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stress response to surgery

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https://www.readbyqxmd.com/read/30312812/the-impact-of-preoperative-mindfulness-based-stress-reduction-on-postoperative-patient-reported-pain-disability-quality-of-life-and-prescription-opioid-use-in-lumbar-spine-degenerative-disease-a-pilot-study
#1
Juneyoung L Yi, Christina A Porucznik, Lisa H Gren, Jian Guan, Evan Joyce, Darrel S Brodke, Andrew T Dailey, Mark A Mahan, Robert S Hood, Brandon D Lawrence, William R Spiker, Nicholas T Spina, Erica F Bisson
BACKGROUND: Prescription opioid medications negatively affect postoperative outcomes after lumbar spine surgery. Furthermore, opioid-related overdose death rates in the U.S. increased by 200% between 2000 and 2014. Thus, alternatives are imperative. Mindfulness-based stress reduction (MBSR), a mind-body therapy, has been associated with improved activity and mood in opioid-using chronic pain patients. This study assessed whether preoperative MBSR is an effective adjunct to standard postoperative care in adult patients undergoing lumbar spine surgery for degenerative disease...
October 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30312662/topical-nanodelivery-system-of-lutein-for-the-prevention-of-selenite-induced-cataract
#2
Ede Bodoki, Oliviu Vostinaru, Ovidiu Samoila, Elena Dinte, Andreea E Bodoki, Sean Swetledge, Carlos E Astete, Cristina M Sabliov
Cataracts are responsible for half of the world blindness, surgery being the only viable treatment. Lutein, a naturally occurring carotenoid in the eye, has the potential to prevent cataract progression. Its low stability and limited ocular bioavailability upon systemic administration prevented its medical use. To restore the eye's natural line of defense against photo-oxidative stress, a formulation was developed using zein and poly(lactic-co-glycolic acid) nanoparticles (NPs) embedded in an optimized bioadhesive thermosensitive gel for the delivery of lutein via topical application...
October 9, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30305045/effects-of-resveratrol-pretreatment-on-endoplasmic-reticulum-stress-and-cognitive-function-after-surgery-in-aged-mice
#3
Bei Wang, Shengjin Ge, Wanxia Xiong, Zhanggang Xue
BACKGROUND: Postoperative cognitive dysfunction (POCD) seriously reduces quality of life and is associated with increased morbidity and mortality. The causes and neuropathogenesis of POCD remain largely unknown. Resveratrol, a sirtuin 1 (Sirt1) activator, is a polyphenol compound found in red wine that has protective functions in neuropathology paradigms. Endoplasmic reticulum stress (ERS) is a primary cellular response that activates the unfolded protein response (UPR). ERS and UPR mediate molecular and biochemical mechanisms related to neurodegeneration; however, the roles of ERS and Sirt1 in POCD remain unclear...
October 10, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30301691/burnout-depression-perceived-stress-and-self-efficacy-in-vascular-surgery-trainees
#4
Matthew R Janko, Matthew R Smeds
OBJECTIVE: Burnout is a work-related syndrome involving emotional exhaustion, depersonalization, and a sense of reduced personal accomplishment that has become prevalent in all levels of medical training. We sought to understand factors associated with burnout identified in vascular surgery trainees. METHODS: An anonymous electronic survey consisting of demographic and programmatic information as well as validated scales for burnout, depression, perceived stress, self-efficacy, and social support was given to all vascular surgery trainees in the United States...
October 6, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30299022/meeting-nutritional-needs-of-infants-under-3-months-of-life-within-the-first-week-after-cardiovascular-surgery
#5
Carola Saure, Belisario Almeyra Ibarra, Carolina Caminiti, Mariela Krynski, Mercedes Montonati, Ricardo Rodriguez, María Althabe
BACKGROUND: After heart surgery requiring cardiopulmonary bypass, neonates have a profound metabolic response to stress. If adequate nutritional support is not provided this leads to loss of lean mass and deterioration of vital organs. Our objective was to describe the nutritional status and nutritional support achieved in infants younger than 3 months of life undergo in cardiovascular surgery. METHODS: A prospective, descriptive study was conducted in a Pediatric Cardiovascular intensive therapy at tertiary care center...
October 4, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/30296006/sirt3-activator-honokiol-ameliorates-surgery-anesthesia-induced-cognitive-decline-in-mice-through-anti-oxidative-stress-and-anti-inflammatory-in-hippocampus
#6
Ji-Shi Ye, Lei Chen, Ya-Yuan Lu, Shao-Qing Lei, Mian Peng, Zhong-Yuan Xia
AIMS: Increasing evidence indicates that neuroinflammatory and oxidative stress play two pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. The aim of these experiments is to evaluate the effects of HNK on surgery/anesthesia-induced cognitive decline in mice. METHODS: Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia and HNK or SIRT3 inhibitor (3-TYP) treatment...
September 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/30294902/a-comparison-of-the-influence-of-three-different-lumbar-interbody-fusion-approaches-on-stress-in-the-pedicle-screw-fixation-system-finite-element-static-and-vibration-analyses
#7
Wei Fan, Li-Xin Guo
This study aimed to examine breakage risk of the bilateral pedicle screw (BPS) fixation system under static and vibration loadings after three different types of lumbar interbody fusion surgery. A previously validated intact L1-sacrum finite element model was modified to simulate anterior, posterior and transforaminal lumbar interbody fusion (ALIF, PLIF and TLIF) with BPS fixation system (consisting of pedicle screws and rigid connecting rods) at L4-L5. As a risk parameter for breakage, the von Mises stresses in the pedicle screws and the rods for the ALIF, PLIF and TLIF models under static loading (flexion, extension, lateral bending and axial torsion moments) and vibration loading (sinusoidal vertical load) were calculated and compared...
October 7, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/30291832/decreased-pgc-1%C3%AE-post-cardiopulmonary-bypass-leads-to-impaired-oxidative-stress-in-diabetic-patients
#8
Eitezaz Mahmood, Jelliffe Jeganathan, Ruby Feng, Maria Saraf, Kamal Khabbaz, Faraz Mahmood, Senthilnathan Venkatachalam, David Liu, Louis Chu, Samir M Parikh, Robina Matyal
BACKGROUND: The mechanism of mitochondrial dysfunction following cardiopulmonary bypass (CPB) in diabetics lacks understanding. We hypothesized that impaired beta-oxidation of fatty acids leads to worsened stress response in this patient population after cardiac surgery. METHODS: After IRB approval, right atrial tissue samples were collected from 35 diabetic and 33 non-diabetics pre- and post-CPB. Patients with HbA1c ≥ 6.0 and a clinical diagnosis of diabetes mellitus were considered to be diabetic...
October 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30288172/association-between-chronological-depressive-changes-and-physical-symptoms-in-postoperative-pancreatic-cancer-patients
#9
Naoko Sato, Yoshimi Hasegawa, Asami Saito, Fuyuhiko Motoi, Kyohei Ariake, Yu Katayose, Kei Nakagawa, Kei Kawaguchi, Shin Fukudo, Michiaki Unno, Fumiko Sato
Background: Pancreatic cancer (PC) has poorer prognosis and higher surgical invasiveness than many other cancers, with associated psychiatric symptoms including depression and anxiety. Perioperative depression has not been investigated in PC patients regarding surgical stress and relevant interventions. Methods: We evaluated chronological depressive changes and subjective physical symptoms in surgically treated PC patients preoperatively and at 3 and 6 months postoperatively...
2018: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/30286133/role-of-extracellular-matrix-and-microenvironment-in-regulation-of-tumor-growth-and-lar-mediated-invasion-in-glioblastoma
#10
Yangjin Kim, Hyunji Kang, Gibin Powathil, Hyeongi Kim, Dumitru Trucu, Wanho Lee, Sean Lawler, Mark Chaplain
The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of primary brain cancer, depends critically on the migration patterns after surgery and intracellular responses of the individual cancer cells in response to external biochemical cues in the microenvironment. Recent studies have shown that miR-451 regulates downstream molecules including AMPK/CAB39/MARK and mTOR to determine the balance between rapid proliferation and invasion in response to metabolic stress in the harsh tumor microenvironment...
2018: PloS One
https://www.readbyqxmd.com/read/30285881/surgical-peritoneal-stress-creates-a-pro-metastatic-niche-promoting-resistance-to-apoptosis-via-il-8
#11
Jennifer Pasquier, Fabien Vidal, Jessica Hoarau-Véchot, Claire Bonneau, Emile Daraï, Cyril Touboul, Arash Rafii
BACKGROUND: The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5 years. Most recurrences occur in the peritoneal cavity, suggesting the existence of occult sanctuaries where ovarian cancer cells (OCC) are protected. In murine models, surgical stress favors tumor growth; however, it has never been established that surgery may affect OCC sensitivity to subsequent chemotherapy...
October 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30274910/simvastatin-ameliorates-total-liver-ischemia-reperfusion-injury-via-klf2-mediated-mechanism-in-rats
#12
Zhongzhong Liu, Chin-Hui Lai, Xingjian Zhang, Jun Luo, Xiaoying Huang, Xiao Qi, Wei Wang, Zibiao Zhong, Fan Xiaoli, Ling Li, Yan Xiong, Norbert Senninger, Yanfeng Wang, Qifa Ye, Shaojun Ye
OBJECTIVE: The total hepatic ischemia/reperfusion injury (IRI) involves the fact that both liver and gut are subjected to warm ischemia, which is a complex unavoidable process encountered during liver transplantation and a serious threat to graft outcome. The ways to improve hepatic IRI are currently limited. The aim of the present study was to explore the protective effect of simvastatin on total hepatic IRI and examine the underlying mechanisms. METHODS: Male Sprague Dawley rats were subjected to total (100%) hepatic warm ischemia to induce hepatic IRI...
September 28, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30264660/a-systematic-review-of-caudal-anesthesia-and-postoperative-outcomes-in-pediatric-cardiac-surgery-patients
#13
Malak Maharramova, Katherine Taylor
OBJECTIVES: In pediatric cardiac surgery, does caudal anesthesia promote early extubation, reduce pain scores, reduce stress responses, and length of stay (LOS)? DESIGN: A systematic review. PARTICIPANTS: Inclusion criteria included cardiac surgical procedures (with or without cardiopulmonary bypass) in any subject between the ages of full-term newborn and 18 years receiving caudal anesthesia of any medication combination. Searches were conducted with assistance of an Academic librarian from 1947 to July 2017...
September 28, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/30260818/psychosocial-predictors-of-adjustment-to-disability-among-patients-with-breast-cancer-a-cross-sectional-descriptive-study
#14
Qingyue Zhang, Shan Xiao, Ling Yan, Liyuan Sun, Yan Wang, Mengqiu Huang
BACKGROUND: Acceptance of disability relates to the process of adaptation, which reflects how the values of a patient change over time to accept herself or himself as an intrinsically worthy person. Acceptance of disability (AOD) plays an important role in the adjustment of persons with physical disability to their environment. However, no studies on the level of AOD in patients with breast cancer are available in the literature. PURPOSE: The aim of this study was to explore the significant factors that influence disability acceptance in Chinese women with breast cancer...
September 26, 2018: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/30259310/alterations-in-hypothalamic-pituitary-adrenal-function-immediately-after-resection-of-adrenal-adenomas-in-patients-with-cushing-s-syndrome-and-others-with-incidentalomas-and-subclinical-hypercortisolism
#15
Dena Khawandanah, Nadine ElAsmar, Baha M Arafah
BACKGROUND: Patients with cortisol secreting adrenal adenomas present with Cushing's syndrome (CS), while 5-15% of subjects with adrenal incidentalomas have subclinical hypercortisolism (SH) as they have biochemical abnormalities suggesting autonomous cortisol secretion without associated clinical features of CS. GOALS: Examine HPA function immediately after resection of either of these adenomas and utilize the data to decide on initiating glucocorticoid replacement...
September 27, 2018: Endocrine
https://www.readbyqxmd.com/read/30255736/feasibility-of-intraoperative-neuromonitoring-during-thyroid-surgery-using-trans-cartilage-surface-recording-electrodes
#16
Che-Wei Wu, Feng-Yu Chiang, Gregory W Randolph, Gianlorenzo Dionigi, Hoon Yub Kim, Yi-Chu Lin, Hui-Chun Chen, Hsiu-Ya Chen, Dipti Kamani, Tsung-Yi Tsai, I-Cheng Lu, Pi-Ying Chang
BACKGROUND: Intraoperative neural monitoring (IONM) has gained widespread acceptance as an adjunct to the gold standard of visual identification of the recurrent laryngeal nerve (RLN) during thyroid surgery. Currently, laryngeal electromyography (EMG) recording during IONM is almost always performed using endotracheal tube (ETT) surface electrodes placed adjacent to vocal folds originating from the inner surface of the thyroid cartilage (TC). Therefore, we hypothesized that surface recording electrodes placed on the outer surface of the TC should enable access to the EMG response of the vocal folds during IONM...
September 26, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30255058/combining-a-joint-health-supplement-with-tibial-plateau-leveling-osteotomy-in-dogs-with-cranial-cruciate-ligament-rupture-an-exploratory-controlled-trial
#17
Filippo M Martini, Anna Brandstetter de Bellesini, Alda Miolo, Laura Del Coco, Francesco P Fanizzi, Antonio Crovace
Canine cranial cruciate ligament rupture (CrCLR) is a very common pathology. Surgical stabilization is the first choice treatment, although it does not fully eliminate the increased risk of osteoarthritis. This preliminary study was carried out to explore whether a newly formulated joint health supplement would benefit metabolic, clinical and radiographic changes in dogs with CrCLR surgically treated with tibial plateau leveling osteotomy (TPLO). Besides chondroitin sulfate and glucosamine hydrochloride, the studied supplement contained anti-inflammatory and antioxidant ingredients, the main ones being N-palmitoyl-D-glucosamine (Glupamid®) and quercetin...
December 2017: International Journal of Veterinary Science and Medicine
https://www.readbyqxmd.com/read/30240823/sex-differences-in-the-effects-of-adult-short-term-isolation-rearing-on-contextual-fear-memory-and-extinction
#18
Shingo Matsuda, Suguru Tohyama, Akihiro Mizutani
Fear conditioning and extinction is a useful tool for understanding the pathogenesis of fear-related disorders including post-traumatic stress disorder (PTSD) and for developing treatments for them. To investigate the role of sub-brain regions or molecular mechanisms in fear conditioning and extinction, neuroscientists have been employing an optogenetic or in vivo recording technique, in which placement of an optical fiber or an electrode into the brain region of a free-moving mouse is essential. These methods require isolation rearing (at least one week) from the brain surgery to the behavioral test...
September 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30235427/the-effect-of-dexmedetomidine-on-oral-mucosal-blood-flow-and-the-absorption-of-lidocaine
#19
Shu Tomita, Shinya Yamazaki, Kohei Togami, Hitoshi Tada, Hiroyoshi Kawaai
Dexmedetomidine (DEX) is a sedative and analgesic agent that acts via the alpha-2 adrenoreceptor and is associated with reduced anesthetic requirements, as well as attenuated blood pressure and heart rate in response to stressful events. A previous study reported that cat gingival blood flow was controlled via sympathetic alpha-adrenergic fibers involved in vasoconstriction. In the present study, experiment 1 focused on the relationship between the effects of DEX on alpha adrenoreceptors and vasoconstriction in the tissues of the oral cavity and compared the palatal mucosal blood flow (PMBF) in rabbits between general anesthesia with sevoflurane and sedation with DEX...
2018: Anesthesia Progress
https://www.readbyqxmd.com/read/30232593/psychosocial-functioning-of-parents-of-children-with-heart-disease-describing-the-landscape
#20
Jo Wray, Amy Cassedy, Michelle M Ernst, Rodney C Franklin, Katherine Brown, Bradley S Marino
The aim was to describe the psychological functioning of parents of school-age children with heart disease (HD) in a large-scale, transnational evaluation of parent dyads across the spectrum of cardiac diagnoses and a range of psychosocial domains. Parents of children with HD attending routine out-patient cardiology follow-up visits completed questionnaires assessing their mental health, coping, and family functioning. Parents (1197 mothers and 1053 fathers) of 1214 children (mean age: 12.6 years; S.D. 3.0 years; median time since last surgery: 8...
September 19, 2018: European Journal of Pediatrics
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