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https://www.readbyqxmd.com/read/30557191/female-sexual-function-and-sexual-well-being-before-and-after-breast-reduction-a-pilot-cross-sectional-study-and-review-of-literature
#1
Piotr E Janik, Daria Charytonowicz, Jakub Miszczyk, Michał Charytonowicz
BACKGROUND: Breast reduction is one of the most frequently performed procedures in plastic surgery practice. Patients often undergo this procedure for not only aesthetic but also functional reasons because breast hypertrophy may hinder daily activities because of chronic spinal pain. Breast reduction has a documented impact on quality of life. However, there are only a few reports on the influence of breast reduction on sexuality. OBJECTIVE: The aim of the study was to analyze the impact of breast reduction on female sexual dysfunction and on sexual well-being...
December 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/30557169/intracranial-hemorrhage-in-children-with-inherited-bleeding-disorders-a-single-center-study-in-china
#2
Qareen Haque, Yilifan Abuduaini, Huiping Li, Jianyun Wen, Xuedong Wu, Xiaqin Feng
BACKGROUND: Intracranial hemorrhage (ICH) is a life-threatening condition in children. Inherited bleeding disorders (IBD) have high risk of ICH. AIM: This single center study aims to identify the incidence, risk factors, and neurological outcome of ICH in children who suffer from IBD. METHODS: From 2005 to 2017, 241 children with IBDs from Nanfang hospital, Department of Pediatrics, were evaluated. The ICH episodes were identified by medical history, general physical examination, detailed neurological examination, and computed tomographic or magnetic resonance imaging examination...
December 14, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30557099/prophylaxis-of-chemotherapy-induced-neutropenia-and-febrile-neutropenia-with-lipegfilgrastim-in-2489-cancer-patients-final-results-from-the-non-interventional-study-nadir
#3
Thomas Fietz, Andreas Lück, Holger Schulz, Johanna Harde, Christoph Losem, Sina Grebhardt, Thomas Wolff, Karin Potthoff, Udo Müller, Matthias Zaiss, Christian Martin Kurbacher
OBJECTIVES: The non-interventional study (NIS) NADIR (DRKS00005711) evaluated the effectiveness and safety of prophylaxis with lipegfilgrastim, a glycopegylated granulocyte-colony stimulating factor, in 2500 patients undergoing chemotherapy in routine clinical practice. Primary objective was the incidence of chemotherapy-induced severe neutropenia, febrile neutropenia (FN) and neutropenia-associated complications. METHODS: NADIR was a prospective NIS conducted in 201 study centers in Germany...
December 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30556892/99mtc-diphosphonates-bone-scintigraphy-for-vitality-evaluation-in-cleft-palate
#4
A Ballini, S Cantore, C Altini, G Dipalma, C Ferrari, A Niccoli Asabella, G Rubini, F Inchingolo
Cleft of the lip, palate and alveolus are congenital oro-maxillofacial malformation with an established treatment protocol. At present, there is great interest in the alveolar bone grafting procedures that involve the use of platelet-rich-plasma (PRP), to enhance bone formation and specifically to promote bone graft healing in head and neck tissues regeneration. The aim of this retrospective case report study was to assess the condition and viability of the standard bone grafting in association with PRP (platelet rich plasma) to enhance osteogenesis and maintain osteointegration in alveolar cleft with a follow up of eight years from the surgical procedure...
December 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30556833/dancing-dorsal-quadrilaterals-a-novel-peripherally-induced-movement-disorder
#5
Karlo J Lizarraga, Philip D Thompson, Henry P Moore, Gabriel Mizraji, Oscar S Gershanik, Carlos Singer, Anthony E Lang
Importance: Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias. Objective: To introduce and characterize the dancing dorsal quadrilaterals, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation. Design, Setting, and Participants: Between 1990 and 2015, a total of 4 patients who developed abnormal movements of the dorsal quadrilateral muscles after upper spine instrumentation were referred to movement disorders clinics at 3 academic medical centers in the United States, Canada, and Argentina...
December 17, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30556741/bevacizumab-in-refractory-higher-grade-and-atypical-meningioma-the-current-state-of-affairs
#6
Constantin A Dasanu, Juliana Alvarez-Argote, Farhad M Limonadi, Ion Codreanu
Historically, systemic agents had shown limited efficacy in meningioma, at the expense of significant pharmacologic and/or financial toxicity. As meningiomas are highly vascularized, they might derive benefit from antiangiogenic therapy. Areas covered: This review summarizes the literature regarding bevacizumab pharmacology, safety and efficacy in patients with refractory meningioma. We have searched PubMed/Medline database for pertinent articles published from inception to 1 September 2018. Expert commentary: Results of two prospective phase II trials, supported by several retrospective cohorts, suggest a clinical benefit for the vascular endothelial growth factor inhibitor bevacizumab in meningiomas refractory to surgery and radiation therapy...
December 17, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/30556658/hypothyroidism-in-young-children-following-exposure-to-iodinated-contrast-media-an-observational-study-and-a-review-of-the-literature
#7
Vered Rosenberg, Alexander Michel, Gabriel Chodick, Yingkai Cheng, Petra Palkowitsch, Gideon Koren, Varda Shalev
While it is well documented that exposure to iodinated contrast media (ICM) can interfere with thyroid function in adults, much less is known about the incidence and risk factors associated with ICM induced hypothyroidism in young children. Using a computerized database we identified 843 children who were exposed to ICM between 1998 and 2015. The incidence rate of ICM induced hypothyroidism per 1000 person-years was 9.66 (95% CI: 4.17-19.04). When compared to the rest of the cohort, children with hypothyroidism were more likely to be younger, weigh less and to have undergone cardio-angiography...
December 2018: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/30556595/the-impact-of-pediatric-atopic-dermatitis-on-families-a-review
#8
REVIEW
Eric J Yang, Kristen M Beck, Sahil Sekhon, Tina Bhutani, John Koo
BACKGROUND: Atopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well-documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance. OBJECTIVE: This literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD...
December 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/30556432/hormone-therapy-and-breast-cancer-risk-communication-and-the-perfect-storm
#9
R L Reid
Many factors are considered when a woman estimates her personal risk of breast cancer. Common to most decisions are four separate influences that have convinced the public and many health-care providers that breast cancer is the greatest concern for menopausal women and that menopausal hormone therapy (MHT) is generally responsible. Historically there have been well-documented situations in which big pharma and doctors have not put patient interests first. Conflicting reports about the safety of MHT and the media imperative to always increase readership by presenting a compelling scary story have created an underlying distrust of science, doctors, and MHT...
December 17, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30556430/strength-measurement-after-achilles-tendon-repair
#10
Henrik C Bäcker, Adrian J Yenchak, David P Trofa, J Turner Vosseller
The goal of treatment after Achilles tendon rupture (ATR) is to restore appropriate tension to the tendon, so that normal baseline strength and functional soft-tissue length can be achieved. The assessment of plantarflexion strength has shown widespread variability. The purpose of this study is to document variations in strength assessment after the treatment of ATR in the literature. A comprehensive literature review was performed. In total, 2758 articles were found on Achilles tendon rupture and Achilles tendon strength measurement...
December 17, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/30556418/diabetes-care-and-management-using-electronic-medical-records-a-systematic-review
#11
Stephanie E Lessing, Laura L Hayman
BACKGROUND: Diabetes treatment and management provide a unique opportunity for examination of the effectiveness of electronic health records (EHRs) on patient health outcomes, continuity of care, and areas for further development. This systematic literature review was designed to identify the strengths and limitations of EHR and opportunities for improvement proposed in original research and recent rigorous systematic reviews. METHODS: This review utilized methodology adapted from PRISMA...
December 17, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/30556413/adapting-project-red-to-skilled-nursing-facilities
#12
Lori L Popejoy, Amy A Vogelsmeier, Bonnie J Wakefield, Colleen M Galambos, Alexandria M Lewis, Diane Huneke, David R Mehr
This article describes our recommendation for adapting hospital-based RED (Reengineered Discharge) processes to skilled nursing facilities (SNFs). Using focus groups, the SNFs' discharge processes were assessed twice additionally, research staff then recorded field notes documenting discussions about facility discharge processes as they related to RED processes. Data were systematically analyzed using thematic analysis to identify recommendations for adapting RED to the SNF setting including (a) rapidly identifying, involving, and preparing family/caregivers to implement a patient focused SNF discharge plan; (b) reconnecting patients quickly to primary care providers; and (c) educating patients at discharge about their target health condition, medications, and impact of changes on other chronic health needs...
December 17, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/30556270/dermoscopic-pre-and-posttreatment-evaluation-in-patients-with-androgenetic-alopecia-on-platelet-rich-plasma-a-prospective-study
#13
Vinma H Shetty, Saumya Goel
BACKGROUND: Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders. OBJECTIVES: To evaluate and study the role of dermoscopy in patients with androgenetic alopecia (AGA) pre- and posttreatment with platelet-rich plasma (PRP). METHODS: It is a prospective comparative study...
December 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/30556032/mitochondrial-oxidative-stress-and-antioxidants-balance-in-fatty-liver-disease
#14
REVIEW
Carmen García-Ruiz, José C Fernández-Checa
Fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are intermediate stages of ALD and NAFLD, which can progress to more advanced forms, including cirrhosis and hepatocellular carcinoma. Oxidative stress and particularly alterations in mitochondrial function are thought to play a significant role in both ASH and NASH and recognized to contribute to the generation of reactive oxygen species (ROS), as documented in experimental models...
December 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30555934/content-analysis-of-50-clinical-negligence-claims-involving-test-results-management-systems-in-general-practice
#15
Diane Baylis, Julie Price, Paul Bowie
Background and aims: Laboratory test results management systems are a complex safety issue in primary care settings worldwide. Related failures lead to avoidable patient harm, medicolegal action, patient complaints and additional workload to problem solve identified issues. We aimed to review and learn from 50 clinical negligence cases involving system failures related to the management of test results. Methods: The Medical Protection Society database was searched and a convenience sample of 50 claims identified from a 3-year period covering 2014-2016...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/30555928/reducing-inappropriate-antibiotic-prescribing-in-upper-respiratory-tract-infection-in-a-primary-care-setting-in-kolkata-india
#16
Amy Dehn Lunn
Inappropriate antibiotic use is a key factor in the emergence of antibiotic resistance. The majority of antibiotics are prescribed in primary care, where upper respiratory tract infection (URTI) is a common presentation. Inappropriate antibiotic prescribing in URTI is common globally and has increased markedly in developing and transitional countries. Antibiotic stewardship is crucial to prevent the emergence and spread of resistant microbes. This project aimed to reduce inappropriate antibiotic prescribing in URTI in a non-governmental organisation's primary care outreach clinics in Kolkata, India, from 62...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/30555256/germline-brca1-and-brca2-deleterious-mutations-and-variants-of-unknown-clinical-significance-associated-with-breast-ovarian-cancer-a-report-from-north-india
#17
Anurag Mehta, Smreti Vasudevan, Sanjeev Kumar Sharma, Dushyant Kumar, Manoj Panigrahi, Moushumi Suryavanshi, Garima Gupta
Background: The spectrum of BRCA mutations that predispose to development of breast/ovarian cancer in Indian population remains unexplored. We report incidence and various types of pathogenic, likely pathogenic and variants of unknown significance (VUS) mutations in BRCA1 and BRCA2 genes observed at a tertiary cancer center in North India. Materials and methods: A total of 206 unrelated breast and/or ovarian cancer patients, who met the National Comprehensive Cancer Network (NCCN) guidelines for genetic testing, were screened for germline BRCA1 / BRCA 2 mutations on high-throughput sequencing platform; large genomic rearrangements were assessed by multiple ligation probe assay...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30555138/effects-of-platelet-function-on-the-haemorrhagic-manifestations-and-mortality-in-crimean-congo-haemorrhagic-fever
#18
Fazilet Duygu, Tugba Sari, Hakim Celik
Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease which can lead to life-threatening with haemorrhagic manifestations. We aimed here in this study was to evaluate the effect of the platelet count and volume-related indices, such as the mean platelet volume (MPV), platelet distribution width (PDW) which is a measure of platelet anisocytosis and plateletcrit, in the haemorrhagic manifestations and mortality seen in CCHF cases. We retrospectively examined data derived from 173 patients. The age, gender, alanine transaminase (ALT), aspartate transaminase (AST), platelet counts and MPV, PDW and PCT values upon admission (MPV1, PDW1 and PCT1) and those values measured at the time when the PLT was at the lowest level (MPV2, PDW2 and PCT2), haemorrhagic manifestations and the mortality status of patients diagnosed with CCHF were recorded...
December 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/30554880/an-integrative-care-bundle-to-prevent-surgical-site-infections-among-surgical-hip-patients-a-retrospective-cohort-study
#19
Wen Qi Mok, Mallya Jagadish Ullal, Su Su, Pok Ling Yiap, Lee Hoon Yu, Siew Ming Meliza Lim, Sin Yu Jeanice Ker, Jiexun Wang
BACKGROUND: Surgical site infections (SSIs) following hip fracture surgeries have profound clinical and economic implications. The study aims to analyze the effect of an integrative SSI prevention care bundle on the SSI incidence among surgical hip patients. The study also aims to examine the association between SSI and mortality, readmission, duration of hospitalization, and hospital cost. METHODS: A retrospective cohort study was carried out to assess the incidence of SSI in an acute hip unit in Singapore from January 2015 to September 2017...
December 14, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/30554748/effect-of-point-of-care-c-reactive-protein-testing-on-antibiotic-prescription-in-febrile-patients-attending-primary-care-in-thailand-and-myanmar-an-open-label-randomised-controlled-trial
#20
Thomas Althaus, Rachel C Greer, Myo Maung Maung Swe, Joshua Cohen, Ni Ni Tun, James Heaton, Supalert Nedsuwan, Daranee Intralawan, Nithima Sumpradit, Sabine Dittrich, Zoë Doran, Naomi Waithira, Hlaing Myat Thu, Han Win, Janjira Thaipadungpanit, Prapaporn Srilohasin, Mavuto Mukaka, Pieter W Smit, Ern Nutcha Charoenboon, Marco Johannes Haenssgen, Tri Wangrangsimakul, Stuart Blacksell, Direk Limmathurotsakul, Nicholas Day, Frank Smithuis, Yoel Lubell
BACKGROUND: In southeast Asia, antibiotic prescription in febrile patients attending primary care is common, and a probable contributor to the high burden of antimicrobial resistance. The objective of this trial was to explore whether C-reactive protein (CRP) testing at point of care could rationalise antibiotic prescription in primary care, comparing two proposed thresholds to classify CRP concentrations as low or high to guide antibiotic treatment. METHODS: We did a multicentre, open-label, randomised, controlled trial in participants aged at least 1 year with a documented fever or a chief complaint of fever (regardless of previous antibiotic intake and comorbidities other than malignancies) recruited from six public primary care units in Thailand and three primary care clinics and one outpatient department in Myanmar...
January 2019: Lancet Global Health
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