keyword
MENU ▼
Read by QxMD icon Read
search

H. Pylori

keyword
https://www.readbyqxmd.com/read/29054320/eradication-of-helicobacter-pylori-infection-with-a-new-bismuth-based-quadruple-therapy-in-clinical-practice
#1
Elena Pérez-Arellano, María Isabel Rodriguez-Garcia, Ana Belen Galera Rodenas, Emilio de la Morena-Madrigal
INTRODUCTION: The eradication of Helicobacter pylori infection represents a clinical challenge. OBJECTIVE: To evaluate the efficacy and safety of quadruple therapy with esomeprazole plus a 3-in-1 capsule containing bismuth subcitrate, metronidazole and tetracycline, plus probiotics in patients diagnosed with H. pylori infection in routine clinical practice. METHODS: A prospective, interventional, single-centre and open-label study in consecutive patients with a confirmed indication for eradication of H...
October 17, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29053425/association-of-mannose-binding-lectin-rs1800450-and-tumor-necrotic-factor-%C3%AE-rs1800620-polymorphism-with-helicobacter-pylori-in-type-ii-diabetes-mellitus
#2
Elnaz Mortazavi, Behnaz Eslami, Parisa Aghahosseini, Fatemeh Ahron, Armagan Amininejad, Sepideh Mahmoodi, Hadis Satarpour, Nilofar Radmanesh, Hossein Rassi
Type II diabetes mellitus (T2DM) is the prevalent type of diabetes, including 90% of the cases world-wide. Helicobacter pylori plays a pathogenic role in the development of T2DM. The host genetic factors have a significant impact on the clinical outcome and anatomical distribution of H. pylori infection and polymorphisms in several genes such as tumor necrotic factor (TNF)-α and mannose-binding lectin (MBL) and are considered to increase the risk for the development of T2DM. In this study, we investigate the prevalence rate of H...
October 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29050151/-relationship-between-helicobacter-pylori-infection-and-mir-24-3p-expression-during-the-development-of-gastric-mucosa-lesions
#3
C Li, Y L Zhu, Q Li, D S Li, G B Yang
Objectives: To explore the expression of micro RNA-24-3p (miR-24-3p) in different gastric mucosa lesions, and analyze the potential correlation between Helicobacter pylori (H.pylori) infection and miR-24-3p expression in different gastric lesions. Methods: 158 gastric biopsy specimens were divided into four groups, including 35 chronic superficial gastritis (CSG) samples, 43 chronic atrophic gastritis (CAG) samples, 41 intestinal metaplasia (IM) samples and 39 dysplasia (Dys) samples. Those samples were collected from patients undergoing gastroscopy at the Department of Gastroenterology, Aerospace Center Hospital, from September 2005 to June 2012...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29050004/study-on-clinical-factors-involved-in-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#4
Yusuke Horiuchi, Junko Fujisaki, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. METHODS: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014...
October 19, 2017: Digestion
https://www.readbyqxmd.com/read/29049360/the-bacterial-virulence-factor-caga-induces-microbial-dysbiosis-that-contributes-to-excessive-epithelial-cell-proliferation-in-the-drosophila-gut
#5
Tiffani Alvey Jones, Diane Z Hernandez, Zoë C Wong, Anica M Wandler, Karen Guillemin
Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysbiosis contributes to disease in this case is unknown. Many H. pylori human disease phenotypes are associated with a potent virulence protein, CagA, which is translocated into host epithelial cells where it alters cell polarity and manipulates host-signaling pathways to promote disease...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29046726/helicobacter-pylori-virulence-genes-of-minor-ethnic-groups-in-north-thailand
#6
Phawinee Subsomwong, Muhammad Miftahussurur, Ratha-Korn Vilaichone, Thawee Ratanachu-Ek, Rumiko Suzuki, Junko Akada, Tomohisa Uchida, Varocha Mahachai, Yoshio Yamaoka
BACKGROUND: There are few studies analyzed concurrently the prevalence and genotypes of Helicobacter pylori infection with the ancestor origins from different ethnics, especially with including minority groups. We recruited a total of 289 patients in MaeSot, Thailand (154 Thai, 14 Thai-Chinese, 29 Karen and 92 Hmong ethnics). The virulence genes and genealogy of the strains were determined by PCR-based sequencing. RESULTS: Based on culture and histology/immunohistochemistry, the prevalence of H...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29044219/association-of-anaemia-with-helicobacter-pylori-infection-a-retrospective-study
#7
Mei-Yan Xu, Bing Cao, Bao-Shi Yuan, Jian Yin, Lan Liu, Qing-Bin Lu
The role of Helicobacter pylori (H. pylori) infection in haematological system diseases is not well understood. We conducted this retrospective study to explore the association between H. pylori infection and anaemia in the Chinese population. This retrospective study was performed in Aerospace Center Hospital in Beijing. We derived the data from the registration system of the physical population between 2012-2016. Logistic regression models were used to explore the association between H. pylori infection and anaemia...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044185/structural-analysis-of-variant-of-helicobacter-pylori-motb-in-its-activated-form-engineered-as-chimera-of-motb-and-leucine-zipper
#8
Daniel A Andrews, Yuri E Nesmelov, Matthew C Wilce, Anna Roujeinikova
Rotation of the bacterial flagellum is powered by a proton influx through the peptidoglycan (PG)-tethered stator ring MotA/B. MotA and MotB form an inner-membrane complex that does not conduct protons and does not bind to PG until it is inserted into the flagellar motor. The opening of the proton channel involves association of the plug helices in the periplasmic region of the MotB dimer into a parallel coiled coil. Here, we have characterised the structure of a soluble variant of full-length Helicobacter pylori MotB in which the plug helix was engineered to be locked in a parallel coiled coil state, mimicking the open state of the stator...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042646/effects-of-long-term-aspirin-use-on-molecular-alterations-in-precancerous-gastric-mucosa-in-patients-with-and-without-gastric-cancer
#9
Yuki Michigami, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Takeshi Morimoto, Kiron M Das, Hiroto Miwa
The risk of gastric cancer (GC) remains even after H. pylori eradication; thus, other combination treatments, such as chemopreventive drugs, are needed. We evaluated the effects of aspirin on genetic/epigenetic alterations in precancerous conditions, i.e., atrophic mucosa (AM) and intestinal metaplasia (IM), in patients with chronic gastritis who had taken aspirin for more than 3 years. A total of 221 biopsy specimens from 74 patients, including atrophic gastritis (AG) cases without aspirin use (control), AG cases with aspirin use (AG group), and GC cases with aspirin use (GC group), were analyzed...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040466/outer-inflammatory-protein-a-oipa-of-helicobacter-pylori-is-regulated-by-host-cell-contact-and-mediates-caga-translocation-and-interleukin-8-response-only-in-the-presence-of-a-functional-cag-pathogenicity-island-type-iv-secretion-system
#10
Danielle N Horridge, Allison A Begley, June Kim, Neeraja Aravindan, Kexin Fan, Mark H Forsyth
OipA is a phase variable virulence factor of Helicobacter pylori. Mutations in oipA to turn the gene phase on in a cag pathogenicity island (PAI) negative strain of H. pylori (J68), or phase off in a cag PAI positive strain (26695) demonstrated that phase on oipA alleles in both strains had both increased oipA mRNA and AGS cell adherence compared to isogenic oipA phase off mutants. An oipA phase off mutant of H. pylori 26695 demonstrated decreased IL-8 secretion by AGS cells and failure to translocate the cag PAI effector, CagA...
October 12, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29039529/inhibitory-effect-of-1%C3%A2-tetradecanol-on-helicobacter%C3%A2-pylori%C3%A2-induced-production-of-interleukin%C3%A2-8-and-vascular-endothelial-growth-factor-in-gastric-epithelial-cells
#11
Green Kim, Jae-Eun Kim, Min-Jung Kang, Ah-Ra Jang, Young Ran Kim, Sunoh Kim, Kyu-Tae Chang, Jung Joo Hong, Jong-Hwan Park
Helicobacter pylori (H. pylori) infection activates pro‑inflammatory mediators, including interleukin (IL)‑8 and vascular endothelial growth factor (VEGF) in gastric epithelial cells. 1‑Tetradecanol (1‑TD) has been purified from Dendropanax morbifera Leveille; its physiological activities are poorly understood. The present study assessed whether 1‑TD has an effect on H. pylori‑mediated inflammation in AGS gastric epithelial cells. 1‑TD reduced IL‑8 production by AGS cells in response to H...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038542/store-operated-ca-2-entry-facilitates-the-lipopolysaccharide-induced-cyclooxygenase-2-expression-in-gastric-cancer-cells
#12
Jhen-Hong Wong, Kuo-Hao Ho, Sean Nam, Wen-Li Hsu, Chia-Hsien Lin, Che-Mai Chang, Jaw-Yuan Wang, Wei-Chiao Chang
Helicobacter pylori has been identified as one of the major causes of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria, and H. pylori LPS might play an exclusively important role in activating inflammatory pathways in monocytes and macrophages. To study the role of LPS in the underlying mechanism of inflammatory responses, we established an in vitro model using the human AGS gastric cancer cell line...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036792/are-helicobacter-pylori-highly-cytotoxic-genotypes-and-cardia-gastric-adenocarcinoma-linked-lessons-from-iran
#13
Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Saber Zahri, Fatemeh Sadat Bakhti, Naser Hajavi, Abbas Yazdanbod
BACKGROUND: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE: We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS: A total of 601 Iranian patients were enrolled...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29036565/long-term-risk-of-acute-myocardial-infarction-stroke-and-death-with-outpatient-use-of-clarithromycin-a-retrospective-cohort-study
#14
Andrew D Mosholder, Joo-Yeon Lee, Esther H Zhou, Elizabeth M Kang, Mayurika Ghosh, Rima Izem, Jacqueline M Major, David J Graham
This retrospective cohort study of subjects enrolled in the United Kingdom Clinical Practice Research Datalink from 2000-2013 evaluated long-term risks of death, stroke, and acute myocardial infarction (AMI) in adults prescribed clarithromycin. Subjects were outpatients aged 40-85 years prescribed clarithromycin, doxycycline, or erythromycin (287,748, 267,729, and 442,999 patients, respectively), or H. pylori eradication therapy with a proton pump inhibitor, amoxicillin, and either clarithromycin (27,639 patients) or metronidazole (14,863 patients)...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29035012/regulatory-effects-of-black-rice-extract-on-helicobacter-pylori-infection-induced-apoptosis
#15
Sa-Hyun Kim, Min Ho Lee, Min Park, Hyun Jun Woo, Yoon Suk Kim, Nagendran Tharmalingam, Woo-Duck Seo, Jong-Bae Kim
SCOPE: Black rice extract (BRE) contains cyanidin 3-O-glucoside (C3G), an anthocyanin, as the major component. In this study, we found that BRE inhibited the mRNA and protein expression of genes encoding cytotoxin-associated protein A (cagA) and vacuolating protein A (vacA) in Helicobacter pylori 60190 strain. METHODS AND RESULTS: We performed RT-PCR and western blotting to show that BRE inhibited the mRNA and protein expression of SecA. Because SecA is involved in VacA export in bacteria, our result suggested a positive correlation between BRE-induced inhibition of secA expression and VacA secretion...
October 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29035009/prevalence-antibiotic-resistance-and-mlst-typing-of-helicobacter-pylori-in-algiers-algeria
#16
Naïma Raaf, Wahiba Amhis, Houria Saoula, Ahmed Abid, Mhamed Nakmouche, Abdelmalek Balamane, Nassima Ali Arous, Mounira Ouar-Korichi, Filipa F Vale, Lucie Bénéjat, Francis Mégraud
BACKGROUND: Helicobacter pylori infection is common in Algeria, but there are few data on the characterization of isolated strains. The aim of this study was to update data on the prevalence of H. pylori in patients submitted to endoscopy, antibiotic resistance, and phylogeography of H. pylori strains isolated in Algiers. MATERIALS AND METHODS: This is a prospective study carried out between November 2015 and August 2016. The culture of H. pylori was performed on antral and fundic gastric biopsies of adult patients from 3 hospitals...
October 16, 2017: Helicobacter
https://www.readbyqxmd.com/read/29034535/psychological-effects-of-helicobacter-pylori-associated-atrophic-gastritis-in-patients-under-50%C3%A2-years-a-cross-sectional-study
#17
Atsushi Takeoka, Jun Tayama, Masakazu Kobayashi, Ikuko Sagara, Sayaka Ogawa, Tatsuo Saigo, Masaki Hayashida, Hironori Yamasaki, Shin Fukudo, Susumu Shirabe
BACKGROUND: While gastrointestinal function is known to be closely related to psychological status, the influence of Helicobacter pylori-associated atrophic gastritis is currently unknown. We aimed to determine whether atrophic gastritis status or H. pylori infection is associated with psychological distress or depressed mood. MATERIALS AND METHODS: We performed a cross-sectional, observational study involving 975 Japanese individuals (503 females; mean age, 44 ± 8 years) who underwent a health checkup...
October 16, 2017: Helicobacter
https://www.readbyqxmd.com/read/29033421/the-resolution-of-helicobacter-suis-associated-gastric-lesions-after-eradication-therapy
#18
Satoru Nakagawa, Tadashi Shimoyama, Masahiko Nakamura, Daisuke Chiba, Hidezumi Kikuchi, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda
A reddish depressed lesion was found in the corpus of the stomach of a 56-year-old man. Gastric biopsy showed no findings of MALT lymphoma, including lympho-epithelial lesions. A urea breath test, stool antigen test and serum IgG antibody to Helicobacter pylori test were negative. Magnifying endoscopy using narrow-band-imaging showed no malignant structures. Gastric biopsy specimens were subjected to immunohistochemistry and a PCR, which identified Helicobacter suis infection. Triple therapy with esomeprazole, metronidazole, and amoxicillin was administered for 10 days...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29033302/the-antimicrobial-susceptibility-of-helicobacter-pylori-in-strains-isolated-from-children-in-israel
#19
Nina Pastukh, Avi Peretz, Diana Brodsky, Natlya Isakovich, Maya Azrad, Avi On
BACKGROUND: Helicobacter pylori is a pathogen that causes inflammation in the gastric mucosa, and may lead to a peptic ulcer, perforation, or malignancy. Children are at risk of contracting H. pylori and developing subsequent morbidity. In children, diagnosis and management are difficult and merit a different approach than with adults. OBJECTIVE: To describe resistance rates of H. pylori to antibiotics such as amoxicillin, tetracycline, clarithromycin, metronidazole, levofloxacin, and Rifampicin...
October 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29031421/tlr2-activation-induced-by-h-pylori-lps-promotes-the-differential-expression-of-claudin-4-6-7-and-9-via-either-stat3-and-erk1-2-in-ags-cells
#20
Christian O Chavarría-Velázquez, Ana C Torres-Martínez, Luis F Montaño, Erika P Rendón-Huerta
Gastric carcinogenesis has been associated to H. pylori virulence factors that induce a chronic inflammation process. Lipopolysaccharides play a role in chronic inflammatory responses via TLR2- and TLR4-dependent signaling pathways. Similarly, cellular invasiveness, metastatic potential and prognosis are usually associated to claudin-4, -6, -7 and -9 expression in gastric carcinogenesis. Therefore, the aim of this study was to determine if H. pylori LPS exerts an influence on carcinogenesis-related claudin expression and if it was directly regulated through the TLR2 pathway...
October 6, 2017: Immunobiology
keyword
keyword
16285
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"