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Julianne Megaw, Brendan F Gilmore
Here, we report the draft genome sequence of Halomonas sp. CSM-2. This moderately halophilic bacterium was isolated from a brine sample obtained from a Triassic salt mine.
July 2018: Microbiology resource announcements
(no author information available yet)
No abstract text is available yet for this article.
January 2019: Journal of Neurologic Physical Therapy: JNPT
Elio Mazzone, Sophie Knipper, Francesco A Mistretta, Zhe Tian, Felix Preisser, Andrea Gallina, Denis Soulieres, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Juan Wisnivesky, Pierre I Karakiewicz
BACKGROUND: Patients with organ confined muscle-invasive bladder cancer (MIBC) who are candidates for radical cystectomy (RC) should receive neoadjuvant chemotherapy (CHT). However, the most contemporary CHT use rates indicate low adherence to these guidelines. We tested contemporary neoadjuvant CHT rates and associated cancer-specific mortality (CSM) and overall mortality (OM) in pT2N0 MIBC patients treated with RC. MATERIALS AND METHODS: Within the SEER database (2004-2015), we identified patients with pT2N0 MIBC patients who underwent RC...
December 5, 2018: Cancer Epidemiology
Elio Mazzone, Felix Preisser, Sebastiano Nazzani, Zhe Tian, Nicola Fossati, Giorgio Gandaglia, Andrea Gallina, Denis Soulieres, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: Radical cystectomy (RC) may occasionally be performed in individuals with metastatic urothelial carcinoma of the bladder (mUCB). However, the role of lymph node dissection (LND) for such cases is unknown. Thus, we tested the effect of RC on cancer-specific mortality (CSM) and overall mortality in mUCB patients and the effect of LND and its extent on CSM. PATIENTS AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2013), we identified patients with mUCB who underwent RC with or without LND or non-RC management...
November 17, 2018: Clinical Genitourinary Cancer
N Aujla, M Walker, K Vedhara, N Sprigg
The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecting other aspects of post-stroke recovery (i.e., Health-Related Quality of Life (HRQL) and disability). The purpose of this study was to examine relationships between baseline illness beliefs and three-month post-stroke HRQL, mood and disability. A longitudinal observational design was adopted, involving 50 survivors (mean age = 66...
December 11, 2018: Psychology, Health & Medicine
Yi Ma, Yuxuan Song, Xianwei Huang, Zhongli Chen, Taihua Zhang
Room-temperature creep tests are performed at the plastic regions of two different metallic glassy films under Berkovich nanoindetation. Relying on the strain rate sensitivity of the steady-state creep curve, shear transformation zone (STZ) size is estimated based on the cooperative shear model (CSM). By applying various indentation depths, loading rates, and holding times, the testing effects on the STZ size of metallic glasses are systematically studied. Experimental results indicate that STZ size is greatly increased with increased indentation depth and shortened holding time...
November 30, 2018: Micromachines
Olaoluwa Lediju, Joshua Ikuemonisan, Simpa S Salami, Oluwakayode Adejoro
OBJECTIVE: To assess the influence of race on presentation of poorly differentiated/undifferentiated prostate cancer, use of radical prostatectomy (RP) as primary treatment and survival outcomes. METHODS: Using the 2004-2014 files of the Surveillance, Epidemiology, and End Results (SEER) data, we identified 244,167 black and white men diagnosed with poorly differentiated/undifferentiated prostate cancer. Demographic and tumor characteristics of study patients were compared by race...
November 30, 2018: Journal of Racial and Ethnic Health Disparities
Ning Jia, Charlie Y Mo, Chongyuan Wang, Edward T Eng, Luciano A Marraffini, Dinshaw J Patel
Type ΙΙΙ CRISPR-Cas systems provide robust immunity against foreign RNA and DNA by sequence-specific RNase and target RNA-activated sequence-nonspecific DNase and RNase activities. We report on cryo-EM structures of Thermococcus onnurineus CsmcrRNA binary, CsmcrRNA -target RNA and CsmcrRNA -target RNAanti-tag ternary complexes in the 3.1 Å range. The topological features of the crRNA 5'-repeat tag explains the 5'-ruler mechanism for defining target cleavage sites, with accessibility of positions -2 to -5 within the 5'-repeat serving as sensors for avoidance of autoimmunity...
November 27, 2018: Molecular Cell
Lilan You, Jun Ma, Jiuyu Wang, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang, Yanli Wang
Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unknown. Here, we report the structure of Csm in complex with crRNA together with structures of cognate or non-cognate target RNA bound Csm complexes. We show that depending on complementarity with the 5' tag of crRNA, the 3' anti-tag region of target RNA binds at two distinct sites of the Csm complex...
November 26, 2018: Cell
(no author information available yet)
OBJECTIVEComplete radiographic and clinical evaluations are essential in the surgical treatment of cervical spondylotic myelopathy (CSM). Prior studies have correlated cervical sagittal imbalance and kyphosis with disability and worse health-related quality of life. However, little is known about C2-3 disc angle and its correlation with postoperative outcomes. The present study is the first to consider C2-3 disc angle as an additional radiographic predictor of postoperative adverse events.METHODSA retrospective chart review was performed to identify patients with CSM who underwent surgeries from 2010 to 2014...
October 1, 2018: Journal of Neurosurgery. Spine
Eugene Pak-Lin Ng, Andrew Siu-Leung Yip, Keith Hay-Man Wan, Michael Siu-Hei Tse, Kam-Kwong Wong, Tik-Koon Kwok, Wing-Cheung Wong
Study Design: A retrospective review of patients who underwent 2-level anterior cervical discectomy and fusion (ACDF) with standalone polyetheretherketone (PEEK) cages for cervical spondylotic myelopathy (CSM). Purpose: To evaluate the efficacy of stand-alone PEEK cage in 2-level cervical interbody fusion for CSM. Overview of Literature: ACDF is a standard surgical procedure to treat degenerative disc disease. However, the use of additional anterior plating for 2-level ACDF remains controversial...
November 27, 2018: Asian Spine Journal
Yue-Jiang Zhao, Cai Cheng, Han-Wen Chen, Min Li, Lu Wang, Zhi-Yuan Guo
Laminectomy is an effective surgical treatment for multi-segment cervical spondylotic myelopathy (M-CSM) but usually results in C5 palsy. Some surgical techniques to restore the spinal sequence, increase the intervertebral foramen diameter, and limit the spinal cord drift distance have been proposed; however, it is unclear whether these procedures can avoid this complication.To investigate the clinical efficacy of limited laminectomy and foraminal decompression with fixation (LLFDF) for improving neurological recovery and preventing C5 palsy...
November 2018: Medicine (Baltimore)
De-Wei Song, Yu-Dong Wu, Dong-Dong Tian
BACKGROUND: Cervical spondylotic myelopathy (CSM), a common degenerative disorder, is characterized by chronic progressive compression of the cervical spinal cord. The present case-control study aimed to explore the potential role of VDR-FokI and VDBP-Thr420Lys polymorphisms in the susceptibility to CSM in the Chinese population. METHODS: The study enrolled 318 CSM patients and 282 healthy individuals whose clinical data were retrospectively analyzed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype VDR-FokI and VDBP-Thr420Lys polymorphisms...
November 21, 2018: Journal of Clinical Laboratory Analysis
Hai-Ming Yu, Xiao-Lei Chen, Wu Wei, Xue-Dong Yao, Jing-Qun Sun, Xiao-Tao Su, Shu-Feng Lin
OBJECTIVE: Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction. Our study aims to explore the correlation of osteoprotegerin (OPG) gene polymorphisms and the risk factors and severity of CSM. PATIENTS AND METHODS: The peripheral blood samples from 494 CSM patients and 515 healthy individuals were collected for detecting the 950T/C, 1181G/C and 163A/G genotypes and genetic equilibrium of OPG in the CSM and control groups and analyzing the genotype distribution and allele frequency...
December 2018: Clinical Neurology and Neurosurgery
Immacolata d'Errico
In this paper I'm going to illustrate my experience related to the six month narrative laboratory with the psychiatric patients of the Daily Psychiatric Center located in Rutigliano. This project originated from my own way of conceiving the concept of Psychiatric and Psychosocial Rehabilitation in terms of Therapeìa, that is in my view the regaining "sense and meaning" as the essence of rehabilitation therapy. My goal was to awaken thoughts, words, gestures, emotions in order to reconnect an interrupted dialogue with themselves and start an initial storytelling experience...
November 2018: Psychiatria Danubina
Debasish Sundi, Jeffrey J Tosoian, Yaw A Nyame, Ridwan Alam, Mary Achim, Chad A Reichard, Jianbo Li, Lamont Wilkins, Zeyad Schwen, Misop Han, John W Davis, Eric A Klein, Edward M Schaeffer, Andrew J Stephenson, Ashley E Ross, Brian F Chapin
BACKGROUND: Among men with localized high-risk prostate cancer (PCa), patients who meet very high-risk (VHR) criteria have been shown to experience worse outcomes after radical prostatectomy (RP) in a previous study. Variations of VHR criteria have been suggested to be prognostic in other single-center cohorts, but multicenter outcomes validating VHR criteria have not been described. This study was designed to validate VHR criteria for identifying which PCa patients are at greatest risk for cancer progression...
November 13, 2018: Cancer
Jipeng You, Xiaohui Tang, Wenshan Gao, Yong Shen, Wen-Yuan Ding, Bao Ren
The purpose of this study is to explore perioperative factors predicting symptomatic adjacent segment disease (ASD) after anterior cervical discectomy and fusion (ACDF) for patients with cervical spondylotic myelopathy (CSM) at 5-year follow-up.This study included 356 patients who underwent ACDF for CSM from Jan.2011 to Jan.2013. Up to Jan. 2018, 39 patients suffered from ASD and 317 did not. Assessments include: age, sex, body mass index (BMI), diabetes, smoking, alcohol, duration of symptoms, preoperative Cobb angle of C2 to 7, T1 slope, C2 to 7 range of motion (C2-7 range of motion [ROM]), C2 to 7 sagittal vertical axis (C2-7 SVA), fusion level involved, superior fusion segment, high signal intensity on T2-WI of magnetic resonance imaging (MRI), preoperative visual analogue scale (VAS)-neck, VAS-Arm, Neck Disability Index (NDI) and Japanese Orthopaedic Association (JOA)...
October 2018: Medicine (Baltimore)
Giorgio Gandaglia, Matteo Soligo, Antonino Battaglia, Tim Muilwijk, Daniele Robesti, Elio Mazzone, Francesco Barletta, Nicola Fossati, Marco Moschini, Marco Bandini, Steven Joniau, R Jeffrey Karnes, Francesco Montorsi, Alberto Briganti
BACKGROUND: A role for local therapies including radical prostatectomy (RP) in prostate cancer (PCa) patients with clinical lymphadenopathies has been proposed. However, no data are available to identify men who would benefit from RP in this setting. OBJECTIVE: To identify predictors of clinical recurrence (CR) in surgically managed PCa patients with clinical lymphadenopathies. DESIGN, SETTING, AND PARTICIPANTS: We identified 162 patients with lymphadenopathies treated with RP and lymph node dissection at three referral centers...
November 5, 2018: European Urology
Luke R G Pike, William L Hwang, Trevor J Royce, Nina N Sanford, Brandon A Mahal
OBJECTIVE: We sought to further define prognostic and predictive value of human papillomavirus (HPV) status in metastatic squamous cell carcinoma of the oropharynx (OPC). MATERIALS AND METHODS: A Surveillance, Epidemiology, and End Results custom database identified 5940 adult patients, >18-years-old, with primary SCCHN and known HPV status, diagnosed from 2013 to 2014. Wilcoxon rank-sum and Mantel-Haenszel χ2 tests compared distributions of continuous and categorical covariates...
November 2018: Oral Oncology
Zachary Farhood, Matthew Simpson, Gregory M Ward, Ronald J Walker, Nosayaba Osazuwa-Peters
OBJECTIVE: To determine if there are differences in mortality from oral cavity squamous cell carcinoma (OCSCC) based on oral cavity (OC) subsites. METHODS: Using the Surveillance, Epidemiology, and End Results Program (SEER) 9 database, patients with sequence number 0 or 1 squamous cell OCSCC were analyzed by OC subsite for 5-year cause-specific mortality (CSM) from OCSCC. Proportional hazards regression determined the association between 5-year CSM and OC subsites while controlling for treatment modality, stage, and demographic characteristics using hazard ratios...
November 8, 2018: Laryngoscope
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