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H. Pylori

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https://www.readbyqxmd.com/read/29675800/secretion-expression-of-human-neutrophil-peptide-1-hnp1-in-pichia-pastoris-and-its-functional-analysis-against-antibiotic-resistant-helicobacter-pylori
#1
Xiaolin Zhang, Anmin Jiang, Banghua Qi, Hao Yu, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang
Human neutrophil peptide 1 (HNP1) is a small (3.44 kDa) cationic peptide that is a distinct member of the defensin family. HNP1 plays a crucial role in controlling bacterial infections, particularly by antibiotic-resistant bacteria, through membrane perforation patterns. The structural characteristics of HNP1's three intramolecular disulfide bridges cause difficulty in its synthesis via chemical methods. In this study, bioactive recombinant HNP1 was produced using the Pichia pastoris (P. Pichia) expression system...
April 19, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29675003/role-of-micrornas-and-exosomes-in-helicobacter-pylori-and-epstein-barr-virus-associated-gastric-cancers
#2
REVIEW
Iva Polakovicova, Sofia Jerez, Ignacio A Wichmann, Alejandra Sandoval-Bórquez, Nicolás Carrasco-Véliz, Alejandro H Corvalán
Emerging evidence suggests that chronic inflammation caused by pathogen infection is connected to the development of various types of cancer. It is estimated that up to 20% of all cancer deaths is linked to infections and inflammation. In gastric cancer, such triggers can be infection of the gastric epithelium by either Helicobacter pylori ( H. pylori ), a bacterium present in half of the world population; or by Epstein-Barr virus (EBV), a double-stranded DNA virus which has recently been associated with gastric cancer...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29672549/tumor-development-in-japanese-patients-with-lynch-syndrome
#3
Chiaki Saita, Tatsuro Yamaguchi, Shin-Ichiro Horiguchi, Rin Yamada, Misato Takao, Takeru Iijima, Rika Wakaume, Tomoyuki Aruga, Taku Tabata, Koichi Koizumi
BACKGROUND: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients. METHODS: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. RESULTS: The median age at the diagnosis of the first malignant tumor and first LS-related tumor was 44 (range, 19-65) and 44 (range, 24-66) years, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29672300/clinical-significance-of-reddish-depressed-lesions-observed-in-the-gastric-mucosa-after-helicobacter-pylori-eradication
#4
Takahiro Kotachi, Masanori Ito, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Kosaku Hata, Toru Kawamura, Yoji Sanomura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METHODS: We enrolled 301 consecutive patients with H. pylori eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29671784/epidemiology-of-helicobacter-pylori-and-caga-positive-infections-and-global-variations-in-gastric-cancer
#5
REVIEW
Jin Young Park, David Forman, Langgeng Agung Waskito, Yoshio Yamaoka, Jean E Crabtree
Gastric cancer is a major health burden and is the fifth most common malignancy and the third most common cause of death from cancer worldwide. Development of gastric cancer involves several aspects, including host genetics, environmental factors, and Helicobacter pylori infection. There is increasing evidence from epidemiological studies of the association of H. pylori infection and specific virulence factors with gastric cancer. Studies in animal models indicate H. pylori is a primary factor in the development of gastric cancer...
April 19, 2018: Toxins
https://www.readbyqxmd.com/read/29671413/non-variceal-upper-gastrointestinal-bleeding
#6
REVIEW
Angel Lanas, Jean-Marc Dumonceau, Richard H Hunt, Mitsuhiro Fujishiro, James M Scheiman, Ian M Gralnek, Helen E Campbell, Alaa Rostom, Càndid Villanueva, Joseph J Y Sung
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori infection or use of NSAIDs and low-dose aspirin (LDA), are the most common cause. Although the incidence and mortality associated with NVUGIB have been decreasing owing to considerable advances in the prevention and management of NVUGIB over the past 20 years, it remains a common clinical problem with an annual incidence of ∼67 per 100,000 individuals in the United States in 2012...
April 19, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29670656/the-antibacterial-activity-of-mass-galla-chinesis-et-camelliae-fermentata-on-helicobacter-pylori-infection
#7
Jing Yu, Hui Ye, Jiang Li, Ning Li, Zong-Ming Shi, Xue-Zhi Zhang
Mass Galla chinesis et camelliae Fermentata ( Chinese gall leaven , CGL) was investigated for activities against Helicobacter pylori (H. pylori) both in vitro and in vivo . The agar dilution method and time-kill curves, as in vitro assays and an in vivo study using a Kunming mice model, were performed. CGL demonstrated a strong anti- Helicobacter pylori activity in vitro with the minimal inhibitory concentrations (MICs) against multiple H. pylori strains of 0.5~8 mg/ml and the decreasing trend time-kill curves when increasing CGL concentrations...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29669354/effectiveness-and-safety-of-pylera%C3%A2-in-patients-infected-by-helicobacter-pylori-a-multicenter-retrospective-real-life-study
#8
Antonio Tursi, Marilisa Franceschi, Leonardo Allegretta, Edoardo Savarino, Rudi De Bastiani, Walter Elisei, Gianluca Baldassarre, Antonio Ferronato, Serena Scida, Chiara Miraglia, Antonio Penna, Claudio Licci, Giovanni Luca Rizzo, Giuseppe Pranzo, Claudio Cassieri, Giovanni Brandimarte, Marcello Picchio, Francesco Di Mario
BACKGROUND: Our aims were to assess the real life effectiveness and safety of the new bismuth-containing quadruple therapy in a large population of patients infected by Helicobacter pylori. METHODS: Consecutive dyspeptic H. pylori-positive patients were enrolled, both naïve for treatment and already unsuccessfully treated. Patients were treated with Pylera® 3 capsules 4 times/daily plus omeprazole 20 mg or esomeprazole 40 mg 2 times/daily for 10 days. Eradication was confirmed using a urea-breath test (at least 30 days after the end of the treatment)...
April 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29669273/in-vivo-structures-of-the-helicobacter-pylori-cag-type-iv-secretion-system
#9
Yi-Wei Chang, Carrie L Shaffer, Lee A Rettberg, Debnath Ghosal, Grant J Jensen
The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal the molecular architecture of the Helicobacter pylori cag T4SS. Although most components are unique to H. pylori, the cag T4SS exhibits remarkable architectural similarity to other T4SSs. Our images revealed that, when H. pylori encounters host cells, the bacterium elaborates membranous tubes perforated by lateral ports...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29668771/ivth-brazilian-consensus-conference-on-helicobacter-pylori-infection
#10
Luiz Gonzaga Vaz Coelho, James Ramalho Marinho, Robert Genta, Laercio Tenório Ribeiro, Maria do Carmo Friche Passos, Schlioma Zaterka, Paulo Pimentel Assumpção, Alfredo José A Barbosa, Ricardo Barbuti, Lucia Libanês Braga, Helenice Breyer, Aloisio Carvalhaes, Décio Chinzon, Marcelo Cury, Gerson Domingues, Jorge Luiz Jorge, Ismael Maguilnik, Frederico Passos Marinho, Joaquim Prado de Moraes-Filho
Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting...
April 16, 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29668600/chilean-gastric-cancer-task-force-a-study-protocol-to-obtain-a-clinical-and-molecular-classification-of-a-cohort-of-gastric-cancer-patients
#11
Gareth I Owen, Mauricio P Pinto, Ignacio N Retamal, María F Fernádez, Betzabe Cisternas, Sebastian Mondaca, Cesar Sanchez, Hector Galindo, Bruno Nervi, Carolina Ibañez, Francisco Acevedo, Jorge Madrid, José Peña, Maria Loreto Bravo, Maria Jose Maturana, Miguel Cordova-Delgado, Diego Romero, Nathaly de la Jara, Javiera Torres, Maria Rodriguez-Fernandez, Manuel Espinoza, Carlos Balmaceda, Matías Freire, Valentina Gárate-Calderón, Fernando Crovari, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas, Ariel Zwenger, Ricardo Armisen, Alejandro H Corvalan, Marcelo Garrido
Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667211/randomised-clinical-trial-gastrointestinal-events-in-arthritis-patients-treated-with-celecoxib-ibuprofen-or-naproxen-in-the-precision-trial
#12
N D Yeomans, D Y Graham, M E Husni, D H Solomon, T Stevens, J Vargo, Q Wang, L M Wisniewski, K E Wolski, J S Borer, P Libby, A M Lincoff, T F Lüscher, W Bao, C Walker, S E Nissen
BACKGROUND: We evaluated GI safety of celecoxib compared with 2 nonselective (ns) NSAIDs, as a secondary objective of a large trial examining multiorgan safety. METHODS: This randomised, double-blind controlled trial analysed 24 081 patients. Osteoarthritis or rheumatoid arthritis patients, needing ongoing NSAID treatment, were randomised to receive celecoxib 100-200 mg b.d., ibuprofen 600-800 mg t.d.s. or naproxen 375-500 mg b.d. plus esomeprazole, and low-dose aspirin or corticosteroids if already prescribed...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29666614/-helicobacter-pylori-the-latent-human-pathogen-or-an-ancestral-commensal-organism
#13
REVIEW
Jackie Li, Guillermo I Perez-Perez
We dedicated this review to discuss Helicobacter pylori as one of the latest identified bacterial pathogens in humans and whether its role is mainly as a pathogen or a commensal. Diseases associated with this bacterium were highly prevalent during the 19th century and gradually have declined. Most diseases associated with H. pylori occurred in individuals older than 40 years of age. However, acquisition of H. pylori occurs mainly in young children inside the family setting. Prevalence and incidence of H. pylori has had a dramatic change in the last part of the 20th century and beginning of the 21th century...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666402/expression-of-kk-lc-1-a-cancer-testis-antigen-at-non-tumour-sites-of-the-stomach-carrying-a-tumour
#14
Takashi Fukuyama, Nobue Futawatari, Rui Yamamura, Taiga Yamazaki, Yoshinobu Ichiki, Akira Ema, Hideki Ushiku, Yatsushi Nishi, Yoshihito Takahashi, Toshikazu Otsuka, Hitoshi Yamazaki, Wasaburo Koizumi, Kosei Yasumoto, Noritada Kobayashi
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666390/distribution-and-clinical-associations-of-integrating-conjugative-elements-and-cag-pathogenicity-islands-of-helicobacter-pylori-in-indonesia
#15
Langgeng Agung Waskito, Muhammad Miftahussurur, Maria Inge Lusida, Ari Fahrial Syam, Rumiko Suzuki, Phawinee Subsomwong, Tomohisa Uchida, Muhammad Hamdan, Nasronudin, Yoshio Yamaoka
The clinical associations and correlations with other virulence factors such as cag pathogenicity island (PAI) of the Integrating Conjugative Elements Helicobacter pylori TFSS (ICEHptfs), a new type IV secretion system (TFSS) in H. pylori has not been described. Among 103 studied strains from Indonesia, almost all strains (99.0%) contained cag PAI with more than half (55.8%) were intact cag PAI. Patients infected with intact cag PAI strains showed significantly higher antral activity, inflammation and atrophy as well as corporal inflammation than those with non-intact cag PAI strains, confirming the virulence of cag PAI...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665777/systematic-review-of-the-relationship-of-helicobacter-pylori-infection-with-geographical-latitude-average-annual-temperature-and-average-daily-sunshine
#16
Chao Lu, Ye Yu, Lan Li, Chaohui Yu, Ping Xu
BACKGROUND: Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshine time and H. pylori infection. METHODS: The PubMed, ClinicalTrials.gov , EBSCO and Web of Science databases were searched to identify studies reporting H. pylori infection. Latitude 30° was the cut-off level for low and mid-latitude areas...
April 17, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29665437/multiplex-serology-of-helicobacter-pylori-antigens-in-detection-of-current-infection-and-atrophic-gastritis-a-simple-and-cost-efficient-method
#17
Ebrahim Shafaie, Samaneh Saberi, Maryam Esmaeili, Zeynab Karimi, Saeed Najafi, Mohammad Tashakoripoor, Afshin Abdirad, Mahmoud Eshagh Hosseini, Mohammad Ali Mohagheghi, Vahid Khalaj, Marjan Mohammadi
INTRODUCTION: Helicobacter pylori express a large array of antigens, each of which is duly responsible for successful colonization and pathogenesis. Here, we have studied host serum antibody responses to four of its immunodominant antigens in association with the infection status and the resulting clinical outcomes. METHODS: For this purpose, four individual H. pylori proteins (UreB, CagA, Tip-α and HP0175) were produced in recombinant forms. Serum antibody responses of 246 (75 GC and 171 NUD) patients, against the above antigens, were evaluated by multiplex immunoblotting...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29663251/histopathological-findings-in-morbid-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-does-h-pylori-infection-effective-on-pathological-changes
#18
Ramazan İlyas Öner, Sabri Özdaş
AıM: To determine the prevalence of histopathological findings requiring clinical follow-up in morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG) and evaluate the relationship between these findings and Helicobacter pylori as well as to add more data to the published literature in this regard. MATERıAL AND METHODS: Overall, 161 morbidly obese patients with body mass index (BMI) > 40 kg/m2 who underwent LSG between May 1, 2014 and May 31, 2017 were retrospectively included in the study...
April 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29662609/dec205-mediates-local-and-systemic-immune-responses-to-helicobacter-pylori-infection-in-humans
#19
Masahide Kita, Kenji Yokota, Chihiro Kageyama, Susumu Take, Kazuyoshi Goto, Yoshiro Kawahara, Osamu Matsushita, Hiroyuki Okada
Helicobacter pylori infections cause gastritis and affect systemic immune responses; however, no direct association between immune cells and stomach bacteria has yet been reported. The present study investigated DEC205-mediated phagocytosis of H. pylori and the role of DEC205-positive macrophages in the human gastric mucosa. DEC205 mediated phagocytosis of H. pylori was detected immunocytochemically in PMA-stimulated macrophages differentiated from NOMO1 cells. Expression of DEC205 mRNA in peripheral blood mononuclear cells (PBMCs) from H...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662291/punctual-mutations-in-23s-rrna-gene-of-clarithromycin-resistant-helicobacter-pylori-in-colombian-populations
#20
Andrés Jenuer Matta, Diana Carolina Zambrano, Alvaro Jairo Pazos
AIM: To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori ( H. pylori ) and determine their association with therapeutic failure. METHODS: PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, and 5 from a high-risk population: Tuquerres-Colombia) and 40 from a susceptible population (28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis...
April 14, 2018: World Journal of Gastroenterology: WJG
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