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Marlene Barroso, Luis-Ernesto Arriola-Guillén, Yalil-Augusto Rodríguez-Cárdenas, Gustavo-Armando Ruíz-Mora, Maria-Eugenia Guerrero, Carlos Flores-Mir
Background: The present study was performed to compare follicle dimensions of impacted mandibular third molar (IMTM) with different impaction angulations using cone beam computed tomography (CBCT). Material and Methods: Forty-nine individuals with IMTM (24 male, 25 female) were selected. Their age range was 25-55 years. The sample was divided into three IMTM groups either vertical (n=16), mesioangular (n=18) or horizontal (n=15) position based on Winter's classification (the angle between the longitudinal axis of the second and third molars)...
August 2018: Journal of Clinical and Experimental Dentistry
David Gurpegui, Felipe Ortuño, Manuel Gurpegui
BACKGROUND: The aim of this naturalistic longitudinal study was to add evidence regarding the potential of Cloninger's temperament traits (novelty seeking, harm avoidance, reward dependence and persistence) for predicting the effect of pharmacological treatment on the rates of therapeutic response and remission. METHODS: The study was based on 200 outpatients with unipolar depressive disorders of different severity and course of illness, and extended up to 6 months of follow-up...
January 15, 2019: Journal of Affective Disorders
Ramón Fuentes, Alain Arias, María Florencia Lezcano, Diego Saravia, Gisaku Kuramochi, Pablo Navarro, Fernando José Dias
The aim of this study was to analyze the general, geometric, and kinematic characteristics of the masticatory cycle's movements in a tridimensional way, using a method developed by our study group to provide a new insight into the analysis of mandibular movements due to advancement in the potential of computational analysis. Ten individuals (20.1 ± 2.69 years), molar class I, without mandibular movement problems participated in this study. The movements of the masticatory cycles, frontal and sagittal mandibular border movements, were recorded using 3D electromagnetic articulography and processed with computational scripts developed by our research group...
2018: BioMed Research International
Michele Bellesi, Luisa de Vivo, Samuel Koebe, Giulio Tononi, Chiara Cirelli
Astrocytic glycogen represents the only form of glucose storage in the brain, and one of the outcomes of its breakdown is the production of lactate that can be used by neurons as an alternative energetic substrate. Since brain metabolism is higher in wake than in sleep, it was hypothesized that glycogen stores are depleted during wake and replenished during sleep. Furthermore, it was proposed that glycogen depletion leads to the progressive increase in adenosine levels during wake, providing a homeostatic signal that reflects the buildup of sleep pressure...
2018: Frontiers in Cellular Neuroscience
Alejandra Herrera-Morande, Victor Castro-Fernández, Felipe Merino, Cesar A Ramírez-Sarmiento, Francisco J Fernández, M Cristina Vega, Victoria Guixé
During evolution, some homologs proteins appear with different connectivity between secondary structures (different topology) but conserving the tridimensional arrangement of them (same architecture). These events can produce two types of arrangements; circular permutation or non-cyclic permutations. The first one results in the N and C terminus transferring to a different position on a protein sequence while the second refers to a more complex arrangement of the structural elements. In ribokinase superfamily, two different topologies can be identified, which are related to each other as a non-cyclic permutation occurred during the evolution...
September 12, 2018: Biochimica et biophysica acta. General subjects
Barón Zárate-Kalfópulos, Héctor R Martínez-Ríos, Francisco López-Meléndez, Carla L García-Ramos, Luis M Rosales-Olivarez, Alejandro A Reyes-Sánchez
Antecedentes: La escoliosis idiopática del adolescente se define como una deformidad tridimensional de la columna vertebral que se presenta entre los 10 y los 18 años, y que se manifiesta con una curvatura vertebral en el plano coronal mayor de 10°. Esta deformidad afecta al 2-3% de la población general, pero solo el 10% del total requerirá en algún momento tratamiento quirúrgico. El método de elección para el manejo es el uso de tornillos transpediculares y barras desrotadoras...
2018: Cirugia y Cirujanos
Raquel Garcia, Elisabete P Carreiro, João P Prates Ramalho, Anthony J Burke, João C Lima, Marco D R Gomes da Silva, Ana Maria Costa Freitas, Maria João Cabrita
This work describes the development of a new selective photocontrollable molecularly imprinted-based sorbent for the selective enrichment/pre-concentration of dimethoate from spiked olive oil samples. To achieve this goal an improved molecularly imprinted strategy relying on the embedding of a functional monomer containing an azobenzene chromophore as light-responsive element, on the crosslinked tridimensional molecular imprinted network, has been assessed. To address the mechanisms underlying template recognition and uptake/release of the analyte from the functional imprinted material, computational studies using a quantum chemical approach, have been explored...
December 4, 2018: Analytica Chimica Acta
S V Guevara Perez, G de la Rosa Castolo, L Thollon, M Behr
PURPOSE: The aim of this study was to perform an exploratory analysis of the morphological variations of mandibles at diverse states of edentulousness using tridimensional geometric morphometrics. METHODS: Twelve cadaveric mandibles were selected and divided in three groups: dentate (G1), partially edentate (G2) and totally edentate (G3). CT scans, segmentation and digital reconstruction of 3D surfaces of each specimen was made. Thirteen landmarks were defined; the measurement error was determined and 3D morphometrics exploratory analysis by principal components (PCs) and PC scores was performed...
September 6, 2018: Morphologie: Bulletin de L'Association des Anatomistes
Carlos Antônio do Nascimento Santos, Radovan Borojevic, Luiz Eurico Nasciutti, Christina M Maedatakiya
To understand the molecular mechanisms involved in gastric disorders and regeneration, we need an in vitro tridimensional (3D) culture model, which can mimic the in vivo gastric microenvironment. A 3D coculture system named gastrosphere is proposed herein, composed of primary human gastric epithelial and stromal cells. The primary cultures were obtained from endoscopic gastric biopsies, and after mechanical and enzymatic dispersion, epithelial (HGE3) and stromal (HGS12) cells were expanded. After extensive immunocytochemical characterization, cells were seeded onto 96-well round bottom plates previously covered with 1% agarose...
2018: Methods in Molecular Biology
Fábio L S Costa, Maria Elena De Lima, Suely G Figueiredo, Rafaela S Ferreira, Núbia S Prates, Tetsu Sakamoto, Carlos E Salas
Background: Lethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic, nociceptive and edematogenic activities in vivo. This work describes the cloning and molecular identification of two toxin subunits, denominated Sp-CTx-α and Sp-CTx-β, from scorpionfish venom ( Scorpaena plumieri ). Methods: The primary structures were deduced after cDNA amplification by PCR with primers from conserved sequences described in Scorpaeniformes toxins...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
Lei Ma, Jing Wan, Xiaoyan Shen
BACKGROUND: Understanding individual differences of these indexes in response to stress is important for developing effective interventions. The Tridimensional Personality Questionnaire (TPQ), which has three dimensions, may reflect such individual differences. Meanwhile, there is increasing interest in the relationship between mental stress and non-invasive markers. OBJECTIVES: We examined whether these three dimensions were associated with cognitive behavior tests and the related sAA responses...
2018: Advances in Experimental Medicine and Biology
Kleyton Torikai, Rafael Furlan de Oliveira, Davi H Starnini de Camargo, Carlos C Bof Bufon
Organic thin-film transistors (OTFTs) are an ever-growing subject of research, powering recent technologies such as flexible and wearable electronics. Currently, many studies are being carried out to push forward the state-of-the-art OTFT technology to achieve characteristics that include high carrier mobility, low power consumption, flexibility, and the ability to operate under harsh conditions. Here, we tackle this task by proposing a novel OTFT architecture exploring the so-called rolled-up nanomembrane technology to fabricate low-voltage (<2 V), ultracompact OTFTs...
August 27, 2018: Nano Letters
Daniele Cardaropoli, Lorenzo Tamagnone, Alessandro Roffredo, Andrea De Maria, Lorena Gaveglio
Alveolar ridge preservation is of great importance for successful implant therapy. This study investigated the effects of a xenogeneic tridimensional collagen matrix (CM) in conjunction with deproteinized bovine bone mineral blended with 10% collagen (DBBM-C) on the healing of 12 intact extraction sockets in the esthetic area. Cone beam computed tomograpy examinations revealed nearly stable alveolar ridge dimensions (> 90% of the ridge horizontal dimension was preserved). New bone formation of approximately 45% and adequate resorption of the grafted material were histologically observed...
2018: International Journal of Periodontics & Restorative Dentistry
Anna Urciuolo, Paolo De Coppi
Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure and composition of the extracellular matrix (ECM) are preserved. Such scaffolds retain biological activity, are biocompatible and do not show immune rejection upon allogeneic or xenogeneic transplantation...
August 14, 2018: International Journal of Molecular Sciences
Guillaume Collet, Timothée Lathion, Céline Besnard, Claude Piguet, Stéphane Petoud
We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal-organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4π-4π photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage...
August 29, 2018: Journal of the American Chemical Society
Daniel D Cavalcanti, Bárbara A Morais, Eberval G Figueiredo, Robert F Spetzler, Mark C Preul
BACKGROUND: Despite the latest developments in microsurgery, electrophysiological monitoring, and neuroimaging, the surgical management of intrinsic brainstem lesions remains challenging. Several safe entry points have been described to access the different surfaces of the brainstem. Knowledge of this entry zone anatomy is critical to performing a safe and less morbid approach. To access the anterior midbrain surface, a well-known entry point is the anterior mesencephalic (AM) zone. Our aim was to quantify surgical AM zone exposure through the orbitozygomatic (OZ) and subtemporal (ST) approaches...
August 7, 2018: World Neurosurgery
Wei-Ting Liu, Liang-Ping Zhang, Mei-Feng Zheng
The correlation between meridians and viscera is the key content of the meridian theory in acupuncture medicine. This paper introduces the close relationship between the meridians running on the body surface and viscera from ancient lite-rature, modern experimental studies (such as acupoint sensitization, neuro-endocrine-immune networks, etc.), and clinical application in the treatment of various conditions with acupuncture, moxibustion, Guasha (scraping) therapies, etc. We also presented some related research ideas (i...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Michael Green, Edith M Marom, Eli Konen, Nahum Kiryati, Arnaldo Mayer
CCTA has become an important tool for coronary arteries assessment in low and medium risk patients. However, it exposes the patient to significant radiation doses, resulting from high image quality requirements and acquisitions at multiple cardiac phases. For widespread use of CCTA for coronary assessment, significant reduction of radiation exposure with minimal image quality loss is still needed. A neural denoising scheme, relying on a fully convolutional neural network (FCNN) architecture, is developed and applied to noisy CCTA...
July 29, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
M Todd Allen
Avoidance is a common feature of post-traumatic stress disorder (PTSD) as well as anxiety and depressive disorders. Avoidance can be expressed behaviorally as well as cognitively. Most personality assessments for avoidance involve self-report inventories which are susceptible to biased responding. The avatar task (Myers et al., 2016a) was developed as an objective measure of behavioral inhibition (BI) which is defined as a tendency for avoidance of unfamiliar people and situations. The avatar task has been demonstrated to screen avoidant behaviors related to BI, PTSD, as well as harm avoidance (HA) as measured by the Tridimensional Personality Questionnaire (TPQ)...
2018: PeerJ
Jérémie Mortier, Pratik Dhakal, Andrea Volkamer
Pharmacophore models are an accurate and minimal tridimensional abstraction of intermolecular interactions between chemical structures, usually derived from a group of molecules or from a ligand-target complex. Only a limited amount of solutions exists to model comprehensive pharmacophores using the information of a particular target structure without knowledge of any binding ligand. In this work, an automated and customable tool for truly target-focused (T²F) pharmacophore modeling is introduced. Key molecular interaction fields of a macromolecular structure are calculated using the AutoGRID energy functions...
August 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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