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https://www.readbyqxmd.com/read/29145789/helicobacter-pylori-controls-nlrp3-expression-by-regulating-hsa-mir-223-3p-and-il-10-in-cultured-and-primary-human-immune-cells
#1
Suneesh Kumar Pachathundikandi, Steffen Backert
Inflammasome-mediated production of mature IL-1β and IL-18 cytokines represents an important innate immune response against infecting pathogens. Helicobacter pylori, one of the most successful and persistent human pathogens, induces severe inflammation leading to gastritis and more serious gastric diseases. H. pylori modulates different immune responses for its survival and inflammasome signaling is manipulated by the cag pathogenicity island ( cagPAI), urease and VacA cytotoxin. Here we report that H. pylori regulates NLRP3 expression, an inflammasome forming regulator, in infected THP-1 monocytes...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/29138921/world-trends-for-h-pylori-eradication-therapy-and-gastric-cancer-prevention-strategy-by-h-pylori-test-and-treat
#2
REVIEW
Hidekazu Suzuki, Hideki Mori
Helicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies.
November 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29138645/chinese-classical-formula-sijunzi-decoction-and-chronic-atrophic-gastritis-evidence-for-treatment-approach
#3
REVIEW
Danan Gan, Aili Xu, Hongbo Du, Yong'an Ye
Objective: This aim is to evaluate the effect of Sijunzi decoction (SJZD) treating chronic atrophic gastritis (CAG). Methods: We performed searches in seven databases. The randomized controlled trials (RCTs) comparing SJZD with standard medical care or inactive intervention for CAG were enrolled. Combined therapy of SJZD plus conventional therapies compared with conventional therapies alone was also retrieved. The primary outcome included the incidence of gastric cancer and the improvement of atrophy, intestinal metaplasia, and dysplasia based on the gastroscopy and pathology...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29138101/primary-antibiotic-resistance-of-helicobacter-pylori-in-chinese-patients-a-multi-region-prospective-7-year-study
#4
Dong-Sheng Liu, You-Hua Wang, Zhi-Rong Zeng, Zhen-Yu Zhang, Hong Lu, Jian-Ming Xu, Yi-Qi Du, Yan Li, Jiang-Bin Wang, San-Ping Xu, Ye Chen, Chun-Hui Lan, Hong Cheng, Ming-de Jiang, Ling-Xia Zhang, Li-Juan Huo, Shi-Yao Chen, Guo-Xin Zhang, Kai-Chun Wu, Xuan Zhu, You-Xiang Chen, Yin Zhu, Xu Shu, Yong Xie, Nong-Hua Lu
OBJECTIVES: To explore the characteristics of H. pylori resistance in China and the association between antibiotic resistance and several clinical factors. METHODS: H. pylori strains were collected from patients in 13 provinces/cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Epsilometer test and the Kirby-Bauer disk diffusion method...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29133389/selective-killing-of-helicobacter-pylori-with-ph-responsive-helix-coil-conformation-transitionable-antimicrobial-polypeptides
#5
Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M Peek, Lichen Yin, Lin-Feng Chen, Jianjun Cheng
Current clinical treatment of Helicobacter pylori infection, the main etiological factor in the development of gastritis, gastric ulcers, and gastric carcinoma, requires a combination of at least two antibiotics and one proton pump inhibitor. However, such triple therapy suffers from progressively decreased therapeutic efficacy due to the drug resistance and undesired killing of the commensal bacteria due to poor selectivity. Here, we report the development of antimicrobial polypeptide-based monotherapy, which can specifically kill H...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29132476/helicobacter-pyloriassociation-with-expression-of-cdx2-in-intestinal-metaplasia
#6
Tayyab Hamid Malik, WangYu, XuHong
OBJECTIVE: To assess whether helicobacter pylori was associated with CDX2 expression in intestinal metaplasia, atrophic gastritis, dysplasia and gastric cancer. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Department of Pathology, The First Hospital of Jilin University, Changchun, China, from August 2016 to January 2017. METHODOLOGY: CDX2 expression was evaluated in 62 gastric antral biopsies; including 32 cases of intestinal metaplasia (IM) and 10 cases each of atrophic gastritis (AG), dysplasia and gastric cancer...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29130516/microrna-329-inhibits-cell-proliferation-and-tumor-growth-while-facilitates-apoptosis-via-negative-regulation-of-kdm1a-in-gastric-cancer
#7
Lisheng Cai, Qiuxian Chen, Shunyong Fang, Mingqiao Lian, Mingzhi Cai
OBJECTIVE: Altered expression of microRNA (miRNA) is strongly implicated in gastric cancer (GC). Here, we demonstrated a decreased expression of miRNA-329 in GC. Then we explored the regulatory mechanisms responsible for its effect on GC cells. METHODS: GC tissues and their adjacent non-tumor tissues were collected. Complete follow-up was updated. A series of inhibitors, mimics, and siRNA against KDM1A were introduced to validate regulatory mechanisms for miR-497 and KDM1A in BGC-823 cells...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29127549/preservation-of-the-celiac-branch-of-the-vagal-nerve-for-pylorus-preserving-gastrectomy-is-it-meaningful
#8
Haruna Furukawa, Manabu Ohashi, Michitaka Honda, Koshi Kumagai, Souya Nunobe, Takeshi Sano, Naoki Hiki
BACKGROUND: Preserving the hepatic and pyloric branches of the vagal nerve in laparoscopic pylorus-preserving gastrectomy (LPPG) is considered necessary to maintain the function of the pyloric cuff. However, the clinical benefits of preservation of the celiac branch of the vagal nerve (CBVN) remain unclear. METHODS: Of 391 patients who underwent LPPG for early gastric cancer, 116 patients in whom the CBVN was preserved (CBP group) and 58 patients in whom it was not preserved (non-CBP group) were selected through the propensity score-matching method...
November 10, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29121583/a-case-report-of-gastric-lymphocytic-phlebitis-a-rare-mimic-for-malignancy
#9
Daniel L Chan, Praveen Ravindran, Dorothy Chua, Jason D Smith, King S Wong, Michael A Ghusn
INTRODUCTION: Lymphocytic phlebitis is a benign condition characterised by inflammation of the veins and rarely affects the gastrointestinal tract. Reported cases present as acute abdomen and involve the colon or small intestine. We report the fourth case of gastric lymphocytic phlebitis in the literature. PRESENTATION OF CASE: A 74-year-old female presented with eight weeks of abdominal pain. Findings at endoscopy were suggestive of a malignant ulcer on the greater curvature of antrum, while biopsies showed chronic gastritis without malignancy...
November 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29118872/demographic-endoscopic-and-histopathologic-features-among-stool-h-pylori-positive-and-stool-h-pylori-negative-patients-with-dyspepsia
#10
Mohamed Hassan Emara, Rasha Ibrahim Salama, Amira Amin Salem
Background: Dyspepsia is a common presentation for many patients in gastroenterology clinics. Helicobacter pylori (H. pylori) infection is endemic in many countries around the world and its relation to dyspepsia has long been questioned. This study aimed at comparing demographic, endoscopic and histologic features among dyspeptic patients with and without stool H. pylori antigen positivity. Methods: One hundred and fifty-one consecutive patients with dyspepsia were divided into group I (n = 80) and group II (n = 71) according to positive or negative H...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29113260/expression-of-c-met-and-hepatocyte-growth-factor-in-various-gastric-pathologies-and-its-association-with-helicobacter-pylori-infection
#11
Chuan Xie, Zhen Yang, Yi Hu, Ximei Cao, Jiang Chen, Yin Zhu, Nonghua Lu
Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori-negative and -positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES-1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co-culture with H...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112667/pica-in-pregnancy-an-unusual-presentation
#12
Katharine E Epler, Arand Pierce, Valerie J Rappaport
BACKGROUND: Pica is common in pregnancy and is often felt to be benign. The following case of severe pica presenting without anemia is unusual in its presentation, laboratory findings, and treatment. CASE: A 31-year-old multiparous woman at 37 0/7 weeks of gestation presented with esophagitis and gastritis secondary to laundry detergent consumption. She had borderline anemia (hemoglobin of 11 g/dL and hematocrit of 37%, mean corpuscular volume 80%) but was severely iron-deficient (serum ferritin 7 micrograms/dL)...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29110387/cholesterol-%C3%AE-glucosyltransferase-gene-is-present-in-most-helicobacter-species-including-gastric-non-helicobacter-pylori-helicobacters-obtained-from-japanese-patients
#13
Masatomo Kawakubo, Kazuki Horiuchi, Takehisa Matsumoto, Jun Nakayama, Taiji Akamatsu, Tsutomu Katsuyama, Hiroyoshi Ota, Junji Sagara
BACKGROUND: Non-Helicobacter pylori helicobacters (NHPHs) besides H. pylori infect human stomachs and cause chronic gastritis and mucosa-associated lymphoid tissue lymphoma. Cholesteryl-α-glucosides have been identified as unique glycolipids present in H. pylori and some Helicobacter species. Cholesterol-α-glucosyltransferase (αCgT), a key enzyme for the biosynthesis of cholesteryl-α-glucosides, plays crucial roles in the pathogenicity of H. pylori. Therefore, it is important to examine αCgTs of NHPHs...
November 7, 2017: Helicobacter
https://www.readbyqxmd.com/read/29108982/eosinophilic-gastritis-with-involvement-of-esophageal-gastric-inlet-patch
#14
David G Forcione, Gregory Y Lauwers, John J Garber
No abstract text is available yet for this article.
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29108235/regulation-of-sirt3-signal-related-metabolic-reprogramming-in-gastric-cancer-by-helicobacter-pylori-oncoprotein-caga
#15
Do Yeon Lee, Dawoon E Jung, Sung Sook Yu, Yeo Song Lee, Beom Ku Choi, Yong Chan Lee
Injection of the Helicobacter pylori cytotoxin-associated gene A (CagA) is closely associated with the development of chronic gastritis and gastric cancer. Individuals infected with H. pylori possessing the CagA protein produce more reactive oxygen species (ROS) and show an increased risk of developing gastric cancer. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases and mitochondrial SIRT3 is known to be a tumor suppressor via its ability to suppress ROS and hypoxia inducible factor 1α (HIF-1α)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107979/helicobacter-pylori-bab-characterization-in-clinical-isolates-from-bhutan-myanmar-nepal-and-bangladesh
#16
Shamshul Ansari, Evariste Tshibangu Kabamba, Pradeep Krishna Shrestha, Hafeza Aftab, Thein Myint, Lotay Tshering, Rabi Prakash Sharma, Nwe Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Thawee Ratanachu-Ek, Ratha-Korn Vilaichone, Varocha Mahachai, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka
BACKGROUND: Helicobacter pylori BabA is an important outer membrane protein that involves in the attachment to the gastric mucosa and enhances the virulence property of the bacterium. This study was aimed to characterize the bab genotypes, to evaluate its association with cagA, vacA and clinical diseases as well as degree of gastric inflammation. METHODS: H. pylori isolates from four countries were subjected for the characterization of bab. The locus specific forward and bab specific reverse primers were used to get the specific products by PCR, which could distinguish the three locus (A, B and C)...
2017: PloS One
https://www.readbyqxmd.com/read/29105139/editorial-the-non-invasive-diagnosis-of-atrophic-gastritis
#17
EDITORIAL
P Malfertheiner
No abstract text is available yet for this article.
December 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29103763/occurrence-of-metachronous-or-synchronous-lesions-after-endoscopic-treatment-of-gastric-epithelia-dysplasia-impact-of-histologic-features-of-background-mucosa
#18
Won-Young Park, So-Jeong Lee, Young-Keum Kim, Ahrong Kim, Do Youn Park, Bong-Eun Lee, Geun-Am Song, Gwang Ha Kim
AIMS: Endoscopic resection is a safe and effective method to treat gastric epithelia dysplasia (GED). However, the development of metachronous and synchronous lesions after treatment has become a major concern. In this study, we investigated clinicopathologic features of 105 GED lesions from endoscopic resections between January 2008 and December 2009. Our goal is to find histologic factors that predict synchronous and metachronous lesions after ESD treatment. We assessed the degree of intestinal metaplasia (IM) and atrophy, type of IM, presence of gastritis cystica profunda, and crypt dysplasia in the adjacent mucosa...
October 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29103535/practical-approach-to-the-flattened-duodenal-biopsy
#19
REVIEW
Thomas C Smyrk
Celiac disease features duodenal intraepithelial lymphocytosis with or without villous atrophy. Lymphocytosis without villous atrophy will be proven to represent celiac disease in 10% to 20% of cases. The differential diagnosis is broad: Helicobacter pylori gastritis, NSAID injury and bacterial overgrowth are considerations. Lymphocytosis with villous atrophy is very likely to be celiac disease, but there are mimics to consider, including collagenous sprue, tropical sprue, drug injury, and common variable immunodeficiency...
December 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29103534/patterns-of-gastric-injury-beyond-helicobacter-pylori
#20
REVIEW
Won-Tak Choi, Gregory Y Lauwers
Gastric biopsies are routinely obtained from patients with symptoms related to the gastrointestinal tract and, as a result, a variety of histologic changes are observed in patients with or without endoscopic evidence of mucosal injury. Although Helicobacter pylori-related gastritis is still common, several other patterns of mucosal injury are increasingly encountered. These patterns of injury are classified based on the nature and distribution of inflammation, location of epithelial cell injury, presence of crystal or pigment deposition, and/or other unique features...
December 2017: Surgical Pathology Clinics
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