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Tan Chen Wu, Denise T Hachul, Francisco Carlos da Costa Darrieux, Maurício I Scanavacca
BACKGROUND: Carotid sinus hypersensitivity (CSH) is a frequent finding in the evaluation of syncope. However, its significance in the clinical setting is still dubious. A new criterion was proposed by Solari et al. with a symptomatic systolic blood pressure (SBP) cut-off value of ≤ 85 mmHg to refine the vasodepressor (VD) response diagnosis. OBJECTIVE: To determine and compare the response to carotid sinus massage (CSM) in patients with and without syncope according to standard and proposed criteria...
July 2018: Arquivos Brasileiros de Cardiologia
Luoyi Zhu, Ao Yang, Yang Mu, Niya Zhang, Lvhui Sun, Shahid Ali Rajput, Desheng Qi
The aim of this study was to evaluate the effects of dietary non-gossypol cottonseed oil (CSO) or cottonseed meal (CSM) and their interactions on the texture properties, structure, nutritional composition, and edible safety of egg yolk. A total of 162 24-wk-old Hy-line Brown laying hens were randomly allocated into 9 diet treatments with 6 replicates of 3 hens per cage. A 3 × 3 factorial design using corn soybean meal-based diets supplemented with 0, 6, or 12% CSM and 0, 2, or 4% CSO in place of soybean meal and soybean oil, respectively, was utilized...
August 11, 2018: Poultry Science
Byung-Jou Lee, Jin Hoon Park, Sang-Ryong Jeon, Seung-Chul Rhim, Sung Woo Roh
PURPOSE: To investigate the effect of the preoperative cross-sectional area (CSA) of the semispinalis cervicis on postoperative loss of cervical lordosis (LCL) after laminoplasty. METHODS: A total of 144 patients who met the inclusion criteria between January 1999 and December 2015 were enrolled. Radiographic assessments were performed to evaluate the T1 slope, C2-7 sagittal vertical axis (SVA), cephalad vertebral level undergoing laminoplasty (CVLL), preoperative C2-7 Cobb angle, and preoperative CSA of the semispinalis cervicis...
August 13, 2018: European Spine Journal
Alessandro Antonelli, Andrea Minervini, Marco Sandri, Roberto Bertini, Riccardo Bertolo, Marco Carini, Maria Furlan, Alessandro Larcher, Guglielmo Mantica, Andrea Mari, Francesco Montorsi, Carlotta Palumbo, Francesco Porpiglia, Paola Romagnani, Claudio Simeone, Carlo Terrone, Umberto Capitanio
BACKGROUND: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. OBJECTIVE: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). DESIGN, SETTING, AND PARTICIPANTS: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1-2 RCC between 1990 and 2015...
August 10, 2018: European Urology
Shoji Kimura, Andrea Mari, Beat Foerster, Mohammad Abufaraj, Mihai D Vartolomei, Judith Stangl-Kremser, Pierre I Karakiewicz, Shin Egawa, Shahrokh F Shariat
PURPOSE: To investigate the prognostic impact of concomitant carcinoma in situ (CIS) in radical cystectomy (RC) specimens. MATERIALS AND METHODS: A systematic review and meta-analysis was performed using the MEDLINE, SCOPUS, Web of Science and Cochrane Library in 10th October 2017 to identify the eligible studies published until October 2017. Studies were eligible if they compared patients with concomitant CIS in RC specimens for bladder cancer (BC) to patients without concomitant CIS to determine its value for prognosticating overall mortality (OM), recurrence free survival (RFS), cancer specific mortality (CSM) and ureter involvement using multivariable analysis...
August 2, 2018: Journal of Urology
Niranjan Khadka, Helen Borges, Adantchede L Zannou, Jongmin Jang, Byunggik Kim, Kiwon Lee, Marom Bikson
BACKGROUND: The adoption of transcranial Direct Current Stimulation (tDCS) is encouraged by portability and ease-of-use. However, the preparation of tDCS electrodes remains the most cumbersome and error-prone step. Here, we validate the performance of the first "dry" electrodes for tDCS. A "dry electrode" excludes 1) any saline or other electrolytes, that are prone to spread and leaving a residue; 2) any adhesive at the skin interface; or 3) any electrode preparation steps except the connection to the stimulator...
July 29, 2018: Brain Stimulation
Zhao Chen, Qiu Wang, Meng Liang, Rui Zhao, Jiajia Zhu, Wuyi Xiong, Zhe Su, Chunshui Yu, Yuan Xue
PURPOSE: We sought to investigate visual cortex neural activity and functional connectivity (FC) alterations in cervical spondylotic myelopathy (CSM) patients using resting-state fMRI (rs-fMRI) and to explore the relationships of these alterations with visual disorder. METHODS: Twenty-seven CSM patients and 11 healthy controls were recruited as the study and control groups. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values were calculated to represent neural activity, seed-based correlation analysis (SCA) was performed to analyze the FC of visual cortex, and the outcomes were compared between groups...
July 31, 2018: Neuroradiology
Robert F Heary, Anna MacDowall, Nitin Agarwal
Context Cervical myelopathy occurs as a result of compression of the cervical spinal cord. Symptomatology includes, but is not limited to, pain, weakness, paresthesias, or gait/balance difficulties. Objective To present a two-decade experience with the management of cervical myelopathy. Methods Literature was reviewed to provide current guidelines for management as well as accompanying clinical presentations. Results Surgical decompression, if necessary, may be achieved from either an anterior, a posterior, or a combined anterior-posterior (AP) approach...
July 26, 2018: Journal of Spinal Cord Medicine
Fabio Muttin, Angela Pecoraro, Alessandro Larcher, Paolo Dell'Oglio, Alessandro Nini, Francesco Cianflone, Francesco Trevisani, Federico Dehò, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
PURPOSE: A significant proportion of patients affected by renal cell carcinoma (RCC) shows a suspicious lymph node involvement (LNI) at preoperative imaging. We sought to evaluate the effect of lymphadenopathies (cN1) on survival in surgical RCC patients with no evidence of LNI at final pathology (pN0). METHODS: 719 patients underwent either radical or partial nephrectomy and lymph node dissection at a single tertiary care referral centre between 1987 and 2015. All patients had pathologically no LNI (pN0)...
July 25, 2018: World Journal of Urology
Jiolanda Zika, George A Alexiou, Sotirios Giannopoulos, Ioannis Kastanioudakis, Athanasios P Kyritsis, Spyridon Voulgaris
CONTEXT/OBJECTIVE: To investigate prospectively preoperative parameters that might be related to the outcome of surgically treated patients for cervical spondylotic myelopathy (CSM). DESIGN: Prospective study. SETTING: Single Center in Ioannina, Greece. PARTICIPANTS: Thirty-six patients were included in the study. There were 21 males and 15 females, mean age 50.8 years, range 39-70 years. The mean BMI was 27.3. OUTCOME MEASURES: From each patient, we recorded age, sex, BMI, symptoms, duration of symptoms, comorbidities, lifestyle, myelopathy grade based on MRI and levels of compression...
July 24, 2018: Journal of Spinal Cord Medicine
Henry Syukur Purwanto, Mi-Sook Kang, Lenny Ferrer, Sang-Soo Han, Jin-Young Lee, Hak-Sung Kim, Jin-Ho Lee
4-Hydroxybenzoate (4HBA) is a valuable platform intermediate for the production of commodity and fine chemicals, including protocatechuate, cis,cis-muconic acid, adipic acid, terephthalic acid, phenol, vanillin, and 4-hydroxybenzyl alcohol glycoside (gastrodin). Here we describe rational engineering of the shikimate and related pathways in Corynebacterium glutamicum ATCC13032 for over-producing 4HBA. As an approach to increase the carbon flux to 4HBA, we first introduced a mutated chorismate-pyruvate lyase (CPLpr ) and feedback-resistant 3-deoxy-d-arabinoheptulosonate-7-phosphate synthases encoded by ubiCpr and aroFfbr /aroGfbr , respectively, from Escherichia coli along with blockage of carbon flux to the biosynthetic pathways for aromatic amino acids and the catabolic pathway for 4HBA by deletion of the genes trpE (encoding anthranilate synthase I), csm (chorismate mutase), and pobA (4HBA hydroxylase)...
July 19, 2018: Journal of Biotechnology
Kyung-Jae Park, Hideyuki Kano, Aditya Iyer, Xiaomin Liu, Daniel A Tonetti, Craig Lehocky, Andrew Faramand, Ajay Niranjan, John C Flickinger, Douglas Kondziolka, L Dade Lunsford
OBJECTIVE The authors of this study evaluate the long-term outcomes of stereotactic radiosurgery (SRS) for cavernous sinus meningioma (CSM). METHODS The authors retrospectively assessed treatment outcomes 5-18 years after SRS in 200 patients with CSM. The median patient age was 57 years (range 22-83 years). In total, 120 (60%) patients underwent Gamma Knife SRS as primary management, 46 (23%) for residual tumors, and 34 (17%) for recurrent tumors after one or more surgical procedures. The median tumor target volume was 7...
July 20, 2018: Journal of Neurosurgery
Weipeng Zheng, Haoyi Chen, Ning Wang, YingJie Liang, Wende Xiao, Weifeng Xiong, Bofu Zhong, Hongbin Ju, Junnan Luo, B M Xin Jiang, Shifeng Wen
BACKGROUND: Magnetic resonance imaging (MRI) plays an important role in assessment of spinal cord status for cervical spondylotic myelopathy (CSM). Diffusion tensor imaging (DTI) also is a novel investigation tool with good sensitivity to detect changes in CSM but not routinely used in spinal cord evaluation. METHODS: Sixty-six patients with CSM who required surgical decompression were included. All the patients were divided into four subgroups according to Japanese Orthopaedic Association (JOA) recovery rate...
July 16, 2018: World Neurosurgery
Xiao-Qian Zhai, Lang Bao, Tao Luo, Xuan Peng, Chang-Feng Sun, Guo-Ping Yang
OBJECTIVE: To determine how Csm4 protein expression affects intracellular survival of Mycobacterium smegmatis (MS). METHODS: Csm 4 gene was amplified by PCR to construct pMV261- Csm 4 shuttle expression plasmid. The Csm4 protein expression in MS _Csm 4 was detected by Western blot after electroporation of the recombinant plasmid into MS. The growth kinetics of MS _Csm 4 in vitro and the influence of reactive N,O species on the growth of MS _Csm 4were observed. The intracellular survival of MS _Csm 4 and expressions of inducible nitric oxide synthase gene ( iNOS ) and nitric oxide production (NO) were detected after infection with THP-1 macrophages...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Bing Wang, Guohua Lü, Lei Kuang
BACKGROUND: The optimal treatment for multi-level cervical spondylotic myelopathy (CSM) remains controversial. Posterior approach is most commonly used, but complicated with insufficient decompression and postoperative axial neck pain. The anterior approach is effective in neural decompression with less surgical trauma. However, the profile of the plate or the possible construct failure may cause dysphagia after surgery. Recently, anterior cervical discectomy and fusion (ACDF) with self-anchored cage is reported to have a superior result over ACDF with anterior plates and screws in three-level CSM...
July 12, 2018: BMC Musculoskeletal Disorders
Xuecheng Huang, Linqiang Ye, Zixian Wu, Lichang Liang, Qianli Wang, Weibo Yu, De Liang, Xiaobing Jiang
Background: Most studies report that the common position of cervical spinal manipulation (CSM) for treating symptomatic cervical disc herniation (CDH) is lateral bending to the herniated side. However, the rationality of lateral bending position on performing CSM for CDH is still unclear. Objective: The purpose of this study is to investigate the biomechanical effects of lateral bending position on performing CSM for CDH. Methods: A finite element (FE) model of CDH (herniated on the left side) was generated in C5-6 segment based on the normal FE model...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Wei Sheng, Hongwei Zhang, Yong Lu
PURPOSE: To assess survival outcomes of locally advanced prostate cancer (LAPC) in patients aged < 50 years after local therapy (LT), as compared to that in the older patients (≥ 50 years). Moreover, effectiveness of postoperative radiation therapy (PRT) after radical prostatectomy (RP) was also assessed in patients aged < 50 years. METHODS: Within the Surveillance, Epidemiology, and End results database (2004-2014), non-metastatic cT3-4 LAPC patients treated with LT (RP, RT or RP+RT) were identified...
August 2018: International Urology and Nephrology
Hajime Tanaka, Soichiro Yoshida, Fumitaka Koga, Kazuma Toda, Ryoichi Yoshimura, Yutaka Nakajima, Emiko Sugawara, Takumi Akashi, Yuma Waseda, Masaharu Inoue, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
PURPOSE: Bladder-sparing strategy is a useful option for patients with muscle-invasive bladder cancer (MIBC), in which the response to chemoradiotherapy (CRT) is primarily important in achieving favorable oncological outcomes. Our objective is to evaluate the impact of immunohistochemistry (IHC)-based subtyping in MIBC on prediction of CRT-response. MATERIALS AND METHODS: Treatment protocol consisted of induction CRT followed by partial/radical cystectomy as consolidative surgery; 118 eligible patients with non-metastatic MIBC were retrospectively analyzed...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Koji Tamai, Akinobu Suzuki, Akito Yabu, Shinji Takahashi, Hiromitsu Toyoda, Masatoshi Hoshino, Hidetomi Terai, Hiroaki Nakamura
BACKGROUND CONTEXT: The impact of preoperative facet degeneration (FD) on surgical outcomes following laminoplasty has not been established. PURPOSE: To elucidate the influence of preoperative FD on pre- and postoperative clinical symptoms and radiographic parameters. STUDY DESIGN: Retrospective analysis of prospectively collected data. PATIENT SAMPLE: A total of 135 consecutive patients who underwent laminoplasty for cervical spondylotic myelopathy (CSM) with greater than 2 years follow-up...
June 26, 2018: Spine Journal: Official Journal of the North American Spine Society
Ram Haddas, Isador Lieberman, Akwasi Boah, Raj Arakal, Theodore Belanger, Kevin L Ju
STUDY DESIGN: A prospective cohort study. OBJECTIVE: Quantify the amount of sway associated with maintaining a balanced posture in a group of untreated cervical spondylotic myelopathy (CSM) patients. SUMMARY OF BACKGROUND DATA: Balance is defined as the ability of the human body to maintain its center of mass (COM) within the base of support with minimal postural sway. Sway is the movement of the COM in the horizontal plane when a person is standing in a static position...
June 28, 2018: Spine
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