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Daniele Cardaropoli, Lorenzo Tamagnone, Alessandro Roffredo, Andrea De Maria, Lorena Gaveglio
Alveolar ridge preservation is of great importance for successful implant therapy. This study investigated the effects of a xenogeneic tridimensional collagen matrix (CM) in conjunction with deproteinized bovine bone mineral blended with 10% collagen (DBBM-C) on the healing of 12 intact extraction sockets in the esthetic area. Cone beam computed tomograpy examinations revealed nearly stable alveolar ridge dimensions (> 90% of the ridge horizontal dimension was preserved). New bone formation of approximately 45% and adequate resorption of the grafted material were histologically observed...
2018: International Journal of Periodontics & Restorative Dentistry
Anna Urciuolo, Paolo De Coppi
Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure and composition of the extracellular matrix (ECM) are preserved. Such scaffolds retain biological activity, are biocompatible and do not show immune rejection upon allogeneic or xenogeneic transplantation...
August 14, 2018: International Journal of Molecular Sciences
Guillaume Collet, Timothée Lathion, Céline Besnard, Claude Piguet, Stéphane Petoud
We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal-organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4π-4π photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage...
August 15, 2018: Journal of the American Chemical Society
Daniel D Cavalcanti, Bárbara A Morais, Eberval G Figueiredo, Robert F Spetzler, Mark C Preul
BACKGROUND: Despite the latest development of microsurgery, electrophysiological monitoring and neuroimaging, the surgical management of intrinsic brainstem lesions remains a challenge. Several safe entry points have been described to access the different surfaces of the brainstem. The knowledge of this entry zones anatomy is critical to perform a safe and less morbid approach. To access the anterior midbrain surface a well-known entry point is the anterior mesencephalic (AM) zone. Our aim was to quantify the surgical AM zone exposure trough the orbitozygomatic (OZ) and subtemporal (ST) approaches...
August 7, 2018: World Neurosurgery
Wei-Ting Liu, Liang-Ping Zhang, Mei-Feng Zheng
The correlation between meridians and viscera is the key content of the meridian theory in acupuncture medicine. This paper introduces the close relationship between the meridians running on the body surface and viscera from ancient lite-rature, modern experimental studies (such as acupoint sensitization, neuro-endocrine-immune networks, etc.), and clinical application in the treatment of various conditions with acupuncture, moxibustion, Guasha (scraping) therapies, etc. We also presented some related research ideas (i...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Michael Green, Edith M Marom, Eli Konen, Nahum Kiryati, Arnaldo Mayer
CCTA has become an important tool for coronary arteries assessment in low and medium risk patients. However, it exposes the patient to significant radiation doses, resulting from high image quality requirements and acquisitions at multiple cardiac phases. For widespread use of CCTA for coronary assessment, significant reduction of radiation exposure with minimal image quality loss is still needed. A neural denoising scheme, relying on a fully convolutional neural network (FCNN) architecture, is developed and applied to noisy CCTA...
July 29, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
M Todd Allen
Avoidance is a common feature of post-traumatic stress disorder (PTSD) as well as anxiety and depressive disorders. Avoidance can be expressed behaviorally as well as cognitively. Most personality assessments for avoidance involve self-report inventories which are susceptible to biased responding. The avatar task (Myers et al., 2016a) was developed as an objective measure of behavioral inhibition (BI) which is defined as a tendency for avoidance of unfamiliar people and situations. The avatar task has been demonstrated to screen avoidant behaviors related to BI, PTSD, as well as harm avoidance (HA) as measured by the Tridimensional Personality Questionnaire (TPQ)...
2018: PeerJ
Jérémie Mortier, Pratik Dhakal, Andrea Volkamer
Pharmacophore models are an accurate and minimal tridimensional abstraction of intermolecular interactions between chemical structures, usually derived from a group of molecules or from a ligand-target complex. Only a limited amount of solutions exists to model comprehensive pharmacophores using the information of a particular target structure without knowledge of any binding ligand. In this work, an automated and customable tool for truly target-focused (T²F) pharmacophore modeling is introduced. Key molecular interaction fields of a macromolecular structure are calculated using the AutoGRID energy functions...
August 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Marco Solmi, Enrico Collantoni, Paolo Meneguzzo, Elena Tenconi, Angela Favaro
BACKGROUND: Network analysis is increasingly applied to psychiatric populations to understand relationships among symptoms. METHODS: Network analysis was applied on 955 patients with anorexia nervosa (AN; 631 restricting-type [ANR] and 324 binge eating-/purging-type [ANBP]), assessed with Symptom Check-List 90 (SCL-90), Eating Disorder Inventory (EDI), and Tridimensional Personality Questionnaire. RESULTS: Depression, anxiety, interpersonal sensitivity (SCL-90), and ineffectiveness (EDI) had the highest centrality (strength from 1...
July 31, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
Mauricio Vega-Teijido, Jorge Cantero, Maria J Rodrigo, Carolina López, Margot Paulino Zunini
The coloration of Citrus fruits is related with the concentration of carotenoids, isoprenoid pigments of 40 carbon atoms (C40 ). Rodrigo et al. (2013a) and Ma et al. (2013), reported a CCD4-type citrus dioxygenase responsible for the generation of C30 apocarotenoids providing a reddish-orange pigmentation to the peel of many mandarins and oranges. Among them, CCD4b was the first case described of a dioxygenase that cleaves carotenoids C40 in the double bond 7', 8' or 7, 8, generating β-citraurin or 8-β-apocarotenal...
July 25, 2018: Journal of Biomolecular Structure & Dynamics
Andrés Úbeda, Brayan S Zapata-Impata, Santiago T Puente, Pablo Gil, Francisco Candelas, Fernando Torres
This paper presents a system that combines computer vision and surface electromyography techniques to perform grasping tasks with a robotic hand. In order to achieve a reliable grasping action, the vision-driven system is used to compute pre-grasping poses of the robotic system based on the analysis of tridimensional object features. Then, the human operator can correct the pre-grasping pose of the robot using surface electromyographic signals from the forearm during wrist flexion and extension. Weak wrist flexions and extensions allow a fine adjustment of the robotic system to grasp the object and finally, when the operator considers that the grasping position is optimal, a strong flexion is performed to initiate the grasping of the object...
July 20, 2018: Sensors
Andrea S Rojas-Mercado, Iván E Moreno-Cortez, Raúl Lucio-Porto, Luis López Pavón
In this work, ficin extract (, >1.0 u/mg) was immobilized for the first time in poly (vinyl alcohol) (PVA) electrospun nanofibers in order to preserve its tridimensional molecular structure. The analysis of the morphology of the electrospun nanofibers was carried out using scanning electron microscopy (SEM) showing a diameter in the range of 124-194 nm. The interaction of the ficin extract with the nanofibers structure was analyzed by infrared spectroscopy (FTIR) analysis. The immobilization step was achieved through crosslinking involving the exposure to glutaraldehyde (GA) vapor...
July 18, 2018: International Journal of Biological Macromolecules
Sio-Hoi Ieng, Joao Carneiro, Marc Osswald, Ryad Benosman
3D reconstruction from multiple viewpoints is an important problem in machine vision that allows recovering tridimensional structures from multiple two-dimensional views of a given scene. Reconstructions from multiple views are conventionally achieved through a process of pixel luminance-based matching between different views. Unlike conventional machine vision methods that solve matching ambiguities by operating only on spatial constraints and luminance, this paper introduces a fully time-based solution to stereovision using the high temporal resolution of neuromorphic asynchronous event-based cameras...
2018: Frontiers in Neuroscience
Timothée Jacquesson, Carole Frindel, Gabriel Kocevar, Moncef Berhouma, Emmanuel Jouanneau, Arnaud Attyé, Francois Cotton
BACKGROUND: Diffusion imaging tractography caught the attention of the scientific community by describing the white matter architecture in vivo and noninvasively, but its application to small structures such as cranial nerves remains difficult. The few attempts to track cranial nerves presented highly variable acquisition and tracking settings. OBJECTIVE: To conduct and present a targeted review collecting all technical details and pointing out challenges and solutions in cranial nerve tractography...
July 12, 2018: Neurosurgery
Corentin Dallet, Caroline Helen Roney, Ruairidh Martin, Takeshi Kitamura, Stephane Puyo, Josselin Duchateau, Carole Dumas-Pomier, Gwladys Ravon, Laura Rachel Bear, Nicolas Derval, Frederic Sacher, Edward Vigmond, Michel Haissaguerre, Meleze Hocini, Remi Dubois
Ventricular (VT) and atrial (AT) tachycardias are some of the most common clinical cardiac arrhythmias. For ablation of tachycardia substrates, two clinical diagnosis methods are used: invasive electro-anatomical mapping for an accurate diagnosis using electrograms (EGMs) acquired with intra-cardiac catheters, and localized on the surface mesh of the studied cavities; and non-invasive electrocardiographic imaging (ECGi) for a global view of the arrhythmia, with EGMs mathematically reconstructed from body surface electrocardiograms using 3-D cardio-thoracic surface meshes obtained from CT-scans...
May 28, 2018: IEEE Transactions on Bio-medical Engineering
G Antunes, F M Simoes-de-Souza
Historically, long-term potentiation (LTP) and long-term depression (LTD), the best-characterized forms of long-term synaptic plasticity, are viewed as experience-dependent and input-specific processes. However, cumulative experimental and theoretical data have demonstrated that LTP and LTD can promote compensatory alterations in non-stimulated synapses. In this work, we have developed a computational model of a tridimensional spiny dendritic segment to investigate the role of AMPA receptor (AMPAR) trafficking during synaptic plasticity at specific synapses and its consequences for the populations of AMPAR at nearby synapses...
July 9, 2018: Scientific Reports
Milena Suemi Irie, Gustavo Davi Rabelo, Rubens Spin-Neto, Paula Dechichi, Juliana Simeão Borges, Priscilla Barbosa Ferreira Soares
Micro computed tomography (µCT) follows the same principle of computed-tomography used for patients, however providing higher-resolution. Using a non-destructive approach, samples can be scanned, and each section obtained is used to build a volume using tridimensional reconstruction. For bone analysis, it is possible to obtain information about the tissue's microarchitecture and composition. According to the characteristics of the bone sample (e.g. human or animal origin, long or irregular shape, epiphysis or diaphysis region) the pre-scanning parameters must be defined...
May 2018: Brazilian Dental Journal
Andrea Chiavenna, Alessandro Scano, Matteo Malosio, Lorenzo Molinari Tosatti, Franco Molteni
Exoskeleton devices for upper limb neurorehabilitation are one of the most exploited solutions for the recovery of lost motor functions. By providing weight support, passively compensated exoskeletons allow patients to experience upper limb training. Transparency is a desirable feature of exoskeletons that describes how the device alters free movements or interferes with spontaneous muscle patterns. A pilot study on healthy subjects was conducted to evaluate the feasibility of assessing transparency in the framework of muscle synergies...
2018: Applied Bionics and Biomechanics
Paulo H T Almeida, Sergio H Cacciacane, Fabiana M G França
Purpose: To make a comparative evaluation, by means of the finite element method, of the stress generated on supporting tissues and prosthetic system components, using zygomatic implants with the exteriorized and extramaxillary techniques, and different placement positions, associated either with inclined anterior implants, or those without inclination. Materials and methods: Eight (8) tridimensional models were created to represent the clinical situations being researched, using the dataset of scanned images of an edentulous model...
June 2018: Annals of Medicine and Surgery
Maria Helena Macedo, Francisca Araújo, Elena Martínez, Cristina Barrias, Bruno Sarmento
Intestinal cell models have been widely studied and used to evaluate absorption and metabolism of drugs in the small intestine, constituting valuable tools as a first approach to evaluate the behavior of new drugs. However, such cell models might not be able to fully predict the absorption mechanisms and metabolic pathways of the tested compounds. In recent years, induced pluripotent stem cells (iPSCs) differentiated into enterocyte-like cells have been proposed as more biorelevant intestinal models. In this review, we describe mechanisms underlying the differentiation of iPSCs into enterocyte-like cells, appraise the usefulness of these cells in tridimensional intestinal models, and discuss their suitability to be used in the future for drug screening...
August 2018: Trends in Molecular Medicine
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