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Acute congestive heart failure

Alberto Palazzuoli, Gaetano Ruocco, Pierpaolo Pellicori, Eufemia Incampo, Cristina Di Tommaso, Roberto Favilli, Isabella Evangelista, Ranuccio Nuti, Jeffrey M Testani
OBJECTIVE: Worsening renal function (WRF) is common in patients treated for acute heart failure (AHF) and might be associated with a significant increase in blood nitrogen urea (BUN). Although many patients develop WRF during hospitalisation, its prognostic role is still unclear. Thus, we aimed to evaluate the prognostic relevance of WRF according to BUN changes during hospitalization. METHODS: We studied patients with AHF screened for Diur-HF Trial (NCT01441245)...
November 23, 2018: International Journal of Cardiology
Matthew M Fleming, Fangfang Liu, Jiajun Luo, Yawei Zhang, Kevin Y Pei
BACKGROUND: High-risk patients undergoing cholecystectomy may experience increased morbidity and mortality. Percutaneous cholecystostomy (PC) has been utilized as a treatment option for acute cholecystitis in this cohort. Little is known about risk factors for readmission following PC. MATERIALS AND METHODS: Patients who had PC from 2013 to 2014 were identified from the National Readmission Database by the Healthcare Cost and Utilization Project. A 30-d readmission was defined as a subsequent admission within 30 d following the first admission discharge date...
January 2019: Journal of Surgical Research
Carol R Reinero, L Ari Jutkowitz, Nathan Nelson, Isabelle Masseau, Samuel Jennings, Kurt Williams
BACKGROUND: Histologic features of pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description. OBJECTIVES: To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH. ANIMALS: Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small-sized to medium-sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both...
November 29, 2018: Journal of Veterinary Internal Medicine
Hiltrud Merzenich, Maria Blettner, Dorothea Niehoff, Lukas Schwentner, Marcus Schmidt, Margit Schmitt, Daniel Wollschläger
BACKGROUND: Self-administered health-status questionnaires are important tools in epidemiology. The objective of the presented validation study is to measure the agreement between breast cancer patients' self-reports and their physicians' information on late cardiac events, and to investigate determinants of agreement. To estimate possible misclassification is an important requirement for observational studies on cardiovascular endpoints. METHODS: A retrospective, multi-center cohort study included 11,982 women diagnosed with breast cancer in Germany in 1998-2008...
November 29, 2018: BMC Cardiovascular Disorders
Şehnaz Olgun Yıldızeli, Umut Sabri Kasapoğlu, Hüseyin Arıkan, Canan Çimşit, Nuri Çagatay Çimşit, Melek Süzer Aslan, Derya Kocakaya, Emel Eryüksel, Berrin Ceyhan, Sait Karakurt
Introduction: Pulmonary embolism (PE) is known as one of the major causes of cardiovascular morbidity and mortality. Identification of high risk patients for short term and long-term mortality is crucial. The purpose of this study is to demonstrate the prognostic importance of simplified pulmonary embolism severity index (sPESI), radiological investigations and comorbidities in terms of short-term mortality by simultaneous assessment of sPESI score, pulmonary computed tomography (CT) angiography findings and underlying comorbidities in patients diagnosed with acute pulmonary embolism...
September 2018: Tüberküloz Ve Toraks
Xiangjiu Ding, Yang Liu, Qingbo Su, Sanyuan Hu, Jianjun Jiang
OBJECTIVE: Acute aortic occlusion is a rare but life-threatening medical condition that can result from aortic saddle embolism, thrombosis of an atherosclerotic aorta, or aortic dissection. Herein are described the diagnostic and therapeutic characteristics for a series of patients with aortic saddle embolism. METHODS: A retrospective review of medical records was performed for patients receiving treatment for aortic saddle embolism at a university hospital in China between January 2001 and September 2017...
November 23, 2018: Annals of Vascular Surgery
Christ Ordookhanian, Sean W Kaloostian, Paul E Kaloostian
Anti-coagulation medications are widely used in clinical practice, especially in the United States as cardiac-related emergencies are on the rise. An overarching caveat in using anti-coagulation drugs as a long-term treatment regimen, such as warfarin, is that patients are closely monitored by their primary care provider. Routine monthly laboratory examinations are strictly required to assess the international normalized ratio (INR) which measures prothrombin time (PT), providing insight into how long it takes for blood to clot...
September 22, 2018: Curēus
Sofia Isabel Jardim, Luís Ramos Dos Santos, Inês Araújo, Filipa Marques, Patrícia Branco, Augusta Gaspar, Cândida Fonseca
Heart failure is a high burden disease with elevated direct and indirect costs. Current treatment includes drugs that alter disease progression and drugs used to improve symptoms. Loop diuretics remain the cornerstone of congestion relief for acute management, as well as for chronic stabilization. In heart failure patients, maximal diuretic response is decreased by many individual factors. Diuretic resistance is defined as the failure to achieve effective congestion relief despite appropriate or escalating diuretic doses...
November 20, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Bassel Bashjawish, Shreya Patel, Suat Kılıç, Peter F Svider, Wayne D Hsueh, James K Liu, Soly Baredes, Jean Anderson Eloy
BACKGROUND: Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and complications of sinonasal cancer (SNC) patients receiving surgery. METHODS: A retrospective database analysis was performed using cases from the Nationwide Inpatient Sample (NIS) from 2003 to 2012...
November 23, 2018: International Forum of Allergy & Rhinology
Naohide Ageyama, Hiroyuki Kurosawa, Ousuke Fujimoto, Tomoya Uehara, Michiaki Hiroe, Yasushi Arano, Toshimichi Yoshida, Yasuhiro Yasutomi, Kyoko Imanaka-Yoshida
Inflammation after myocardial infarction (MI) may be a major factor influencing ventricular remodeling, leading to congestive heart failure and arrhythmia. Therefore, inflammation in the heart needs to be monitored. Tenascin-C (TNC) is an extracellular matrix molecule not normally expressed, but it is strongly upregulated when associated with active inflammation. Based on this characteristic, we successfully imaged in vivo inflammatory lesions in rat models using 111 Indium (111 In)-labeled anti-TNC antibodies...
November 20, 2018: International Heart Journal
Mohita Singh, Khurrum Khan, Evan Fisch, Christopher Frey, Kristen Mathias, Hani Jneid, Daniel M Musher, Neal R Barshes
Recent studies have shown an association between infections, such as influenza, pneumonia, or bacteremia, and acute cardiac events. We studied the association between foot infection and myocardial infarction, arrhythmia, and/or congestive heart failure. We analyzed the records of 318 consecutive episodes of deep soft tissue infection, gangrene, and/or osteomyelitis in 274 patients referred to a vascular surgery service at a tertiary center. We identified 24 acute cardiac events in 21 of 318 (6.6%) episodes of foot infection or foot gangrene...
November 21, 2018: International Journal of Lower Extremity Wounds
Lan Wang, Dajun Pei, Yan-Qiong Ouyang, Xiaofei Nie
AIM: To quantitatively analyse factors related to gastrointestinal bleeding after percutaneous coronary intervention and provide evidence for the prevention of gastrointestinal bleeding. DATA SOURCES AND REVIEW METHODS: Cochrane Library, Pubmed, Embase, and Ovid databases were searched from inception to 31 May 2018; case-control and cohort studies published in English were included. The methodological quality of each study was assessed by two independent reviewers using the Newcastle-Ottawa Scale...
November 19, 2018: International Journal of Nursing Practice
Osmar Antonio Centurión, Karina Elizabeth Scavenius, Laura B García, Luis Miño, Judith Torales, Orlando Sequeira
The development of atrial fibrillation (AF) during the course of the evolution of heart failure (HF) worsens the clinical outcomes and the prognosis accounting for an enormous economic burden on healthcare. AF is considered to be an independent predictor of morbidity and mortality increasing the risk of death and hospitalization in 76% in HF patients. Despite the good clinical results obtained with conventional pharmacological agents and different new drugs, the optimal medical treatment can fail in the intention to improve symptoms and quality of life of HF patients with severe left ventricular dysfunction and AF with uncontrolled ventricular rate...
June 2018: Journal of Atrial Fibrillation
Noemi Pavo, Rajashri Yarragudi, Heidi Puttinger, Henrike Arfsten, Guido Strunk, Andja Bojic, Martin Hülsmann, Andreas Vychytil
BACKGROUND: In patients with refractory heart failure (HF) peritoneal dialysis (PD) is associated with improved functional status and decrease in hospitalization. However, previous studies did not focus on right ventricular dysfunction as an important pathophysiologic component of cardiorenal syndrome. METHODS: In a prospective cohort study PD was started in 40 patients with refractory right HF (with/without left HF). Refractoriness to conservative therapy was defined as persistent right heart congestion/ascites with intensified diuretic treatment and/or ≥2 hospitalizations within 6 months because of cardiac decompensation despite optimal medical treatment, and/or acute renal failure during intensified conservative treatment of cardiac decompensations...
2018: PloS One
Caroline Harris, Rowena Mills, Ezgi Seager, Sarah Blackstock, Tamanda Hiwa, James Pumphrey, Josephine Langton, Neil Kennedy
BACKGROUND: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS. AIMS: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. METHODS: A prospective, descriptive study was undertaken in Queen Elizabeth Central Hospital over 12 months in 2015/2016...
November 19, 2018: Paediatrics and International Child Health
Frances M Russell, Robert R Ehrman, Robinson Ferre, Luna Gargani, Vicki Noble, Jordan Rupp, Sean P Collins, Benton Hunter, Kathleen A Lane, Phillip Levy, Xiaochun Li, Christopher O'Connor, Peter S Pang
BACKGROUND: Medical treatment for acute heart failure (AHF) has not changed substantially over the last four decades. Emergency department (ED)-based evidence for treatment is limited. Outcomes remain poor, with a 25% mortality or re-admission rate within 30 days post discharge. Targeting pulmonary congestion, which can be objectively assessed using lung ultrasound (LUS), may be associated with improved outcomes. METHODS: BLUSHED-AHF is a multicenter, randomized, pilot trial designed to test whether a strategy of care that utilizes a LUS-driven treatment protocol outperforms usual care for reducing pulmonary congestion in the ED...
November 15, 2018: Heart & Lung: the Journal of Critical Care
Malgorzata Chlabicz, Remigiusz Kazimierczyk, Paulina Lopatowska, Monika Gil-Klimek, Bartosz Kudlinski, Marcin Ligowski, Bozena Sobkowicz, Marek Gierlotka, Karol Kaminski, Agnieszka Tycinska
PURPOSE: Fluid therapy in congestive acute decompensated heart failure (ADHF) patients might be inappropriate and worsening the prognosis. The aim of our study was to analyze the effect of fluid administration on mortality in non-septic, ADHF patients with reduced ejection fraction. MATERIAL AND METHODS: We analyzed 41 ADHF consecutive 'cold-wet' patients (mean age 69.3 ± 14.9 years, 27 men, LVEF 22.8 ± 11.1%, lactates 2.2 ± 1.6 mmol/L) without sepsis...
November 13, 2018: Advances in Medical Sciences
Olli-Pekka Ryynänen, Timo Leppänen, Pekka Kekolahti, Esa Mervaala, Juha Töyräs
Objectives: The association between obstructive sleep apnea (OSA) and mortality or serious cardiovascular events over a long period of time is not clearly understood. The aim of this observational study was to estimate the clinical effectiveness of continuous positive airway pressure (CPAP) treatment on an outcome variable combining mortality, acute myocardial infarction (AMI), and cerebrovascular insult (CVI) during a follow-up period of 15.5 years (186 ± 58 months). Methods: The data set consisted of 978 patients with an apnea-hypopnea index (AHI) ≥5...
October 2018: Healthcare Informatics Research
Ruth Ladenstein, Ulrike Pötschger, Dominique Valteau-Couanet, Roberto Luksch, Victoria Castel, Isaac Yaniv, Genevieve Laureys, Penelope Brock, Jean Marie Michon, Cormac Owens, Toby Trahair, Godfrey Chi Fung Chan, Ellen Ruud, Henrik Schroeder, Maja Beck Popovic, Guenter Schreier, Hans Loibner, Peter Ambros, Keith Holmes, Maria Rita Castellani, Mark N Gaze, Alberto Garaventa, Andrew D J Pearson, Holger N Lode
BACKGROUND: Immunotherapy with the chimeric anti-GD2 monoclonal antibody dinutuximab, combined with alternating granulocyte-macrophage colony-stimulating factor and intravenous interleukin-2 (IL-2), improves survival in patients with high-risk neuroblastoma. We aimed to assess event-free survival after treatment with ch14.18/CHO (dinutuximab beta) and subcutaneous IL-2, compared with dinutuximab beta alone in children and young people with high-risk neuroblastoma. METHODS: We did an international, open-label, phase 3, randomised, controlled trial in patients with high-risk neuroblastoma at 104 institutions in 12 countries...
November 12, 2018: Lancet Oncology
Junya Takagawa, Hidetsugu Asanoi, Tomoyuki Tobushi, Naoto Kumagai, Toshiaki Kadokami, Kaoru Dohi, Shuji Joho, Osamu Wada, Takashi Koyama, Nobuhiko Haruki, Shin-Ichi Ando, Shin-Ichi Momomura
BACKGROUND: The respiratory instability frequently observed in advanced heart failure (HF) is likely to mirror the clinical status of worsening HF. The present multicenter study was conducted to examine whether the noble respiratory stability index (RSI), a quantitative measure of respiratory instability, reflects the recovery process from HF decompensation. Methods and Results: Thirty-six of 44 patients hospitalized for worsening HF completed all-night measurements of RSI both at deterioration and recovery phases...
November 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
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