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stress response to surgery

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Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period...
December 2018: BJS open
Miro Jukić, Zenon Pogorelić, Daniela Šupe-Domić, Ana Jerončić
BACKGROUND: The aim of this study was to compare inflammatory stress response between laparoscopic percutaneous inguinal ring suturing (PIRS) and open modified Marcy technique for pediatric inguinal hernia repair. METHODS: From May 2017 to April 2018, 32 male children with median age of 4.5 years undergoing inguinal hernia repair were included in randomized controlled trial. The patients were divided in two groups, by using random number generator, depending on surgical approach...
December 3, 2018: Surgical Endoscopy
Haojia Wu, Yuhei Kirita, Erinn L Donnelly, Benjamin D Humphreys
BACKGROUND: A challenge for single-cell genomic studies in kidney and other solid tissues is generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate cell types and is free of both RNA degradation and artifactual transcriptional stress responses. METHODS: We compared single-cell RNA sequencing (scRNA-seq) using the DropSeq platform with single-nucleus RNA sequencing (snRNA-seq) using sNuc-DropSeq, DroNc-seq, and 10X Chromium platforms on adult mouse kidney...
December 3, 2018: Journal of the American Society of Nephrology: JASN
C Strumann, K Flägel, T Emcke, J Steinhäuser
BACKGROUND: In response to a rising shortage of general practitioners (GPs), physicians in general internal medicine (GIM) have become part of the German primary care physician workforce. Previous studies have shown substantial differences in practice patterns between both specialties. The aim of this study was to analyse and compare the application of procedures by German GPs and GIM physicians based on routine data. METHODS: The Association of Statutory Health Insurance Physicians in the federal state Schleswig-Holstein (Northern Germany) provided invoicing data of the first quarters of 2013 and 2015...
December 3, 2018: BMC Family Practice
Başar Erdivanlı, Özlem Çelebi Erdivanlı, Ahmet Şen, Abdullah Özdemir, Ersagun Tuğcugil, Engin Dursun
Objective: Controlled hypotension is commonly induced during functional endoscopic sinus surgery to limit mucosal bleeding. This may be detrimental to elderly patients and patients with arterial stenosis. The aim of this pilot study was to determine if a normotensive anaesthetic technique with sufficient analgesia and without profound vasodilation may reduce intraoperative bleeding and incidence of adverse haemodynamic effects associated with vasodilation and variable rate continuous infusions...
December 2018: Turkish Journal of Anaesthesiology and Reanimation
Sylvain Gagné, Daniel I McIsaac
Enhanced recovery after surgery (ERAS) programs include a variety of pre-, intra- and post-operative interventions that seek to decrease the stress response to surgery and facilitate the recovery of surgical patients. There are a number of patient factors that may increase the risk of postoperative complications (POC) after lung cancer surgery and delay recovery. Some of these factors may be amenable to optimization preoperatively and potentially decrease the incidence of these complications. We have chosen to discuss the incidence and complications associated with factors we felt were both relatively common and significant contributors to POCs...
November 2018: Journal of Thoracic Disease
Chutima Rattanasopa, Jonathan A Kirk, Tepmanas Bupha-Intr, Maria Papadaki, Pieter P de Tombe, Jonggonnee Wattanapermpool
Here, we aimed to explore sex differences and the impact of sex hormones on cardiac contractile properties in doxorubicin-induced cardiotoxicity. Male and female Sprague Dawley rats were subjected to sham surgery or gonadectomy and then treated or untreated with doxorubicin (DOX), 2 mg/kg every other week for 10 weeks. Estrogen preserved maximum active tension (Tmax ) with DOX exposure while progesterone and testosterone did not. The effects of sex hormones and DOX correlated with both altered myosin heavy chain isoform expression and myofilament protein oxidation, suggesting both as possible mechanisms...
November 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Michio Sato, Keishi Miyata, Zhe Tian, Tsuyoshi Kadomatsu, Yoshihiro Ujihara, Jun Morinaga, Haruki Horiguchi, Motoyoshi Endo, Jiabin Zhao, Shunshun Zhu, Taichi Sugizaki, Kimihiro Igata, Masashi Muramatsu, Takashi Minami, Takashi Ito, Marco E Bianchi, Satoshi Mohri, Kimi Araki, Koichi Node, Yuichi Oike
BACKGROUND: The rapid increase in the number of heart failure (HF) patients in parallel with the increase in the number of older people is receiving attention worldwide. HF not only increases mortality but decreases quality of life, creating medical and social problems. Thus, it is necessary to define molecular mechanisms underlying HF development and progression. HMGB2 is a member of the high-mobility group superfamily characterized as nuclear proteins that bind DNA to stabilize nucleosomes and promote transcription...
November 27, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Anna Reustle, Michael Torzewski
Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in atherosclerosis therapy, whereas no pharmacological interventions are available for the treatment of aortic valve sclerosis. Therefore, valve replacement surgery to prevent acute heart failure is the only option for patients with severe aortic stenosis. Both atherosclerosis and aortic valve sclerosis are not simply the consequence of degenerative processes, but rather diseases driven by inflammatory processes in response to lipid-deposition in the blood vessel wall and the aortic valve, respectively...
November 27, 2018: International Journal of Molecular Sciences
Jèssica Latorre, José M Moreno-Navarrete, Mónica Sabater, Maria Buxo, José I Rodriguez-Hermosa, Jordi Girones, José M Fort, Ramón Vilallonga, Wifredo Ricart, Rafael Simo, Jose-Manuel Fernandez-Real, Francisco J Ortega
BACKGROUND/AIMS: Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores the impact of different inflammatory/ anti-inflammatory paradigms on the expression of toll-like receptors (TLR) found in adipocyte cultures, adipose tissue, and blood. METHODS: We evaluated by real time PCR the impact of acute surgery stress in vivo (adipose tissue) and macrophages (MCM) in vitro (adipocytes)...
November 26, 2018: Cellular Physiology and Biochemistry
Maysa Isernhagen Schaedler, Rhanany Alan Calloi Palozi, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Valdinei de Oliveira Araújo, Emerson Luiz Botelho Lourenço, Lauro Mera de Souza, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior
BACKGROUND: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Macbr. (Lythraceae), popularly known as 'sete sangrias', being found in Brazil, Hawaii and in South Pacific Islands. Despite the widespread use of this species by the population, its long-term antihypertensive and cardioprotective activities have not yet been scientifically evaluated. PURPOSE: To evaluate the possible cardioprotective effects of an ethanol-soluble fraction obtained from C...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Yifan Chen, Tianzheng Yu
AIMS: Testosterone is implicated as a potential contributing factor to heat-induced injury. We examined effects of testosterone on thermal response of mice to heat exposure. MAIN METHODS: Adult C57BL/6J male mice received gonadectomy or sham surgery subsequent vehicle (Gnx) or testosterone implants (Gnx+T). Body core temperature (Tc) of mice was recorded telemetrically during acute heat exposure. Thermal responses to heat exposure were also examined in age-matched female mice at each stage of the estrous cycle...
December 1, 2018: Life Sciences
Inge Søkilde Pedersen, Mads Thomassen, Qihua Tan, Torben Kruse, Ole Thorlacius-Ussing, Jens Peter Garne, Henrik Bygum Krarup
BACKGROUND: Gene expression profiles of normal and tumor tissue reflect both differences in biological processes taking place in vivo and differences in response to stress during surgery and sample handling. The effect of cold (room temperature) ischemia in the time interval between surgical removal of the specimen and freezing is described in a few studies. However, not much is known about the effect of warm (body temperature) ischemia during surgery. METHODS: Three women with primary operable breast cancer underwent in situ biopsies from normal breast and tumor tissue prior to radical mastectomy...
November 16, 2018: Molecular Medicine
Patricia Rouet-Benzineb, Régine Merval, Evelyne Polidano
We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca2+ -homeostasis, pro/anti-hypertrophic, endoplasmic reticulum stress (ER stress), pro- or anti-apoptotic effectors, and MAP kinase activation, and redox signaling...
November 2018: Physiological Reports
Annelyn Torres-Reverón, Leslie L Rivera-Lopez, Idhaliz Flores, Caroline B Appleyard
Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding effective, non-hormonal and long-term treatments for endometriosis still remains one of the most significant challenges in the field. Corticotropin releasing hormone (CRH) is one of the main signaling peptides within the hypothalamic pituitary adrenal (HPA) axis released in response to stress. CRH can affect nervous and visceral tissues such as the uterus and gut via activation of two types of CRH receptors: CRHR1 and CRHR2...
2018: PloS One
Tianci Li, Lin Chen, Hailin Zhao, Lingzhi Wu, Joe Masters, Chongfang Han, Kazuyoshi Hirota, Daqing Ma
BACKGROUND: Retrospective studies indicate that the use of regional anaesthesia causes a reduction in cancer recurrence after oncological surgery, which could be due to anaesthetic's negating effect on immunosuppression related to the surgical stress response. Local anaesthetics may also exert direct suppressive effects on malignant cells, an area where further investigation is urgently needed. METHODS: Human colon cancer cells and human melanoma cells were cultured and then treated with 1 mM bupivacaine or levobupivacaine for up to 24 or 48 h...
November 13, 2018: Journal of Anesthesia
Sarinnapha M Vasunilashorn, Long H Ngo, Richard N Jones, Sharon K Inouye, Kathryn T Hall, Jacqueline Gallagher, Simon T Dillon, Zhongcong Xie, Towia A Libermann, Edward R Marcantonio
OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in degrading catecholamines associated with the stress response, may influence susceptibility to delirium. Individuals with the COMT (rs4680) Val/Val genotype (designated "warriors") withstand the onset of neuropsychiatric disorders and cognitive decline, whereas individuals with Met/Met and Val/Met genotypes ("nonwarriors") are more susceptible to these conditions. We evaluated whether COMT genotype modifies the established association between acute phase reactant (stress marker) C-reactive protein (CRP) and postoperative delirium...
September 14, 2018: American Journal of Geriatric Psychiatry
Lauren Tennyson, Matthew Rytel, Stacy Palcsey, Leslie Meyn, Rui Liang, Pamela Moalli
BACKGROUND: Polypropylene mesh is widely used for surgical treatment of pelvic organ prolapse and stress urinary incontinence. While these surgeries demonstrate favorable functional and anatomical outcomes, their use has been limited by complications, the two most common being exposure and pain. Growing evidence suggests T lymphocytes play a critical role in regulating the host response to biomaterials. OBJECTIVES: To define and characterize the T cell response and correlate the response to collagen deposition in fibrotic capsules in mesh tissue complexes removed for the complications of pain versus exposure...
November 9, 2018: American Journal of Obstetrics and Gynecology
Kapritsou Maria, Konstantinou A Evangelos, Korkolis P Dimitris, Kalafati Maria, Kaklamanos Ioannis, Giannakopoulou Margarita
AIM: To assess the clinical parameters and compare the stress and pain response between fast-track recovery protocol and conventional treatment in patients undergoing major liver resection. METHODS: Eighty-eight patients suffering from malignant liver tumours were surgically treated from May 2012 to March 2015. After randomisation, they were prospectively divided into two groups: group fast-track patients (n = 46) and group conventional treatment patients (n = 42)...
November 12, 2018: Journal of Perioperative Practice
Elizabeth V Dray, Marybeth Hall, Diana Covalschi, Ann P Cameron
OBJECTIVES: To evaluate the efficacy of urethral bulking agents for stress urinary incontinence in the setting of prior failed sling. METHODS: This is a retrospective review of patients who underwent urethral bulking agent injections for a primary complaint of stress urinary incontinence following prior failed sling surgery. The outcomes assessed were patient reported improvement, need for further interventions for incontinence and validated questionnaires. Values for questionnaires were obtained from the patient's pre-procedure visit, at the first visit following their last injection and at their most recent visit within our system...
November 6, 2018: Urology
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