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Katsuya Hirata, Masatoshi Nozaki, Narutaka Mochizuki, Shinya Hirano, Kazuko Wada
OBJECTIVE:  To assess effects of neonatal transport on transient tachypnea of the newborn (TTN) in outborn term neonates. STUDY DESIGN:  This retrospective cohort study included 66 term neonates diagnosed with TTN and transported to the Osaka Women's and Children's Hospital neonatal intensive care unit between January 2003 and March 2018. A multivariate logistic regression analysis identified perinatal and neonatal transport factors associated with adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 hours, pulmonary hemorrhage, and requirement for inhaled nitric oxide, thoracentesis, or surfactant replacement therapy...
December 14, 2018: American Journal of Perinatology
Mingliang Sui, Weibing Tang, Changjiang Wu
RATIONALE: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis. PATIENT CONCERNS: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. DIAGNOSES: The initial investigation showed elevated liver enzyme levels, creatine kinase levels, creatine kinase isoenzyme levels, and elevated serum myoglobin...
December 2018: Medicine (Baltimore)
C David, J Pouchot, B Ranque
BACKGROUND: Repeated use of inhaled β2 agonists is common in asthma or COPD exacerbations. It can lead to hyperlactatemia. CASE REPORTS: We report two asthmatic patients who presented in the emergency department for an asthma exacerbation. The first patient developed hyperlactatemia at 3.9 mmol/L and the second patient developed hyperlactatemia at 5.6 mmol/L after terbutaline treatment. Both patients had a favorable outcome after adjusting the aerosol dose to clinical parameters...
December 9, 2018: La Revue de Médecine Interne
Leah Carlisle, Julie Ann Justo, Majdi N Al-Hasan
An increasing number of reports describing Escherichia coli isolates with piperacillin/tazobactam resistance, despite retained cephalosporin susceptibility, suggest further emergence of this phenotypic resistance pattern. In this report, a patient with metastatic breast cancer presented to medical care after two days of chills, nausea, vomiting, reduced oral intake, and generalized weakness. Blood and urine cultures grew E. coli as identified by rapid diagnostics multiplex PCR and MALDI-TOF, respectively. The patient continued to manifest signs of sepsis with hypotension and tachypnea during the first three days of hospitalization despite empirical antimicrobial therapy with intravenous piperacillin/tazobactam...
December 1, 2018: Antibiotics
Shiyang Sun, Lianlian Bian, Fan Gao, Ruixiao Du, Yalin Hu, Ying Fu, Yao Su, Xing Wu, Qunying Mao, Zhenglun Liang
Enterovirus D68 (EV-D68) is a causative agent of recent outbreaks of severe respiratory illness, pneumonia and acute flaccid myelitis (AFM) worldwide. The study of the pathogenesis, vaccines and anti-viral drugs for EV-D68 infection has been reported. Given the previously described mouse model of EV-D68, we sought to establish a neonatal mice model inducing both pneumonia and AFM. The neonatal BALB/c mice were inoculated intraperitoneally with the EV-D68 strain (named15296-virus) which was produced by the reverse genetics method...
November 29, 2018: Antiviral Research
Arshad Khushdil, Shehla Baqai, Madiha Ahmed, Zeeshan Ahmed
OBJECTIVE: To determine the effect of dexamethasone administration to women between 37 to 39 weeks of gestation on neonatal outcome in terms of respiratory morbidity and the need for NICU admission. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Department of Neonatology, Military Hospital, Rawalpindi, Pakistan, from February to July 2017. METHODOLOGY: Women with singleton pregnancies, undergoing elective cesarean section between 37-39 weeks...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Casey O Diekman, Peter J Thomas, Christopher G Wilson
We have previously introduced a model for closed-loop respiratory control incorporating an explicit conductance-based model of bursting pacemaker cells driven by hypoxia sensitive chemosensory feedback. Numerical solution of the model equations revealed two qualitatively distinct asymptotically stable dynamical behaviors: one analogous to regular breathing (eupnea), and a second analogous to pathologically rapid, shallow breathing (tachypnea). As an experimental test of this model, we created a hybrid in vitrolin silico circuit...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mona Ahmed Ammar, Noha Sayed Hussein
Background: Traumatic brain injury (TBI) correlated with increased sympathetic activity on the expense of parasympathetic system due to loss of cortical control after brain injury. Manifestations of sympathetic storm include tachycardia, hypertension, tachypnea, and hyperthermia. The neuroprotective effects via reducing cerebral metabolism and lowering O2 and glucose consumption are the targets early after trauma. Beta-blockers reduce sympathetic activity. Objectives: We suppose that using propranolol blunts the sympathetic storming phenomenon as it is a nonselective β inhibitor and has a lipophilic property to steadily penetrate blood-brain barrier...
October 2018: Saudi Journal of Anaesthesia
Guo Chen, Xian-di Wang, Hong-Fei Nie, Zhi-Qiang Yang, Kang Chen, Zhu-Hai Li, Yue-Ming Song, Fu-Xing Pei, Jian-Cheng Zeng
BACKGROUND: Negative pressure pulmonary edema (NPPE) is a rare complication that is more prevalent in young patients. NPPE usually results from acute upper airway obstruction, which is most commonly caused by laryngospasm during extubation. NPPE is characterized by the sudden onset of coughing, hemoptysis, tachycardia, tachypnea, and hypoxia, and is dramatically improved with supportive care, which prevents severe sequelae. To our knowledge, there is no report of a patient developing NPPE after percutaneous endoscopic interlaminar lumbar discectomy...
November 14, 2018: BMC Musculoskeletal Disorders
Erdem Topal, Mehmet Halil Çeliksoy, Mustafa Arga, Mustafa Sinan Kaynak, Yücel Duman, Semih Demirtaş, Cem Alataş, Hayrettin Tonbul, Zeynep Hazıroğlu Ökmen, Huri Maral Dalkılıç
BACKGROUND: Cow's milk protein allergy (CMPA) is usually transient, with most children tolerating ingested cow's milk by 3 years of age. This study aimed to determine factors that promote or hindering the development of tolerance to CMPA. METHODS: A logistic regression model was used to determine independent risk factors associated with tolerance and persistence of CMPA. RESULT: A total of 178 children diagnosed with CMPA were included in the study...
October 30, 2018: International Forum of Allergy & Rhinology
Elaine Fernanda da Silva, Mirian Bassi, José Vanderlei Menani, Débora Simões Almeida Colombari, Daniel Breseghello Zoccal, Gustavo Rodrigues Pedrino, Eduardo Colombari
NEW FINDINGS: What is the central question of this study? Does carotid body input contribute to the hyperosmotic responses? What is the main finding and its importance? The response to NaCl overload is sympathorespiratory excitation. Eliminating the carotid body input reduced sympathoexcitation but did not affect the increase in phrenic burst frequency, whereas eliminating the hypothalamus prevented the tachypnoea and sympathoexcitation. We conclude that the carotid body inputs are essential for the full expression of the sympathetic activity during acute NaCl overload, whereas the tachypnoea depends on hypothalamic mechanisms...
October 29, 2018: Experimental Physiology
Luciana Nascimento Pinto Canela, Maria Clara de Magalhães-Barbosa, Carlos Eduardo Raymundo, Sharon Carney, Marilda Mendonca Siqueira, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha
OBJECTIVES: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic. METHOD: Longitudinal observational retrospective study, with patients aged 0-18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009...
October 23, 2018: Brazilian Journal of Infectious Diseases
Elie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Lilia Berrahil-Meksen, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Achille Kouatchet, Vincent Peigne, Igor Théodose, Pierre Perez, Christophe Girault, Samir Jaber, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Christine Lebert, Alexandre Lautrette, Naike Bigé, Jean-Herlé Raphalen, Laurent Papazian, Michael Darmon, Sylvie Chevret, Alexandre Demoule
Importance: High-flow nasal oxygen therapy is increasingly used for acute hypoxemic respiratory failure (AHRF). Objective: To determine whether high-flow oxygen therapy decreases mortality among immunocompromised patients with AHRF compared with standard oxygen therapy. Design, Setting, and Participants: The HIGH randomized clinical trial enrolled 776 adult immunocompromised patients with AHRF (Pao2 <60 mm Hg or Spo2 <90% on room air, or tachypnea >30/min or labored breathing or respiratory distress, and need for oxygen ≥6 L/min) at 32 intensive care units (ICUs) in France between May 19, 2016, and December 31, 2017...
November 27, 2018: JAMA: the Journal of the American Medical Association
Hamed Mansoor Lakooraj, Mahmood Ahmadi-Hamedani, Omid Dezfoulian, Masoud Selk Ghaffari
A 10-year-old, male Rottweilerdog was presented to Small Animal Hospital of Tehran University with a history of lethargy, anorexia, weight loss, vomiting, polyuria, polydipsia and blindness. The dog showed symptoms of depression, high body temperature (39.2 ˚C), tachypnea (40 breaths min-1 ) and cachexia. In ophthalmic examination, bilateral hyphema (hemmorrahge in anterior chamber of the eye) and blindness were detected. The pulse of the animal was normal (90 beats min-1 ) and obvious general lymphadenopathy was determined...
2018: Veterinary Research Forum
Sagarika Patyal, Arun Kumar Yadav, Atul Kotwal
Purpose: High-altitude pulmonary edema (HAPO) is an acute medical emergency occurring typically in lowlanders, who ascend rapidly to heights of 3000 m or more. It presents with marked dyspnea on exertion, fatigue with minimal-to-moderate effort, prolonged recovery time, and dry cough with manifestations of cyanosis, tachycardia, tachypnea, and temperature which generally does not increase beyond 38.5°C. The condition may be fatal if not treated in time with supplemental oxygen or hyperbaric oxygen or rapid descent to lower altitude...
November 2018: Indian Journal of Ophthalmology
Amit Gupta, Timothy Roehrs, Kenneth Moss, Syed Jaffery, Luisa Bazan, Laura Spear, Larry Darnell, Thomas Roth
We report a case series of four patients where tachypnea was observed during positive airway titration studies, double the baseline breathing rate (tachypnea range 46-68 breaths/min). It happened mainly during non-rapid eye movement to rapid eye movement sleep transitions without significant changes in oxygen saturation or signs of autonomic hyperactivity such as an increased heart rate. The increased respiratory rate may be a normal physiological extreme outlier seen during phasic rapid eye movement sleep triggered by high pressure ventilation and it may also indicate underlying ventilatory instability, making patients predisposed to central sleep apnea...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Joshua I Rosenbloom, Adam K Lewkowitz, Kristina E Sondgeroth, Jessica L Hudson, George A Macones, Alison G Cahill, Methodius G Tuuli, Su-Hsin Chang
OBJECTIVE: To evaluate whether administration of antenatal late-preterm betamethasone is cost-effective in the immediate neonatal period. STUDY DESIGN: Cost-effectiveness analysis of late-preterm betamethasone administration with a time horizon of 7.5 days was conducted using a health-system perspective. Data for neonatal outcomes, including respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), and hypoglycemia, were from the Antenatal Betamethasone for Women at Risk for Late-Preterm Delivery trial...
November 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
Saeed Ali, Abdul Rauf, Ling Bing Meng, Zeeshan Sattar, Sana Hussain, Umair Majeed
Background: Bronchogenic cysts are congenital malformations from abnormal budding of embryonic foregut and tracheobronchial tree. We present a case of bronchogenic cyst with severe back pain, epigastric distress and refractory nausea and vomiting.   Case Presentation: A 44-year-old Hispanic female presented with a 3-week history of recurrent sharp interscapular pain radiating to epigastrium with refractory nausea and vomiting. She underwent cholecystectomy 2-years ago. Computed tomography (CT) abdomen at that time showed a subcarinal mass measuring 5...
2018: F1000Research
En-Pei Lee, Meng-Kung Yu, Shu-Chun Lee, Feng-Xia Gao, Han-Ping Wu
The aim of this study was to identify the clinical parameters indicative of serious etiology of neonatal hyperthermia and to determine the appropriate cutoff value of body temperature (BT) for predicting the need to transfer the newborn to the special care (SC) nursery.The nursery records of newborns diagnosed with hyperthermia between 2007 and 2013 were retrospectively reviewed. The clinical characteristics of newborns with hyperthermia remained in the nursery were compared with those transferred to the SC nursery...
October 2018: Medicine (Baltimore)
Ai Sawaoka, Toshiki Ito, Takayuki Yoshida, Koichiro Muromachi, Tomoko Sakai, Kunio Hamada, Nobuyuki Tani-Ishii, Akihide Ito
Altered mental status is a common, yet challenging, clinical presentation encountered by physicians. Here, we report a case of a 68-year-old Japanese female who was transferred to the emergency department due to faint. The laboratory results showed hyponatremia, ketonuria, hyperglycemia and acute kidney injury without fever or inflammatory findings. Although these abnormalities were corrected, her mental status was exacerbated, and apnea/tachypnea appeared. She was eventually diagnosed with acute apical abscess and recovered immediately after dental extractions...
November 2018: Oxford Medical Case Reports
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