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Yoon Soo Hah, Kwang Suk Lee, In Young Choi, Ji Youl Lee, Jun Hyuk Hong, Choung-Soo Kim, Hyun Moo Lee, Sung Kyu Hong, Seok-Soo Byun, Seung Hwan Lee, Koon Ho Rha, Byung Ha Chung, Kyo Chul Koo
A multicenter Korean Prostate Cancer Database (K-CaP) has been established to provide information regarding Korean patients with prostate cancer (PCa). We used the K-CaP registry to investigate the value of age and comorbidity for predicting cancer-specific mortality (CSM) and other-cause mortality (OCM) according to risk grouping.The K-CaP registry includes 2253 patients who underwent radical prostatectomy (RP) between May 2001 and April 2013 at 5 institutions. Preoperative clinicopathologic data were collected and stratified according to the National Comprehensive Cancer Network risk criteria...
October 2018: Medicine (Baltimore)
Elio Mazzone, Marco Bandini, Felix Preisser, Sebastiano Nazzani, Zhe Tian, Firas Abdollah, Denis Soulieres, Markus Graefen, Francesco Montorsi, Shahrokh Shariat, Fred Saad, Alberto Briganti, Pierre Karakiewicz
INTRODUCTION: Local therapy (LT) may offer a survival advantage in highly select newly diagnosed metastatic prostate cancer (mPCa) patients. However, it is unknown whether the benefits vary according to Caucasian vs. African American (AA) patients. METHODS: Within the Surveillance Epidemiology and End Results database (2004-2014), we focused on Caucasians and AA patients with newly diagnosed mPCa treated with LT: radical prostatectomy (RP) and brachytherapy (RT)...
October 15, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Michael Xiang, F Christopher Holsinger, A Dimitrios Colevas, Michelle M Chen, Quynh-Thu Le, Beth M Beadle
BACKGROUND: Cisplatin and cetuximab are both systemic therapies commonly used in combination with radiation (RT) for the definitive treatment of head and neck cancers, but their comparative efficacy is unclear. METHODS: Patients with locoregionally advanced (American Joint Committee on Cancer stage III-IVB) squamous cell carcinomas of the oropharynx, larynx, or hypopharynx were identified in the Surveillance, Epidemiology, and End Results-Medicare database. Patients received either cisplatin or cetuximab concurrent with RT, as determined by Medicare claims...
October 17, 2018: Cancer
D Subirá-Ríos, F Herranz-Amo, M Moralejo-Gárate, J Caño-Velasco, T Renedo-Villar, G Barbas-Bernardos, G Bueno-Chomón, E Rodríguez-Fernández, C Hernández-Fernández
INTRODUCTION AND AIM: The main aim of the study was to establish the oncological safety of the laparoscopic approach to radical cystectomy for high-risk, non-organ-confined urothelial tumours. MATERIAL AND METHODS: A retrospective cohort study of 216 stage pT3-4 cystectomies operated between 2003 and 2016; using an open approach (ORC, n=108), and using a laparoscopic approach (LRC, n=108). RESULTS: Both groups have similar pathological features except, in G3 TUR, there were more lyphadenectomies and greater pN+, and more adjuvant chemotherapies using the LRC...
October 13, 2018: Actas Urologicas Españolas
Yu Wang, Wangfei Wang, Minyu Zhu, Jing Wang, Yang Zhou, Kelun Huang, Jianhong Wang, Honglin Teng
OBJECTIVE: To investigate the clinical characteristics and surgical outcomes of patients with cervical spondylotic myelopathy (CSM) and prior cerebral infarction (CI); to identify whether "prior CI" correlates with poor surgical outcomes. PATIENTS AND METHODS: Twenty-two patients with CSM and prior CI were retrospectively reviewed and included as the CI group while 100 CSM patients without CI were included as the control group (matched for gender, age, symptom duration and surgical approach)...
September 24, 2018: Clinical Neurology and Neurosurgery
Stephen L Brown, Juliet Bell, Richard J Shaw
OBJECTIVE: Greater time that patients take to present symptoms to health care providers (HCPs) increases the likelihood of later stage cancer, which increases mortality and morbidity in symptomatic cancers. The common-sense model (CSM) is used to understand time to first consultation with a healthcare provider, but inconsistencies exisy between its current use and important empirical findings. METHOD: To resolve inconsistencies, we conducted a qualitative examination to determine how the CSM could be revised to better account for these findings...
November 2018: Journal of Psychosomatic Research
John K Houten, Gila R Weinstein, Michael Collins
INTRODUCTION: Cervical spondylotic myelopathy (CSM) most commonly occurs at the C3-7 levels and is successfully treated by multilevel anterior cervical discectomy and fusion (ACDF) or cervical laminectomy and fusion (CLF), but no procedure has clearly demonstrated superiority. Most prior investigations comparing approaches are limited by marked heterogeneity in the composition of the study groups. This investigation compares ACDF versus CLF surgery specifically at C3-7 in terms of long-term neurological outcome and the fate of the adjacent levels...
October 2, 2018: Journal of Neurosurgical Sciences
Lixia Huang, Lin Xiao, Abishek Jung Poudel, Jixiang Li, Ping Zhou, Mario Gauthier, Haiqing Liu, Zhihong Wu, Guang Yang
Highly porous chitosan microspheres (CSM) were prepared through emulsion-based thermally induced phase separation (TIPS) without using toxic crosslinkers and chemical porogenic agents other than ice. The CSM had an average diameter of ∼150 μm with interconnected pores varying from 20∼50 μm in size. Due to their excellent biocompatibility and unique porous structure, high-performance hepatocyte culture in three-dimensional (3D) space was achieved using the CSM as microcarriers, as cell growth also took place within the internal pores of the CSM, besides their external surface, and multidirectional cell-cell interactions were observed...
December 15, 2018: Carbohydrate Polymers
Xiang Zhou, Feng Qi, Ruhua Zhou, Shangqian Wang, Yamin Wang, Yi Wang, Chen Chen, Yichun Wang, Jie Yang, Ninghong Song
The significance of perineural invasion (PNI) present in penile cancer (PC) is controversial. In order to clarify the predictive role of PNI in the inguinal lymph node metastases (ILNM) and oncologic outcome of patients, we performed this meta-analysis and systematic review. The search of PubMed, EMBASE and Web of Science was conducted for appropriate studies, up to January 20th, 2018. The pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval (CI) were applied to evaluate the difference in ILNM and oncologic outcome between patients present with PNI and those who were absent...
October 2, 2018: Bioscience Reports
Sebastiano Nazzani, Felix Preisser, Elio Mazzone, Zhe Tian, Francesco A Mistretta, Denis Soulières, Emanuele Montanari, Pietro Acquati, Alberto Briganti, Shahrokh F Shariat, Firas Abdollah, Luca Carmignani, Pierre I Karakiewicz
BACKGROUND: Few studies examined the rates of guideline implementation and the survival effect of bladder cuff excision (BCE) at nephroureterectomy (NU). OBJECTIVE: To assess the rates of guideline implementation regarding NU with BCE relative to NU without BCE in patients with upper tract urothelial carcinoma (UTUC) and to test the effect of BCE on cancer-specific (CSM) and other-cause mortality (OCM). DESIGN, SETTING, AND PARTICIPANTS: We relied on Surveillance, Epidemiology, and End Results database (2004-2014) for UTUC of the renal pelvis patients (T1-T3, N0, M0) treated with NU with or without BCE...
September 25, 2018: European Urology Focus
Boris Gershman, R Houston Thompson, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: Nephron-sparing surgery is the preferred surgical management of cT1 renal masses, but observational and randomized data conflict regarding a survival benefit. OBJECTIVE: To examine the associations of radical nephrectomy (RN) versus partial nephrectomy (PN) with oncologic and nononcologic outcomes. DESIGN, SETTING, AND PARTICIPANTS: A total of 2459 adults were treated with RN or PN between 1990 and 2011 for a unilateral, sporadic, cT1, M0 solid renal mass...
September 24, 2018: European Urology
Leixin Wei, Peng Cao, Chen Xu, Huiqiao Wu, Bo Hu, Ye Tian, Wen Yuan
OBJECTIVE: To investigate whether different quantitative measurements of increased signal intensity (ISI) on T2-weighted magnetic resonance imaging are useful for predicting surgical outcome in patients with cervical spondylotic myelopathy (CSM). METHODS: We retrospectively reviewed 108 patients with ISI who underwent surgery for CSM. Clinical outcome was evaluated via the Japanese Orthopaedic Association (JOA) score and the recovery rate. Patients were divided into 2 groups based on the JOA recovery rate: good (≥50%) and fair (<50%)...
October 2018: World Neurosurgery
Mariano Marrodan, Catalina Bensi, Lucas Alessandro, Alejandro D Muggeri, Mauricio F Farez
Background and Purpose: Although incidence rates vary, infectious, autoimmune, and neoplastic diseases can all cause chronic and subacute meningitis (CSM). We report a Latin-American, single center, CSM case series, analyzing the main clinical characteristics as well as ancillary diagnostic methods differentiating neoplastic from non-neoplastic etiologies. Methods: Retrospective review of CSM cases from a single center in Buenos Aires, Argentina. Results: Seventy patients with CSM diagnosis were identified, 49 with neoplastic and 21 with non-neoplastic meningitis...
October 2018: Neurohospitalist
Josianne Scerri, Therese Saliba, George Saliba, Christian A Scerri, Liberato Camilleri
PURPOSE: To examine the illness perceptions of informal carers of persons with depression, using the theoretical framework of Leventhal's Common-Sense Model (CSM) and to determine whether these illness perceptions are predictors of anxiety and depression, as measures of psychological well-being. METHODS: A cross-sectional survey was conducted with 94 Maltese individuals caring for a person with depression within a community setting. The informal carers completed the modified Illness Perception Questionnaire (IPQS-Relatives version) and the Hospital Anxiety and Depression Scale (HADS)...
September 22, 2018: Quality of Life Research
Michael Cloney, Andrew C Smith, Taylor Coffey, Monica Paliwal, Yasin Dhaher, Todd Parrish, James Elliott, Zachary A Smith
Cervical spondylotic myelopathy (CSM) is among the most common spinal cord disorders of the elderly. Muscle fat infiltration (MFI), a potential pathological sign of muscle adiposity, may contribute to or be associated with pain/disability/impairments in patients with CSM. We examined the relationship between MFI and CSM's clinical manifestations by enrolling nine CSM patients and five aged-matched controls to undergo MRI imaging of the cervical spine with MFI. A blinded investigator calculated MFI for each of the bilateral multifidii muscles from C3 to C7 on the MRI images...
November 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Xiang-Yu Li, Shi-Bao Lu, Xiang-Yao Sun, Chao Kong, Ma-Chao Guo, Si-Yuan Sun, Jun-Zhe Ding, Yi-Ming Yang
OBJECTIVE: To determine whether clinical characteristics and signal and morphologic changes on magnetic resonance (MR) images of the spinal cord (SC) are associated with surgical outcomes for cervical spondylotic myelopathy (CSM). PATIENTS AND METHODS: A total of 113 consecutive patients with cervical myelopathy underwent cervical decompression surgery in our hospital from January 2015 to January 2018. All patients with preoperative MR images available for review were recruited for this study...
September 5, 2018: Clinical Neurology and Neurosurgery
Johannes Bründl, Christina Neppl, Thomas Hommer, Wolfgang Otto, Johannes Breyer, Sabine Brookman-May, Florian Weber, Maximilian Burger, Matthias May, Christian Eichelberg
BACKGROUND:  Human papillomavirus (HPV) infection plays an important role in the pathogenesis of penile squamous cell carcinoma (PSCC) in about one third of the affected patients. Initial data indicate that HPV status could facilitate optimised risk stratification and individualised targeted therapy. The polymerase chain reaction (PCR) assay is the reference method for detection of HPV DNA. It is unclear if alternatives such as in situ hybridisation (ISH) or various surrogate markers (defined as immunohistochemical detection of p16INK4a, histological subtype, tumour invasion front, koilocytosis) are sufficient to determine HPV status METHODS:  In this single centre study on 34 patients with PSCC, multiplex nested PCR and ISH were conducted for HPV detection and identification of HPV DNA genotypes...
September 18, 2018: Aktuelle Urologie
Sita LeBlanc Thilsted, Ingrid Egerod, Freddy Knudsen Lippert, Hejdi Gamst-Jensen
OBJECTIVES: To examine the relation between patients' illness representations, presented in telephone consultation to out-of-hours (OOH) services, and self-reported degree-of-worry (DOW), as a measure of self-evaluated urgency. If a clear relation is found, incorporating DOW during telephone triage could aid the triage process, potentially increasing patient safety. DESIGN: A convergent parallel mixed methods design with quantitative data; DOW and qualitative data from recorded telephone consultations...
September 17, 2018: BMJ Open
Ram Haddas, Isador Lieberman, Raj Arakal, Akwasi Boah, Theodore Belanger, Kevin Ju
STUDY DESIGN: This is a prospective cohort study. OBJECTIVE: To evaluate the effect of cervical decompression surgery on the biomechanics of the spine and lower extremities in cervical spondylotic myelopathy (CSM) patients and compare with asymptomatic controls. SUMMARY OF BACKGROUND DATA: Difficulties with balance and gait are one of the most common manifestations of CSM. Patients with CSM have a slower gait speed, prolonged double support duration, and reduced cadence compared with healthy controls...
September 15, 2018: Clinical Spine Surgery
Jie Jane Chen, Jeremy P Harris, Christina S Kong, John B Sunwoo, Vasu Divi, Kathleen C Horst, Sumaira Z Aasi, S Tyler Hollmig, Wendy Y Hara
OBJECTIVES: Clinical perineural invasion (CPNI) of cutaneous head and neck cancer is associated with poor prognosis and presents a therapeutic dilemma. The purpose of this study was to determine the relationship between CPNI and nerve growth factor receptors (NGFR), and the impact of radiotherapy (RT), imaging, and NGFR on symptom control and disease-related outcomes. MATERIALS AND METHODS: We retrospectively reviewed patients with CPNI of cutaneous head and neck cancer who were treated with RT between 2010 and 2015 at our institution...
October 2018: Oral Oncology
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