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Jaime Nivala, Stefanie Kahl, Johannes Boog, Manfred van Afferden, Thorsten Reemtsma, Roland A Müller
Six pilot-scale treatment wetlands treating municipal wastewater were monitored for classical wastewater parameters and selected Emerging Organic Compounds (EOCs): caffeine (CAF), ibuprofen (IBU), naproxen (NPX), benzotriazole (BTZ), diclofenac (DCL), acesulfame (ACE) and carbamazepine (CBZ) on a weekly basis over the course of one year. Treatment efficacy of the wetland systems was compared to that of a municipal wastewater treatment plant adjacent to the research site (activated sludge technology). The aerated wetlands VAp and HAp, and the two-stage vertical flow system VGp + VSp showed the highest treatment efficacy (>70% removal on a mass basis) and comparable treatment efficacy to the conventional WWTP for removal of CAF, IBU, NPX, BTZ, and DCL...
February 1, 2019: Science of the Total Environment
Mei Wu, Hongbin Ma, Xinghong Zhang
Robot localization, particularly multirobot localization, is an important task for multirobot teams. In this paper, a decentralized cooperative localization (DCL) algorithm with fault detection and isolation is proposed to estimate the positions of robots in mobile robot teams. To calculate the interestimate correlations in a distributed manner, the split covariance intersection filter (SCIF) is applied in the algorithm. Based on the split covariance intersection filter cooperative localization (SCIFCL) algorithm, we adopt fault detection and isolation (FDI) to improve the robustness and accuracy of the DCL results...
October 8, 2018: Sensors
Monica R Lininger, Theresa E Leahy, Elise C Haug, Thomas G Bowman
Background: A reliable measure of dynamic postural control is needed for inclusion in the sports-related concussion assessment battery. Currently, there is not a clinical gold standard. The Limits of Stability (LOS) test has potential to be a useful tool to collect objective data on important dynamic postural stability variables. Psychometric properties of the LOS test with healthy young adults are yet to be established. Hypothesis/Purpose: The purpose of this study was to examine the intra-session and test-retest reliability for the LOS on the NeuroCom® VSR Sport when performed by young adults...
August 2018: International Journal of Sports Physical Therapy
Timothy M Brown, Blanton R Gillespie, Caleb A Smith, Matthew J Nestler, George L Heard, Donald W Setser, Bert E Holmes
The five unimolecular HX and DX (X = F, Cl) elimination pathways of CD2ClCHFCl* were examined using the chemical-activation technique; the molecules were generated with 92 kcal mol-1 of vibrational energy in a room temperature bath gas by combination of CD2Cl and CHFCl radicals. The total unimolecular rate constant is 9.7 x 107 s-1 and branching fractions for each channel are 0.52 (2,1-DCl), 0.29 (1,1-HCl), 0.10 (2,1-DF), 0.07 (1,1-HF), and 0.02 (1,2-HCl). Comparison of the individual experimental rate constants to calculated statistical rate constants gave threshold energies for each process as 63, 72, 66, 73 and 70 kcal mol-1 listed in the same order as the branching fractions...
September 28, 2018: Journal of Physical Chemistry. A
Beatriz Gonçalves Neves, Rafael Nóbrega Stipp, Daniela da Silva Bezerra, Sarah Florindo de Figueiredo Guedes, Lidiany Karla Azevedo Rodrigues
OBJECTIVE: Monitoring selected key species related to health or disease may facilitate caries risk assessment and discovery of novel ecological preventive and therapeutic approaches. This study aimed at quantifying Actinomyces naeslundii, Bifidobacterium spp., Lactobacillus acidophilus, Lactobacillus casei group, Streptococcus gordonii, Mitis group and Streptococcus mutans by quantitative polymerase chain reaction (qPCR) in dental biofilm from Brazilian children with different stages of early childhood caries (ECC)...
September 15, 2018: Archives of Oral Biology
Muhammad Arif, Saif Ul Islam, Muhammad Adnan, Muhammad Anwar, Habib Ali, Zujian Wu
Noncoding RNAs play essential functions during epigenetic regulation of gene expression and development in numerous organisms. Three type of small noncoding RNAs found in eukaryotes, which are small interfering RNAs (siRNAs), microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs). Small RNAs (sRNAs) originated from infecting viruses are known as virus-derived small interfering RNAs (vsiRNAs), are responsible for RNA silencing in plants. However, Virus-induced gene silencing (VIGS) is mainly dependent on RNA silencing (RNAi)...
September 19, 2018: Microbial Pathogenesis
Benjamin R Riegger, Regina Kowalski, Luise Hilfert, Günter E M Tovar, Monika Bach
Glutaraldehyde-crosslinked chitosan nanoparticles (Chi-NPs) were prepared reproducibly via miniemulsion crosslinking for effective adsorption of the active pharmaceutical ingredient (API) Diclofenac (DCL). Three different molecular weights (MWs) of highly deacetylated (>90%) chitosans (low, medium and high MW) were used to vary the disperse phase viscosity. Particle formation was evaluated ranging from one to seven homogenization cycles at 40 MPa. Particles were prepared successfully with the low and medium MW chitosan in the range of 125 nm-250 nm (z-average)...
December 1, 2018: Carbohydrate Polymers
Graciela Carlos, Alvicler Magalhães, Ana Cristina Isler, Eloisa Comiran, Pedro Eduardo Fröehlich
Lisdexamfetamine dimesylate (LDX), a long-acting prodrug stimulant indicated for the treatment of the attention-deficit/hyperactivity disorder (ADHD), was subjected to forced degradation studies by acid and alkaline hydrolysis and the degradation profile was studied. To obtain between 10-30% of degraded product, acid and alkaline conditions were assessed with solutions of 0.01 M, 0.1 M, 0.5 M and 1 M of DCl and NaOD. These solutions were analyzed through 1H NMR spectra. Acid hydrolysis produced no degradation in 0...
September 20, 2018: Drug Development and Industrial Pharmacy
Amy Yuet Ting Lau, Xuanjin Cheng, Chi Keung Cheng, Wenyan Nong, Man Kit Cheung, Raymond Hon-Fu Chan, Jerome Ho Lam Hui, Hoi Shan Kwan
Coprinopsis cinerea is a model mushroom particularly suited for the study of fungal fruiting body development and the evolution of multicellularity in fungi. While microRNAs (miRNAs) have been extensively studied in animals and plants for their essential roles in post-transcriptional regulation of gene expression, miRNAs in fungi are less well characterized and their potential roles in controlling mushroom development remain unknown. To identify miRNA-like RNAs (milRNAs) in C. cinerea and explore their expression patterns during the early developmental transition of mushroom development, small RNA libraries of vegetative mycelium and primordium were generated and putative milRNA candidates were identified following the standards of miRNA prediction in animals and plants...
2018: PloS One
Athanasios Dalakouras, Wolfgang Jarausch, Guenther Buchholz, Alexandra Bassler, Mario Braun, Thorsten Manthey, Gabi Krczal, Michael Wassenegger
Since its discovery, RNA interference has been widely used in crop protection. Recently, transgene-free procedures that were based on exogenous application of RNA molecules having the capacity to trigger RNAi in planta have been reported. Yet, efficient delivery of such RNA molecules to plants and particularly to trees poses major technical challenges. Here, we describe simple methods for efficient delivery of hairpin RNAs (hpRNAs) and small interfering RNAs (siRNAs) to Malus domestica , Vitis vinifera , and Nicotiana benthamiana that are based on trunk injection and/or petiole absorption...
2018: Frontiers in Plant Science
Tian Wang, Zhiqi Deng, Xi Zhang, Hongzheng Wang, Yu Wang, Xiuying Liu, Songyu Liu, Feng Xu, Tao Li, Daqi Fu, Benzhong Zhu, Yunbo Luo, Hongliang Zhu
The tomato encode four functional DCL families, of which DCL2 is poorly studied. Here, we generated loss-of-function mutants for a tomato DCL2 gene, dcl2b , and we identified its major role in defending against tomato mosaic virus in relation to both natural and manual infections. Genome-wide small RNA expression profiling revealed that DCL2b was required for the processing 22-nt small RNAs, including a few species of miRNAs. Interestingly, these DCL2b -dependent 22-nt miRNAs functioned similarly to the DCL1 -produced 22-nt miRNAs in Arabidopsis and could serve as triggers to generate a class of secondary siRNAs...
2018: Horticulture Research
Luke R Johnston, Matthew J Bradley, Carlos J Rodriguez, Michael P Mcnally, Eric A Elster, James E Duncan
INTRODUCTION: The role for diverting ostomy as a method to help reduce morbidity and mortality has been well established in the combat trauma population. However, factors that influence the type of ostomy used and which ostomies become permanent are poorly studied. We examine patterns of ostomy usage and reversal in a large series of combat trauma patients. METHODS: We performed a retrospective review of combat casualties treated at our continental U.S. military treatment facility from 2003 to 2015...
August 20, 2018: World Journal of Surgery
Nicole Engel, Alicia Rovo, Manuela Badoglio, Myriam Labopin, Grzegorz W Basak, Yves Beguin, Denis Guyotat, Per Ljungman, Arnon Nagler, Anton Schattenberg, Thomas Schroeder, Wilfried Schroyens, Johanna Tischer, Gerard Socie, Hans-Jochem Kolb, Andre Tichelli, Nina Salooja, Rafael F Duarte
Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors...
July 26, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Raquel Salvador-Guirao, Patricia Baldrich, Shiho Tomiyama, Yue-Ie Hsing, Kazunori Okada, Blanca San Segundo
Background and Aims: MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional regulators of gene expression via sequence-specific cleavage or translational repression of target transcripts. They are transcribed as long single-stranded RNA precursors with unique stem-loop structures that are processed by a DICER-Like (DCL) ribonuclease, typically DCL1, to produce mature miRNAs. Although a plethora of miRNAs have been found to be regulated by pathogen infection in plants, the biological function of most miRNAs remains largely unknown...
July 18, 2018: Annals of Botany
Sâmia Sousa Duarte, Ricardo Olímpio de Moura, Patricia Mirella da Silva
Perkinsus protozoan parasites have been associated with high mortality of bivalves worldwide, including Brazil. The use of antiproliferative drugs to treat the Perkinsosis is an unusual prophylactic strategy. However, because of their environment impact it could be used to control parasite proliferation in closed system, such as hatchery. This study evaluated the anti-Perkinsus activity potential of synthesized and commercial compounds. Viability of hypnospores of Perkinsus spp. was assessed in vitro. Cells were incubated with three 2-amino-thiophene (6AMD, 6CN, 5CN) and one acylhydrazone derivatives (AMZ-DCL), at the concentrations of 31...
September 2018: Experimental Parasitology
Karen M Fisher, Alayna Lilak, Joseph Garner, Corinna Darian-Smith
The corticospinal tract (CST) forms the major descending pathway mediating voluntary hand movements in primates, and originates from ∼nine cortical subdivisions in the macaque. While the terminals of spared motor CST axons are known to sprout locally within the cord in response to spinal injury, little is known about the response of the other CST subcomponents. We previously reported that following a cervical dorsal root lesion (DRL), the primary somatosensory (S1) CST terminal projection retracts to 60% of its original terminal domain, while the primary motor (M1) projection remains robust (Darian-Smith et al...
July 17, 2018: Journal of Comparative Neurology
Anne Bouvier, Bénédicte Ribourtout, Sylvie François, Corentin Orvain, Damien Luque Paz, Annaëlle Beucher, Alexandre Guérard, Philippe Guardiola, Valérie Ugo, Odile Blanchet, Franck Geneviève, Aline Schmidt, Mathilde Hunault-Berger
Donor cell leukemia (DCL) is an infrequent complication after allogeneic hematopoietic stem cell transplantation (HSCT). Its true incidence is difficult to assess, although improvements in chimerism studies contributed to a better diagnosis of DCL. We report two rare cases of donor cell-derived acute promyelocytic leukemia (APL). To our knowledge, only two cases have been described in the literature. Here, we report one male and one female patients with acute myeloid leukemia (AML), who developed an APL in donor cells after HSCT...
October 2018: European Journal of Haematology
Daniel Rico Del Cerro, Raúl Mera-Adasme, Alistair W T King, Jesus E Perea-Buceta, Sami Heikkinen, Tapio Hase, Dage Sundholm, Kristiina Wähälä
Comprehensive spectroscopic kinetic studies illustrate an alternative mechanism for the traditional free-carbene intermediated H/D exchange reaction of 1,3-dialkylimidazolium salts under neutral (D2 O) and acidic conditions (DCl/D2 O 35 wt % solution). The deuteration of high purity [bmim]Cl in D2 O is studied at different temperatures, in absence of catalyst or impurities, to yield an activation energy. DFT transition-state modelling, of a small water cluster and [bmim] cation, also yields an activation energy which strongly supports the proposed mechanism...
September 3, 2018: Angewandte Chemie
Zacarías Sánchez-Mila, Jaime Salom-Moreno, César Fernández-de-Las-Peñas
OBJECTIVE: To determine the effects of inclusion of deep dry needling into a treatment session following the Bobath concept on spasticity, motor function and postural control after a stroke. METHODS: 26 patients who had suffered a stroke were randomly assigned to one of two treatment groups: Bobath only, or Bobath plus dry needling. Both groups received a session including strengthening, stretching and reconditioning exercises following the principles of the Bobath concept...
July 9, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Hyeonjun Hong, Man-Il Huh, Sang Min Park, Kyoung-Pil Lee, Hong Kyun Kim, Dong Sung Kim
Recently, compressed collagen has attracted much attention as a potential alternative for a limbal epithelial stem cell (LESC) carrier to treat limbal stem cell deficiency (LSCD), in that it can provide mechanically improved collagen fibrillar structures compared to conventional collagen hydrogel. However, its clinical efficacy as an LESC carrier has not yet been studied through in vivo transplantation due to limited mechanical strength that cannot withstand a force induced by surgical suturing and low resistance to enzymatic degradation...
July 23, 2018: Biofabrication
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