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Jessica L Ward, Gregory R Lisciandro, Teresa C DeFrancesco
OBJECTIVE: To assess distribution of alveolar-interstitial syndrome (AIS) detected by lung ultrasound (LUS) compared to thoracic radiographs (TXR). DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: Seventy-six dogs and 24 cats with acute respiratory distress or tachypnea. INTERVENTIONS: Patients underwent LUS and TXR within 6 hours. Lung ultrasound images were scored for presence and quantity of B-lines in 4 lung quadrants (right cranial, right caudal, left cranial, left caudal)...
August 3, 2018: Journal of Veterinary Emergency and Critical Care
Hannah Pischon, Anne Petrick, Matthias Müller, Nils Köster, Jörg Pietsch, Lars Mundhenk
Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually due to ingestion of plants of the Ericaceae family, such as Rhododendron. Here, we report the ingestion of Pieris japonica as the cause of grayanotoxin I intoxication in 2 miniature pigs that were kept as pets. The pigs showed sudden onset of pale oral mucosa, tachycardia, tachypnea, hypersalivation, tremor, and ataxia that progressed to lateral recumbency. The pathological examination of one pig revealed no specific indications for intoxication except for the finding of plant material of Pieris japonica in the intestine...
August 2, 2018: Veterinary Pathology
Fiona P Havers, Alicia M Fry, Doli Goswami, Kamrun Nahar, Amina Tahia Sharmin, Mustafizur Rahman, W Abdullah Brooks
BACKGROUND: The contribution of respiratory viruses to childhood pneumonia in tropical low- and middle-income countries is poorly understood. We used population-based respiratory illness surveillance in children <5 years old in Dhaka, Bangladesh, to characterize these illnesses. METHODS: We conducted weekly home visits to children who were referred to clinic for fever or respiratory symptoms. Standardized clinical data were collected. Nasopharyngeal washes were collected for one fifth of children diagnosed with a febrile or respiratory syndrome, with virus isolation testing for influenza and RT-PCR testing for other viruses...
July 31, 2018: Pediatric Infectious Disease Journal
Syed Javed Zaidi, Shaista Shaik, Caitlin Agrawal, Waseem Cossor
INTRODUCTION: Kaposiform hemangioendothelioma (KHE) is a rare and aggressive vascular tumor that can be associated with a consumptive coagulopathy and thrombocytopenia (Kasabach-Merritt phenomenon). Only one case of an intracardiac KHE has been reported which was treated with surgical excision and then expectant management. CASE PRESENTATION: We present a patient with an intracardiac KHE which presented as a large mass surrounding the atria, pulmonary veins, superior vena cava, and infiltrating the atrial septum with moderate compression of the superior vena cava and mild compression of the pulmonary veins...
July 31, 2018: Journal of Pediatric Hematology/oncology
Jonathan L Chang, Raquel Reyes, Michael Matte, Moses Ntaro, Edgar Mulogo, Matthew O Wiens, Steven R Meshnick, Mark J Siedner, Ross Boyce
Not much is known about clinical decision-making in rural, low-resource settings regarding fever, a common reason for presentation to care. In this prospective cohort study of patients presenting with febrile illness to a rural Ugandan health center, we examined demographic and clinical factors predictive of an initial disposition of inpatient admission after clinical evaluation, but before laboratory testing. We then assessed the association of laboratory results and system factors with a change between initial and final disposition plans...
July 30, 2018: American Journal of Tropical Medicine and Hygiene
Rajeev Sandal, Aditya Jandial, Kundan Mishra, Alka Khadwal, Pankaj Malhotra
A 66-year-old gentleman, presented with history of fever and cough for 2 weeks. He was a known case of diabetes mellitus type 2 for five years. He was febrile, had tachypnea, trachycardia and 96% oxygen saturation at room air. Chest auscultation revealed crackles in bilateral infrascapular area. Chest x-ray was within normal limit. Diagnosis of communityacquired pneumonia was made, he was admitted, and started on levofloxacin along with insulin therapy. On day three of therapy his condition worsened. CT-chest images showed bilateral lung consolidation with air lucency in between...
July 28, 2018: QJM: Monthly Journal of the Association of Physicians
Kathryn T Kopec, Caroline Freiermuth, Susan Maynard, Michael Beuhler
INTRODUCTION: 2,4-Dinitrophenol (DNP) is a known uncoupler of oxidative phosphorylation that clinically leads to hyperthermia, tachycardia, tachypnea, and metabolic acidosis. Intentional overdoses of DNP are often fatal. We present an analytically confirmed fatal case of DNP overdose with a falsely positive elevated salicylate concentration. We further explored this cross reactivity of DNP with two salicylate assays. METHODS: Clinically relevant serial dilutions of DNP were prepared in drug-free serum and analyzed using two different colorimetric NADH/NAD-based analytical methodologies...
July 26, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Yoko Ikoma, Ikue Kusumoto-Yoshida, Akihiro Yamanaka, Youichirou Ootsuka, Tomoyuki Kuwaki
The medullary raphé nuclei are involved in controlling cardiovascular, respiratory, and thermoregulatory functions, as well as mediating stress-induced tachycardia and hyperthermia. Although the serotonergic system of the medullary raphé has been suggested as the responsible entity, specific evidence has been insufficient. In the present study, we tested this possibility by utilizing an optogenetic approach. We used genetically modified mice [tryptophan hydroxylase 2 (Tph2); archaerhodopsin-T (ArchT) mice] in which ArchT, a green light-driven neuronal silencer, was selectively expressed in serotonergic neurons under the regulation of Tph2 promoters...
2018: Frontiers in Physiology
Ashraf Soliman, Husam Salama, Hilal Al Rifai, Vincenzo De Sanctis, Sawsan Al-Obaidly, Mai Al Qubasi, Tawa Olukade
AIMS OF THE STUDY: We describe the impact of different forms of dysglycemia on maternal and neonatal health. This research is a part of the PEARL-Peristat Maternal and newborn registry, funded by Qatar National Research Fund (QNRF) Doha, Qatar. METHODS: A population-based retrospective data analysis of 12,255 women with singleton pregnancies screened during the year 2016-2017, of which 3,027 women were identified with gestation diabetes mellitus (GDM) during pregnancy and 233 were diabetic before pregnancy...
May 23, 2018: Acta Bio-medica: Atenei Parmensis
M Ibrahim, A Omran, N B AbdAllah, M Ibrahim, S El-Sharkawy
BACKGROUND: Transient tachypnea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD). However, distinguishing TTN from other causes of RD may be difficult during the first 12:24 h after birth. Lung ultrasonography (LUS) has been successfully utilized in the diagnosis and differential diagnosis of neonatal RD. This study aimed to investigate the diagnostic value of LUS for early diagnosis of TTN as well as differentiate it from other causes of neonatal RD in near and full term Egyptian neonates...
July 16, 2018: Journal of Neonatal-perinatal Medicine
Grace K Clark, Alan Spier, Derek Nestor, Scott Rizzo
An 11 yr old female spayed golden retriever weighing 30.3 kg presented for evaluation of progressive lethargy, anorexia, tachypnea, stiff gait, and nonlocalized pain. On physical exam, the patient was febrile and tachycardic, and an arrhythmia with pulse deficits was noted. Clinicopathological abnormalities included thrombocytopenia, leukocytosis, nonregenerative anemia, and mild hypoalbuminemia. The patient progressed overnight to develop a productive cough, and an echocardiogram performed the next morning revealed irregular proliferative lesions of the pulmonic valve with moderate pulmonic regurgitation...
July 24, 2018: Journal of the American Animal Hospital Association
Dana M DeSandre-Robinson, Mariana T Quina, David M Lurie
A 10 yr old papillon was evaluated for lethargy, inappetence, tachypnea, and labored breathing. Physical examination findings included dehydration, tachypnea, tachycardia, and muffled heart sounds. Thoracic radiographs revealed an enlarged cardiac silhouette. Echocardiography revealed a mild volume of pericardial effusion and no evidence of right atrial tamponade or a cardiac-associated mass. Cytological analysis of the pericardial effusion was consistent with blood. There was no evidence of neoplasia. Coagulation parameters were within normal limits...
July 24, 2018: Journal of the American Animal Hospital Association
Seda Yılmaz Semerci, Burak Yücel, Ibrahim Mert Erbas, Osman Samet Gunkaya, Merve Talmac, Merih Çetinkaya
BACKGROUND: Amniotic fluid (AF) is a complex structure with a changing content by gestation. Lower genomic expression of Na channels in airways was shown to be associated with respiratory distress syndrome (RDS). The aim of this study was to determine the possible role of amniotic fluid pH and electrolytes for prediction of neonatal respiratory morbidities. METHODS: This was a prospective controlled cohort study. During C-section, 1 ml of AF was aspirated before incision of membranes...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
P Deo, J R Bach
This case series of five patients with Duchenne muscular dystrophy demonstrates the nutritional advantages of instituting noninvasive intermittent positive pressure ventilatory support via 15mm angled mouthpieces to relieve tachypnea and provide more time to swallow food safely. In each case weight loss was reversed.
July 19, 2018: Pulmonology
Rahim Vakili, Somayyeh Hashemian
Beta-ketothiolase deficiency is a rare autosomal recessive disorder characterized by an inborn error of isoleucine catabolism and affecting ketone body metabolism. Clinical features characterized by intermittent keto acidotic episodes are associated with clinical signs and symptoms of toxic encephalopathy such as lethargy, hypotonia, vomiting, tachypnea, and coma in some patients, with an onset during infancy or toddler-hood. A two months old girl presented to pediatric ward of Imam Reza Hospital in Mashhad City, Northwestern Iran in October 2016, with acute episode of fever and toxic encephalopathy with attack of vomiting, hypotonia, lethargy, tonic-clonic seizures and then a day in coma, few days after vaccination...
2018: Iranian Journal of Child Neurology
Ashley N Battarbee, Mark A Clapp, Kim A Boggess, Anjali Kaimal, Carrie Snead, Jay Schulkin, Sofia Aliaga
OBJECTIVE:  The objective of this study was to measure knowledge and practice variation in late preterm steroid use. STUDY DESIGN:  Electronic survey of American College of Obstetricians and Gynecologists (ACOG) members about data supporting the ACOG/Society for Maternal-Fetal Medicine (SMFM) recommendations and practice when caring for women with anticipated late preterm birth (PTB), 340/7 to 366/7 weeks. RESULTS:  Of 352 administered surveys, we obtained 193 completed responses (55%); 82...
July 17, 2018: American Journal of Perinatology
Caroline Bodi Winn, Stephen C Artim, Morgan S Jamiel, Monika A Burns, Jennifer L Haupt, James G Fox, Sureshkumar Muthupalani
A 6-y-old, intact, pair-housed male common marmoset (Callithrix jacchus) presented with acute onset dyspnea and tachypnea immediately after sedation with alfaxalone; a history of gradual weight loss initiated the examination under sedation. Thoracic radiographs revealed significant right-lung consolidation, with a vesicular gas pattern in the right caudodorsal lung field, pleural effusion, and dorsal displacement of the heart. The marmoset was euthanized due to his unstable condition and poor prognosis. At necropsy, the cranial and middle lobes of the right lung were homogenously dark red-brown, enlarged, edematous, and twisted around the longitudinal axis at the hilus...
July 16, 2018: Comparative Medicine
John P Buchweitz, Douglas Mader, Andreas F Lehner
A case of canine intoxication and fatality with the pyrethroid insecticide bifenthrin is described. A 5-year-old female spayed Pit Bull Terrier was off leash and unsupervised at home for 15-20 min prior to discovery by her owner. The patient was in lateral recumbency, having what the owner described as a seizure. The patient was transported to an emergency veterinary hospital where she presented with tachycardia, tachypnea and intractable tremors/seizures. Despite aggressive medical intervention, the patient went into respiratory and cardiac arrest and died at 28 h after presentation...
July 11, 2018: Journal of Analytical Toxicology
Hyeon Su Kim, Na Young Kim, Yong Wook Kim
Paroxysmal sympathetic hyperactivity (PSH) is characterized by increased activity of the sympathetic nervous system. Although several treatments have been proposed for PSH, their efficacies are uncertain. We report a case of a patient with intractable PSH after pontine hemorrhage who was treated with intrathecal baclofen (ITB). A 61-year-old man was diagnosed with pontine hemorrhage expanding to the bilateral midbrain. Beginning 2 weeks after onset, he developed paroxysmal hyperthermia, tachycardia, tachypnea, hypertension, and generalized dystonic movements...
July 2018: Clinical Neuropharmacology
Daniel Agustin Godoy, Jose Orquera, Alejandro A Rabinstein
Paroxysmal sympathetic hyperactivity represents an uncommon and potentially life-threatening complication of severe brain injuries, which are most commonly traumatic. This syndrome is a clinical diagnosis based on the recurrent occurrence of tachycardia, hypertension, diaphoresis, tachypnea, and occasionally high fever and dystonic postures. The episodes may be induced by stimulation or may occur spontaneously. Underdiagnosis is common, and delayed recognition may increase morbidity and long-term disability...
April 2018: Revista Brasileira de Terapia Intensiva
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