaluated based on clinical data and complementary examinations...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Faraz Shafiq, Muhammad Faisal Khan, Muhammad Ali Asghar, Faisal Shamim, Muhammad Sohaib
Background and Objective: Acute pancreatitis (AP) is an inflammatory disease. Patients presenting with severe disease may require intensive care unit (ICU) admission. Factors predicting mortality and morbidity need to be identified for improving outcome. The objective of this study was to see the outcome of these patient presented to single center over a period of ten years. The secondary objective was to identify the factors responsible for adverse outcome. Methods: The medical records of adult patients from year 2006 to 2016 requiring ICU admission for AP were reviewed retrospectively...
September 2018: Pakistan Journal of Medical Sciences Quarterly
J Enrique Dominguez-Munoz, Asbjørn M Drewes, Björn Lindkvist, Nils Ewald, László Czakó, Jonas Rosendahl, J Matthias Löhr
BACKGROUND: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. METHODS: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system...
October 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
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